IMP: Integrative Multi-species Prediction

Saccharomyces cerevisiae

71 known processes

MSH3 (YCR092C)

Msh3p

SGD: S000000688
Entrez: 850454
UniProtKB: P25336

Process Predictions
Disease Predictions

MSH3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
meiotic mismatch repair	GO:0000710	9	0.738
mismatch repair	GO:0006298	14	0.658
dna repair	GO:0006281	236	0.624
intracellular signal transduction	GO:0035556	112	0.557
dna recombination	GO:0006310	172	0.480
signal transduction	GO:0007165	208	0.410
single organism signaling	GO:0044700	208	0.374
meiotic cell cycle process	GO:1903046	229	0.354
dna biosynthetic process	GO:0071897	33	0.354
mitotic recombination	GO:0006312	55	0.353
meiotic cell cycle	GO:0051321	272	0.341
cellular nitrogen compound catabolic process	GO:0044270	494	0.330
chromatin silencing at silent mating type cassette	GO:0030466	53	0.328
nucleotide excision repair	GO:0006289	50	0.299
nucleic acid phosphodiester bond hydrolysis	GO:0090305	194	0.299
organic cyclic compound catabolic process	GO:1901361	499	0.281
cell communication	GO:0007154	345	0.270
rna catabolic process	GO:0006401	118	0.266
cellular response to dna damage stimulus	GO:0006974	287	0.260
negative regulation of nitrogen compound metabolic process	GO:0051172	300	0.254	Human
organelle fission	GO:0048285	272	0.253
signaling	GO:0023052	208	0.235
postreplication repair	GO:0006301	24	0.235
nucleobase containing compound catabolic process	GO:0034655	479	0.231
heterocycle catabolic process	GO:0046700	494	0.226
aromatic compound catabolic process	GO:0019439	491	0.220
cellular macromolecule catabolic process	GO:0044265	363	0.218
meiotic nuclear division	GO:0007126	163	0.217
meiosis i	GO:0007127	92	0.201
ribonucleoside monophosphate metabolic process	GO:0009161	265	0.185
non recombinational repair	GO:0000726	33	0.166
double strand break repair	GO:0006302	105	0.166
negative regulation of cellular metabolic process	GO:0031324	407	0.163	Human
negative regulation of macromolecule metabolic process	GO:0010605	375	0.157	Human
purine nucleoside monophosphate metabolic process	GO:0009126	262	0.153
nuclear division	GO:0000280	263	0.150
regulation of catalytic activity	GO:0050790	307	0.150	Human
negative regulation of nucleobase containing compound metabolic process	GO:0045934	295	0.148	Human
atp metabolic process	GO:0046034	251	0.146
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	289	0.144
ribonucleoside metabolic process	GO:0009119	389	0.140
positive regulation of hydrolase activity	GO:0051345	112	0.137	Human
macromolecule catabolic process	GO:0009057	383	0.127
response to abiotic stimulus	GO:0009628	159	0.126
single organism developmental process	GO:0044767	258	0.118
regulation of biological quality	GO:0065008	391	0.113
dna replication	GO:0006260	147	0.112
negative regulation of biosynthetic process	GO:0009890	312	0.109
dna catabolic process endonucleolytic	GO:0000737	31	0.109
carbohydrate derivative metabolic process	GO:1901135	549	0.108
positive regulation of rna biosynthetic process	GO:1902680	286	0.106
dna catabolic process	GO:0006308	42	0.101
chromosome segregation	GO:0007059	159	0.098
purine ribonucleoside catabolic process	GO:0046130	330	0.098
organophosphate catabolic process	GO:0046434	338	0.097
positive regulation of nucleobase containing compound metabolic process	GO:0045935	409	0.095
regulation of signal transduction	GO:0009966	114	0.094
negative regulation of macromolecule biosynthetic process	GO:0010558	291	0.092
nucleoside triphosphate catabolic process	GO:0009143	329	0.091
cell differentiation	GO:0030154	161	0.090
glycosyl compound metabolic process	GO:1901657	398	0.089
nuclear transcribed mrna catabolic process	GO:0000956	89	0.088
nucleobase containing small molecule metabolic process	GO:0055086	491	0.088
protein complex biogenesis	GO:0070271	314	0.085
dna strand elongation	GO:0022616	29	0.084
dna conformation change	GO:0071103	98	0.082
nuclear transcribed mrna catabolic process deadenylation dependent decay	GO:0000288	44	0.081
lagging strand elongation	GO:0006273	10	0.080
maintenance of dna repeat elements	GO:0043570	20	0.080	Human
programmed cell death	GO:0012501	30	0.080
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	252	0.080
nucleoside triphosphate metabolic process	GO:0009141	364	0.079
gene silencing	GO:0016458	151	0.079
regulation of hydrolase activity	GO:0051336	133	0.078	Human
positive regulation of transcription dna templated	GO:0045893	286	0.075
nucleoside catabolic process	GO:0009164	335	0.072
cellular developmental process	GO:0048869	191	0.071
protein complex assembly	GO:0006461	302	0.071
positive regulation of macromolecule biosynthetic process	GO:0010557	325	0.070
negative regulation of nucleic acid templated transcription	GO:1903507	260	0.070
gene conversion at mating type locus	GO:0007534	11	0.069
purine ribonucleotide metabolic process	GO:0009150	372	0.069
purine ribonucleoside monophosphate metabolic process	GO:0009167	262	0.068
single organism catabolic process	GO:0044712	619	0.068
negative regulation of rna metabolic process	GO:0051253	262	0.068
regulation of molecular function	GO:0065009	320	0.068	Human
gene conversion	GO:0035822	14	0.067
organophosphate metabolic process	GO:0019637	597	0.067
negative regulation of gene expression	GO:0010629	312	0.067
ribonucleoside triphosphate catabolic process	GO:0009203	327	0.067
purine ribonucleoside triphosphate catabolic process	GO:0009207	327	0.067
nucleotide catabolic process	GO:0009166	330	0.066
telomere organization	GO:0032200	75	0.065
reproduction of a single celled organism	GO:0032505	191	0.064
mrna catabolic process	GO:0006402	93	0.063
ribose phosphate metabolic process	GO:0019693	384	0.063
positive regulation of nucleic acid templated transcription	GO:1903508	286	0.063
purine nucleoside metabolic process	GO:0042278	380	0.062
rna 3 end processing	GO:0031123	88	0.061
purine ribonucleotide catabolic process	GO:0009154	327	0.061
oxidative phosphorylation	GO:0006119	26	0.060
dna geometric change	GO:0032392	43	0.060
mrna processing	GO:0006397	185	0.060
regulation of transcription from rna polymerase ii promoter	GO:0006357	394	0.059
organonitrogen compound biosynthetic process	GO:1901566	314	0.057
nucleotide metabolic process	GO:0009117	453	0.057
nucleoside phosphate catabolic process	GO:1901292	331	0.057
ribonucleotide catabolic process	GO:0009261	327	0.056
purine ribonucleoside metabolic process	GO:0046128	380	0.056
purine containing compound metabolic process	GO:0072521	400	0.056
purine nucleoside triphosphate metabolic process	GO:0009144	356	0.056
meiotic chromosome segregation	GO:0045132	31	0.056
purine nucleotide catabolic process	GO:0006195	328	0.055
homeostatic process	GO:0042592	227	0.055
negative regulation of rna biosynthetic process	GO:1902679	260	0.055
regulation of cellular component organization	GO:0051128	334	0.055
positive regulation of nitrogen compound metabolic process	GO:0051173	412	0.054
response to uv	GO:0009411	4	0.054
positive regulation of cellular biosynthetic process	GO:0031328	336	0.053
negative regulation of dna metabolic process	GO:0051053	36	0.053	Human
nuclear transport	GO:0051169	165	0.052
double strand break repair via single strand annealing	GO:0045002	7	0.052
mating type switching	GO:0007533	28	0.052
positive regulation of biosynthetic process	GO:0009891	336	0.052
nucleoside monophosphate metabolic process	GO:0009123	267	0.052
positive regulation of catalytic activity	GO:0043085	178	0.051	Human
reproductive process in single celled organism	GO:0022413	145	0.051
ribonucleoside catabolic process	GO:0042454	332	0.050
dna dependent dna replication	GO:0006261	115	0.050
regulation of intracellular signal transduction	GO:1902531	78	0.050
purine nucleoside catabolic process	GO:0006152	330	0.049
purine ribonucleoside triphosphate metabolic process	GO:0009205	354	0.049
regulation of cell communication	GO:0010646	124	0.049
organic acid metabolic process	GO:0006082	352	0.049
carboxylic acid biosynthetic process	GO:0046394	152	0.048
response to chemical	GO:0042221	390	0.047
negative regulation of transcription dna templated	GO:0045892	258	0.047
regulation of protein metabolic process	GO:0051246	237	0.046
cell fate commitment	GO:0045165	32	0.045
mrna 3 end processing	GO:0031124	54	0.044
regulation of organelle organization	GO:0033043	243	0.044
glycosyl compound catabolic process	GO:1901658	335	0.044
atp catabolic process	GO:0006200	224	0.044
nucleoside metabolic process	GO:0009116	394	0.043
carbohydrate derivative catabolic process	GO:1901136	339	0.042
mrna metabolic process	GO:0016071	269	0.042
actin filament based process	GO:0030029	104	0.042
positive regulation of rna metabolic process	GO:0051254	294	0.042
protein deacetylation	GO:0006476	26	0.042
chemical homeostasis	GO:0048878	137	0.041
positive regulation of macromolecule metabolic process	GO:0010604	394	0.041
regulation of protein modification process	GO:0031399	110	0.041
regulation of response to stimulus	GO:0048583	157	0.041
death	GO:0016265	30	0.039
purine ribonucleoside monophosphate catabolic process	GO:0009169	224	0.039
cellular homeostasis	GO:0019725	138	0.039
telomere maintenance	GO:0000723	74	0.039
mitotic cell cycle	GO:0000278	306	0.039
purine nucleoside triphosphate catabolic process	GO:0009146	329	0.039
cell death	GO:0008219	30	0.039
negative regulation of cellular biosynthetic process	GO:0031327	312	0.038
organonitrogen compound catabolic process	GO:1901565	404	0.038
synapsis	GO:0007129	19	0.037
chromatin silencing	GO:0006342	147	0.037
rna dependent dna replication	GO:0006278	25	0.037
endosomal transport	GO:0016197	86	0.037
regulation of dna recombination	GO:0000018	24	0.037	Human
regulation of cellular component biogenesis	GO:0044087	112	0.036
positive regulation of gene expression	GO:0010628	321	0.036
regulation of signaling	GO:0023051	119	0.036
dna duplex unwinding	GO:0032508	42	0.036
ribonucleoside triphosphate metabolic process	GO:0009199	356	0.036
positive regulation of molecular function	GO:0044093	185	0.035	Human
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	137	0.035
nucleoside monophosphate catabolic process	GO:0009125	224	0.035
purine containing compound catabolic process	GO:0072523	332	0.035
purine nucleoside monophosphate catabolic process	GO:0009128	224	0.035
nucleoside phosphate metabolic process	GO:0006753	458	0.033
negative regulation of signal transduction	GO:0009968	30	0.033
regulation of phosphorus metabolic process	GO:0051174	230	0.033
heteroduplex formation	GO:0030491	9	0.033
regulation of phosphate metabolic process	GO:0019220	230	0.032
regulation of dna metabolic process	GO:0051052	100	0.032	Human
translesion synthesis	GO:0019985	16	0.032
nitrogen compound transport	GO:0071705	212	0.032
generation of precursor metabolites and energy	GO:0006091	147	0.032
nucleocytoplasmic transport	GO:0006913	163	0.032
nuclear export	GO:0051168	124	0.032
ribonucleotide metabolic process	GO:0009259	377	0.031
nucleus organization	GO:0006997	62	0.031
mitotic cell cycle process	GO:1903047	294	0.031
dna strand elongation involved in dna replication	GO:0006271	26	0.031
establishment of protein localization	GO:0045184	367	0.030
single organism nuclear import	GO:1902593	56	0.030
reciprocal dna recombination	GO:0035825	54	0.029
nucleobase containing compound transport	GO:0015931	124	0.029
negative regulation of intracellular signal transduction	GO:1902532	27	0.029
cell wall organization or biogenesis	GO:0071554	190	0.029
apoptotic process	GO:0006915	30	0.028
establishment of organelle localization	GO:0051656	96	0.028
cytoskeleton organization	GO:0007010	230	0.028
regulation of small gtpase mediated signal transduction	GO:0051056	47	0.028
ras protein signal transduction	GO:0007265	29	0.028
vacuole organization	GO:0007033	75	0.028
cell cycle g1 s phase transition	GO:0044843	64	0.028
reciprocal meiotic recombination	GO:0007131	54	0.028
g1 s transition of mitotic cell cycle	GO:0000082	64	0.028
phosphorylation	GO:0016310	291	0.027
chromatin organization	GO:0006325	242	0.027
organelle localization	GO:0051640	128	0.027
protein deacylation	GO:0035601	27	0.027
telomere maintenance via recombination	GO:0000722	32	0.027
nuclear transcribed mrna poly a tail shortening	GO:0000289	14	0.026
negative regulation of mitotic cell cycle phase transition	GO:1901991	57	0.026
mitotic nuclear division	GO:0007067	131	0.026
regulation of ras protein signal transduction	GO:0046578	47	0.025
mating type determination	GO:0007531	32	0.024
cellular protein complex assembly	GO:0043623	209	0.024
regulation of mitotic cell cycle	GO:0007346	107	0.024
protein targeting to nucleus	GO:0044744	57	0.024
oxoacid metabolic process	GO:0043436	351	0.024
macromolecule methylation	GO:0043414	85	0.024
mitotic cell cycle checkpoint	GO:0007093	56	0.023
chromatin silencing at telomere	GO:0006348	84	0.023
establishment of rna localization	GO:0051236	92	0.023
cellular amino acid biosynthetic process	GO:0008652	118	0.023
regulation of gene expression epigenetic	GO:0040029	147	0.023
ribonucleoside monophosphate catabolic process	GO:0009158	224	0.023
response to external stimulus	GO:0009605	158	0.023
negative regulation of cell cycle process	GO:0010948	86	0.022
chromatin modification	GO:0016568	200	0.022
anion transport	GO:0006820	145	0.022
negative regulation of gene expression epigenetic	GO:0045814	147	0.022
regulation of translation	GO:0006417	89	0.021
telomere maintenance via telomerase	GO:0007004	21	0.021
negative regulation of response to stimulus	GO:0048585	40	0.021
cellular lipid metabolic process	GO:0044255	229	0.020
sex determination	GO:0007530	32	0.020
ion homeostasis	GO:0050801	118	0.020
growth	GO:0040007	157	0.019
response to organic cyclic compound	GO:0014070	1	0.019
chromosome organization involved in meiosis	GO:0070192	32	0.019
double strand break repair via nonhomologous end joining	GO:0006303	27	0.019
ion transport	GO:0006811	274	0.019
cell surface receptor signaling pathway	GO:0007166	38	0.019
rna export from nucleus	GO:0006405	88	0.019
organelle assembly	GO:0070925	118	0.019
small gtpase mediated signal transduction	GO:0007264	36	0.019
negative regulation of cellular protein metabolic process	GO:0032269	85	0.018
methylation	GO:0032259	101	0.018
cell division	GO:0051301	205	0.018
single organism membrane fusion	GO:0044801	71	0.018
amine metabolic process	GO:0009308	51	0.018
protein localization to organelle	GO:0033365	337	0.018
regulation of purine nucleotide catabolic process	GO:0033121	106	0.018
endocytosis	GO:0006897	90	0.018
cellular response to chemical stimulus	GO:0070887	315	0.018
negative regulation of signaling	GO:0023057	30	0.018
response to starvation	GO:0042594	96	0.017
developmental process	GO:0032502	261	0.017
purine nucleotide metabolic process	GO:0006163	376	0.017
small molecule biosynthetic process	GO:0044283	258	0.017
regulation of cellular protein metabolic process	GO:0032268	232	0.017
cellular response to abiotic stimulus	GO:0071214	62	0.017
protein dna complex assembly	GO:0065004	105	0.017
chromosome localization	GO:0050000	20	0.017
anatomical structure homeostasis	GO:0060249	74	0.016
hexose metabolic process	GO:0019318	78	0.016
negative regulation of cell cycle phase transition	GO:1901988	59	0.016
protein phosphorylation	GO:0006468	197	0.016
histone deacetylation	GO:0016575	26	0.016
positive regulation of phosphorus metabolic process	GO:0010562	147	0.016
cellular response to extracellular stimulus	GO:0031668	150	0.016
negative regulation of protein metabolic process	GO:0051248	85	0.016
base excision repair	GO:0006284	14	0.016
organic acid catabolic process	GO:0016054	71	0.016
positive regulation of programmed cell death	GO:0043068	3	0.016
regulation of purine nucleotide metabolic process	GO:1900542	109	0.016
error free translesion synthesis	GO:0070987	9	0.015
positive regulation of apoptotic process	GO:0043065	3	0.015
double strand break repair via break induced replication	GO:0000727	25	0.015
regulation of cell cycle	GO:0051726	195	0.015
mitotic dna integrity checkpoint	GO:0044774	18	0.015
protein localization to nucleus	GO:0034504	74	0.015
carboxylic acid metabolic process	GO:0019752	338	0.015
cellular amide metabolic process	GO:0043603	59	0.015
covalent chromatin modification	GO:0016569	119	0.015
macromolecule deacylation	GO:0098732	27	0.014
error prone translesion synthesis	GO:0042276	11	0.014
lipid metabolic process	GO:0006629	269	0.014
regulation of meiosis i	GO:0060631	14	0.014
rna phosphodiester bond hydrolysis	GO:0090501	112	0.014
reproductive process	GO:0022414	248	0.014
mrna splicing via spliceosome	GO:0000398	108	0.014
peroxisome organization	GO:0007031	68	0.014
dna integrity checkpoint	GO:0031570	41	0.014
cellular response to organic substance	GO:0071310	159	0.014
regulation of cellular catabolic process	GO:0031329	195	0.014
negative regulation of cellular component organization	GO:0051129	109	0.014
regulation of catabolic process	GO:0009894	199	0.013
telomere capping	GO:0016233	10	0.013
telomere maintenance via telomere lengthening	GO:0010833	22	0.013
negative regulation of dna recombination	GO:0045910	13	0.013	Human
cellular response to heat	GO:0034605	53	0.013
endomembrane system organization	GO:0010256	74	0.013
posttranscriptional regulation of gene expression	GO:0010608	115	0.013
cellular chemical homeostasis	GO:0055082	123	0.013
nuclear import	GO:0051170	57	0.013
organophosphate ester transport	GO:0015748	45	0.013
positive regulation of cellular component organization	GO:0051130	116	0.013
vesicle mediated transport	GO:0016192	335	0.012
positive regulation of cell death	GO:0010942	3	0.012
cellular response to external stimulus	GO:0071496	150	0.012
cellular ion homeostasis	GO:0006873	112	0.012
mitotic sister chromatid segregation	GO:0000070	85	0.012
posttranscriptional tethering of rna polymerase ii gene dna at nuclear periphery	GO:0000973	16	0.012
regulation of nucleoside metabolic process	GO:0009118	106	0.012
single organism cellular localization	GO:1902580	375	0.012
sister chromatid cohesion	GO:0007062	49	0.012
dna replication removal of rna primer	GO:0043137	5	0.012
regulation of gtpase activity	GO:0043087	84	0.012
gtp metabolic process	GO:0046039	107	0.012
mitochondrial genome maintenance	GO:0000002	40	0.012
alpha amino acid metabolic process	GO:1901605	124	0.012
energy derivation by oxidation of organic compounds	GO:0015980	125	0.012
anion transmembrane transport	GO:0098656	79	0.012
spindle organization	GO:0007051	37	0.012
histone modification	GO:0016570	119	0.012
organic acid biosynthetic process	GO:0016053	152	0.012
multi organism reproductive process	GO:0044703	216	0.012
mrna export from nucleus	GO:0006406	60	0.011
positive regulation of cellular protein metabolic process	GO:0032270	89	0.011
translation	GO:0006412	230	0.011
negative regulation of organelle organization	GO:0010639	103	0.011
response to osmotic stress	GO:0006970	83	0.011
multi organism process	GO:0051704	233	0.011
rna phosphodiester bond hydrolysis endonucleolytic	GO:0090502	79	0.011
coenzyme metabolic process	GO:0006732	104	0.011
regulation of chromatin silencing	GO:0031935	39	0.011
small molecule catabolic process	GO:0044282	88	0.011
regulation of nucleotide metabolic process	GO:0006140	110	0.011
response to oxidative stress	GO:0006979	99	0.011
ion transmembrane transport	GO:0034220	200	0.011
vacuolar transport	GO:0007034	145	0.011
maintenance of location	GO:0051235	66	0.011
rna localization	GO:0006403	112	0.011
response to heat	GO:0009408	69	0.011
negative regulation of cell communication	GO:0010648	33	0.011
regulation of transport	GO:0051049	85	0.011
cellular response to osmotic stress	GO:0071470	50	0.011
developmental process involved in reproduction	GO:0003006	159	0.011
dna replication okazaki fragment processing	GO:0033567	7	0.011
fungal type cell wall organization or biogenesis	GO:0071852	169	0.011
cellular modified amino acid metabolic process	GO:0006575	51	0.010
monosaccharide metabolic process	GO:0005996	83	0.010
positive regulation of cytoplasmic transport	GO:1903651	4	0.010
cellular biogenic amine metabolic process	GO:0006576	37	0.010
cellular amino acid catabolic process	GO:0009063	48	0.010
sulfur compound biosynthetic process	GO:0044272	53	0.010
sexual reproduction	GO:0019953	216	0.010

MSH3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.035
disease of anatomical entity	DOID:7	0.033
cancer	DOID:162	0.017
organ system cancer	DOID:0050686	0.017
inherited metabolic disorder	DOID:655	0.011
disease of metabolism	DOID:0014667	0.011

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