IMP: Integrative Multi-species Prediction

Drosophila melanogaster

147 known processes

Sir2 (Dmel_CG5216)

CG5216 gene product from transcript CG5216-RA

(Aliases: sir2,BEST:LD38188,Dmel\CG5216,CG5216,dSir2,l(2)05326,dSIR2,SIR2,Sir2L,D.mel1,dsir2,dmSRT406,DSir2)

Entrez: 34708
FLYBASE: FBgn0024291
UniProtKB: Q9VK34

Process Predictions
Disease Predictions

Sir2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
chromatin organization	GO:0006325	207	1.000
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.998
chromosome organization	GO:0051276	360	0.998
negative regulation of cellular biosynthetic process	GO:0031327	277	0.996
negative regulation of rna biosynthetic process	GO:1902679	240	0.994
chromatin silencing	GO:0006342	76	0.992
histone modification	GO:0016570	106	0.992
negative regulation of biosynthetic process	GO:0009890	277	0.991
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.988
negative regulation of gene expression epigenetic	GO:0045814	77	0.977
chromatin modification	GO:0016568	147	0.969
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.968
response to organic substance	GO:0010033	284	0.968
gene silencing	GO:0016458	138	0.967
regulation of gene expression epigenetic	GO:0040029	128	0.962
negative regulation of rna metabolic process	GO:0051253	251	0.957
negative regulation of gene expression	GO:0010629	387	0.955
cellular response to chemical stimulus	GO:0070887	199	0.953	Human Mouse
cellular catabolic process	GO:0044248	372	0.948	Human Mouse
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.937
intracellular signal transduction	GO:0035556	300	0.932	Human Mouse
histone acetylation	GO:0016573	38	0.928
negative regulation of cell communication	GO:0010648	223	0.927	Human Mouse
negative regulation of cellular metabolic process	GO:0031324	382	0.911
regulation of organelle organization	GO:0033043	196	0.907
response to oxygen containing compound	GO:1901700	200	0.902
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.846	Human Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.842	Human Mouse
covalent chromatin modification	GO:0016569	106	0.840
negative regulation of transcription dna templated	GO:0045892	237	0.839
protein acetylation	GO:0006473	39	0.815
protein acylation	GO:0043543	42	0.815
positive regulation of rna metabolic process	GO:0051254	271	0.813	Human Mouse
positive regulation of response to stimulus	GO:0048584	323	0.794
negative regulation of signaling	GO:0023057	219	0.785	Human Mouse
peptidyl lysine acetylation	GO:0018394	39	0.772
positive regulation of cellular biosynthetic process	GO:0031328	316	0.771	Human Mouse
peptidyl amino acid modification	GO:0018193	105	0.764
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.754	Human Mouse
single organism cellular localization	GO:1902580	180	0.745	Human
regulation of cellular response to stress	GO:0080135	89	0.744	Human Mouse
muscle structure development	GO:0061061	224	0.720
regulation of cell differentiation	GO:0045595	302	0.713	Mouse
positive regulation of macromolecule metabolic process	GO:0010604	405	0.707	Human Mouse
cell death	GO:0008219	279	0.698
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.677	Human Mouse
positive regulation of autophagy	GO:0010508	21	0.664	Human Mouse
protein localization to organelle	GO:0033365	82	0.663	Human
transcription from rna polymerase ii promoter	GO:0006366	368	0.662	Human Mouse
growth	GO:0040007	359	0.645	Human
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.618
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.606	Human Mouse
positive regulation of organelle organization	GO:0010638	65	0.601	Human
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.581	Human Mouse
response to endogenous stimulus	GO:0009719	119	0.572	Human Mouse
determination of adult lifespan	GO:0008340	137	0.550
regulation of cell cycle process	GO:0010564	181	0.547
negative regulation of signal transduction	GO:0009968	206	0.547	Human Mouse
intracellular transport	GO:0046907	228	0.537	Human
cellular response to dna damage stimulus	GO:0006974	223	0.525	Human Mouse
regulation of cell development	GO:0060284	215	0.521
protein localization to nucleus	GO:0034504	55	0.517	Human
heterocycle catabolic process	GO:0046700	166	0.516	Human
negative regulation of neuron death	GO:1901215	18	0.513	Mouse
jnk cascade	GO:0007254	50	0.512
positive regulation of transcription dna templated	GO:0045893	266	0.512	Human Mouse
regionalization	GO:0003002	416	0.504
cellular response to starvation	GO:0009267	61	0.495	Human Mouse
regulation of apoptotic process	GO:0042981	130	0.495
catabolic process	GO:0009056	409	0.494	Human Mouse
cellular macromolecule localization	GO:0070727	220	0.484	Human
regulation of response to stress	GO:0080134	200	0.456	Human Mouse
protein localization to chromatin	GO:0071168	3	0.433
response to alcohol	GO:0097305	95	0.423
regulation of intracellular signal transduction	GO:1902531	236	0.416	Human Mouse
cellular protein localization	GO:0034613	160	0.406	Human
internal peptidyl lysine acetylation	GO:0018393	38	0.398
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	11	0.392	Human Mouse
cellular response to ionizing radiation	GO:0071479	15	0.381	Mouse
regulation of catabolic process	GO:0009894	170	0.375	Human Mouse
internal protein amino acid acetylation	GO:0006475	38	0.371
cell type specific apoptotic process	GO:0097285	38	0.366	Mouse
regulation of chromosome organization	GO:0033044	64	0.366
regulation of histone modification	GO:0031056	20	0.365
cell migration	GO:0016477	238	0.355
cellular protein modification process	GO:0006464	438	0.352
response to nitrogen compound	GO:1901698	90	0.344	Human Mouse
positive regulation of gene expression	GO:0010628	290	0.339	Human Mouse
positive regulation of biosynthetic process	GO:0009891	316	0.337	Human Mouse
response to organonitrogen compound	GO:0010243	75	0.330	Human Mouse
male gamete generation	GO:0048232	201	0.327	Mouse
positive regulation of developmental process	GO:0051094	143	0.317	Human
heterochromatin organization	GO:0070828	25	0.313
spindle organization	GO:0007051	253	0.309
response to organic cyclic compound	GO:0014070	89	0.299	Human
regulation of anatomical structure morphogenesis	GO:0022603	242	0.289
response to ionizing radiation	GO:0010212	32	0.289	Mouse
regulation of cell death	GO:0010941	173	0.287
establishment of protein localization	GO:0045184	163	0.274	Human
immune response	GO:0006955	246	0.266	Human
negative regulation of cell differentiation	GO:0045596	143	0.263	Mouse
protein modification process	GO:0036211	438	0.263
eye morphogenesis	GO:0048592	260	0.258
dna damage checkpoint	GO:0000077	78	0.257
regulation of autophagy	GO:0010506	62	0.248	Human Mouse
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.248	Human Mouse
peptidyl lysine modification	GO:0018205	57	0.248
cellular response to insulin stimulus	GO:0032869	28	0.238	Human
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.236	Mouse
protein targeting	GO:0006605	64	0.223	Human
cellular response to nutrient levels	GO:0031669	62	0.215	Human Mouse
autophagy	GO:0006914	108	0.212	Human Mouse
stress activated mapk cascade	GO:0051403	52	0.209
response to lipid	GO:0033993	38	0.207	Human
histone h4 k16 acetylation	GO:0043984	4	0.205
regulation of stress activated mapk cascade	GO:0032872	41	0.203
positive regulation of catabolic process	GO:0009896	105	0.203	Human Mouse
regulation of growth	GO:0040008	233	0.200	Human
positive regulation of phosphorus metabolic process	GO:0010562	139	0.199	Human Mouse
protein complex biogenesis	GO:0070271	201	0.199
death	GO:0016265	284	0.199
localization of cell	GO:0051674	257	0.196
regulation of cellular ketone metabolic process	GO:0010565	3	0.193	Mouse
macromolecular complex assembly	GO:0065003	256	0.188
regulation of multicellular organismal development	GO:2000026	414	0.186
adult behavior	GO:0030534	137	0.181
regulation of cellular catabolic process	GO:0031329	157	0.181	Human Mouse
organelle fission	GO:0048285	340	0.180
cellular macromolecular complex assembly	GO:0034622	153	0.176
regulation of protein metabolic process	GO:0051246	256	0.174
positive regulation of multicellular organismal process	GO:0051240	143	0.168
positive regulation of rna biosynthetic process	GO:1902680	266	0.167	Human Mouse
camera type eye morphogenesis	GO:0048593	2	0.163
response to extracellular stimulus	GO:0009991	116	0.161
response to bacterium	GO:0009617	198	0.159
positive regulation of response to external stimulus	GO:0032103	44	0.158	Human Mouse
regulation of cellular amino acid metabolic process	GO:0006521	0	0.154
response to abiotic stimulus	GO:0009628	341	0.154	Human Mouse
regulation of histone acetylation	GO:0035065	7	0.152
response to sterol	GO:0036314	34	0.151
protein targeting to nucleus	GO:0044744	51	0.151	Human
single organism catabolic process	GO:0044712	228	0.150	Human Mouse
stress activated protein kinase signaling cascade	GO:0031098	55	0.150
regulation of chromatin organization	GO:1902275	32	0.147
protein transport	GO:0015031	155	0.147	Human
regulation of cell cycle phase transition	GO:1901987	130	0.145
regulation of chromatin modification	GO:1903308	28	0.144
single organism behavior	GO:0044708	391	0.143
purine nucleoside catabolic process	GO:0006152	112	0.140
male pronucleus assembly	GO:0035039	6	0.139
positive regulation of multicellular organism growth	GO:0040018	21	0.138
negative regulation of programmed cell death	GO:0043069	72	0.137	Human Mouse
negative regulation of apoptotic process	GO:0043066	63	0.132	Human Mouse
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.132
negative regulation of organelle organization	GO:0010639	56	0.130
protein localization	GO:0008104	284	0.129	Human
regulation of immune system process	GO:0002682	176	0.127	Human
eye development	GO:0001654	323	0.126
positive regulation of macroautophagy	GO:0016239	8	0.125	Human Mouse
regulation of cellular amine metabolic process	GO:0033238	3	0.125
organic substance catabolic process	GO:1901575	308	0.124	Human
positive regulation of multi organism process	GO:0043902	40	0.122
dna packaging	GO:0006323	91	0.122
purine ribonucleotide catabolic process	GO:0009154	109	0.118
response to other organism	GO:0051707	293	0.117
rhythmic process	GO:0048511	106	0.116	Human Mouse
cell motility	GO:0048870	251	0.115
regulation of phosphorylation	GO:0042325	147	0.114	Human Mouse
regulation of jnk cascade	GO:0046328	40	0.112
cellular macromolecule catabolic process	GO:0044265	136	0.111	Human
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.110
regulation of dna metabolic process	GO:0051052	34	0.110	Human
regulation of notch signaling pathway	GO:0008593	100	0.109
dna metabolic process	GO:0006259	227	0.107	Human Mouse
photoreceptor cell differentiation	GO:0046530	170	0.106
dna integrity checkpoint	GO:0031570	81	0.106
developmental growth	GO:0048589	280	0.104
positive regulation of cellular catabolic process	GO:0031331	95	0.100	Human Mouse
establishment of localization in cell	GO:0051649	402	0.099	Human
epithelial cell differentiation	GO:0030855	322	0.098
positive regulation of immune response	GO:0050778	63	0.098	Human
stem cell maintenance	GO:0019827	67	0.097
cellular response to organic substance	GO:0071310	132	0.096	Human Mouse
regulation of programmed cell death	GO:0043067	152	0.096
regulation of neuron death	GO:1901214	26	0.094	Mouse
nucleoside triphosphate metabolic process	GO:0009141	120	0.092
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.091	Mouse
nucleobase containing compound catabolic process	GO:0034655	165	0.090	Human
pigmentation	GO:0043473	75	0.090
negative regulation of cellular component organization	GO:0051129	108	0.089
chromatin remodeling	GO:0006338	72	0.089	Human
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.088
positive regulation of cell communication	GO:0010647	250	0.087	Human Mouse
mitotic nuclear division	GO:0007067	213	0.087
dendrite morphogenesis	GO:0048813	199	0.086
rna catabolic process	GO:0006401	37	0.086
regulation of cellular component biogenesis	GO:0044087	201	0.086
cellular ketone metabolic process	GO:0042180	24	0.085	Mouse
macroautophagy	GO:0016236	42	0.085	Human Mouse
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	26	0.082
macromolecule catabolic process	GO:0009057	161	0.082	Human
response to external biotic stimulus	GO:0043207	293	0.082
embryonic morphogenesis	GO:0048598	206	0.081
negative regulation of chromatin silencing	GO:0031936	9	0.080
protein complex assembly	GO:0006461	200	0.080
regulation of response to external stimulus	GO:0032101	115	0.079	Human Mouse
regulation of chromatin silencing	GO:0031935	36	0.078	Human
multicellular organism growth	GO:0035264	46	0.078
nucleotide catabolic process	GO:0009166	109	0.077
regulation of phosphorus metabolic process	GO:0051174	210	0.077	Human Mouse
glial cell differentiation	GO:0010001	35	0.076
signal transduction by phosphorylation	GO:0023014	107	0.075
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.075
regulation of cell cycle	GO:0051726	291	0.074	Human
myotube differentiation	GO:0014902	46	0.074
sex differentiation	GO:0007548	81	0.073	Mouse
heterochromatin organization involved in chromatin silencing	GO:0070868	9	0.073
reproductive structure development	GO:0048608	74	0.073	Mouse
establishment of protein localization to organelle	GO:0072594	62	0.072	Human
programmed cell death	GO:0012501	257	0.072
vesicle mediated transport	GO:0016192	381	0.071
response to starvation	GO:0042594	97	0.071	Human Mouse
purine ribonucleotide metabolic process	GO:0009150	145	0.070
mapk cascade	GO:0000165	107	0.069
intracellular protein transport	GO:0006886	104	0.069	Human
regulation of multicellular organism growth	GO:0040014	40	0.069
purine nucleoside metabolic process	GO:0042278	127	0.068
positive regulation of growth	GO:0045927	75	0.068
compound eye photoreceptor cell differentiation	GO:0001751	140	0.067
amine metabolic process	GO:0009308	12	0.066
cell division	GO:0051301	248	0.065
camera type eye development	GO:0043010	4	0.065
negative regulation of response to stimulus	GO:0048585	258	0.064	Human Mouse
stem cell development	GO:0048864	79	0.063
regulation of macroautophagy	GO:0016241	15	0.061	Human Mouse
regulation of epithelial cell differentiation	GO:0030856	4	0.061
regulation of organ morphogenesis	GO:2000027	78	0.059
nuclear division	GO:0000280	332	0.059
regulation of defense response	GO:0031347	102	0.057
apoptotic signaling pathway	GO:0097190	27	0.055	Human Mouse
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.055
compound eye development	GO:0048749	307	0.055
response to virus	GO:0009615	28	0.054
neurological system process	GO:0050877	358	0.054
epithelial cell development	GO:0002064	274	0.054
cellular response to endogenous stimulus	GO:0071495	80	0.054	Human Mouse
positive regulation of signal transduction	GO:0009967	223	0.054	Human
proteolysis	GO:0006508	192	0.053	Human
response to biotic stimulus	GO:0009607	294	0.053
embryo development ending in birth or egg hatching	GO:0009792	152	0.053
morphogenesis of a branching epithelium	GO:0061138	45	0.052
organic substance transport	GO:0071702	257	0.052	Human Mouse
regulation of phosphate metabolic process	GO:0019220	210	0.052	Human Mouse
protein alkylation	GO:0008213	43	0.052	Human
notch signaling pathway	GO:0007219	120	0.051
establishment or maintenance of cell polarity	GO:0007163	167	0.050
response to ketone	GO:1901654	34	0.050	Human
positive regulation of protein metabolic process	GO:0051247	128	0.050	Human Mouse
positive regulation of programmed cell death	GO:0043068	62	0.050	Human Mouse
response to lipopolysaccharide	GO:0032496	4	0.049
endocytosis	GO:0006897	310	0.049
cellular protein complex assembly	GO:0043623	71	0.048
negative regulation of protein metabolic process	GO:0051248	85	0.048	Human
eye photoreceptor cell differentiation	GO:0001754	145	0.048
hemopoiesis	GO:0030097	46	0.047
purine nucleotide catabolic process	GO:0006195	109	0.047
regulation of mapk cascade	GO:0043408	92	0.047
phagocytosis	GO:0006909	215	0.047
head development	GO:0060322	135	0.046
nucleoside catabolic process	GO:0009164	112	0.046
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.046
defense response	GO:0006952	300	0.046
single organism membrane organization	GO:0044802	93	0.046
secondary metabolic process	GO:0019748	75	0.045
posttranscriptional regulation of gene expression	GO:0010608	145	0.045	Mouse
organonitrogen compound catabolic process	GO:1901565	128	0.045
positive regulation of phosphate metabolic process	GO:0045937	139	0.045	Human Mouse
negative regulation of developmental process	GO:0051093	201	0.044	Human Mouse
glycosyl compound catabolic process	GO:1901658	112	0.044
columnar cuboidal epithelial cell development	GO:0002066	249	0.043
nuclear import	GO:0051170	51	0.043	Human
positive regulation of phosphorylation	GO:0042327	87	0.043	Human Mouse
central nervous system development	GO:0007417	201	0.042
regulation of proteolysis	GO:0030162	87	0.042	Human
multi multicellular organism process	GO:0044706	123	0.042
behavioral response to ethanol	GO:0048149	49	0.042
positive regulation of jun kinase activity	GO:0043507	4	0.042
muscle cell differentiation	GO:0042692	103	0.041
organophosphate metabolic process	GO:0019637	195	0.041
positive regulation of molecular function	GO:0044093	136	0.041	Human Mouse
protein dna complex subunit organization	GO:0071824	86	0.041
regulation of peptidyl lysine acetylation	GO:2000756	7	0.040
syncytium formation by plasma membrane fusion	GO:0000768	43	0.040
cellular response to nitrogen compound	GO:1901699	51	0.040	Human
positive regulation of response to extracellular stimulus	GO:0032106	8	0.040	Human Mouse
immune system development	GO:0002520	57	0.039
dna replication	GO:0006260	48	0.039
innate immune response	GO:0045087	144	0.039
purine ribonucleoside metabolic process	GO:0046128	127	0.039
carbohydrate derivative catabolic process	GO:1901136	118	0.039
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.039
appendage development	GO:0048736	401	0.039
organic cyclic compound catabolic process	GO:1901361	168	0.038	Human
ribonucleotide catabolic process	GO:0009261	109	0.038
cytoplasmic transport	GO:0016482	130	0.038	Human
aging	GO:0007568	143	0.038
convergent extension	GO:0060026	2	0.037
single organism intracellular transport	GO:1902582	207	0.037	Human
gliogenesis	GO:0042063	80	0.037
single organism nuclear import	GO:1902593	51	0.037	Human
organophosphate catabolic process	GO:0046434	112	0.037
organonitrogen compound metabolic process	GO:1901564	318	0.037
carbohydrate derivative metabolic process	GO:1901135	217	0.036
chromatin assembly	GO:0031497	48	0.036
regulation of protein modification process	GO:0031399	112	0.035
ribonucleotide metabolic process	GO:0009259	145	0.035
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.035
cell cycle checkpoint	GO:0000075	95	0.035
regulation of transport	GO:0051049	181	0.035	Human Mouse
positive regulation of mapk cascade	GO:0043410	63	0.035
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	6	0.034	Mouse
ras protein signal transduction	GO:0007265	88	0.034
tube development	GO:0035295	244	0.033
positive regulation of nervous system development	GO:0051962	69	0.033
positive regulation of cellular component organization	GO:0051130	156	0.033	Human
positive regulation of developmental growth	GO:0048639	62	0.032
nucleoside metabolic process	GO:0009116	127	0.032
positive regulation of cellular protein metabolic process	GO:0032270	118	0.032	Human Mouse
regulation of catalytic activity	GO:0050790	185	0.032	Human Mouse
regulation of transcription by chromatin organization	GO:0034401	3	0.032
positive regulation of histone acetylation	GO:0035066	3	0.032
response to wounding	GO:0009611	94	0.031
myoblast fusion	GO:0007520	43	0.031
brain development	GO:0007420	120	0.031
cell proliferation	GO:0008283	299	0.031	Human
cell fate specification	GO:0001708	71	0.031
regulation of defense response to virus by host	GO:0050691	10	0.031
oxoacid metabolic process	GO:0043436	103	0.030	Mouse
macromolecule deacylation	GO:0098732	11	0.030
positive regulation of transport	GO:0051050	92	0.030	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	85	0.030	Human
regulation of developmental pigmentation	GO:0048070	24	0.030
ameboidal type cell migration	GO:0001667	151	0.029
cellular amino acid metabolic process	GO:0006520	61	0.029
muscle organ development	GO:0007517	127	0.029
response to transforming growth factor beta	GO:0071559	18	0.028	Mouse
digestive system development	GO:0055123	149	0.028
protein import into nucleus	GO:0006606	51	0.028	Human
cellular response to organic cyclic compound	GO:0071407	32	0.028	Human
organic acid metabolic process	GO:0006082	103	0.027	Mouse
aromatic compound catabolic process	GO:0019439	166	0.027	Human
posttranscriptional gene silencing	GO:0016441	46	0.027
response to hormone	GO:0009725	45	0.027	Human Mouse
purine containing compound catabolic process	GO:0072523	112	0.027
development of primary sexual characteristics	GO:0045137	50	0.027	Mouse
organelle assembly	GO:0070925	198	0.027
positive regulation of catalytic activity	GO:0043085	118	0.026	Human Mouse
compound eye photoreceptor development	GO:0042051	78	0.026
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.026
nucleobase containing small molecule metabolic process	GO:0055086	174	0.026
carboxylic acid metabolic process	GO:0019752	92	0.026	Mouse
cellular response to radiation	GO:0071478	52	0.026	Mouse
stem cell differentiation	GO:0048863	117	0.025
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.025
telencephalon development	GO:0021537	2	0.025
positive regulation of signaling	GO:0023056	243	0.025	Human
positive regulation of intracellular signal transduction	GO:1902533	116	0.025
nucleoside triphosphate catabolic process	GO:0009143	108	0.025
regulation of jun kinase activity	GO:0043506	8	0.025
chromatin mediated maintenance of transcription	GO:0048096	7	0.024
neural precursor cell proliferation	GO:0061351	75	0.024
developmental pigmentation	GO:0048066	68	0.024
cellular protein catabolic process	GO:0044257	83	0.023	Human
regulation of apoptotic signaling pathway	GO:2001233	10	0.023	Human Mouse
hindbrain development	GO:0030902	2	0.023
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.023	Mouse
body morphogenesis	GO:0010171	2	0.023
regulation of photoreceptor cell differentiation	GO:0046532	34	0.022
cellular amine metabolic process	GO:0044106	12	0.022
cellular response to lipid	GO:0071396	20	0.022	Human
photoreceptor cell development	GO:0042461	96	0.022
negative regulation of multicellular organismal process	GO:0051241	142	0.022
sensory organ morphogenesis	GO:0090596	260	0.021
gland development	GO:0048732	191	0.021
ubiquitin dependent protein catabolic process	GO:0006511	78	0.021	Human
imaginal disc derived wing morphogenesis	GO:0007476	337	0.021
cellular nitrogen compound catabolic process	GO:0044270	165	0.021	Human
apoptotic process	GO:0006915	159	0.021
mrna catabolic process	GO:0006402	33	0.021
positive regulation of response to biotic stimulus	GO:0002833	31	0.021
regulation of immune effector process	GO:0002697	52	0.021
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.021	Human Mouse
small molecule metabolic process	GO:0044281	305	0.021	Mouse
regulation of sequence specific dna binding transcription factor activity	GO:0051090	12	0.020	Human
purine ribonucleoside catabolic process	GO:0046130	112	0.020
negative regulation of notch signaling pathway	GO:0045746	41	0.020
prostaglandin biosynthetic process	GO:0001516	1	0.020	Mouse
retina development in camera type eye	GO:0060041	4	0.020
cellular response to extracellular stimulus	GO:0031668	64	0.020	Human Mouse
immune system process	GO:0002376	347	0.020	Human
positive regulation of neurogenesis	GO:0050769	41	0.019
response to insulin	GO:0032868	29	0.019	Human Mouse
epithelial cell migration	GO:0010631	148	0.019
cellular response to oxidative stress	GO:0034599	28	0.019	Human
gonad development	GO:0008406	50	0.019	Mouse
positive regulation of immune system process	GO:0002684	68	0.019	Human
purine containing compound metabolic process	GO:0072521	155	0.019
inositol lipid mediated signaling	GO:0048017	4	0.018
intrinsic apoptotic signaling pathway	GO:0097193	16	0.018	Human Mouse
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.018	Mouse
atp dependent chromatin remodeling	GO:0043044	22	0.018
organ growth	GO:0035265	56	0.018
positive regulation of production of molecular mediator of immune response	GO:0002702	28	0.018
ribose phosphate metabolic process	GO:0019693	145	0.018
wound healing	GO:0042060	75	0.018
positive regulation of proteolysis	GO:0045862	52	0.018	Human
autophagic vacuole fusion	GO:0000046	15	0.017
purine nucleotide metabolic process	GO:0006163	146	0.017
positive regulation of cell differentiation	GO:0045597	64	0.017
negative regulation of protein processing	GO:0010955	31	0.017
regulation of developmental growth	GO:0048638	174	0.017
nucleosome positioning	GO:0016584	3	0.017
humoral immune response	GO:0006959	117	0.017
mitotic spindle organization	GO:0007052	220	0.017
dna methylation	GO:0006306	4	0.016
dorsal ventral pattern formation	GO:0009953	133	0.016
methylation	GO:0032259	47	0.016	Human
regulation of nucleocytoplasmic transport	GO:0046822	35	0.016	Human
regulation of hydrolase activity	GO:0051336	97	0.016	Human
forebrain development	GO:0030900	2	0.016
dna methylation or demethylation	GO:0044728	4	0.016
pigment metabolic process	GO:0042440	84	0.016
regulation of cell morphogenesis	GO:0022604	163	0.016
interspecies interaction between organisms	GO:0044419	16	0.016
regulation of dna replication	GO:0006275	13	0.015
regulation of dna templated transcription in response to stress	GO:0043620	4	0.015
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.015
positive regulation of gene expression epigenetic	GO:0045815	16	0.015
chromatin assembly or disassembly	GO:0006333	52	0.015
regulation of reproductive process	GO:2000241	54	0.015
connective tissue development	GO:0061448	3	0.015
nurse cell apoptotic process	GO:0045476	17	0.015
negative regulation of intracellular signal transduction	GO:1902532	57	0.015	Human Mouse
mitotic cell cycle checkpoint	GO:0007093	88	0.015
positive regulation of cell cycle	GO:0045787	43	0.015
regulation of neuron apoptotic process	GO:0043523	16	0.014
compound eye morphogenesis	GO:0001745	249	0.014
organelle inheritance	GO:0048308	2	0.014
ribonucleoside catabolic process	GO:0042454	112	0.014
cellular response to oxygen containing compound	GO:1901701	79	0.014	Human
regulation of purine nucleotide metabolic process	GO:1900542	62	0.014
regulation of compound eye cone cell fate specification	GO:0042682	4	0.014
defense response to bacterium	GO:0042742	178	0.014
dendrite development	GO:0016358	204	0.014
signal transduction in response to dna damage	GO:0042770	3	0.014	Human
mesoderm development	GO:0007498	78	0.014
protein catabolic process	GO:0030163	101	0.014	Human
anterior posterior pattern specification	GO:0009952	136	0.014
tissue morphogenesis	GO:0048729	297	0.014
negative regulation of defense response	GO:0031348	35	0.014
regulation of phosphatase activity	GO:0010921	3	0.014
multi organism reproductive behavior	GO:0044705	121	0.014
axis specification	GO:0009798	167	0.014
nucleosome organization	GO:0034728	59	0.013
regulation of cell motility	GO:2000145	23	0.013
regulation of chromatin assembly	GO:0010847	9	0.013
modification dependent protein catabolic process	GO:0019941	78	0.013	Human
response to peptide	GO:1901652	29	0.013	Human Mouse
positive regulation of cell death	GO:0010942	69	0.013	Human Mouse
circadian rhythm	GO:0007623	105	0.013	Human Mouse
regulation of molecular function	GO:0065009	217	0.013	Human Mouse
regulation of localization	GO:0032879	275	0.013	Human Mouse
protein kinase b signaling	GO:0043491	1	0.013	Human Mouse
dna conformation change	GO:0071103	105	0.013
nucleoside phosphate catabolic process	GO:1901292	110	0.013
negative regulation of small gtpase mediated signal transduction	GO:0051058	13	0.013
mitochondrial membrane organization	GO:0007006	3	0.013
membrane organization	GO:0061024	112	0.012
icosanoid biosynthetic process	GO:0046456	1	0.012	Mouse
positive regulation of cell motility	GO:2000147	3	0.012
hematopoietic or lymphoid organ development	GO:0048534	57	0.012
positive regulation of cellular amine metabolic process	GO:0033240	0	0.012
meiotic cell cycle	GO:0051321	171	0.012
response to ethanol	GO:0045471	59	0.012
signal transduction by p53 class mediator	GO:0072331	6	0.012	Human Mouse
larval development	GO:0002164	104	0.012	Worm
regulation of cellular protein metabolic process	GO:0032268	243	0.012
reproductive system development	GO:0061458	74	0.012	Mouse
bmp signaling pathway	GO:0030509	27	0.012
negative regulation of neuron apoptotic process	GO:0043524	14	0.012
mitotic dna damage checkpoint	GO:0044773	74	0.012
regulation of synaptic plasticity	GO:0048167	14	0.012
histone h3 acetylation	GO:0043966	11	0.012	Worm
immune response activating signal transduction	GO:0002757	2	0.012
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.012	Human Mouse
cellular response to transforming growth factor beta stimulus	GO:0071560	18	0.012	Mouse
regulation of ras protein signal transduction	GO:0046578	93	0.011
mitotic sister chromatid segregation	GO:0000070	87	0.011

Sir2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.013

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