IMP: Integrative Multi-species Prediction

Drosophila melanogaster

220 known processes

rl (Dmel_CG12559)

rolled

(Aliases: pERK,Mapk,CT39192,DpErk,MAP-k,ERKA,DERK,DmErk,Rl,SR2-1,sem,CG12559,DmMAPK,ERK,Erk1,dpMAPK,MapK,l(2)41Ac,dpERK,D-ERK,ERKa,Dmel\CG12559,SEM,CT34260,EY2-2,rll,DmERK-A,dp-ERK,DmERKA,BcDNA:RE08694,dpERK1,DERK-A,ErkA,12559,Erk,GroupII,l(2R)EMS45-39,Su(Raf)2B,E(sina)7,MAPK,dpErk,ERK-A,CG18732,EK2-1,rl/MAPK,dERK,mapk,pMapK,Sem,Dsor2,Erk/Map kinase,erk)

Entrez: 3354888
FLYBASE: FBgn0003256
UniProtKB: P40417
UniProtKB: A8Y4W5

Process Predictions
Disease Predictions

rl biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of cell communication	GO:0010648	223	0.999
negative regulation of response to stimulus	GO:0048585	258	0.998
immune system process	GO:0002376	347	0.995	Mouse
negative regulation of signaling	GO:0023057	219	0.995	Yeast
chorion containing eggshell formation	GO:0007304	105	0.990
embryonic morphogenesis	GO:0048598	206	0.990	Zebrafish
imaginal disc derived wing morphogenesis	GO:0007476	337	0.989
mapk cascade	GO:0000165	107	0.985
eggshell formation	GO:0030703	105	0.984
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.984
regulation of response to external stimulus	GO:0032101	115	0.983
regulation of phosphate metabolic process	GO:0019220	210	0.982
regulation of protein kinase activity	GO:0045859	51	0.982
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.981
regulation of immune system process	GO:0002682	176	0.980	Mouse
regulation of catalytic activity	GO:0050790	185	0.975
appendage development	GO:0048736	401	0.972
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.972
regulation of cell differentiation	GO:0045595	302	0.967
regulation of protein metabolic process	GO:0051246	256	0.965	Human Rat
post embryonic appendage morphogenesis	GO:0035120	385	0.963
epithelium migration	GO:0090132	148	0.960
regulation of map kinase activity	GO:0043405	17	0.960
border follicle cell migration	GO:0007298	113	0.959
phosphorylation	GO:0016310	294	0.959
ovarian follicle cell development	GO:0030707	248	0.958
signal transduction by phosphorylation	GO:0023014	107	0.957
negative regulation of signal transduction	GO:0009968	206	0.957	Yeast
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.956	Human Rat
regulation of cell proliferation	GO:0042127	163	0.955
positive regulation of macromolecule metabolic process	GO:0010604	405	0.953	Human Rat
epithelial cell migration	GO:0010631	148	0.952
response to abiotic stimulus	GO:0009628	341	0.952	Human
immune response	GO:0006955	246	0.949	Mouse
regulation of erbb signaling pathway	GO:1901184	42	0.946
negative regulation of cellular metabolic process	GO:0031324	382	0.945
columnar cuboidal epithelial cell development	GO:0002066	249	0.943
regulation of cellular amino acid metabolic process	GO:0006521	0	0.943
tube development	GO:0035295	244	0.942	Zebrafish
macroautophagy	GO:0016236	42	0.942
epithelial cell development	GO:0002064	274	0.941
response to organic substance	GO:0010033	284	0.940
regulation of immune response	GO:0050776	118	0.937	Mouse
autophagy	GO:0006914	108	0.935
epithelial cell differentiation	GO:0030855	322	0.934
protein modification process	GO:0036211	438	0.934
tracheal outgrowth open tracheal system	GO:0007426	18	0.934
regulation of multicellular organism growth	GO:0040014	40	0.933
muscle structure development	GO:0061061	224	0.933
negative regulation of developmental process	GO:0051093	201	0.932	Mouse Worm
regulation of cell development	GO:0060284	215	0.929
activation of protein kinase activity	GO:0032147	12	0.928
cellular protein modification process	GO:0006464	438	0.923
regulation of cellular protein metabolic process	GO:0032268	243	0.920	Human Rat
positive regulation of cellular protein metabolic process	GO:0032270	118	0.919	Human Rat
regulation of cellular component biogenesis	GO:0044087	201	0.913
regulation of cellular catabolic process	GO:0031329	157	0.908
appendage morphogenesis	GO:0035107	397	0.903
cellular response to growth factor stimulus	GO:0071363	30	0.896
regulation of kinase activity	GO:0043549	53	0.892
regulation of macroautophagy	GO:0016241	15	0.888
wing disc morphogenesis	GO:0007472	344	0.888
regulation of response to stress	GO:0080134	200	0.887
germ line stem cell maintenance	GO:0030718	50	0.886
ovarian follicle cell migration	GO:0007297	121	0.881
tissue migration	GO:0090130	155	0.881
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.876
regulation of organ growth	GO:0046620	42	0.869
regulation of photoreceptor cell differentiation	GO:0046532	34	0.863
negative regulation of intracellular signal transduction	GO:1902532	57	0.861	Yeast
guanosine containing compound catabolic process	GO:1901069	74	0.858
positive regulation of photoreceptor cell differentiation	GO:0046534	12	0.835
growth	GO:0040007	359	0.833	Yeast
cell migration	GO:0016477	238	0.832	Rat
regulation of neurogenesis	GO:0050767	158	0.826
response to endogenous stimulus	GO:0009719	119	0.825	Human Rat
organonitrogen compound metabolic process	GO:1901564	318	0.825	Mouse
tube morphogenesis	GO:0035239	191	0.824	Zebrafish
r7 cell differentiation	GO:0045466	43	0.819
torc1 signaling	GO:0038202	12	0.816
positive regulation of protein modification process	GO:0031401	58	0.816	Human
negative regulation of cell differentiation	GO:0045596	143	0.812	Mouse
negative regulation of mitotic cell cycle	GO:0045930	109	0.811	Worm
lipid metabolic process	GO:0006629	121	0.810	Rat
positive regulation of r7 cell differentiation	GO:0045678	7	0.809
negative regulation of cell cycle	GO:0045786	116	0.799	Yeast Worm
cellular response to endogenous stimulus	GO:0071495	80	0.797
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.793
cellular response to abiotic stimulus	GO:0071214	58	0.792	Human
ameboidal type cell migration	GO:0001667	151	0.787
regulation of protein serine threonine kinase activity	GO:0071900	25	0.784
cellular response to radiation	GO:0071478	52	0.783
cellular response to nutrient levels	GO:0031669	62	0.782
regulation of epithelial cell proliferation	GO:0050678	4	0.759
regulation of catabolic process	GO:0009894	170	0.757
respiratory system development	GO:0060541	213	0.752
digestive system development	GO:0055123	149	0.751	Zebrafish
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.750
positive regulation of protein metabolic process	GO:0051247	128	0.749	Human Rat
negative regulation of erbb signaling pathway	GO:1901185	29	0.746
regulation of protein modification process	GO:0031399	112	0.739	Human
negative regulation of immune system process	GO:0002683	50	0.738
response to growth factor	GO:0070848	31	0.732	Human
positive regulation of protein kinase activity	GO:0045860	25	0.729
regulation of growth	GO:0040008	233	0.721
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.717
regulation of anatomical structure size	GO:0090066	163	0.713
regulation of apoptotic signaling pathway	GO:2001233	10	0.711
regulation of intracellular signal transduction	GO:1902531	236	0.704
response to starvation	GO:0042594	97	0.699
regulation of protein phosphorylation	GO:0001932	64	0.694	Human
negative regulation of cellular component organization	GO:0051129	108	0.683
apoptotic signaling pathway	GO:0097190	27	0.679
digestive tract development	GO:0048565	149	0.678	Zebrafish
oxoacid metabolic process	GO:0043436	103	0.678	Rat
protein complex assembly	GO:0006461	200	0.675	Rat
regulation of apoptotic process	GO:0042981	130	0.669
positive regulation of signaling	GO:0023056	243	0.668
primary branching open tracheal system	GO:0007428	6	0.668
small molecule metabolic process	GO:0044281	305	0.662	Mouse Rat
cognition	GO:0050890	141	0.659
organic substance catabolic process	GO:1901575	308	0.652	Worm
negative regulation of multicellular organismal process	GO:0051241	142	0.636	Worm
negative regulation of transcription dna templated	GO:0045892	237	0.621
chemical homeostasis	GO:0048878	92	0.619
vesicle localization	GO:0051648	55	0.616
regulation of dna metabolic process	GO:0051052	34	0.610
positive regulation of protein phosphorylation	GO:0001934	34	0.608	Human
apoptotic process	GO:0006915	159	0.604	Worm
open tracheal system development	GO:0007424	204	0.604
cell death	GO:0008219	279	0.600	Worm
regulation of organelle organization	GO:0033043	196	0.600	Human
cellular ketone metabolic process	GO:0042180	24	0.599
cell proliferation	GO:0008283	299	0.595
establishment of localization in cell	GO:0051649	402	0.593	Yeast Rat
immune system development	GO:0002520	57	0.592
imaginal disc derived appendage development	GO:0048737	399	0.589
cellular macromolecular complex assembly	GO:0034622	153	0.589
erbb signaling pathway	GO:0038127	58	0.575	Human
organ growth	GO:0035265	56	0.575
r7 cell fate commitment	GO:0007465	12	0.570
regulation of transferase activity	GO:0051338	58	0.567
protein phosphorylation	GO:0006468	169	0.564
regulation of cellular component size	GO:0032535	98	0.562
regulation of cell cycle	GO:0051726	291	0.557	Yeast Worm
negative regulation of kinase activity	GO:0033673	16	0.557
compound eye photoreceptor fate commitment	GO:0001752	36	0.557
regulation of developmental growth	GO:0048638	174	0.553
developmental growth	GO:0048589	280	0.550
negative regulation of protein phosphorylation	GO:0001933	17	0.549
intracellular signal transduction	GO:0035556	300	0.548
negative regulation of autophagy	GO:0010507	16	0.547
regulation of erk1 and erk2 cascade	GO:0070372	39	0.541
programmed cell death	GO:0012501	257	0.540	Worm
regulation of phosphorylation	GO:0042325	147	0.539
eye photoreceptor cell fate commitment	GO:0042706	37	0.537
gtp catabolic process	GO:0006184	72	0.534
cardiovascular system development	GO:0072358	82	0.533	Mouse
catabolic process	GO:0009056	409	0.530
peptidyl tyrosine phosphorylation	GO:0018108	24	0.516	Human
regulation of defense response	GO:0031347	102	0.511
stem cell differentiation	GO:0048863	117	0.509
cellular amino acid metabolic process	GO:0006520	61	0.500
small gtpase mediated signal transduction	GO:0007264	88	0.499
cellular component assembly involved in morphogenesis	GO:0010927	151	0.498
single organism catabolic process	GO:0044712	228	0.493
negative regulation of phosphorus metabolic process	GO:0010563	45	0.490	Yeast
positive regulation of catabolic process	GO:0009896	105	0.486
eggshell chorion assembly	GO:0007306	66	0.485
regionalization	GO:0003002	416	0.480
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.474
positive regulation of nervous system development	GO:0051962	69	0.472
negative regulation of macroautophagy	GO:0016242	6	0.471
regulation of cellular amine metabolic process	GO:0033238	3	0.461
erk1 and erk2 cascade	GO:0070371	39	0.460
cellular macromolecule localization	GO:0070727	220	0.456	Yeast Rat
regulation of mapk cascade	GO:0043408	92	0.453
protein catabolic process	GO:0030163	101	0.453	Worm
cellular catabolic process	GO:0044248	372	0.450
carboxylic acid metabolic process	GO:0019752	92	0.449	Rat
negative regulation of cell size	GO:0045792	19	0.446
multicellular organismal aging	GO:0010259	140	0.445	Worm
actin filament bundle organization	GO:0061572	28	0.438
macromolecular complex assembly	GO:0065003	256	0.428	Rat
hematopoietic or lymphoid organ development	GO:0048534	57	0.425
gland development	GO:0048732	191	0.420	Mouse
cellular response to extracellular stimulus	GO:0031668	64	0.420
positive regulation of cell communication	GO:0010647	250	0.419
amine metabolic process	GO:0009308	12	0.418
actin filament organization	GO:0007015	126	0.410
regulation of molecular function	GO:0065009	217	0.406	Yeast Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.403	Human Rat
negative regulation of cell cycle phase transition	GO:1901988	103	0.403
regulation of phosphatidylinositol 3 kinase activity	GO:0043551	2	0.403
learning	GO:0007612	75	0.398
digestive tract morphogenesis	GO:0048546	127	0.398	Zebrafish
regulation of multicellular organismal development	GO:2000026	414	0.397
protein localization to organelle	GO:0033365	82	0.397	Rat
regulation of proteolysis	GO:0030162	87	0.390
regulation of r7 cell differentiation	GO:0045676	15	0.385
localization of cell	GO:0051674	257	0.384	Rat
gtp metabolic process	GO:0046039	72	0.373
negative regulation of rna metabolic process	GO:0051253	251	0.373
positive regulation of multicellular organismal process	GO:0051240	143	0.372
germarium derived egg chamber formation	GO:0007293	101	0.369
establishment of vesicle localization	GO:0051650	51	0.366
photoreceptor cell fate commitment	GO:0046552	41	0.364
compound eye morphogenesis	GO:0001745	249	0.364
response to osmotic stress	GO:0006970	14	0.362
negative regulation of cell proliferation	GO:0008285	69	0.362
cellular response to starvation	GO:0009267	61	0.361
negative regulation of phosphorylation	GO:0042326	35	0.357	Yeast
chromatin organization	GO:0006325	207	0.353	Human
positive regulation of kinase activity	GO:0033674	25	0.350
response to biotic stimulus	GO:0009607	294	0.350	Mouse
positive regulation of wound healing	GO:0090303	12	0.350
regulation of cellular ketone metabolic process	GO:0010565	3	0.350
regulation of cell size	GO:0008361	63	0.350
microtubule based transport	GO:0010970	42	0.349
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.347
positive regulation of cell proliferation	GO:0008284	47	0.345
organic cyclic compound catabolic process	GO:1901361	168	0.342
negative regulation of phosphate metabolic process	GO:0045936	45	0.341	Yeast
negative regulation of apoptotic process	GO:0043066	63	0.341
positive regulation of response to stimulus	GO:0048584	323	0.340
compound eye development	GO:0048749	307	0.335
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.334	Human
death	GO:0016265	284	0.333	Worm
activation of mapk activity	GO:0000187	9	0.331
negative regulation of mapk cascade	GO:0043409	23	0.327	Yeast
aging	GO:0007568	143	0.326	Worm
response to extracellular stimulus	GO:0009991	116	0.319
morphogenesis of a branching epithelium	GO:0061138	45	0.314
macromolecule catabolic process	GO:0009057	161	0.311	Worm
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.310
positive regulation of phosphorylation	GO:0042327	87	0.309
cellular amine metabolic process	GO:0044106	12	0.309
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.308	Human
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.307
peptidyl tyrosine modification	GO:0018212	24	0.304	Human
autophagic vacuole assembly	GO:0000045	2	0.304
hemocyte differentiation	GO:0042386	38	0.303
developmental cell growth	GO:0048588	52	0.299
nucleobase containing compound catabolic process	GO:0034655	165	0.297
negative regulation of catalytic activity	GO:0043086	42	0.296
cellular nitrogen compound catabolic process	GO:0044270	165	0.290
photoreceptor cell differentiation	GO:0046530	170	0.283
innate immune response	GO:0045087	144	0.282
dorsal appendage formation	GO:0046843	47	0.282
negative regulation of cell development	GO:0010721	62	0.281
response to nutrient levels	GO:0031667	114	0.281
morphogenesis of embryonic epithelium	GO:0016331	94	0.281
response to radiation	GO:0009314	155	0.279
response to organic cyclic compound	GO:0014070	89	0.278	Mouse Rat
positive regulation of cell size	GO:0045793	21	0.277
multicellular organism growth	GO:0035264	46	0.277
memory	GO:0007613	94	0.276
transcription from rna polymerase ii promoter	GO:0006366	368	0.275	Human
skin development	GO:0043588	65	0.269
regulation of nervous system development	GO:0051960	248	0.269
negative regulation of immune response	GO:0050777	39	0.267
wnt signaling pathway	GO:0016055	98	0.266
negative regulation of cellular protein metabolic process	GO:0032269	85	0.263
hemocyte migration	GO:0035099	19	0.263
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.260
synaptic growth at neuromuscular junction	GO:0051124	119	0.256
negative regulation of neurogenesis	GO:0050768	53	0.249
organophosphate metabolic process	GO:0019637	195	0.248
positive regulation of transferase activity	GO:0051347	26	0.248
positive regulation of cell differentiation	GO:0045597	64	0.247
associative learning	GO:0008306	65	0.247
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.243
regulation of phosphorus metabolic process	GO:0051174	210	0.242
central nervous system development	GO:0007417	201	0.239	Zebrafish
determination of adult lifespan	GO:0008340	137	0.238	Worm
positive regulation of biosynthetic process	GO:0009891	316	0.238	Human Rat
positive regulation of rna metabolic process	GO:0051254	271	0.238	Human Rat
axonogenesis	GO:0007409	290	0.234	Zebrafish
organelle localization	GO:0051640	148	0.234
response to light stimulus	GO:0009416	124	0.234
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.233
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.228
axon development	GO:0061564	297	0.226	Zebrafish
tissue morphogenesis	GO:0048729	297	0.225
guanosine containing compound metabolic process	GO:1901068	74	0.224
positive regulation of signal transduction	GO:0009967	223	0.222
cellular response to external stimulus	GO:0071496	66	0.222
axis specification	GO:0009798	167	0.221
negative regulation of compound eye retinal cell programmed cell death	GO:0046673	7	0.220
establishment of synaptic vesicle localization	GO:0097480	50	0.220
paracrine signaling	GO:0038001	7	0.220
embryonic development via the syncytial blastoderm	GO:0001700	148	0.219
immune effector process	GO:0002252	98	0.217
actin filament based process	GO:0030029	220	0.215
heterocycle catabolic process	GO:0046700	166	0.212
micropyle formation	GO:0046844	4	0.208
sensory organ morphogenesis	GO:0090596	260	0.208
chromosome organization	GO:0051276	360	0.208	Human
germ line cyst formation	GO:0048134	44	0.205
stem cell maintenance	GO:0019827	67	0.205
peptidyl amino acid modification	GO:0018193	105	0.204	Human Mouse Rat Worm
branching involved in open tracheal system development	GO:0060446	45	0.203
chromatin modification	GO:0016568	147	0.202	Human
muscle organ development	GO:0007517	127	0.201
homeostatic process	GO:0042592	199	0.199
positive regulation of mapk cascade	GO:0043410	63	0.197
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.196
regulation of cell shape	GO:0008360	113	0.195
single organismal cell cell adhesion	GO:0016337	45	0.195
hemopoiesis	GO:0030097	46	0.194
cellular protein catabolic process	GO:0044257	83	0.193
defense response	GO:0006952	300	0.193
ion transport	GO:0006811	145	0.192
positive regulation of intracellular signal transduction	GO:1902533	116	0.190
cellular macromolecule catabolic process	GO:0044265	136	0.188
compound eye photoreceptor cell differentiation	GO:0001751	140	0.188
negative regulation of response to extracellular stimulus	GO:0032105	6	0.185
cellular pigmentation	GO:0033059	12	0.183
negative regulation of organelle organization	GO:0010639	56	0.183
response to axon injury	GO:0048678	12	0.180
regulation of execution phase of apoptosis	GO:1900117	5	0.179
maintenance of epithelial integrity open tracheal system	GO:0035160	12	0.171
peripheral nervous system development	GO:0007422	52	0.169
cellular response to organic substance	GO:0071310	132	0.168	Human Yeast Mouse Rat
regulation of programmed cell death	GO:0043067	152	0.166
multicellular organismal reproductive behavior	GO:0033057	110	0.163
cell cycle arrest	GO:0007050	4	0.163	Yeast
dorsal ventral pattern formation	GO:0009953	133	0.161
regulation of response to biotic stimulus	GO:0002831	63	0.160
negative regulation of cellular catabolic process	GO:0031330	34	0.160
regulation of nucleotide catabolic process	GO:0030811	48	0.160
oocyte maturation	GO:0001556	3	0.156	Worm
multi multicellular organism process	GO:0044706	123	0.156
positive regulation of gtp catabolic process	GO:0033126	43	0.155
cell growth	GO:0016049	108	0.154
establishment of tissue polarity	GO:0007164	87	0.152
purine containing compound catabolic process	GO:0072523	112	0.151
determination of imaginal disc primordium	GO:0007445	11	0.149
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.149
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.149
mitotic dna integrity checkpoint	GO:0044774	75	0.149
cellular response to chemical stimulus	GO:0070887	199	0.146
negative regulation of protein metabolic process	GO:0051248	85	0.146
response to oxygen containing compound	GO:1901700	200	0.145
regulation of ras protein signal transduction	GO:0046578	93	0.143
positive regulation of cellular catabolic process	GO:0031331	95	0.143
purine nucleoside catabolic process	GO:0006152	112	0.142
epithelial cell proliferation	GO:0050673	15	0.142	Mouse
negative regulation of defense response	GO:0031348	35	0.141
urogenital system development	GO:0001655	72	0.141
oocyte differentiation	GO:0009994	145	0.141	Worm
epithelial cell proliferation involved in renal tubule morphogenesis	GO:2001013	11	0.137
regulation of cell death	GO:0010941	173	0.136
negative regulation of apoptotic signaling pathway	GO:2001234	5	0.133
ommatidial rotation	GO:0016318	20	0.133
negative regulation of programmed cell death	GO:0043069	72	0.132
regulation of ras gtpase activity	GO:0032318	38	0.130
regulation of purine nucleotide metabolic process	GO:1900542	62	0.129
response to wounding	GO:0009611	94	0.128
mitotic nuclear division	GO:0007067	213	0.124
regulation of innate immune response	GO:0045088	71	0.124
negative regulation of response to nutrient levels	GO:0032108	6	0.122
positive regulation of organelle organization	GO:0010638	65	0.122	Human
regulation of rap protein signal transduction	GO:0032487	4	0.122
cellular response to heat	GO:0034605	24	0.121
proteolysis	GO:0006508	192	0.120
negative regulation of gene expression	GO:0010629	387	0.119
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	13	0.119
regulation of mitotic cell cycle	GO:0007346	190	0.119	Worm
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.117
regulation of cell projection organization	GO:0031344	92	0.116
neurotrophin signaling pathway	GO:0038179	2	0.116
negative regulation of erk1 and erk2 cascade	GO:0070373	3	0.115
epithelial tube morphogenesis	GO:0060562	88	0.115
modification dependent macromolecule catabolic process	GO:0043632	79	0.113
anterior midgut ectodermal morphogenesis	GO:0007441	4	0.113
chromosome segregation	GO:0007059	157	0.112
wound healing	GO:0042060	75	0.110
negative regulation of catabolic process	GO:0009895	36	0.110
establishment of ommatidial planar polarity	GO:0042067	49	0.108
regulation of cell cycle phase transition	GO:1901987	130	0.108
regulation of response to extracellular stimulus	GO:0032104	18	0.108
positive regulation of immune response	GO:0050778	63	0.107	Mouse
regulation of cell morphogenesis	GO:0022604	163	0.106
positive regulation of ras protein signal transduction	GO:0046579	43	0.105
purine containing compound metabolic process	GO:0072521	155	0.105
positive regulation of cell migration	GO:0030335	2	0.104	Rat
response to other organism	GO:0051707	293	0.103	Mouse
establishment of proximal distal cell polarity	GO:0022606	4	0.102
actin cytoskeleton organization	GO:0030036	206	0.102
response to transforming growth factor beta	GO:0071559	18	0.102
cellular protein complex assembly	GO:0043623	71	0.102
gliogenesis	GO:0042063	80	0.101
eye development	GO:0001654	323	0.101	Zebrafish
transposition rna mediated	GO:0032197	3	0.101	Yeast
regulation of synaptic transmission	GO:0050804	69	0.100
negative regulation of peptidyl tyrosine phosphorylation	GO:0050732	6	0.100
establishment of protein localization	GO:0045184	163	0.099	Yeast Rat
positive regulation of phosphorus metabolic process	GO:0010562	139	0.099
positive regulation of nucleotide metabolic process	GO:0045981	55	0.099
asymmetric stem cell division	GO:0098722	49	0.098
protein localization	GO:0008104	284	0.098	Yeast Rat
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.098
intrinsic apoptotic signaling pathway	GO:0097193	16	0.098
negative regulation of transferase activity	GO:0051348	18	0.097
positive regulation of immune system process	GO:0002684	68	0.097	Mouse
eye morphogenesis	GO:0048592	260	0.097
eye photoreceptor cell differentiation	GO:0001754	145	0.097
positive regulation of growth	GO:0045927	75	0.096
positive regulation of developmental process	GO:0051094	143	0.096
mitotic dna damage checkpoint	GO:0044773	74	0.095
head involution	GO:0008258	35	0.095
dorsal closure	GO:0007391	79	0.094
epidermis development	GO:0008544	65	0.093
reproductive behavior	GO:0019098	122	0.092
cuticle development	GO:0042335	86	0.092
anatomical structure homeostasis	GO:0060249	97	0.092
aromatic compound catabolic process	GO:0019439	166	0.092
cell projection assembly	GO:0030031	94	0.092
negative regulation of developmental growth	GO:0048640	64	0.090
learning or memory	GO:0007611	141	0.089
genital disc development	GO:0035215	44	0.089
regulation of wound healing	GO:0061041	13	0.089
spermatogenesis	GO:0007283	200	0.088
chemotaxis	GO:0006935	249	0.088
establishment of organelle localization	GO:0051656	122	0.087
cellular response to transforming growth factor beta stimulus	GO:0071560	18	0.087
ribonucleoside metabolic process	GO:0009119	127	0.087
compound eye retinal cell programmed cell death	GO:0046667	23	0.086
nucleoside triphosphate catabolic process	GO:0009143	108	0.086
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.086	Human Rat
negative regulation of neuron apoptotic process	GO:0043524	14	0.085
negative regulation of proteolysis	GO:0045861	31	0.084
single organism cell adhesion	GO:0098602	47	0.084
ribonucleoside catabolic process	GO:0042454	112	0.083
positive regulation of cellular component biogenesis	GO:0044089	80	0.083
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.083
neurotransmitter secretion	GO:0007269	35	0.082
positive regulation of neurogenesis	GO:0050769	41	0.081
regulation of neuron projection development	GO:0010975	69	0.081
regulation of localization	GO:0032879	275	0.080	Yeast Rat
positive regulation of gtpase activity	GO:0043547	43	0.080
positive regulation of cell development	GO:0010720	61	0.080
ras protein signal transduction	GO:0007265	88	0.080
positive regulation of rna biosynthetic process	GO:1902680	266	0.078	Human Rat
notch receptor processing	GO:0007220	13	0.078
morphogenesis of an epithelium	GO:0002009	276	0.078
positive regulation of lipid metabolic process	GO:0045834	4	0.077
positive regulation of hydrolase activity	GO:0051345	78	0.077
branching morphogenesis of an epithelial tube	GO:0048754	45	0.077
positive regulation of catalytic activity	GO:0043085	118	0.077
cellular response to reactive oxygen species	GO:0034614	14	0.076
negative regulation of rna biosynthetic process	GO:1902679	240	0.076
embryonic ectodermal digestive tract development	GO:0048611	4	0.076
positive regulation of programmed cell death	GO:0043068	62	0.076
negative regulation of nervous system development	GO:0051961	92	0.076
epidermal cell differentiation	GO:0009913	51	0.076
anterior posterior pattern specification	GO:0009952	136	0.074
stem cell proliferation	GO:0072089	88	0.074
regulation of lipid kinase activity	GO:0043550	2	0.073
regulation of purine nucleotide catabolic process	GO:0033121	48	0.073
regulation of epidermal growth factor activated receptor activity	GO:0007176	4	0.072
cellular response to dna damage stimulus	GO:0006974	223	0.072
regulation of cell fate specification	GO:0042659	27	0.072
cation transport	GO:0006812	110	0.072
exocytosis	GO:0006887	28	0.071
positive regulation of multicellular organism growth	GO:0040018	21	0.070
regulation of nucleoside metabolic process	GO:0009118	50	0.070
regulation of compound eye photoreceptor development	GO:0045314	12	0.069
olfactory learning	GO:0008355	56	0.069
compound eye photoreceptor development	GO:0042051	78	0.068
response to heat	GO:0009408	63	0.068
positive regulation of cell death	GO:0010942	69	0.068
positive regulation of map kinase activity	GO:0043406	11	0.068
regulation of protein complex assembly	GO:0043254	42	0.067
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	4	0.067
response to ionizing radiation	GO:0010212	32	0.065
negative regulation of cell cycle process	GO:0010948	109	0.064
positive regulation of neuron differentiation	GO:0045666	26	0.063
purine nucleoside metabolic process	GO:0042278	127	0.063
negative regulation of protein modification process	GO:0031400	29	0.063
regulation of canonical wnt signaling pathway	GO:0060828	15	0.062
stem cell development	GO:0048864	79	0.062
response to alcohol	GO:0097305	95	0.062
compound eye cone cell fate commitment	GO:0042676	5	0.061
regulation of transposition rna mediated	GO:0010525	3	0.061	Yeast
regulation of protein catabolic process	GO:0042176	55	0.060
regulation of cell cell adhesion	GO:0022407	21	0.060
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.060
regulation of rac protein signal transduction	GO:0035020	3	0.059

rl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.143
cancer	DOID:162	0.143
organ system cancer	DOID:0050686	0.116
respiratory system cancer	DOID:0050615	0.071
lung cancer	DOID:1324	0.071

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