IMP: Integrative Multi-species Prediction

Drosophila melanogaster

71 known processes

Pole2 (Dmel_CG10489)

CG10489 gene product from transcript CG10489-RA

(Aliases: 10489,DNApol-epsilon,Dmel\CG10489,POLE2,CG10489)

Entrez: 38661
FLYBASE: FBgn0035644
UniProtKB: Q9VRQ7

Process Predictions
Disease Predictions

Pole2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
dna metabolic process	GO:0006259	227	0.391
dna conformation change	GO:0071103	105	0.209
cellular response to dna damage stimulus	GO:0006974	223	0.197
dna replication	GO:0006260	48	0.180
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.164
nuclear division	GO:0000280	332	0.096
negative regulation of gene expression	GO:0010629	387	0.089
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.082
cellular catabolic process	GO:0044248	372	0.072
macromolecular complex assembly	GO:0065003	256	0.068
negative regulation of transcription dna templated	GO:0045892	237	0.065
negative regulation of rna metabolic process	GO:0051253	251	0.054
meiotic chromosome segregation	GO:0045132	59	0.053
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.051
heterocycle catabolic process	GO:0046700	166	0.049
nucleobase containing compound catabolic process	GO:0034655	165	0.048
spindle organization	GO:0007051	253	0.047
organelle fission	GO:0048285	340	0.046
dna dependent dna replication	GO:0006261	17	0.046
organic substance catabolic process	GO:1901575	308	0.046
dna packaging	GO:0006323	91	0.046
organic cyclic compound catabolic process	GO:1901361	168	0.046
aromatic compound catabolic process	GO:0019439	166	0.045
regulation of cell cycle process	GO:0010564	181	0.040
positive regulation of cellular biosynthetic process	GO:0031328	316	0.039
dna integrity checkpoint	GO:0031570	81	0.038
regionalization	GO:0003002	416	0.038
cell proliferation	GO:0008283	299	0.037
chromosome segregation	GO:0007059	157	0.037
negative regulation of rna biosynthetic process	GO:1902679	240	0.035
dna repair	GO:0006281	54	0.035
cellular nitrogen compound catabolic process	GO:0044270	165	0.035
protein complex assembly	GO:0006461	200	0.035
regulation of mitotic cell cycle	GO:0007346	190	0.035
chorion containing eggshell formation	GO:0007304	105	0.034
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.033
mitotic cell cycle phase transition	GO:0044772	138	0.032
ovarian follicle cell development	GO:0030707	248	0.032
sister chromatid segregation	GO:0000819	92	0.031
chromosome organization	GO:0051276	360	0.031
catabolic process	GO:0009056	409	0.031
centrosome organization	GO:0051297	163	0.031
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.031
endocytosis	GO:0006897	310	0.031
organic substance transport	GO:0071702	257	0.031
positive regulation of macromolecule metabolic process	GO:0010604	405	0.030
spindle elongation	GO:0051231	83	0.030
regulation of cellular component biogenesis	GO:0044087	201	0.030
nucleobase containing small molecule metabolic process	GO:0055086	174	0.029
cellular amino acid metabolic process	GO:0006520	61	0.029
response to abiotic stimulus	GO:0009628	341	0.028
developmental growth	GO:0048589	280	0.028
glycosyl compound catabolic process	GO:1901658	112	0.028
glycosyl compound metabolic process	GO:1901657	127	0.028
nucleoside metabolic process	GO:0009116	127	0.027
negative regulation of cellular metabolic process	GO:0031324	382	0.027
microtubule organizing center organization	GO:0031023	168	0.026
organonitrogen compound metabolic process	GO:1901564	318	0.025
regulation of cell cycle	GO:0051726	291	0.025
intracellular signal transduction	GO:0035556	300	0.025
nucleotide metabolic process	GO:0009117	161	0.025
protein dna complex subunit organization	GO:0071824	86	0.025
eggshell formation	GO:0030703	105	0.024
macromolecule catabolic process	GO:0009057	161	0.024
regulation of anatomical structure morphogenesis	GO:0022603	242	0.024
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.024
cell cycle checkpoint	GO:0000075	95	0.023
protein complex biogenesis	GO:0070271	201	0.023
body morphogenesis	GO:0010171	2	0.023
growth	GO:0040007	359	0.023
transcription from rna polymerase ii promoter	GO:0006366	368	0.023
negative regulation of biosynthetic process	GO:0009890	277	0.023
cell cycle phase transition	GO:0044770	140	0.023
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.023
programmed cell death	GO:0012501	257	0.023
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.023
meiotic cell cycle process	GO:1903046	132	0.023
ribonucleoside metabolic process	GO:0009119	127	0.022
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.022
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.022
embryo development ending in birth or egg hatching	GO:0009792	152	0.021
cellular response to abiotic stimulus	GO:0071214	58	0.021
cellular macromolecular complex assembly	GO:0034622	153	0.021
nucleoside phosphate metabolic process	GO:0006753	162	0.021
mitotic nuclear division	GO:0007067	213	0.021
nucleotide catabolic process	GO:0009166	109	0.021
cellular macromolecule catabolic process	GO:0044265	136	0.020
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.020
carbohydrate derivative metabolic process	GO:1901135	217	0.020
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.020
nuclear dna replication	GO:0033260	1	0.020
regulation of organelle organization	GO:0033043	196	0.019
small molecule metabolic process	GO:0044281	305	0.019
protein phosphorylation	GO:0006468	169	0.019
cellular protein modification process	GO:0006464	438	0.019
cell fate determination	GO:0001709	91	0.019
response to radiation	GO:0009314	155	0.018
organophosphate metabolic process	GO:0019637	195	0.018
male meiosis	GO:0007140	52	0.018
protein dna complex assembly	GO:0065004	63	0.018
negative regulation of signaling	GO:0023057	219	0.017
purine ribonucleotide catabolic process	GO:0009154	109	0.017
double strand break repair	GO:0006302	26	0.017
mitotic spindle elongation	GO:0000022	81	0.017
regulation of molecular function	GO:0065009	217	0.017
nucleoside triphosphate metabolic process	GO:0009141	120	0.016
rna processing	GO:0006396	147	0.016
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.016
cell death	GO:0008219	279	0.016
single organism catabolic process	GO:0044712	228	0.016
ribonucleoside catabolic process	GO:0042454	112	0.016
purine ribonucleoside catabolic process	GO:0046130	112	0.016
nucleosome organization	GO:0034728	59	0.016
negative regulation of cell communication	GO:0010648	223	0.016
mitotic spindle organization	GO:0007052	220	0.016
dna recombination	GO:0006310	32	0.016
single organism cellular localization	GO:1902580	180	0.016
actin cytoskeleton organization	GO:0030036	206	0.016
organelle assembly	GO:0070925	198	0.016
meiotic nuclear division	GO:0007126	151	0.015
positive regulation of biosynthetic process	GO:0009891	316	0.015
dna biosynthetic process	GO:0071897	24	0.015
purine containing compound catabolic process	GO:0072523	112	0.015
metaphase plate congression	GO:0051310	19	0.015
mitotic cell cycle checkpoint	GO:0007093	88	0.015
regulation of developmental growth	GO:0048638	174	0.015
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.015
appendage morphogenesis	GO:0035107	397	0.015
epithelial cell differentiation	GO:0030855	322	0.014
regulation of multicellular organismal development	GO:2000026	414	0.014
death	GO:0016265	284	0.014
spindle midzone assembly	GO:0051255	4	0.014
lipid metabolic process	GO:0006629	121	0.014
nucleoside catabolic process	GO:0009164	112	0.014
dna damage checkpoint	GO:0000077	78	0.014
purine ribonucleotide metabolic process	GO:0009150	145	0.014
actin filament based process	GO:0030029	220	0.014
regulation of nervous system development	GO:0051960	248	0.014
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.013
purine nucleoside catabolic process	GO:0006152	112	0.013
purine containing compound metabolic process	GO:0072521	155	0.013
centrosome cycle	GO:0007098	137	0.013
regulation of cellular amino acid metabolic process	GO:0006521	0	0.013
regulation of cellular component size	GO:0032535	98	0.013
positive regulation of cellular protein metabolic process	GO:0032270	118	0.013
regulation of programmed cell death	GO:0043067	152	0.013
response to biotic stimulus	GO:0009607	294	0.013
purine ribonucleoside metabolic process	GO:0046128	127	0.013
response to external biotic stimulus	GO:0043207	293	0.013
cell motility	GO:0048870	251	0.013
regulation of cell cycle phase transition	GO:1901987	130	0.013
regulation of cell morphogenesis	GO:0022604	163	0.013
vesicle mediated transport	GO:0016192	381	0.013
regulation of cellular ketone metabolic process	GO:0010565	3	0.013
protein modification process	GO:0036211	438	0.012
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.012
regulation of nucleotide metabolic process	GO:0006140	62	0.012
ribose phosphate metabolic process	GO:0019693	145	0.012
endomembrane system organization	GO:0010256	119	0.012
regulation of anatomical structure size	GO:0090066	163	0.012
regulation of protein complex assembly	GO:0043254	42	0.012
dna geometric change	GO:0032392	16	0.012
negative regulation of cellular biosynthetic process	GO:0031327	277	0.012
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.012
phagocytosis	GO:0006909	215	0.012
columnar cuboidal epithelial cell development	GO:0002066	249	0.012
regulation of protein metabolic process	GO:0051246	256	0.012
regulation of phosphate metabolic process	GO:0019220	210	0.012
gene silencing	GO:0016458	138	0.011
dna replication initiation	GO:0006270	6	0.011
regulation of catalytic activity	GO:0050790	185	0.011
immune system process	GO:0002376	347	0.011
positive regulation of cellular component biogenesis	GO:0044089	80	0.011
response to organophosphorus	GO:0046683	2	0.011
response to other organism	GO:0051707	293	0.011
regulation of catabolic process	GO:0009894	170	0.011
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.011
regulation of growth	GO:0040008	233	0.011
organophosphate catabolic process	GO:0046434	112	0.011
wound healing	GO:0042060	75	0.011
cellular amine metabolic process	GO:0044106	12	0.011
phosphorylation	GO:0016310	294	0.011
response to wounding	GO:0009611	94	0.011
salivary gland development	GO:0007431	162	0.011
ribonucleotide catabolic process	GO:0009261	109	0.011
guanosine containing compound catabolic process	GO:1901069	74	0.011
segmentation	GO:0035282	207	0.011
protein alkylation	GO:0008213	43	0.011
membrane organization	GO:0061024	112	0.011
dna amplification	GO:0006277	11	0.011
embryonic development via the syncytial blastoderm	GO:0001700	148	0.010
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.010
ubiquitin dependent protein catabolic process	GO:0006511	78	0.010
cellular ketone metabolic process	GO:0042180	24	0.010
regulation of gene expression epigenetic	GO:0040029	128	0.010
nucleoside phosphate catabolic process	GO:1901292	110	0.010
mitotic dna integrity checkpoint	GO:0044774	75	0.010
guanosine containing compound metabolic process	GO:1901068	74	0.010
mitotic g2 dna damage checkpoint	GO:0007095	69	0.010
dendrite development	GO:0016358	204	0.010
rho protein signal transduction	GO:0007266	14	0.010

Pole2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.023
	nervous system disease	DOID:863	0	0.011

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