Drosophila melanogaster

71 known processes

Pole2 (Dmel_CG10489)

CG10489 gene product from transcript CG10489-RA

(Aliases: 10489,DNApol-epsilon,Dmel\CG10489,POLE2,CG10489)

Pole2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dna metabolic processGO:00062592270.391
dna conformation changeGO:00711031050.209
cellular response to dna damage stimulusGO:00069742230.197
dna replicationGO:0006260480.180
negative regulation of nitrogen compound metabolic processGO:00511722650.164
nuclear divisionGO:00002803320.096
negative regulation of gene expressionGO:00106293870.089
negative regulation of nucleobase containing compound metabolic processGO:00459342610.082
cellular catabolic processGO:00442483720.072
macromolecular complex assemblyGO:00650032560.068
negative regulation of transcription dna templatedGO:00458922370.065
negative regulation of rna metabolic processGO:00512532510.054
meiotic chromosome segregationGO:0045132590.053
negative regulation of nucleic acid templated transcriptionGO:19035072400.051
heterocycle catabolic processGO:00467001660.049
nucleobase containing compound catabolic processGO:00346551650.048
spindle organizationGO:00070512530.047
organelle fissionGO:00482853400.046
dna dependent dna replicationGO:0006261170.046
organic substance catabolic processGO:19015753080.046
dna packagingGO:0006323910.046
organic cyclic compound catabolic processGO:19013611680.046
aromatic compound catabolic processGO:00194391660.045
regulation of cell cycle processGO:00105641810.040
positive regulation of cellular biosynthetic processGO:00313283160.039
dna integrity checkpointGO:0031570810.038
regionalizationGO:00030024160.038
cell proliferationGO:00082832990.037
chromosome segregationGO:00070591570.037
negative regulation of rna biosynthetic processGO:19026792400.035
dna repairGO:0006281540.035
cellular nitrogen compound catabolic processGO:00442701650.035
protein complex assemblyGO:00064612000.035
regulation of mitotic cell cycleGO:00073461900.035
chorion containing eggshell formationGO:00073041050.034
negative regulation of macromolecule biosynthetic processGO:00105582700.033
mitotic cell cycle phase transitionGO:00447721380.032
ovarian follicle cell developmentGO:00307072480.032
sister chromatid segregationGO:0000819920.031
chromosome organizationGO:00512763600.031
catabolic processGO:00090564090.031
centrosome organizationGO:00512971630.031
regulation of transcription from rna polymerase ii promoterGO:00063573780.031
endocytosisGO:00068973100.031
organic substance transportGO:00717022570.031
positive regulation of macromolecule metabolic processGO:00106044050.030
spindle elongationGO:0051231830.030
regulation of cellular component biogenesisGO:00440872010.030
nucleobase containing small molecule metabolic processGO:00550861740.029
cellular amino acid metabolic processGO:0006520610.029
response to abiotic stimulusGO:00096283410.028
developmental growthGO:00485892800.028
glycosyl compound catabolic processGO:19016581120.028
glycosyl compound metabolic processGO:19016571270.028
nucleoside metabolic processGO:00091161270.027
negative regulation of cellular metabolic processGO:00313243820.027
microtubule organizing center organizationGO:00310231680.026
organonitrogen compound metabolic processGO:19015643180.025
regulation of cell cycleGO:00517262910.025
intracellular signal transductionGO:00355563000.025
nucleotide metabolic processGO:00091171610.025
protein dna complex subunit organizationGO:0071824860.025
eggshell formationGO:00307031050.024
macromolecule catabolic processGO:00090571610.024
regulation of anatomical structure morphogenesisGO:00226032420.024
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.024
cell cycle checkpointGO:0000075950.023
protein complex biogenesisGO:00702712010.023
body morphogenesisGO:001017120.023
growthGO:00400073590.023
transcription from rna polymerase ii promoterGO:00063663680.023
negative regulation of biosynthetic processGO:00098902770.023
cell cycle phase transitionGO:00447701400.023
regulation of mitotic cell cycle phase transitionGO:19019901300.023
programmed cell deathGO:00125012570.023
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.023
meiotic cell cycle processGO:19030461320.023
ribonucleoside metabolic processGO:00091191270.022
ribonucleoside triphosphate catabolic processGO:00092031080.022
columnar cuboidal epithelial cell differentiationGO:00020652560.022
embryo development ending in birth or egg hatchingGO:00097921520.021
cellular response to abiotic stimulusGO:0071214580.021
cellular macromolecular complex assemblyGO:00346221530.021
nucleoside phosphate metabolic processGO:00067531620.021
mitotic nuclear divisionGO:00070672130.021
nucleotide catabolic processGO:00091661090.021
cellular macromolecule catabolic processGO:00442651360.020
ribonucleoside triphosphate metabolic processGO:00091991190.020
carbohydrate derivative metabolic processGO:19011352170.020
positive regulation of nucleobase containing compound metabolic processGO:00459353320.020
nuclear dna replicationGO:003326010.020
regulation of organelle organizationGO:00330431960.019
small molecule metabolic processGO:00442813050.019
protein phosphorylationGO:00064681690.019
cellular protein modification processGO:00064644380.019
cell fate determinationGO:0001709910.019
response to radiationGO:00093141550.018
organophosphate metabolic processGO:00196371950.018
male meiosisGO:0007140520.018
protein dna complex assemblyGO:0065004630.018
negative regulation of signalingGO:00230572190.017
purine ribonucleotide catabolic processGO:00091541090.017
double strand break repairGO:0006302260.017
mitotic spindle elongationGO:0000022810.017
regulation of molecular functionGO:00650092170.017
nucleoside triphosphate metabolic processGO:00091411200.016
rna processingGO:00063961470.016
positive regulation of nitrogen compound metabolic processGO:00511733540.016
cell deathGO:00082192790.016
single organism catabolic processGO:00447122280.016
ribonucleoside catabolic processGO:00424541120.016
purine ribonucleoside catabolic processGO:00461301120.016
nucleosome organizationGO:0034728590.016
negative regulation of cell communicationGO:00106482230.016
mitotic spindle organizationGO:00070522200.016
dna recombinationGO:0006310320.016
single organism cellular localizationGO:19025801800.016
actin cytoskeleton organizationGO:00300362060.016
organelle assemblyGO:00709251980.016
meiotic nuclear divisionGO:00071261510.015
positive regulation of biosynthetic processGO:00098913160.015
dna biosynthetic processGO:0071897240.015
purine containing compound catabolic processGO:00725231120.015
metaphase plate congressionGO:0051310190.015
mitotic cell cycle checkpointGO:0007093880.015
regulation of developmental growthGO:00486381740.015
purine nucleoside triphosphate metabolic processGO:00091441190.015
appendage morphogenesisGO:00351073970.015
epithelial cell differentiationGO:00308553220.014
regulation of multicellular organismal developmentGO:20000264140.014
deathGO:00162652840.014
spindle midzone assemblyGO:005125540.014
lipid metabolic processGO:00066291210.014
nucleoside catabolic processGO:00091641120.014
dna damage checkpointGO:0000077780.014
purine ribonucleotide metabolic processGO:00091501450.014
actin filament based processGO:00300292200.014
regulation of nervous system developmentGO:00519602480.014
purine nucleoside triphosphate catabolic processGO:00091461080.013
purine nucleoside catabolic processGO:00061521120.013
purine containing compound metabolic processGO:00725211550.013
centrosome cycleGO:00070981370.013
regulation of cellular amino acid metabolic processGO:000652100.013
regulation of cellular component sizeGO:0032535980.013
positive regulation of cellular protein metabolic processGO:00322701180.013
regulation of programmed cell deathGO:00430671520.013
response to biotic stimulusGO:00096072940.013
purine ribonucleoside metabolic processGO:00461281270.013
response to external biotic stimulusGO:00432072930.013
cell motilityGO:00488702510.013
regulation of cell cycle phase transitionGO:19019871300.013
regulation of cell morphogenesisGO:00226041630.013
vesicle mediated transportGO:00161923810.013
regulation of cellular ketone metabolic processGO:001056530.013
protein modification processGO:00362114380.012
positive regulation of macromolecule biosynthetic processGO:00105572830.012
regulation of nucleotide metabolic processGO:0006140620.012
ribose phosphate metabolic processGO:00196931450.012
endomembrane system organizationGO:00102561190.012
regulation of anatomical structure sizeGO:00900661630.012
regulation of protein complex assemblyGO:0043254420.012
dna geometric changeGO:0032392160.012
negative regulation of cellular biosynthetic processGO:00313272770.012
positive regulation of nucleic acid templated transcriptionGO:19035082660.012
phagocytosisGO:00069092150.012
columnar cuboidal epithelial cell developmentGO:00020662490.012
regulation of protein metabolic processGO:00512462560.012
regulation of phosphate metabolic processGO:00192202100.012
gene silencingGO:00164581380.011
dna replication initiationGO:000627060.011
regulation of catalytic activityGO:00507901850.011
immune system processGO:00023763470.011
positive regulation of cellular component biogenesisGO:0044089800.011
response to organophosphorusGO:004668320.011
response to other organismGO:00517072930.011
regulation of catabolic processGO:00098941700.011
microtubule cytoskeleton organization involved in mitosisGO:1902850520.011
regulation of growthGO:00400082330.011
organophosphate catabolic processGO:00464341120.011
wound healingGO:0042060750.011
cellular amine metabolic processGO:0044106120.011
phosphorylationGO:00163102940.011
response to woundingGO:0009611940.011
salivary gland developmentGO:00074311620.011
ribonucleotide catabolic processGO:00092611090.011
guanosine containing compound catabolic processGO:1901069740.011
segmentationGO:00352822070.011
protein alkylationGO:0008213430.011
membrane organizationGO:00610241120.011
dna amplificationGO:0006277110.011
embryonic development via the syncytial blastodermGO:00017001480.010
purine ribonucleoside triphosphate catabolic processGO:00092071080.010
ubiquitin dependent protein catabolic processGO:0006511780.010
cellular ketone metabolic processGO:0042180240.010
regulation of gene expression epigeneticGO:00400291280.010
nucleoside phosphate catabolic processGO:19012921100.010
mitotic dna integrity checkpointGO:0044774750.010
guanosine containing compound metabolic processGO:1901068740.010
mitotic g2 dna damage checkpointGO:0007095690.010
dendrite developmentGO:00163582040.010
rho protein signal transductionGO:0007266140.010

Pole2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.023
nervous system diseaseDOID:86300.011