IMP: Integrative Multi-species Prediction

Drosophila melanogaster

249 known processes

Ark (Dmel_CG6829)

Apaf-1-related-killer

(Aliases: apaf-1,dark/dapaf-1/hac-1,hac-1,Dark/Apaf-I,dApaf-1,DARK,arc,dApaf-1/DARK/HAC-1,ark,Dark/Hac-1/dApaf1,CG6829,Apaf1,Dark/Dapaf-1/HAC1,dark/hac-1/dapaf-1,Dapaf-1/HAC-1,dapaf,Hac1,dAPAF-1,Dark,Dmel\CG6829,D-Apaf-1,apaf1,dApaf1,anon-53Fa,Dapaf-1,Dark/Hac-1/dApaf-1,Hac-1/Dark,T1,dark,Apaf-1,dapaf-1S,Hac-1,hac1,dapaf-1,dArk,APAF1,ARK,dapaf-1L)

FLYBASE: FBgn0024252
Entrez: 36914
UniProtKB: Q9U8R4
UniProtKB: Q7KLI1

Process Predictions
Disease Predictions

Ark biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
melanin metabolic process	GO:0006582	47	0.293
immune effector process	GO:0002252	98	0.223
eye development	GO:0001654	323	0.197
positive regulation of endopeptidase activity	GO:0010950	26	0.191
regulation of intracellular signal transduction	GO:1902531	236	0.171
catabolic process	GO:0009056	409	0.153
response to bacterium	GO:0009617	198	0.150
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	26	0.145
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.143
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.135
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.132
sensory organ morphogenesis	GO:0090596	260	0.131
gland morphogenesis	GO:0022612	145	0.130
spermatid development	GO:0007286	98	0.127
eye morphogenesis	GO:0048592	260	0.126
regulation of anatomical structure morphogenesis	GO:0022603	242	0.126
nuclear division	GO:0000280	332	0.125
immune response	GO:0006955	246	0.125
compound eye development	GO:0048749	307	0.125
compound eye morphogenesis	GO:0001745	249	0.122
positive regulation of compound eye retinal cell programmed cell death	GO:0046672	9	0.118
defense response	GO:0006952	300	0.118
cellular catabolic process	GO:0044248	372	0.116
spermatid differentiation	GO:0048515	114	0.114
positive regulation of cellular biosynthetic process	GO:0031328	316	0.112
zymogen activation	GO:0031638	20	0.112
execution phase of apoptosis	GO:0097194	7	0.110	Mouse
positive regulation of macromolecule metabolic process	GO:0010604	405	0.110
positive regulation of peptidase activity	GO:0010952	29	0.110
regulation of cellular catabolic process	GO:0031329	157	0.108	Mouse
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.107
male gamete generation	GO:0048232	201	0.107
response to abiotic stimulus	GO:0009628	341	0.107
proteolysis	GO:0006508	192	0.106
defense response to other organism	GO:0098542	225	0.104
regulation of catabolic process	GO:0009894	170	0.104	Mouse
single organism catabolic process	GO:0044712	228	0.104
central nervous system development	GO:0007417	201	0.103
cellular amide metabolic process	GO:0043603	80	0.102
response to biotic stimulus	GO:0009607	294	0.101
intracellular signal transduction	GO:0035556	300	0.101
positive regulation of signal transduction	GO:0009967	223	0.100	Mouse
positive regulation of proteolysis	GO:0045862	52	0.100
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.098
embryonic morphogenesis	GO:0048598	206	0.097	Mouse
phenol containing compound metabolic process	GO:0018958	57	0.096
salivary gland development	GO:0007431	162	0.095
hemocyte differentiation	GO:0042386	38	0.092
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.092	Mouse
tissue death	GO:0016271	102	0.090
gland development	GO:0048732	191	0.087
spermatogenesis	GO:0007283	200	0.087
response to external biotic stimulus	GO:0043207	293	0.086
protein complex biogenesis	GO:0070271	201	0.085
organonitrogen compound metabolic process	GO:1901564	318	0.085
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.085
organelle fission	GO:0048285	340	0.085
phagocytosis	GO:0006909	215	0.084
histolysis	GO:0007559	102	0.083
exocrine system development	GO:0035272	162	0.082
response to other organism	GO:0051707	293	0.081
cell death	GO:0008219	279	0.081
meiotic cell cycle	GO:0051321	171	0.078
organic substance transport	GO:0071702	257	0.077
ovarian follicle cell development	GO:0030707	248	0.077
macromolecular complex assembly	GO:0065003	256	0.077
salivary gland morphogenesis	GO:0007435	145	0.076
regulation of response to biotic stimulus	GO:0002831	63	0.076
programmed cell death	GO:0012501	257	0.075
melanization defense response	GO:0035006	45	0.074
humoral immune response	GO:0006959	117	0.072
regulation of production of molecular mediator of immune response	GO:0002700	44	0.070
developmental programmed cell death	GO:0010623	138	0.069
amide biosynthetic process	GO:0043604	42	0.069
protein complex assembly	GO:0006461	200	0.069
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.069
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.069
regulation of antimicrobial peptide production	GO:0002784	44	0.068
positive regulation of signaling	GO:0023056	243	0.067	Mouse
protein localization	GO:0008104	284	0.066
embryo development ending in birth or egg hatching	GO:0009792	152	0.066	Mouse
ovarian follicle cell migration	GO:0007297	121	0.066
organic substance catabolic process	GO:1901575	308	0.064
death	GO:0016265	284	0.064
peptide metabolic process	GO:0006518	80	0.063
positive regulation of response to extracellular stimulus	GO:0032106	8	0.063
regulation of peptidase activity	GO:0052547	39	0.062
sperm individualization	GO:0007291	48	0.062
regulation of humoral immune response	GO:0002920	51	0.062
regulation of defense response	GO:0031347	102	0.062
secondary metabolic process	GO:0019748	75	0.061
positive regulation of biosynthetic process	GO:0009891	316	0.061
columnar cuboidal epithelial cell development	GO:0002066	249	0.060
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.060
establishment of localization in cell	GO:0051649	402	0.060
mitotic dna integrity checkpoint	GO:0044774	75	0.060
antibacterial humoral response	GO:0019731	44	0.060
positive regulation of catabolic process	GO:0009896	105	0.059
regulation of molecular function	GO:0065009	217	0.059
cellularization	GO:0007349	90	0.058
endocytosis	GO:0006897	310	0.058
negative regulation of cell communication	GO:0010648	223	0.058
apoptotic process	GO:0006915	159	0.057
dendrite development	GO:0016358	204	0.057
cell migration	GO:0016477	238	0.056
positive regulation of response to stimulus	GO:0048584	323	0.056	Mouse
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.055
negative regulation of cell cycle phase transition	GO:1901988	103	0.054
response to radiation	GO:0009314	155	0.054
embryonic development via the syncytial blastoderm	GO:0001700	148	0.053
regulation of innate immune response	GO:0045088	71	0.053
immune system process	GO:0002376	347	0.053
regulation of antimicrobial humoral response	GO:0002759	50	0.052
defense response to bacterium	GO:0042742	178	0.052
cell proliferation	GO:0008283	299	0.052
regulation of proteolysis	GO:0030162	87	0.052
response to lipopolysaccharide	GO:0032496	4	0.052
positive regulation of hydrolase activity	GO:0051345	78	0.051
cell motility	GO:0048870	251	0.051
antimicrobial peptide biosynthetic process	GO:0002777	38	0.050
localization of cell	GO:0051674	257	0.050
vesicle mediated transport	GO:0016192	381	0.050
pigment metabolic process	GO:0042440	84	0.049
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.048
positive regulation of programmed cell death	GO:0043068	62	0.048
production of molecular mediator of immune response	GO:0002440	46	0.048
synaptic transmission	GO:0007268	288	0.048
protein secretion	GO:0009306	45	0.048
antimicrobial peptide production	GO:0002775	46	0.047
imaginal disc derived appendage development	GO:0048737	399	0.047
epithelial cell differentiation	GO:0030855	322	0.047
regulation of response to stress	GO:0080134	200	0.047
positive regulation of transcription dna templated	GO:0045893	266	0.047
positive regulation of cell communication	GO:0010647	250	0.047	Mouse
macromolecule catabolic process	GO:0009057	161	0.047	Mouse
autophagy	GO:0006914	108	0.046
protein catabolic process	GO:0030163	101	0.046
positive regulation of autophagy	GO:0010508	21	0.045
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.045
protein ubiquitination	GO:0016567	70	0.045
secretion by cell	GO:0032940	101	0.045
positive regulation of cell death	GO:0010942	69	0.045
negative regulation of signaling	GO:0023057	219	0.044
regulation of organ morphogenesis	GO:2000027	78	0.044
defense response to virus	GO:0051607	23	0.044
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.044
appendage morphogenesis	GO:0035107	397	0.044
spindle organization	GO:0007051	253	0.043
epithelial cell development	GO:0002064	274	0.043
neuron remodeling	GO:0016322	29	0.043
positive regulation of gene expression	GO:0010628	290	0.042
cellular response to dna damage stimulus	GO:0006974	223	0.040
determination of adult lifespan	GO:0008340	137	0.040
cell division	GO:0051301	248	0.039
regulation of protein metabolic process	GO:0051246	256	0.039
regulation of apoptotic process	GO:0042981	130	0.039
multicellular organismal aging	GO:0010259	140	0.038
organonitrogen compound biosynthetic process	GO:1901566	117	0.038
establishment of protein localization	GO:0045184	163	0.038
defense response to gram negative bacterium	GO:0050829	94	0.038
regulation of protein transport	GO:0051223	57	0.038
lateral inhibition	GO:0046331	206	0.038
negative regulation of mitotic cell cycle	GO:0045930	109	0.037
transcription from rna polymerase ii promoter	GO:0006366	368	0.037
regulation of organelle organization	GO:0033043	196	0.037
salivary gland histolysis	GO:0035070	88	0.037
appendage development	GO:0048736	401	0.036
nucleoside metabolic process	GO:0009116	127	0.036
regulation of cell cycle	GO:0051726	291	0.036
retinal cell programmed cell death	GO:0046666	25	0.036
regulation of localization	GO:0032879	275	0.036
regulation of catalytic activity	GO:0050790	185	0.036
antimicrobial humoral response	GO:0019730	99	0.036
compound eye retinal cell programmed cell death	GO:0046667	23	0.036
salivary gland cell autophagic cell death	GO:0035071	83	0.035
regulation of transport	GO:0051049	181	0.034
regulation of defense response to virus	GO:0050688	14	0.034
nurse cell apoptotic process	GO:0045476	17	0.034
negative regulation of gene expression	GO:0010629	387	0.034
autophagic cell death	GO:0048102	83	0.034
positive regulation of immune response	GO:0050778	63	0.034
ribonucleoside metabolic process	GO:0009119	127	0.034
peptide biosynthetic process	GO:0043043	42	0.034
response to ionizing radiation	GO:0010212	32	0.033
signal transduction in response to dna damage	GO:0042770	3	0.033
positive regulation of multicellular organismal process	GO:0051240	143	0.033
peptidoglycan recognition protein signaling pathway	GO:0061057	16	0.033
regulation of mitotic cell cycle	GO:0007346	190	0.033
regulation of cellular amide metabolic process	GO:0034248	39	0.033
eggshell formation	GO:0030703	105	0.033
response to organic cyclic compound	GO:0014070	89	0.032
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.032
single organism behavior	GO:0044708	391	0.032
regulation of synaptic transmission	GO:0050804	69	0.032
regulation of defense response to bacterium	GO:1900424	30	0.032
regulation of immune response	GO:0050776	118	0.032
protein k48 linked ubiquitination	GO:0070936	3	0.032
organic hydroxy compound metabolic process	GO:1901615	83	0.032
protein modification by small protein conjugation or removal	GO:0070647	106	0.032
single organism cellular localization	GO:1902580	180	0.032
nitrogen compound transport	GO:0071705	85	0.032
meiotic nuclear division	GO:0007126	151	0.031
positive regulation of rna biosynthetic process	GO:1902680	266	0.031
positive regulation of macroautophagy	GO:0016239	8	0.031
positive regulation of molecular function	GO:0044093	136	0.031
protein modification process	GO:0036211	438	0.031
negative regulation of cell cycle process	GO:0010948	109	0.031
protein transport	GO:0015031	155	0.031
aromatic compound catabolic process	GO:0019439	166	0.031	Mouse
cell type specific apoptotic process	GO:0097285	38	0.031
response to oxygen containing compound	GO:1901700	200	0.031
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.031
positive regulation of defense response to bacterium	GO:1900426	23	0.030
cellular response to extracellular stimulus	GO:0031668	64	0.030
regulation of response to extracellular stimulus	GO:0032104	18	0.030
ribonucleotide metabolic process	GO:0009259	145	0.030
regulation of endopeptidase activity	GO:0052548	36	0.030
positive regulation of defense response	GO:0031349	59	0.030
response to extracellular stimulus	GO:0009991	116	0.030
cellular protein modification process	GO:0006464	438	0.030
brain development	GO:0007420	120	0.030	Mouse
purine nucleoside metabolic process	GO:0042278	127	0.030
regulation of cell cycle phase transition	GO:1901987	130	0.030
taxis	GO:0042330	304	0.030
epithelium migration	GO:0090132	148	0.030
response to unfolded protein	GO:0006986	9	0.029
purine ribonucleoside metabolic process	GO:0046128	127	0.029
apoptotic process involved in development	GO:1902742	20	0.029
antibacterial peptide biosynthetic process	GO:0002780	22	0.029
glycosyl compound metabolic process	GO:1901657	127	0.029
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.029
secretion	GO:0046903	109	0.029
neuron maturation	GO:0042551	31	0.029
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.029
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.028
response to virus	GO:0009615	28	0.028
cellular response to chemical stimulus	GO:0070887	199	0.028
response to x ray	GO:0010165	8	0.028
imaginal disc derived wing morphogenesis	GO:0007476	337	0.028
wing disc morphogenesis	GO:0007472	344	0.028
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.028
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.028
regulation of programmed cell death	GO:0043067	152	0.027
response to organic substance	GO:0010033	284	0.027
positive regulation of production of molecular mediator of immune response	GO:0002702	28	0.027
chemotaxis	GO:0006935	249	0.027
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.027
carbohydrate derivative metabolic process	GO:1901135	217	0.027
cellular response to starvation	GO:0009267	61	0.026
dna integrity checkpoint	GO:0031570	81	0.026
intracellular transport	GO:0046907	228	0.026
regulation of cell death	GO:0010941	173	0.026
neuromuscular synaptic transmission	GO:0007274	67	0.026
regulation of hydrolase activity	GO:0051336	97	0.026
nucleoside phosphate metabolic process	GO:0006753	162	0.026
mitotic nuclear division	GO:0007067	213	0.026
chorion containing eggshell formation	GO:0007304	105	0.025
positive regulation of cellular protein metabolic process	GO:0032270	118	0.025
positive regulation of cellular catabolic process	GO:0031331	95	0.025
positive regulation of antibacterial peptide biosynthetic process	GO:0006963	20	0.025
organophosphate metabolic process	GO:0019637	195	0.025
aging	GO:0007568	143	0.025
chaeta development	GO:0022416	97	0.025
mitochondrion organization	GO:0007005	65	0.025
cellular response to sterol depletion	GO:0071501	3	0.025
positive regulation of antibacterial peptide production	GO:0002803	20	0.024
negative regulation of cell proliferation	GO:0008285	69	0.024
chromosome segregation	GO:0007059	157	0.024
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria	GO:0002813	14	0.024
regulation of neuromuscular synaptic transmission	GO:1900073	15	0.024
cellular protein catabolic process	GO:0044257	83	0.024
cell cycle arrest	GO:0007050	4	0.024
regulation of response to external stimulus	GO:0032101	115	0.024
organic cyclic compound catabolic process	GO:1901361	168	0.024	Mouse
small molecule metabolic process	GO:0044281	305	0.024
cell cycle phase transition	GO:0044770	140	0.024
regulation of cellular localization	GO:0060341	136	0.024
digestive tract morphogenesis	GO:0048546	127	0.024
digestive tract development	GO:0048565	149	0.024
regulation of cell differentiation	GO:0045595	302	0.024
nucleotide catabolic process	GO:0009166	109	0.024
nucleus organization	GO:0006997	45	0.023
regulation of antibacterial peptide production	GO:0002786	22	0.023
antibacterial peptide production	GO:0002778	22	0.023
developmental maturation	GO:0021700	172	0.023
cellular protein localization	GO:0034613	160	0.023
cell maturation	GO:0048469	144	0.023
negative regulation of developmental process	GO:0051093	201	0.023
positive regulation of response to external stimulus	GO:0032103	44	0.023
protein heterooligomerization	GO:0051291	4	0.023
regulation of cell development	GO:0060284	215	0.023
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.023
mating behavior	GO:0007617	106	0.023
forebrain development	GO:0030900	2	0.022	Mouse
mitotic cell cycle checkpoint	GO:0007093	88	0.022
heterocycle catabolic process	GO:0046700	166	0.022	Mouse
epithelial cell migration	GO:0010631	148	0.022
purine nucleotide metabolic process	GO:0006163	146	0.022
ribose phosphate metabolic process	GO:0019693	145	0.022
er nucleus signaling pathway	GO:0006984	9	0.022
peripheral nervous system development	GO:0007422	52	0.022
positive regulation of intracellular signal transduction	GO:1902533	116	0.022
positive regulation of protein metabolic process	GO:0051247	128	0.022
positive regulation of catalytic activity	GO:0043085	118	0.021
nucleotide metabolic process	GO:0009117	161	0.021
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.021
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.021
organonitrogen compound catabolic process	GO:1901565	128	0.021
digestive system development	GO:0055123	149	0.021
positive regulation of protein transport	GO:0051222	37	0.021
positive regulation of cellular amide metabolic process	GO:0034250	26	0.021
positive regulation of immune system process	GO:0002684	68	0.021
extrinsic apoptotic signaling pathway	GO:0097191	1	0.021
purine ribonucleotide catabolic process	GO:0009154	109	0.021
regulation of phosphate metabolic process	GO:0019220	210	0.021
protein processing	GO:0016485	68	0.021
cell cycle checkpoint	GO:0000075	95	0.021
modification dependent macromolecule catabolic process	GO:0043632	79	0.021
cellular response to nutrient levels	GO:0031669	62	0.021
cellular nitrogen compound catabolic process	GO:0044270	165	0.020	Mouse
regulation of protein localization	GO:0032880	76	0.020
border follicle cell migration	GO:0007298	113	0.020
carbohydrate derivative catabolic process	GO:1901136	118	0.020
regulation of macroautophagy	GO:0016241	15	0.020
single organism biosynthetic process	GO:0044711	206	0.020
regulation of antibacterial peptide biosynthetic process	GO:0002808	22	0.020
positive regulation of multi organism process	GO:0043902	40	0.020
oxoacid metabolic process	GO:0043436	103	0.020
regulation of gene expression epigenetic	GO:0040029	128	0.020
chromosome organization	GO:0051276	360	0.020
protein maturation	GO:0051604	71	0.020
regulation of multicellular organismal development	GO:2000026	414	0.020
ubiquitin dependent protein catabolic process	GO:0006511	78	0.020
negative regulation of programmed cell death	GO:0043069	72	0.020
body morphogenesis	GO:0010171	2	0.020
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.019
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.019
regulation of cellular protein metabolic process	GO:0032268	243	0.019
developmental growth	GO:0048589	280	0.019
negative regulation of cell cycle	GO:0045786	116	0.019
head involution	GO:0008258	35	0.019
purine nucleotide catabolic process	GO:0006195	109	0.019
dna packaging	GO:0006323	91	0.019
small gtpase mediated signal transduction	GO:0007264	88	0.019
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.019
cellular macromolecule catabolic process	GO:0044265	136	0.019	Mouse
purine containing compound catabolic process	GO:0072523	112	0.019
carboxylic acid metabolic process	GO:0019752	92	0.019
response to nitrogen compound	GO:1901698	90	0.019
regulation of cell proliferation	GO:0042127	163	0.019
embryonic pattern specification	GO:0009880	174	0.018
positive regulation of response to biotic stimulus	GO:0002833	31	0.018
regulation of retinal cell programmed cell death	GO:0046668	18	0.018
mitotic cell cycle phase transition	GO:0044772	138	0.018
nucleoside triphosphate metabolic process	GO:0009141	120	0.018
positive regulation of rna metabolic process	GO:0051254	271	0.018
purine nucleoside catabolic process	GO:0006152	112	0.018
ion transport	GO:0006811	145	0.018
guanosine containing compound metabolic process	GO:1901068	74	0.018
cytoplasmic transport	GO:0016482	130	0.018
ameboidal type cell migration	GO:0001667	151	0.018
nucleocytoplasmic transport	GO:0006913	72	0.018
tube development	GO:0035295	244	0.017	Mouse
regulation of ras protein signal transduction	GO:0046578	93	0.017
purine ribonucleotide metabolic process	GO:0009150	145	0.017
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.017
positive regulation of developmental process	GO:0051094	143	0.017
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.017
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.017
organelle assembly	GO:0070925	198	0.017
response to endogenous stimulus	GO:0009719	119	0.017
nucleobase containing compound catabolic process	GO:0034655	165	0.017	Mouse
nucleoside triphosphate catabolic process	GO:0009143	108	0.017
chemosensory behavior	GO:0007635	106	0.017
regulation of cellular response to stress	GO:0080135	89	0.017
negative regulation of signal transduction	GO:0009968	206	0.017
regulation of autophagy	GO:0010506	62	0.017
cellular macromolecule localization	GO:0070727	220	0.017
mitotic spindle organization	GO:0007052	220	0.016
ectopic germ cell programmed cell death	GO:0035234	8	0.016
cellular response to oxygen containing compound	GO:1901701	79	0.016
regulation of phosphorus metabolic process	GO:0051174	210	0.016
guanosine containing compound catabolic process	GO:1901069	74	0.016
regulation of membrane potential	GO:0042391	35	0.016
tube morphogenesis	GO:0035239	191	0.016	Mouse
gene silencing	GO:0016458	138	0.016
post embryonic appendage morphogenesis	GO:0035120	385	0.016
reproductive system development	GO:0061458	74	0.016
response to temperature stimulus	GO:0009266	106	0.016
regulation of multi organism process	GO:0043900	131	0.016
positive regulation of humoral immune response	GO:0002922	28	0.016
regulation of compound eye retinal cell programmed cell death	GO:0046669	18	0.016
negative regulation of response to stimulus	GO:0048585	258	0.016
regulation of response to nutrient levels	GO:0032107	18	0.015
adult behavior	GO:0030534	137	0.015
regulation of establishment of protein localization	GO:0070201	61	0.015
ras protein signal transduction	GO:0007265	88	0.015
activation of cysteine type endopeptidase activity	GO:0097202	17	0.015
membrane depolarization	GO:0051899	4	0.015
chromatin organization	GO:0006325	207	0.015
gtp catabolic process	GO:0006184	72	0.015
actin cytoskeleton organization	GO:0030036	206	0.015
telencephalon development	GO:0021537	2	0.015
glycosyl compound catabolic process	GO:1901658	112	0.015
camera type eye development	GO:0043010	4	0.015
proteasomal protein catabolic process	GO:0010498	59	0.015
nucleoside phosphate catabolic process	GO:1901292	110	0.015
multi organism behavior	GO:0051705	175	0.015
cellular response to mechanical stimulus	GO:0071260	2	0.015
macroautophagy	GO:0016236	42	0.015
dendrite morphogenesis	GO:0048813	199	0.014
olfactory behavior	GO:0042048	97	0.014
innate immune response	GO:0045087	144	0.014
cell recognition	GO:0008037	102	0.014
segmentation	GO:0035282	207	0.014
posttranscriptional regulation of gene expression	GO:0010608	145	0.014
purine containing compound metabolic process	GO:0072521	155	0.014
wnt signaling pathway	GO:0016055	98	0.014
nucleoside catabolic process	GO:0009164	112	0.014
regulation of protein secretion	GO:0050708	13	0.014
ribonucleoside catabolic process	GO:0042454	112	0.014
membrane organization	GO:0061024	112	0.014
multicellular organismal reproductive behavior	GO:0033057	110	0.014
organophosphate catabolic process	GO:0046434	112	0.014
response to decreased oxygen levels	GO:0036293	58	0.014
negative regulation of cell death	GO:0060548	81	0.014
single organism intracellular transport	GO:1902582	207	0.013
rna localization	GO:0006403	115	0.013
kidney development	GO:0001822	3	0.013
negative regulation of cellular metabolic process	GO:0031324	382	0.013
purine ribonucleoside catabolic process	GO:0046130	112	0.013
cellular protein complex assembly	GO:0043623	71	0.013
response to oxygen levels	GO:0070482	59	0.013
cellular response to organic substance	GO:0071310	132	0.013
cellular amino acid metabolic process	GO:0006520	61	0.013
ribonucleotide catabolic process	GO:0009261	109	0.013
open tracheal system development	GO:0007424	204	0.013
mitotic cytokinesis	GO:0000281	50	0.013
response to lipid	GO:0033993	38	0.013
cellular response to lipopolysaccharide	GO:0071222	3	0.013
response to heat	GO:0009408	63	0.013
centrosome duplication	GO:0051298	121	0.013
response to hexose	GO:0009746	3	0.013
cellular ketone metabolic process	GO:0042180	24	0.013
tissue migration	GO:0090130	155	0.012
positive regulation of antimicrobial peptide production	GO:0002225	28	0.012
response to glucose	GO:0009749	2	0.012
gtp metabolic process	GO:0046039	72	0.012
response to hypoxia	GO:0001666	53	0.012
meiotic cell cycle process	GO:1903046	132	0.012
regulation of cell shape	GO:0008360	113	0.012
establishment of rna localization	GO:0051236	47	0.012
androgen metabolic process	GO:0008209	1	0.012
asymmetric cell division	GO:0008356	37	0.012
regulation of immune system process	GO:0002682	176	0.012
cellular response to abiotic stimulus	GO:0071214	58	0.012
positive regulation of retinal cell programmed cell death	GO:0046670	9	0.012
modification dependent protein catabolic process	GO:0019941	78	0.012
regulation of secretion	GO:0051046	44	0.012
neuron projection guidance	GO:0097485	241	0.012
locomotory behavior	GO:0007626	176	0.012
regulation of cytoskeleton organization	GO:0051493	89	0.012
mating	GO:0007618	120	0.012
nucleobase containing small molecule metabolic process	GO:0055086	174	0.012
centrosome organization	GO:0051297	163	0.012
negative regulation of immune system process	GO:0002683	50	0.012
reproductive structure development	GO:0048608	74	0.012
positive regulation of antimicrobial humoral response	GO:0002760	28	0.012
regulation of cellular amine metabolic process	GO:0033238	3	0.012
cellular response to external stimulus	GO:0071496	66	0.012
wound healing	GO:0042060	75	0.012
response to starvation	GO:0042594	97	0.012
homeostatic process	GO:0042592	199	0.011
regulation of secretion by cell	GO:1903530	39	0.011
cellular homeostasis	GO:0019725	80	0.011
regulation of anatomical structure size	GO:0090066	163	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
growth	GO:0040007	359	0.011
cellular component assembly involved in morphogenesis	GO:0010927	151	0.011
regulation of cell cycle process	GO:0010564	181	0.011
cellular lipid metabolic process	GO:0044255	83	0.011
mrna processing	GO:0006397	104	0.011
endomembrane system organization	GO:0010256	119	0.011
regulation of erbb signaling pathway	GO:1901184	42	0.011
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.011
response to alcohol	GO:0097305	95	0.011
regulation of cellular ketone metabolic process	GO:0010565	3	0.011
regulation of meiosis	GO:0040020	3	0.011
eggshell chorion assembly	GO:0007306	66	0.011
cellular response to molecule of bacterial origin	GO:0071219	3	0.011

Ark disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.035
nervous system disease	DOID:863	0.017
musculoskeletal system disease	DOID:17	0.013
inherited metabolic disorder	DOID:655	0.012
disease of metabolism	DOID:0014667	0.012
central nervous system disease	DOID:331	0.011

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