IMP: Integrative Multi-species Prediction

Drosophila melanogaster

70 known processes

eag (Dmel_CG10952)

ether a go-go

(Aliases: CIKE,Eag,CG10952,Dmel\CG10952,EAG)

FLYBASE: FBgn0000535
Entrez: 32428
UniProtKB: M9PHT2
UniProtKB: Q0KHS8
UniProtKB: M9MSA6
UniProtKB: M9PH56
UniProtKB: M9MSD1
UniProtKB: Q02280
UniProtKB: M9PHM3

Process Predictions
Disease Predictions

eag biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
sensory perception	GO:0007600	196	0.999	Fly
neurological system process	GO:0050877	358	0.997
single organism behavior	GO:0044708	391	0.995
courtship behavior	GO:0007619	68	0.990
learning or memory	GO:0007611	141	0.990
male courtship behavior	GO:0008049	63	0.987
learning	GO:0007612	75	0.982
ion transmembrane transport	GO:0034220	122	0.977
male mating behavior	GO:0060179	70	0.974
sensory perception of chemical stimulus	GO:0007606	116	0.974
multi organism behavior	GO:0051705	175	0.969	Worm
mating	GO:0007618	120	0.966
cognition	GO:0050890	141	0.959
detection of stimulus	GO:0051606	156	0.936
mating behavior	GO:0007617	106	0.931
synaptic transmission	GO:0007268	288	0.899
sensory perception of mechanical stimulus	GO:0050954	72	0.895	Fly
detection of stimulus involved in sensory perception	GO:0050906	92	0.867
detection of chemical stimulus	GO:0009593	93	0.849
multicellular organismal reproductive behavior	GO:0033057	110	0.847	Worm
response to oxygen containing compound	GO:1901700	200	0.826
multi organism reproductive behavior	GO:0044705	121	0.811	Worm
male courtship behavior veined wing generated song production	GO:0045433	20	0.809
transmembrane transport	GO:0055085	139	0.783
sensory perception of salty taste	GO:0050914	3	0.766
male courtship behavior veined wing extension	GO:0048065	22	0.727
reproductive behavior	GO:0019098	122	0.720	Worm
multi multicellular organism process	GO:0044706	123	0.708	Worm
memory	GO:0007613	94	0.663
associative learning	GO:0008306	65	0.576
response to mechanical stimulus	GO:0009612	28	0.538
response to abiotic stimulus	GO:0009628	341	0.513
mechanosensory behavior	GO:0007638	12	0.499
ion transport	GO:0006811	145	0.481
detection of chemical stimulus involved in sensory perception	GO:0050907	75	0.463
response to organic substance	GO:0010033	284	0.448
regulation of synaptic transmission	GO:0050804	69	0.421
cation transmembrane transport	GO:0098655	88	0.379
regulation of behavior	GO:0050795	75	0.372
cation transport	GO:0006812	110	0.326
long term memory	GO:0007616	62	0.323
metal ion transport	GO:0030001	74	0.310
phosphorylation	GO:0016310	294	0.282
adult behavior	GO:0030534	137	0.279
medium term memory	GO:0072375	8	0.276
response to oxidative stress	GO:0006979	86	0.267
protein complex assembly	GO:0006461	200	0.259
male courtship behavior veined wing vibration	GO:0016545	21	0.237
sensory perception of sound	GO:0007605	56	0.228	Fly
behavioral response to ethanol	GO:0048149	49	0.225
inorganic cation transmembrane transport	GO:0098662	61	0.211
small molecule metabolic process	GO:0044281	305	0.198
positive regulation of synaptic transmission	GO:0050806	15	0.195
response to ethanol	GO:0045471	59	0.192
behavioral response to pain	GO:0048266	3	0.178
olfactory learning	GO:0008355	56	0.169
chemosensory behavior	GO:0007635	106	0.160	Worm
neuromuscular junction development	GO:0007528	149	0.152
response to reactive oxygen species	GO:0000302	24	0.151
homeostatic process	GO:0042592	199	0.146
regulation of transport	GO:0051049	181	0.129
response to monosaccharide	GO:0034284	4	0.124
cell motility	GO:0048870	251	0.124
inter male aggressive behavior	GO:0002121	60	0.123
g protein coupled receptor signaling pathway	GO:0007186	136	0.119
response to starvation	GO:0042594	97	0.117
cellular response to abiotic stimulus	GO:0071214	58	0.114
ion homeostasis	GO:0050801	55	0.114
positive regulation of cellular component biogenesis	GO:0044089	80	0.113
response to pain	GO:0048265	3	0.110
response to glucose	GO:0009749	2	0.110
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.108
developmental growth	GO:0048589	280	0.104
positive regulation of cell communication	GO:0010647	250	0.101
detection of abiotic stimulus	GO:0009582	66	0.099
localization of cell	GO:0051674	257	0.095
detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	2	0.093
inorganic ion transmembrane transport	GO:0098660	73	0.091
response to temperature stimulus	GO:0009266	106	0.090
anesthesia resistant memory	GO:0007615	6	0.087
intraspecies interaction between organisms	GO:0051703	4	0.084
cellular response to chemical stimulus	GO:0070887	199	0.080
intracellular signal transduction	GO:0035556	300	0.079
divalent inorganic cation transport	GO:0072511	30	0.078
response to inorganic substance	GO:0010035	44	0.078
cyclic nucleotide biosynthetic process	GO:0009190	25	0.075
cell migration	GO:0016477	238	0.073
regulation of membrane potential	GO:0042391	35	0.072
organonitrogen compound metabolic process	GO:1901564	318	0.071
neuromuscular synaptic transmission	GO:0007274	67	0.071
protein complex biogenesis	GO:0070271	201	0.070
regulation of localization	GO:0032879	275	0.070
protein phosphorylation	GO:0006468	169	0.067
cellular response to carbohydrate stimulus	GO:0071322	4	0.067
regulation of lyase activity	GO:0051339	14	0.067
response to hexose	GO:0009746	3	0.066
response to carbohydrate	GO:0009743	15	0.063
protein heterooligomerization	GO:0051291	4	0.061
divalent metal ion transport	GO:0070838	26	0.059
macromolecular complex assembly	GO:0065003	256	0.058
regulation of circadian sleep wake cycle sleep	GO:0045187	21	0.058
olfactory behavior	GO:0042048	97	0.058
response to alcohol	GO:0097305	95	0.058
cellular response to oxygen containing compound	GO:1901701	79	0.058
smoothened signaling pathway	GO:0007224	49	0.058
locomotory behavior	GO:0007626	176	0.056
response to nutrient levels	GO:0031667	114	0.055
sensory perception of smell	GO:0007608	80	0.054
carboxylic acid metabolic process	GO:0019752	92	0.052
synapse organization	GO:0050808	196	0.049
circadian sleep wake cycle process	GO:0022410	24	0.047
chemical homeostasis	GO:0048878	92	0.047
neuron neuron synaptic transmission	GO:0007270	14	0.045
feeding behavior	GO:0007631	50	0.045
cell projection assembly	GO:0030031	94	0.044
sensory perception of taste	GO:0050909	25	0.044
positive regulation of response to stimulus	GO:0048584	323	0.044
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.043
intracellular transport	GO:0046907	228	0.043
nucleotide catabolic process	GO:0009166	109	0.043
regulation of multicellular organismal development	GO:2000026	414	0.041
nucleobase containing small molecule metabolic process	GO:0055086	174	0.040
telencephalon development	GO:0021537	2	0.039
response to extracellular stimulus	GO:0009991	116	0.038
regulation of cellular component biogenesis	GO:0044087	201	0.038
forebrain development	GO:0030900	2	0.038
cellular response to organic substance	GO:0071310	132	0.037
regulation of ion transmembrane transport	GO:0034765	27	0.036
organic acid metabolic process	GO:0006082	103	0.036
growth	GO:0040007	359	0.035
blood circulation	GO:0008015	26	0.035
establishment of localization in cell	GO:0051649	402	0.035
response to endogenous stimulus	GO:0009719	119	0.034
detection of light stimulus	GO:0009583	58	0.033
regulation of synapse structure and activity	GO:0050803	128	0.033
synapse assembly	GO:0007416	143	0.032
vesicle mediated transport	GO:0016192	381	0.032
muscle system process	GO:0003012	21	0.032	Worm
reflex	GO:0060004	6	0.031
regulation of catalytic activity	GO:0050790	185	0.031
regulation of phosphorus metabolic process	GO:0051174	210	0.031
nucleobase containing compound catabolic process	GO:0034655	165	0.031
cell death	GO:0008219	279	0.031
negative regulation of response to stimulus	GO:0048585	258	0.031
oxoacid metabolic process	GO:0043436	103	0.030
adult walking behavior	GO:0007628	9	0.030
response to osmotic stress	GO:0006970	14	0.030
cellular macromolecule localization	GO:0070727	220	0.029
calcium ion homeostasis	GO:0055074	23	0.028
regulation of feeding behavior	GO:0060259	16	0.028
cytoskeleton dependent intracellular transport	GO:0030705	44	0.028
organonitrogen compound biosynthetic process	GO:1901566	117	0.028
single organism intracellular transport	GO:1902582	207	0.028
response to organonitrogen compound	GO:0010243	75	0.028
adult locomotory behavior	GO:0008344	76	0.028
purine ribonucleoside metabolic process	GO:0046128	127	0.028
positive regulation of biosynthetic process	GO:0009891	316	0.028
organophosphate metabolic process	GO:0019637	195	0.027
cytosolic calcium ion homeostasis	GO:0051480	11	0.027
single organism catabolic process	GO:0044712	228	0.027
response to wounding	GO:0009611	94	0.027
cellular catabolic process	GO:0044248	372	0.027
cation homeostasis	GO:0055080	51	0.026
positive regulation of cell motility	GO:2000147	3	0.026
cellular homeostasis	GO:0019725	80	0.026
positive regulation of signaling	GO:0023056	243	0.026
aromatic compound catabolic process	GO:0019439	166	0.026
purine ribonucleotide catabolic process	GO:0009154	109	0.025
response to alkaloid	GO:0043279	26	0.025
regulation of multi organism process	GO:0043900	131	0.025
response to trehalose	GO:0010353	3	0.025
metal ion homeostasis	GO:0055065	44	0.024
response to heat	GO:0009408	63	0.024
lipid metabolic process	GO:0006629	121	0.024
organic cyclic compound catabolic process	GO:1901361	168	0.024
cellular protein modification process	GO:0006464	438	0.023
developmental maturation	GO:0021700	172	0.023
positive regulation of signal transduction	GO:0009967	223	0.023
digestive tract morphogenesis	GO:0048546	127	0.023
immune system process	GO:0002376	347	0.022
response to external biotic stimulus	GO:0043207	293	0.022
regulation of transmembrane transporter activity	GO:0022898	6	0.022
regulation of epithelial cell proliferation	GO:0050678	4	0.022
cellular chemical homeostasis	GO:0055082	40	0.022
monovalent inorganic cation homeostasis	GO:0055067	7	0.022
sensory perception of pain	GO:0019233	4	0.022
spinal cord development	GO:0021510	1	0.022
organelle assembly	GO:0070925	198	0.021
negative regulation of cell communication	GO:0010648	223	0.021
cellular response to hexose stimulus	GO:0071331	1	0.021
circulatory system process	GO:0003013	37	0.021
endocytosis	GO:0006897	310	0.021
dopamine receptor signaling pathway	GO:0007212	4	0.020
positive regulation of synaptic transmission glutamatergic	GO:0051968	3	0.020
aggressive behavior	GO:0002118	63	0.020
heart process	GO:0003015	37	0.020
protein localization	GO:0008104	284	0.020
programmed cell death	GO:0012501	257	0.020
positive regulation of cell migration	GO:0030335	2	0.019
synaptic growth at neuromuscular junction	GO:0051124	119	0.019
positive regulation of cellular biosynthetic process	GO:0031328	316	0.019
regulation of molecular function	GO:0065009	217	0.019
molting cycle chitin based cuticle	GO:0007591	56	0.019
morphogenesis of an epithelium	GO:0002009	276	0.019
multicellular organismal response to stress	GO:0033555	5	0.019
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.018
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.018
regulation of heart contraction	GO:0008016	21	0.018
membrane depolarization	GO:0051899	4	0.018
phenol containing compound metabolic process	GO:0018958	57	0.018
ribonucleotide metabolic process	GO:0009259	145	0.018
response to oxygen levels	GO:0070482	59	0.018
response to radiation	GO:0009314	155	0.018
positive regulation of adenylate cyclase activity	GO:0045762	8	0.018
regulation of cellular component movement	GO:0051270	42	0.018
regulation of intracellular signal transduction	GO:1902531	236	0.018
organic hydroxy compound metabolic process	GO:1901615	83	0.017
purine ribonucleotide metabolic process	GO:0009150	145	0.017
positive regulation of neurotransmitter secretion	GO:0001956	2	0.017
purine containing compound catabolic process	GO:0072523	112	0.017
protein modification process	GO:0036211	438	0.017
calcium ion transport	GO:0006816	24	0.017
regulation of cell death	GO:0010941	173	0.016
cell growth	GO:0016049	108	0.016
phagocytosis	GO:0006909	215	0.016
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.016
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.016
cellular response to starvation	GO:0009267	61	0.016
signal transduction by phosphorylation	GO:0023014	107	0.016
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.016
regulation of ion transport	GO:0043269	39	0.016
positive regulation of cell death	GO:0010942	69	0.016
developmental cell growth	GO:0048588	52	0.016
detection of external stimulus	GO:0009581	66	0.016
positive regulation of synapse assembly	GO:0051965	29	0.015
circadian sleep wake cycle	GO:0042745	28	0.015
organonitrogen compound catabolic process	GO:1901565	128	0.015
positive regulation of synaptic vesicle endocytosis	GO:1900244	4	0.015
negative regulation of gene expression	GO:0010629	387	0.015
synaptic transmission cholinergic	GO:0007271	9	0.015
regulation of protein localization	GO:0032880	76	0.015
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.015
central nervous system development	GO:0007417	201	0.015
nucleoside phosphate metabolic process	GO:0006753	162	0.015
organic substance catabolic process	GO:1901575	308	0.015	Worm
phototransduction	GO:0007602	52	0.015
nucleoside phosphate catabolic process	GO:1901292	110	0.015
cellular cation homeostasis	GO:0030003	38	0.015
regulation of blood circulation	GO:1903522	21	0.014
cell proliferation	GO:0008283	299	0.014
regulation of nucleotide metabolic process	GO:0006140	62	0.014
sensory perception of touch	GO:0050975	11	0.014
response to decreased oxygen levels	GO:0036293	58	0.014
immune response regulating signaling pathway	GO:0002764	2	0.014
regulation of protein metabolic process	GO:0051246	256	0.014
positive regulation of locomotion	GO:0040017	8	0.014
death	GO:0016265	284	0.014
catabolic process	GO:0009056	409	0.014	Worm
short term memory	GO:0007614	19	0.014
positive regulation of multicellular organismal process	GO:0051240	143	0.013
nucleotide metabolic process	GO:0009117	161	0.013
regulation of olfactory learning	GO:0090328	8	0.013
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.013
cellular response to growth factor stimulus	GO:0071363	30	0.013
carbohydrate derivative catabolic process	GO:1901136	118	0.013
cellular nitrogen compound catabolic process	GO:0044270	165	0.013
organic substance transport	GO:0071702	257	0.013
positive regulation of transport	GO:0051050	92	0.013
positive regulation of intracellular signal transduction	GO:1902533	116	0.013
rhythmic synaptic transmission	GO:0060024	2	0.013
cellular amino acid metabolic process	GO:0006520	61	0.013
detection of hexose stimulus	GO:0009732	1	0.013
apoptotic process	GO:0006915	159	0.013
regulation of locomotion	GO:0040012	42	0.013
regulation of filopodium assembly	GO:0051489	24	0.012
establishment of organelle localization	GO:0051656	122	0.012
cellular protein localization	GO:0034613	160	0.012
cellular response to organonitrogen compound	GO:0071417	36	0.012
cellular metal ion homeostasis	GO:0006875	31	0.012
anatomical structure homeostasis	GO:0060249	97	0.012
divalent inorganic cation homeostasis	GO:0072507	29	0.012
negative regulation of cellular metabolic process	GO:0031324	382	0.012
regulation of cellular amine metabolic process	GO:0033238	3	0.012
ribose phosphate metabolic process	GO:0019693	145	0.012
cellular response to extracellular stimulus	GO:0031668	64	0.012
positive regulation of immune response	GO:0050778	63	0.012
regulation of phosphatase activity	GO:0010921	3	0.012
glycosyl compound catabolic process	GO:1901658	112	0.012
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	26	0.012
regulation of nucleotide catabolic process	GO:0030811	48	0.012
amine metabolic process	GO:0009308	12	0.012
regulation of nervous system development	GO:0051960	248	0.012
cell cycle phase transition	GO:0044770	140	0.012	Human
regulation of phosphorylation	GO:0042325	147	0.011
negative regulation of cell death	GO:0060548	81	0.011
regulation of cell proliferation	GO:0042127	163	0.011
response to transforming growth factor beta	GO:0071559	18	0.011
positive regulation of molecular function	GO:0044093	136	0.011
response to hypoxia	GO:0001666	53	0.011
regionalization	GO:0003002	416	0.011
heart contraction	GO:0060047	26	0.011
cellular response to lipopolysaccharide	GO:0071222	3	0.011
detection of chemical stimulus involved in sensory perception of taste	GO:0050912	13	0.011
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.010
cellular component assembly involved in morphogenesis	GO:0010927	151	0.010
carbohydrate derivative metabolic process	GO:1901135	217	0.010
ribonucleotide catabolic process	GO:0009261	109	0.010
drinking behavior	GO:0042756	2	0.010
cellular response to dna damage stimulus	GO:0006974	223	0.010
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.010
thermosensory behavior	GO:0040040	19	0.010
intercellular transport	GO:0010496	2	0.010
antimicrobial humoral response	GO:0019730	99	0.010
response to nitrogen compound	GO:1901698	90	0.010
regulation of protein modification process	GO:0031399	112	0.010

eag disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.520
nervous system disease	DOID:863	0.018
central nervous system disease	DOID:331	0.013
disease of cellular proliferation	DOID:14566	0.011
urinary system disease	DOID:18	0.010

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