IMP: Integrative Multi-species Prediction

Drosophila melanogaster

115 known processes

vnd (Dmel_CG6172)

ventral nervous system defective

(Aliases: l(1)1Bf,NK2,l(1)EC6,Dmel\CG6172,HDC16822,NK-2,l(1)RC24,l(1)EA142,VND,nk-2,l(1)VA208,l(1)GA122,EG:118B3.1,l(1)VE769,l(1)GA100,vnd/NK-2,Dm-NK2,Nkx2,dNK-2,lab,EC6,Vnd,CG6172)

Entrez: 31003
FLYBASE: FBgn0261930
UniProtKB: P22808
UniProtKB: Q0KHX8

Process Predictions
Disease Predictions

vnd biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
taxis	GO:0042330	304	0.922
axon development	GO:0061564	297	0.774
dendrite guidance	GO:0070983	21	0.667
axonogenesis	GO:0007409	290	0.649
axon guidance	GO:0007411	233	0.644
neuron projection guidance	GO:0097485	241	0.631
motor neuron axon guidance	GO:0008045	58	0.537
regulation of axon extension involved in axon guidance	GO:0048841	4	0.427
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.426
salivary gland development	GO:0007431	162	0.402
regulation of multicellular organismal development	GO:2000026	414	0.342
positive regulation of axonogenesis	GO:0050772	2	0.334
negative regulation of gene expression	GO:0010629	387	0.310
gland morphogenesis	GO:0022612	145	0.289
negative regulation of cellular metabolic process	GO:0031324	382	0.280
negative regulation of rna biosynthetic process	GO:1902679	240	0.270
exocrine system development	GO:0035272	162	0.242
apoptotic process	GO:0006915	159	0.220
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.215
negative regulation of biosynthetic process	GO:0009890	277	0.204
chemotaxis	GO:0006935	249	0.188
embryo development ending in birth or egg hatching	GO:0009792	152	0.176
gland development	GO:0048732	191	0.158
regulation of protein metabolic process	GO:0051246	256	0.151
positive regulation of cell communication	GO:0010647	250	0.147
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.146
central nervous system development	GO:0007417	201	0.143
ventral cord development	GO:0007419	16	0.142
glial cell differentiation	GO:0010001	35	0.140
gliogenesis	GO:0042063	80	0.138
salivary gland morphogenesis	GO:0007435	145	0.136
negative regulation of rna metabolic process	GO:0051253	251	0.135
dorsal ventral axon guidance	GO:0033563	2	0.132
negative regulation of axon extension	GO:0030517	3	0.126
negative regulation of transcription dna templated	GO:0045892	237	0.124
morphogenesis of an epithelium	GO:0002009	276	0.122
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.119
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.116
multicellular organismal reproductive behavior	GO:0033057	110	0.105
regulation of nervous system development	GO:0051960	248	0.103
regulation of epithelial cell migration open tracheal system	GO:2000274	11	0.102
cardiovascular system development	GO:0072358	82	0.101
regulation of axon guidance	GO:1902667	10	0.098
cell junction organization	GO:0034330	57	0.092
regionalization	GO:0003002	416	0.087
regulation of oocyte development	GO:0060281	27	0.084
regulation of developmental growth	GO:0048638	174	0.082
death	GO:0016265	284	0.079
positive regulation of rna metabolic process	GO:0051254	271	0.079
neuron recognition	GO:0008038	101	0.075
regulation of cell fate commitment	GO:0010453	29	0.072
regulation of cellular protein metabolic process	GO:0032268	243	0.072
spinal cord development	GO:0021510	1	0.071
organelle assembly	GO:0070925	198	0.070
head development	GO:0060322	135	0.069
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.069
multi organism reproductive behavior	GO:0044705	121	0.068
negative regulation of nervous system development	GO:0051961	92	0.068
asymmetric cell division	GO:0008356	37	0.067
oocyte maturation	GO:0001556	3	0.063
body morphogenesis	GO:0010171	2	0.062
embryonic pattern specification	GO:0009880	174	0.062
reproductive system development	GO:0061458	74	0.061
regulation of synapse structure and activity	GO:0050803	128	0.061
developmental growth	GO:0048589	280	0.061
eye photoreceptor cell differentiation	GO:0001754	145	0.061
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.061
organic hydroxy compound metabolic process	GO:1901615	83	0.060
cardioblast differentiation	GO:0010002	20	0.060
response to other organism	GO:0051707	293	0.059
reproductive behavior	GO:0019098	122	0.059
cell motility	GO:0048870	251	0.058
cell junction assembly	GO:0034329	42	0.057
negative regulation of cellular biosynthetic process	GO:0031327	277	0.056
vesicle mediated transport	GO:0016192	381	0.055
regulation of organelle organization	GO:0033043	196	0.055
tube development	GO:0035295	244	0.054
negative regulation of cell differentiation	GO:0045596	143	0.052
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.049
programmed cell death	GO:0012501	257	0.048
adult behavior	GO:0030534	137	0.047
regulation of localization	GO:0032879	275	0.047
proteolysis	GO:0006508	192	0.047
skeletal muscle organ development	GO:0060538	48	0.046
cardioblast cell fate commitment	GO:0042684	14	0.046
positive regulation of biosynthetic process	GO:0009891	316	0.046
synapse assembly	GO:0007416	143	0.044
axon midline choice point recognition	GO:0016199	26	0.043
muscle attachment	GO:0016203	36	0.043
cell projection assembly	GO:0030031	94	0.042
response to abiotic stimulus	GO:0009628	341	0.042
amine metabolic process	GO:0009308	12	0.041
axon choice point recognition	GO:0016198	26	0.041
regulation of immune system process	GO:0002682	176	0.041
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.040
cell maturation	GO:0048469	144	0.040
tissue morphogenesis	GO:0048729	297	0.040
locomotory behavior	GO:0007626	176	0.039
transcription from rna polymerase ii promoter	GO:0006366	368	0.039
digestive system development	GO:0055123	149	0.039
pigment cell differentiation	GO:0050931	3	0.039
asymmetric neuroblast division	GO:0055059	33	0.039
immune system process	GO:0002376	347	0.039
positive regulation of gene expression	GO:0010628	290	0.039
regulation of axonogenesis	GO:0050770	32	0.039
glial cell migration	GO:0008347	31	0.038
neuron fate commitment	GO:0048663	50	0.038
oocyte development	GO:0048599	124	0.038
determination of muscle attachment site	GO:0016204	7	0.038
immune response	GO:0006955	246	0.038
multi organism behavior	GO:0051705	175	0.038
stem cell fate commitment	GO:0048865	25	0.037
negative regulation of growth	GO:0045926	84	0.037
negative regulation of cell communication	GO:0010648	223	0.037
regulation of anatomical structure morphogenesis	GO:0022603	242	0.036
phosphatidylinositol mediated signaling	GO:0048015	4	0.036
glial cell development	GO:0021782	27	0.036
regulation of apoptotic process	GO:0042981	130	0.036
organic substance transport	GO:0071702	257	0.035
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.035
dendrite development	GO:0016358	204	0.035
negative regulation of developmental process	GO:0051093	201	0.034
single organism cell adhesion	GO:0098602	47	0.033
cell migration	GO:0016477	238	0.033
regulation of chromosome organization	GO:0033044	64	0.033
localization of cell	GO:0051674	257	0.033
regulation of cellular amine metabolic process	GO:0033238	3	0.032
cellular catabolic process	GO:0044248	372	0.032
positive regulation of developmental growth	GO:0048639	62	0.032
negative regulation of chemotaxis	GO:0050922	1	0.031
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.031
endocytosis	GO:0006897	310	0.031
regulation of cellular component movement	GO:0051270	42	0.031
response to biotic stimulus	GO:0009607	294	0.031
tube morphogenesis	GO:0035239	191	0.030
negative regulation of phosphate metabolic process	GO:0045936	45	0.030
positive regulation of signaling	GO:0023056	243	0.030
digestive tract morphogenesis	GO:0048546	127	0.030
cardiac cell fate commitment	GO:0060911	17	0.029
retina morphogenesis in camera type eye	GO:0060042	2	0.029
negative regulation of cell development	GO:0010721	62	0.029
positive regulation of cellular component organization	GO:0051130	156	0.029
rna localization	GO:0006403	115	0.029
salivary gland boundary specification	GO:0007432	8	0.029
growth	GO:0040007	359	0.029
neural precursor cell proliferation	GO:0061351	75	0.028
eye photoreceptor cell fate commitment	GO:0042706	37	0.028
chromatin remodeling	GO:0006338	72	0.028
salivary gland cell autophagic cell death	GO:0035071	83	0.028
regulation of cellular component biogenesis	GO:0044087	201	0.027
positive regulation of transcription dna templated	GO:0045893	266	0.027
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.027
response to nitrogen compound	GO:1901698	90	0.027
response to radiation	GO:0009314	155	0.027
carboxylic acid metabolic process	GO:0019752	92	0.027
carbohydrate derivative biosynthetic process	GO:1901137	85	0.026
developmental maturation	GO:0021700	172	0.026
male courtship behavior veined wing extension	GO:0048065	22	0.026
negative regulation of cellular component organization	GO:0051129	108	0.026
telencephalon development	GO:0021537	2	0.026
substrate dependent cell migration	GO:0006929	3	0.025
positive regulation of macromolecule metabolic process	GO:0010604	405	0.025
anatomical structure homeostasis	GO:0060249	97	0.025
regulation of response to external stimulus	GO:0032101	115	0.025
cellular component assembly involved in morphogenesis	GO:0010927	151	0.025
negative regulation of synapse assembly	GO:0051964	39	0.025
positive regulation of epithelial cell differentiation	GO:0030858	1	0.025
negative regulation of cellular protein metabolic process	GO:0032269	85	0.024
regulation of cell projection organization	GO:0031344	92	0.024
establishment of glial blood brain barrier	GO:0060857	14	0.024
cell death	GO:0008219	279	0.024
regulation of protein complex assembly	GO:0043254	42	0.024
chromatin modification	GO:0016568	147	0.024
regulation of cell division	GO:0051302	72	0.024
positive regulation of developmental process	GO:0051094	143	0.024
compound eye morphogenesis	GO:0001745	249	0.023
regulation of protein modification process	GO:0031399	112	0.023
regulation of molecular function	GO:0065009	217	0.023
protein phosphorylation	GO:0006468	169	0.023
mesenchymal cell differentiation	GO:0048762	1	0.023
regulation of cellular localization	GO:0060341	136	0.023
muscle tissue morphogenesis	GO:0060415	2	0.023
positive regulation of cellular biosynthetic process	GO:0031328	316	0.023
positive regulation of cellular protein metabolic process	GO:0032270	118	0.023
regulation of cellular amino acid metabolic process	GO:0006521	0	0.023
regulation of reproductive process	GO:2000241	54	0.022
protein transport	GO:0015031	155	0.022
regulation of growth	GO:0040008	233	0.022
cell fate determination	GO:0001709	91	0.022
negative regulation of phosphorus metabolic process	GO:0010563	45	0.022
synaptic target recognition	GO:0008039	45	0.022
forebrain development	GO:0030900	2	0.022
regulation of proteolysis	GO:0030162	87	0.022
regulation of immune response	GO:0050776	118	0.022
camera type eye morphogenesis	GO:0048593	2	0.021
myofibril assembly	GO:0030239	36	0.021
regulation of cellular ketone metabolic process	GO:0010565	3	0.021
cellular ketone metabolic process	GO:0042180	24	0.021
formation of organ boundary	GO:0010160	30	0.021
development of primary sexual characteristics	GO:0045137	50	0.021
oocyte differentiation	GO:0009994	145	0.021
regulation of notch signaling pathway	GO:0008593	100	0.020
heart development	GO:0007507	82	0.020
response to organic substance	GO:0010033	284	0.020
posttranscriptional regulation of gene expression	GO:0010608	145	0.020
pole plasm oskar mrna localization	GO:0045451	46	0.020
cellular amine metabolic process	GO:0044106	12	0.020
rna processing	GO:0006396	147	0.020
cardiac cell fate determination	GO:0060913	3	0.020
muscle structure development	GO:0061061	224	0.019
nuclear division	GO:0000280	332	0.019
regulation of neuron differentiation	GO:0045664	103	0.019
response to external biotic stimulus	GO:0043207	293	0.019
regulation of chromatin modification	GO:1903308	28	0.019
cellular macromolecular complex assembly	GO:0034622	153	0.018
circulatory system development	GO:0072359	82	0.018
convergent extension	GO:0060026	2	0.018
positive regulation of rna biosynthetic process	GO:1902680	266	0.018
regulation of phosphorus metabolic process	GO:0051174	210	0.018
macromolecular complex assembly	GO:0065003	256	0.018
establishment or maintenance of cell polarity	GO:0007163	167	0.018
phosphorylation	GO:0016310	294	0.018
cell fate specification	GO:0001708	71	0.017
mitotic nuclear division	GO:0007067	213	0.017
cardiocyte differentiation	GO:0035051	29	0.017
lipid metabolic process	GO:0006629	121	0.017
actin cytoskeleton organization	GO:0030036	206	0.017
central nervous system neuron differentiation	GO:0021953	8	0.017
neuroblast division	GO:0055057	35	0.017
positive regulation of protein metabolic process	GO:0051247	128	0.017
compound eye development	GO:0048749	307	0.017
cell recognition	GO:0008037	102	0.017
axonal fasciculation	GO:0007413	12	0.016
positive regulation of axon guidance	GO:1902669	1	0.016
regulation of muscle cell differentiation	GO:0051147	8	0.016
regulation of epithelial cell differentiation	GO:0030856	4	0.016
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.016
negative regulation of multicellular organismal process	GO:0051241	142	0.016
hematopoietic or lymphoid organ development	GO:0048534	57	0.016
salivary gland histolysis	GO:0035070	88	0.016
spindle elongation	GO:0051231	83	0.016
regulation of cardiac cell fate specification	GO:2000043	8	0.016
muscle cell differentiation	GO:0042692	103	0.016
neuron remodeling	GO:0016322	29	0.016
regulation of cell development	GO:0060284	215	0.015
multi multicellular organism process	GO:0044706	123	0.015
regulation of cell proliferation	GO:0042127	163	0.015
axon extension involved in axon guidance	GO:0048846	10	0.015
protein complex biogenesis	GO:0070271	201	0.015
regulation of dendrite development	GO:0050773	37	0.015
central complex development	GO:0048036	9	0.015
homeostatic process	GO:0042592	199	0.015
larval development	GO:0002164	104	0.015
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.015
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.015
response to bacterium	GO:0009617	198	0.015
ectodermal placode morphogenesis	GO:0071697	4	0.015
extrinsic apoptotic signaling pathway	GO:0097191	1	0.015
response to alcohol	GO:0097305	95	0.015
neuroblast differentiation	GO:0014016	29	0.015
response to light stimulus	GO:0009416	124	0.014
retinal cone cell differentiation	GO:0042670	2	0.014
nephron epithelium development	GO:0072009	3	0.014
cellular protein modification process	GO:0006464	438	0.014
reproductive structure development	GO:0048608	74	0.014
synaptic transmission	GO:0007268	288	0.014
sarcomere organization	GO:0045214	26	0.014
photoreceptor cell differentiation	GO:0046530	170	0.014
regulation of catabolic process	GO:0009894	170	0.014
negative regulation of response to stimulus	GO:0048585	258	0.014
cardioblast cell fate specification	GO:0042685	9	0.014
neuron fate specification	GO:0048665	12	0.014
neuron projection extension involved in neuron projection guidance	GO:1902284	10	0.014
columnar cuboidal epithelial cell development	GO:0002066	249	0.014
kidney epithelium development	GO:0072073	3	0.014
ameboidal type cell migration	GO:0001667	151	0.013
gastrulation	GO:0007369	70	0.013
aging	GO:0007568	143	0.013
positive regulation of organelle organization	GO:0010638	65	0.013
positive regulation of response to stimulus	GO:0048584	323	0.013
regulation of cytoskeleton organization	GO:0051493	89	0.013
regulation of cellular catabolic process	GO:0031329	157	0.013
jak stat cascade	GO:0007259	49	0.013
establishment of localization in cell	GO:0051649	402	0.013
regulation of neurogenesis	GO:0050767	158	0.013
regulation of cell fate specification	GO:0042659	27	0.013
epithelial tube morphogenesis	GO:0060562	88	0.013
multicellular organism growth	GO:0035264	46	0.012
synapse organization	GO:0050808	196	0.012
positive regulation of phosphorus metabolic process	GO:0010562	139	0.012
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.012
roundabout signaling pathway	GO:0035385	4	0.012
striated muscle cell differentiation	GO:0051146	90	0.012
negative regulation of immune system process	GO:0002683	50	0.012
photoreceptor cell axon guidance	GO:0072499	23	0.012
protein modification process	GO:0036211	438	0.012
eye antennal disc development	GO:0035214	60	0.012
negative regulation of response to external stimulus	GO:0032102	22	0.012
spermatid differentiation	GO:0048515	114	0.012
dendrite morphogenesis	GO:0048813	199	0.012
defense response to bacterium	GO:0042742	178	0.012
inositol lipid mediated signaling	GO:0048017	4	0.012
negative regulation of protein metabolic process	GO:0051248	85	0.012
histone methylation	GO:0016571	40	0.012
positive regulation of axon extension	GO:0045773	2	0.012
chromatin organization	GO:0006325	207	0.012
glycoprotein biosynthetic process	GO:0009101	41	0.012
regulation of synaptic transmission	GO:0050804	69	0.012
regulation of synapse assembly	GO:0051963	94	0.012
single organism biosynthetic process	GO:0044711	206	0.012
spindle localization	GO:0051653	22	0.012
carbohydrate derivative metabolic process	GO:1901135	217	0.012
positive regulation of behavior	GO:0048520	19	0.012
blastoderm segmentation	GO:0007350	159	0.011
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.011
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.011
ectodermal placode development	GO:0071696	4	0.011
regulation of multi organism process	GO:0043900	131	0.011
cellular response to organic substance	GO:0071310	132	0.011
muscle organ development	GO:0007517	127	0.011
positive regulation of signal transduction	GO:0009967	223	0.011
positive regulation of neurogenesis	GO:0050769	41	0.011
brain development	GO:0007420	120	0.011
single organism behavior	GO:0044708	391	0.011
antennal development	GO:0007469	25	0.011
imaginal disc derived appendage development	GO:0048737	399	0.011
mesenchymal cell development	GO:0014031	1	0.011
single organism intracellular transport	GO:1902582	207	0.011
neuronal stem cell division	GO:0036445	35	0.011
protein polymerization	GO:0051258	42	0.011
muscle organ morphogenesis	GO:0048644	7	0.011
neuron apoptotic process	GO:0051402	17	0.011
neuroblast fate commitment	GO:0014017	19	0.011
regulation of transport	GO:0051049	181	0.011
regulation of catalytic activity	GO:0050790	185	0.011
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.011
regulation of hemocyte proliferation	GO:0035206	37	0.011
cytoplasmic transport	GO:0016482	130	0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.010
lamellipodium organization	GO:0097581	21	0.010
negative regulation of catalytic activity	GO:0043086	42	0.010
organelle fission	GO:0048285	340	0.010
regulation of chromatin organization	GO:1902275	32	0.010
phagocytosis	GO:0006909	215	0.010
ovulation	GO:0030728	4	0.010
positive regulation of cell migration	GO:0030335	2	0.010
outflow tract morphogenesis	GO:0003151	4	0.010
negative regulation of organelle organization	GO:0010639	56	0.010
regulation of hormone levels	GO:0010817	40	0.010
anterior posterior pattern specification	GO:0009952	136	0.010
cellular macromolecule localization	GO:0070727	220	0.010
negative regulation of neuron differentiation	GO:0045665	16	0.010
neural retina development	GO:0003407	4	0.010
segmentation	GO:0035282	207	0.010
spindle organization	GO:0007051	253	0.010
cellular amino acid metabolic process	GO:0006520	61	0.010
actin filament based process	GO:0030029	220	0.010

vnd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.126
disease of cellular proliferation	DOID:14566	0.126
waardenburg s syndrome	DOID:9258	0.057
organ system cancer	DOID:0050686	0.049
musculoskeletal system cancer	DOID:0060100	0.048
disease of anatomical entity	DOID:7	0.032
musculoskeletal system disease	DOID:17	0.010

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