IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

kal-1 (Dmel_CG6173)

CG6173 gene product from transcript CG6173-RA

(Aliases: Dmkal,Dmel\CG6173,CG6173,DmKal-1,CT19368)

Entrez: 42865
FLYBASE: FBgn0039155
UniProtKB: Q9VCC7

Process Predictions
Disease Predictions

kal-1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
torso signaling pathway	GO:0008293	21	0.248
terminal region determination	GO:0007362	25	0.181
positive regulation of developmental process	GO:0051094	143	0.166
imaginal disc derived wing morphogenesis	GO:0007476	337	0.150
appendage morphogenesis	GO:0035107	397	0.144
appendage development	GO:0048736	401	0.137
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.121
negative regulation of transcription dna templated	GO:0045892	237	0.114
regulation of multicellular organismal development	GO:2000026	414	0.113
negative regulation of signaling	GO:0023057	219	0.113
positive regulation of multicellular organismal process	GO:0051240	143	0.110
growth	GO:0040007	359	0.106
body morphogenesis	GO:0010171	2	0.102
negative regulation of gene expression	GO:0010629	387	0.099
renal tubule development	GO:0061326	64	0.097
small molecule metabolic process	GO:0044281	305	0.092
head development	GO:0060322	135	0.091
regionalization	GO:0003002	416	0.085
cell motility	GO:0048870	251	0.083
regulation of nervous system development	GO:0051960	248	0.082
wing disc morphogenesis	GO:0007472	344	0.081
imaginal disc derived appendage development	GO:0048737	399	0.074
post embryonic appendage morphogenesis	GO:0035120	385	0.074
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.073
respiratory system development	GO:0060541	213	0.072
open tracheal system development	GO:0007424	204	0.070
developmental growth	GO:0048589	280	0.064
transcription from rna polymerase ii promoter	GO:0006366	368	0.062
cellular response to chemical stimulus	GO:0070887	199	0.061
organonitrogen compound metabolic process	GO:1901564	318	0.059
positive regulation of macromolecule metabolic process	GO:0010604	405	0.057
imaginal disc derived wing vein specification	GO:0007474	48	0.055
single organism biosynthetic process	GO:0044711	206	0.054
oxoacid metabolic process	GO:0043436	103	0.052
negative regulation of biosynthetic process	GO:0009890	277	0.050
response to abiotic stimulus	GO:0009628	341	0.050
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.049
regulation of anatomical structure size	GO:0090066	163	0.049
cellular ketone metabolic process	GO:0042180	24	0.048
negative regulation of cell communication	GO:0010648	223	0.047
positive regulation of response to stimulus	GO:0048584	323	0.047
multi organism behavior	GO:0051705	175	0.047
mesoderm development	GO:0007498	78	0.046
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.045
positive regulation of signal transduction	GO:0009967	223	0.044
regulation of notch signaling pathway	GO:0008593	100	0.044
axis specification	GO:0009798	167	0.044
regulation of cell development	GO:0060284	215	0.042
nephron development	GO:0072006	3	0.042
gland development	GO:0048732	191	0.042
camera type eye development	GO:0043010	4	0.041
carboxylic acid metabolic process	GO:0019752	92	0.041
negative regulation of response to stimulus	GO:0048585	258	0.040
neurological system process	GO:0050877	358	0.039
regulation of cell differentiation	GO:0045595	302	0.039
tube development	GO:0035295	244	0.038
positive regulation of signaling	GO:0023056	243	0.038
connective tissue development	GO:0061448	3	0.037
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.037
positive regulation of gene expression	GO:0010628	290	0.036
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.036
phagocytosis	GO:0006909	215	0.036
blastoderm segmentation	GO:0007350	159	0.036
negative regulation of developmental process	GO:0051093	201	0.035
zygotic determination of anterior posterior axis embryo	GO:0007354	27	0.035
regulation of imaginal disc derived wing size	GO:0044719	20	0.035
protein modification process	GO:0036211	438	0.035
gastrulation	GO:0007369	70	0.034
renal tubule morphogenesis	GO:0061333	44	0.034
response to other organism	GO:0051707	293	0.034
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.034
embryonic development via the syncytial blastoderm	GO:0001700	148	0.034
organonitrogen compound biosynthetic process	GO:1901566	117	0.033
kidney epithelium development	GO:0072073	3	0.033
digestive system development	GO:0055123	149	0.033
insecticide metabolic process	GO:0017143	2	0.033
regulation of cellular ketone metabolic process	GO:0010565	3	0.032
brain development	GO:0007420	120	0.032
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.032
humoral immune response	GO:0006959	117	0.032
forebrain development	GO:0030900	2	0.032
negative regulation of signal transduction	GO:0009968	206	0.032
lipid metabolic process	GO:0006629	121	0.032
digestive tract morphogenesis	GO:0048546	127	0.031
organic acid metabolic process	GO:0006082	103	0.031
catabolic process	GO:0009056	409	0.030
regulation of hormone levels	GO:0010817	40	0.030
regulation of cellular amino acid metabolic process	GO:0006521	0	0.030
xenobiotic catabolic process	GO:0042178	1	0.030
androgen metabolic process	GO:0008209	1	0.030
stem cell differentiation	GO:0048863	117	0.030
eye development	GO:0001654	323	0.029
positive regulation of cellular biosynthetic process	GO:0031328	316	0.029
embryonic morphogenesis	GO:0048598	206	0.029
segmentation	GO:0035282	207	0.028
endocytosis	GO:0006897	310	0.028
response to temperature stimulus	GO:0009266	106	0.028
cellular amine metabolic process	GO:0044106	12	0.028
anterior posterior pattern specification	GO:0009952	136	0.028
regulation of localization	GO:0032879	275	0.027
embryo development ending in birth or egg hatching	GO:0009792	152	0.027
cellular protein modification process	GO:0006464	438	0.027
hormone catabolic process	GO:0042447	3	0.027
vesicle mediated transport	GO:0016192	381	0.027
regulation of developmental growth	GO:0048638	174	0.027
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.026
response to organic substance	GO:0010033	284	0.026
positive regulation of cell communication	GO:0010647	250	0.026
myotube cell development	GO:0014904	3	0.026
programmed cell death	GO:0012501	257	0.026
anterior posterior axis specification	GO:0009948	109	0.025
amino sugar metabolic process	GO:0006040	10	0.025
embryonic hindgut morphogenesis	GO:0048619	48	0.025
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.025
regulation of cellular amine metabolic process	GO:0033238	3	0.025
protein secretion	GO:0009306	45	0.024
erbb signaling pathway	GO:0038127	58	0.024
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.024
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.024
regulation of immune response	GO:0050776	118	0.024
embryonic axis specification	GO:0000578	107	0.024
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.024
carbohydrate derivative metabolic process	GO:1901135	217	0.024
negative regulation of rna metabolic process	GO:0051253	251	0.023
negative regulation of notch signaling pathway	GO:0045746	41	0.023
response to endogenous stimulus	GO:0009719	119	0.023
chemical homeostasis	GO:0048878	92	0.023
homeostatic process	GO:0042592	199	0.023
localization of cell	GO:0051674	257	0.022
amine metabolic process	GO:0009308	12	0.022
chitin based embryonic cuticle biosynthetic process	GO:0008362	16	0.022
negative regulation of cellular metabolic process	GO:0031324	382	0.022
regulation of epithelial cell differentiation	GO:0030856	4	0.022
tissue morphogenesis	GO:0048729	297	0.022
morphogenesis of an epithelium	GO:0002009	276	0.021
anterior posterior axis specification embryo	GO:0008595	103	0.021
positive regulation of cellular amine metabolic process	GO:0033240	0	0.021
cuticle development	GO:0042335	86	0.021
positive regulation of rna biosynthetic process	GO:1902680	266	0.021
cellular macromolecule catabolic process	GO:0044265	136	0.021
regulation of growth	GO:0040008	233	0.021
organic substance catabolic process	GO:1901575	308	0.020
epithelial tube morphogenesis	GO:0060562	88	0.020
antimicrobial peptide production	GO:0002775	46	0.020
morphogenesis of follicular epithelium	GO:0016333	36	0.019
cellular amide metabolic process	GO:0043603	80	0.019
positive regulation of transcription dna templated	GO:0045893	266	0.019
sensory perception of smell	GO:0007608	80	0.019
cellular response to organic substance	GO:0071310	132	0.019
kidney development	GO:0001822	3	0.019
notch signaling pathway	GO:0007219	120	0.018
l glutamate import	GO:0051938	1	0.018
negative regulation of cellular biosynthetic process	GO:0031327	277	0.018
positive regulation of biosynthetic process	GO:0009891	316	0.018
response to external biotic stimulus	GO:0043207	293	0.018
cellular amino acid metabolic process	GO:0006520	61	0.018
positive regulation of rna metabolic process	GO:0051254	271	0.018
response to wounding	GO:0009611	94	0.018
tripartite regional subdivision	GO:0007351	103	0.018
organic cyclic compound catabolic process	GO:1901361	168	0.018
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.017
chromosome organization	GO:0051276	360	0.017
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.017
response to biotic stimulus	GO:0009607	294	0.017
malpighian tubule development	GO:0072002	64	0.017
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.017
cellular catabolic process	GO:0044248	372	0.017
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.017
regulation of anatomical structure morphogenesis	GO:0022603	242	0.017
inositol lipid mediated signaling	GO:0048017	4	0.017
positive regulation of phosphate metabolic process	GO:0045937	139	0.016
cellular lipid metabolic process	GO:0044255	83	0.016
endomembrane system organization	GO:0010256	119	0.016
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.016
cellular homeostasis	GO:0019725	80	0.016
peptidyl tyrosine phosphorylation	GO:0018108	24	0.016
anatomical structure homeostasis	GO:0060249	97	0.016
cellular nitrogen compound catabolic process	GO:0044270	165	0.016
larval development	GO:0002164	104	0.016
aggressive behavior	GO:0002118	63	0.016
regulation of protein metabolic process	GO:0051246	256	0.016
epithelial cell development	GO:0002064	274	0.016
regulation of embryonic development	GO:0045995	68	0.016
regulation of molecular function	GO:0065009	217	0.016
protein complex biogenesis	GO:0070271	201	0.016
macromolecular complex assembly	GO:0065003	256	0.016
immune response regulating signaling pathway	GO:0002764	2	0.015
chromatin organization	GO:0006325	207	0.015
glucosamine containing compound metabolic process	GO:1901071	9	0.015
organic substance transport	GO:0071702	257	0.015
lipid biosynthetic process	GO:0008610	46	0.015
cell death	GO:0008219	279	0.015
multicellular organismal homeostasis	GO:0048871	41	0.015
heterocycle catabolic process	GO:0046700	166	0.015
multicellular organismal reproductive behavior	GO:0033057	110	0.015
regulation of defense response	GO:0031347	102	0.015
steroid catabolic process	GO:0006706	1	0.015
ovarian follicle cell development	GO:0030707	248	0.015
negative regulation of multicellular organismal process	GO:0051241	142	0.015
reproductive behavior	GO:0019098	122	0.015
exocrine system development	GO:0035272	162	0.015
tor signaling	GO:0031929	32	0.015
skeletal muscle organ development	GO:0060538	48	0.014
olfactory behavior	GO:0042048	97	0.014
segment specification	GO:0007379	33	0.014
carbohydrate derivative biosynthetic process	GO:1901137	85	0.014
regulation of response to stress	GO:0080134	200	0.014
skeletal muscle fiber development	GO:0048741	3	0.014
regulation of neuron projection development	GO:0010975	69	0.014
steroid metabolic process	GO:0008202	20	0.014
anion homeostasis	GO:0055081	3	0.014
salivary gland cell autophagic cell death	GO:0035071	83	0.014
regulation of phosphorus metabolic process	GO:0051174	210	0.014
digestive tract development	GO:0048565	149	0.014
nephron tubule morphogenesis	GO:0072078	3	0.014
protein phosphorylation	GO:0006468	169	0.014
hindgut development	GO:0061525	58	0.014
response to lipopolysaccharide	GO:0032496	4	0.013
actin filament based process	GO:0030029	220	0.013
defense response	GO:0006952	300	0.013
imaginal disc derived leg morphogenesis	GO:0007480	80	0.013
regulation of intracellular signal transduction	GO:1902531	236	0.013
immune response	GO:0006955	246	0.013
cellular hormone metabolic process	GO:0034754	23	0.013
kidney morphogenesis	GO:0060993	3	0.013
insecticide catabolic process	GO:0046701	1	0.013
negative regulation of peptide secretion	GO:0002792	1	0.013
regulation of organ morphogenesis	GO:2000027	78	0.013
biological adhesion	GO:0022610	138	0.013
protein modification by small protein conjugation or removal	GO:0070647	106	0.013
antimicrobial humoral response	GO:0019730	99	0.013
columnar cuboidal epithelial cell development	GO:0002066	249	0.013
tube morphogenesis	GO:0035239	191	0.013
establishment of localization in cell	GO:0051649	402	0.013
phosphatidylinositol 3 kinase signaling	GO:0014065	4	0.013
heart process	GO:0003015	37	0.013
epithelial cell migration	GO:0010631	148	0.013
organonitrogen compound catabolic process	GO:1901565	128	0.013
spiracle morphogenesis open tracheal system	GO:0035277	22	0.013
negative regulation of cell differentiation	GO:0045596	143	0.013
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.013
secretion by cell	GO:0032940	101	0.013
chemotaxis	GO:0006935	249	0.013
regulation of cellular protein metabolic process	GO:0032268	243	0.012
regulation of response to biotic stimulus	GO:0002831	63	0.012
epithelial cell differentiation	GO:0030855	322	0.012
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.012
eye antennal disc development	GO:0035214	60	0.012
signal release	GO:0023061	49	0.012
tube formation	GO:0035148	21	0.012
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.012
response to decreased oxygen levels	GO:0036293	58	0.012
muscle structure development	GO:0061061	224	0.012
developmental cell growth	GO:0048588	52	0.012
phosphatidylinositol mediated signaling	GO:0048015	4	0.012
response to organophosphorus	GO:0046683	2	0.012
dendrite development	GO:0016358	204	0.012
nephron tubule development	GO:0072080	3	0.012
eye photoreceptor cell differentiation	GO:0001754	145	0.012
proteolysis	GO:0006508	192	0.012
regulation of response to wounding	GO:1903034	19	0.012
regulation of protein modification process	GO:0031399	112	0.012
gland morphogenesis	GO:0022612	145	0.012
jak stat cascade	GO:0007259	49	0.012
urogenital system development	GO:0001655	72	0.012
nitrogen compound transport	GO:0071705	85	0.012
fat soluble vitamin biosynthetic process	GO:0042362	1	0.012
spinal cord development	GO:0021510	1	0.011
neuroblast fate commitment	GO:0014017	19	0.011
cell recognition	GO:0008037	102	0.011
cell adhesion	GO:0007155	136	0.011
adipose tissue development	GO:0060612	2	0.011
multi organism reproductive behavior	GO:0044705	121	0.011
cell cycle g1 s phase transition	GO:0044843	31	0.011
hindbrain development	GO:0030902	2	0.011
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.011
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.011
intracellular signal transduction	GO:0035556	300	0.011
mitotic cell cycle phase transition	GO:0044772	138	0.011
salivary gland histolysis	GO:0035070	88	0.011
fat soluble vitamin metabolic process	GO:0006775	1	0.011
autophagic cell death	GO:0048102	83	0.011
regulation of phosphate metabolic process	GO:0019220	210	0.011
sensory organ morphogenesis	GO:0090596	260	0.011
circulatory system process	GO:0003013	37	0.011
response to hypoxia	GO:0001666	53	0.011
regulation of catalytic activity	GO:0050790	185	0.011
regulation of humoral immune response	GO:0002920	51	0.011
single organism cell adhesion	GO:0098602	47	0.011
developmental maturation	GO:0021700	172	0.011
limb morphogenesis	GO:0035108	1	0.011
vitamin metabolic process	GO:0006766	2	0.011
cellular component assembly involved in morphogenesis	GO:0010927	151	0.011
carbohydrate metabolic process	GO:0005975	82	0.011
positive regulation of phosphorus metabolic process	GO:0010562	139	0.010
regulation of bmp signaling pathway	GO:0030510	23	0.010
regulation of synapse structure and activity	GO:0050803	128	0.010
aromatic compound catabolic process	GO:0019439	166	0.010
regulation of mitotic cell cycle	GO:0007346	190	0.010
regulation of antimicrobial humoral response	GO:0002759	50	0.010
regulation of hydrolase activity	GO:0051336	97	0.010
single organism behavior	GO:0044708	391	0.010
tissue death	GO:0016271	102	0.010
hematopoietic progenitor cell differentiation	GO:0002244	1	0.010
response to oxygen containing compound	GO:1901700	200	0.010
multi multicellular organism process	GO:0044706	123	0.010
negative regulation of erbb signaling pathway	GO:1901185	29	0.010
cell fate specification	GO:0001708	71	0.010
nephron morphogenesis	GO:0072028	3	0.010
hormone metabolic process	GO:0042445	33	0.010
long term memory	GO:0007616	62	0.010

kal-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
cardiovascular system disease	DOID:1287	0.049
disease of anatomical entity	DOID:7	0.049
vascular disease	DOID:178	0.014
artery disease	DOID:0050828	0.014
hypertension	DOID:10763	0.014
disease of metabolism	DOID:0014667	0.013
inherited metabolic disorder	DOID:655	0.013
nervous system disease	DOID:863	0.010

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