IMP: Integrative Multi-species Prediction

Drosophila melanogaster

55 known processes

SMC1 (Dmel_CG6057)

CG6057 gene product from transcript CG6057-RA

(Aliases: Dmel\CG6057,Smc1,DmSMC1,dSMC1,smc1,CG6057)

Entrez: 42853
FLYBASE: FBgn0040283
UniProtKB: Q9VCD8

Process Predictions
Disease Predictions

SMC1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
chromosome organization	GO:0051276	360	0.969	Human Yeast
neuron projection guidance	GO:0097485	241	0.862
chromatin silencing	GO:0006342	76	0.790
dna metabolic process	GO:0006259	227	0.702	Human Yeast
sister chromatid segregation	GO:0000819	92	0.606	Yeast
dendrite morphogenesis	GO:0048813	199	0.601
axon guidance	GO:0007411	233	0.535
chromosome segregation	GO:0007059	157	0.520	Human Yeast Worm
spindle organization	GO:0007051	253	0.495
gene silencing	GO:0016458	138	0.488
regulation of gene expression epigenetic	GO:0040029	128	0.480
negative regulation of gene expression	GO:0010629	387	0.477
cell death	GO:0008219	279	0.422
vesicle mediated transport	GO:0016192	381	0.335	Worm
macromolecular complex assembly	GO:0065003	256	0.320
protein complex assembly	GO:0006461	200	0.310
negative regulation of gene expression epigenetic	GO:0045814	77	0.300
chemotaxis	GO:0006935	249	0.293
taxis	GO:0042330	304	0.273
dendrite development	GO:0016358	204	0.270
regulation of cellular catabolic process	GO:0031329	157	0.267
regulation of cellular protein metabolic process	GO:0032268	243	0.222
positive regulation of molecular function	GO:0044093	136	0.217
eye development	GO:0001654	323	0.214
axon development	GO:0061564	297	0.211
organelle fission	GO:0048285	340	0.210	Yeast Mouse
mitotic nuclear division	GO:0007067	213	0.205	Yeast
heterochromatin organization	GO:0070828	25	0.202
single organism catabolic process	GO:0044712	228	0.196
positive regulation of rna biosynthetic process	GO:1902680	266	0.195
mitotic cell cycle checkpoint	GO:0007093	88	0.193	Human
regulation of phosphorus metabolic process	GO:0051174	210	0.187
mitotic spindle organization	GO:0007052	220	0.187
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.185
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.183
chromatin organization	GO:0006325	207	0.181
peptidyl lysine acetylation	GO:0018394	39	0.175
positive regulation of transcription dna templated	GO:0045893	266	0.172
positive regulation of response to stimulus	GO:0048584	323	0.168
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.167
mitotic cell cycle phase transition	GO:0044772	138	0.166	Human
negative regulation of cell cycle phase transition	GO:1901988	103	0.161	Human
death	GO:0016265	284	0.156
response to reactive oxygen species	GO:0000302	24	0.155
positive regulation of gene expression	GO:0010628	290	0.154
regulation of cell cycle process	GO:0010564	181	0.146	Human
cellular response to dna damage stimulus	GO:0006974	223	0.144	Human Yeast
cell cycle phase transition	GO:0044770	140	0.143	Human
telomere organization	GO:0032200	21	0.143
g2 dna damage checkpoint	GO:0031572	69	0.141
positive regulation of multicellular organismal process	GO:0051240	143	0.138
cellular protein modification process	GO:0006464	438	0.133
regulation of anatomical structure morphogenesis	GO:0022603	242	0.131
telomere maintenance	GO:0000723	21	0.128
mitotic sister chromatid segregation	GO:0000070	87	0.120	Yeast
axonogenesis	GO:0007409	290	0.120
regulation of cytoskeleton organization	GO:0051493	89	0.117
regulation of cell cycle phase transition	GO:1901987	130	0.114	Human
protein localization	GO:0008104	284	0.113
positive regulation of catabolic process	GO:0009896	105	0.111
posttranscriptional gene silencing	GO:0016441	46	0.107
programmed cell death	GO:0012501	257	0.105
immune system process	GO:0002376	347	0.102
positive regulation of rna metabolic process	GO:0051254	271	0.096
chromatin assembly	GO:0031497	48	0.092
homeostatic process	GO:0042592	199	0.092
negative regulation of mitotic cell cycle	GO:0045930	109	0.092	Human
regulation of protein metabolic process	GO:0051246	256	0.091
ras protein signal transduction	GO:0007265	88	0.091
protein acetylation	GO:0006473	39	0.090
catabolic process	GO:0009056	409	0.086
positive regulation of macromolecule metabolic process	GO:0010604	405	0.084
tissue morphogenesis	GO:0048729	297	0.083
negative regulation of rna biosynthetic process	GO:1902679	240	0.082
regulation of organelle organization	GO:0033043	196	0.079
regulation of molecular function	GO:0065009	217	0.078
growth	GO:0040007	359	0.077
posttranscriptional gene silencing by rna	GO:0035194	45	0.076
neural precursor cell proliferation	GO:0061351	75	0.075
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.075	Human
embryo development ending in birth or egg hatching	GO:0009792	152	0.075	Worm
response to organic substance	GO:0010033	284	0.074
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.073
gene silencing by rna	GO:0031047	57	0.073
regulation of chromosome organization	GO:0033044	64	0.072
morphogenesis of an epithelium	GO:0002009	276	0.072
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.071
regulation of phosphate metabolic process	GO:0019220	210	0.070
regulation of catabolic process	GO:0009894	170	0.069
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.067
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.066	Human
cellular response to oxygen containing compound	GO:1901701	79	0.066
stem cell proliferation	GO:0072089	88	0.066
regulation of apoptotic process	GO:0042981	130	0.065
cellular macromolecule localization	GO:0070727	220	0.065
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.064
proteolysis	GO:0006508	192	0.063
response to oxygen containing compound	GO:1901700	200	0.063
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.062
stem cell development	GO:0048864	79	0.061	Mouse
organelle assembly	GO:0070925	198	0.060
positive regulation of cellular protein metabolic process	GO:0032270	118	0.059
regulation of ras protein signal transduction	GO:0046578	93	0.059
protein modification by small protein conjugation or removal	GO:0070647	106	0.059
establishment of localization in cell	GO:0051649	402	0.057
negative regulation of cell cycle	GO:0045786	116	0.056	Human
positive regulation of cellular catabolic process	GO:0031331	95	0.056
organic substance catabolic process	GO:1901575	308	0.055
multicellular organismal aging	GO:0010259	140	0.054
imaginal disc derived leg morphogenesis	GO:0007480	80	0.054
cellular component disassembly	GO:0022411	46	0.053
compound eye development	GO:0048749	307	0.052
protein modification process	GO:0036211	438	0.052
imaginal disc fusion	GO:0046528	19	0.051
negative regulation of transcription dna templated	GO:0045892	237	0.051
small gtpase mediated signal transduction	GO:0007264	88	0.050
response to endogenous stimulus	GO:0009719	119	0.049
salivary gland development	GO:0007431	162	0.048
endocytosis	GO:0006897	310	0.047	Worm
heterochromatin organization involved in chromatin silencing	GO:0070868	9	0.046
regulation of intracellular signal transduction	GO:1902531	236	0.046
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.046
reproductive behavior	GO:0019098	122	0.045
positive regulation of protein modification process	GO:0031401	58	0.044
cellular catabolic process	GO:0044248	372	0.044
regulation of multicellular organismal development	GO:2000026	414	0.042
mitotic dna integrity checkpoint	GO:0044774	75	0.042
positive regulation of developmental growth	GO:0048639	62	0.042
stem cell differentiation	GO:0048863	117	0.042	Mouse
peptidyl amino acid modification	GO:0018193	105	0.042
meiotic cell cycle	GO:0051321	171	0.041	Mouse
covalent chromatin modification	GO:0016569	106	0.041
positive regulation of phosphorus metabolic process	GO:0010562	139	0.041
mitotic dna damage checkpoint	GO:0044773	74	0.039
regulation of protein modification process	GO:0031399	112	0.039
organonitrogen compound metabolic process	GO:1901564	318	0.039
regulation of programmed cell death	GO:0043067	152	0.039
mitotic sister chromatid separation	GO:0051306	30	0.037
transcription from rna polymerase ii promoter	GO:0006366	368	0.037
regulation of cell development	GO:0060284	215	0.036
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.036
cellular response to chemical stimulus	GO:0070887	199	0.035
gonad development	GO:0008406	50	0.035	Worm
mitotic g2 m transition checkpoint	GO:0044818	70	0.035
positive regulation of cellular component organization	GO:0051130	156	0.034
negative regulation of rna metabolic process	GO:0051253	251	0.034
response to inorganic substance	GO:0010035	44	0.034
regulation of cell death	GO:0010941	173	0.034
protein transport	GO:0015031	155	0.034
macromolecule catabolic process	GO:0009057	161	0.033
regulation of cell differentiation	GO:0045595	302	0.033	Mouse
intracellular transport	GO:0046907	228	0.033
single organism intracellular transport	GO:1902582	207	0.032
cellular macromolecular complex assembly	GO:0034622	153	0.032
protein complex biogenesis	GO:0070271	201	0.032
regulation of cell morphogenesis	GO:0022604	163	0.032
regulation of catalytic activity	GO:0050790	185	0.032
muscle structure development	GO:0061061	224	0.031
cellular protein localization	GO:0034613	160	0.031
positive regulation of cellular component biogenesis	GO:0044089	80	0.031
single organism behavior	GO:0044708	391	0.030
nuclear division	GO:0000280	332	0.030	Yeast Mouse
metaphase anaphase transition of cell cycle	GO:0044784	28	0.030
nucleotide metabolic process	GO:0009117	161	0.030
central nervous system development	GO:0007417	201	0.030
glycosyl compound metabolic process	GO:1901657	127	0.030
cellular response to organic substance	GO:0071310	132	0.029
positive regulation of developmental process	GO:0051094	143	0.029
regulation of cell cycle	GO:0051726	291	0.029	Human
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.029
regulation of mitotic sister chromatid separation	GO:0010965	28	0.029
ribose phosphate metabolic process	GO:0019693	145	0.029
modification dependent protein catabolic process	GO:0019941	78	0.028
cell proliferation	GO:0008283	299	0.028
response to external biotic stimulus	GO:0043207	293	0.028
regulation of cellular localization	GO:0060341	136	0.027
positive regulation of programmed cell death	GO:0043068	62	0.026
small molecule metabolic process	GO:0044281	305	0.026
positive regulation of phosphate metabolic process	GO:0045937	139	0.026
purine nucleotide metabolic process	GO:0006163	146	0.026
regulation of hydrolase activity	GO:0051336	97	0.026
germarium derived egg chamber formation	GO:0007293	101	0.026
meiotic dna double strand break formation	GO:0042138	1	0.026
heterocycle catabolic process	GO:0046700	166	0.026
positive regulation of phosphorylation	GO:0042327	87	0.026
regulation of mitotic cell cycle	GO:0007346	190	0.026	Human
apoptotic process	GO:0006915	159	0.026
establishment of protein localization to organelle	GO:0072594	62	0.025
stem cell division	GO:0017145	69	0.025
positive regulation of hydrolase activity	GO:0051345	78	0.025
atp metabolic process	GO:0046034	49	0.025
eye photoreceptor cell development	GO:0042462	81	0.025
protein ubiquitination	GO:0016567	70	0.025
regulation of transcription by chromatin organization	GO:0034401	3	0.025
regulation of response to stress	GO:0080134	200	0.025
regulation of neurogenesis	GO:0050767	158	0.025
aging	GO:0007568	143	0.024
regulation of phosphorylation	GO:0042325	147	0.024
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.024	Human
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.024
body morphogenesis	GO:0010171	2	0.023
proteasomal protein catabolic process	GO:0010498	59	0.023
female germ line cyst formation	GO:0048135	42	0.023
multi organism reproductive behavior	GO:0044705	121	0.022
regulation of nuclear division	GO:0051783	58	0.022
positive regulation of signal transduction	GO:0009967	223	0.022
nucleoside triphosphate metabolic process	GO:0009141	120	0.022
larval development	GO:0002164	104	0.022	Worm
sensory organ morphogenesis	GO:0090596	260	0.022
phosphorylation	GO:0016310	294	0.022
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.022
protein catabolic process	GO:0030163	101	0.022
wing disc morphogenesis	GO:0007472	344	0.021
nucleobase containing small molecule metabolic process	GO:0055086	174	0.021
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.021
organophosphate metabolic process	GO:0019637	195	0.021
regulation of proteolysis	GO:0030162	87	0.021
organic substance transport	GO:0071702	257	0.021
positive regulation of organelle organization	GO:0010638	65	0.021
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.021
purine containing compound metabolic process	GO:0072521	155	0.021
actin cytoskeleton organization	GO:0030036	206	0.020
purine containing compound catabolic process	GO:0072523	112	0.020
regulation of establishment of protein localization	GO:0070201	61	0.020
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.020
regulation of sister chromatid segregation	GO:0033045	28	0.020
photoreceptor cell development	GO:0042461	96	0.020
organic cyclic compound catabolic process	GO:1901361	168	0.019
regulation of actin filament based process	GO:0032970	42	0.019
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.019
germarium derived female germ line cyst formation	GO:0030727	42	0.019
signal transduction in response to dna damage	GO:0042770	3	0.019	Human
centrosome organization	GO:0051297	163	0.019
regulation of proteasomal protein catabolic process	GO:0061136	39	0.019
negative regulation of cell cycle process	GO:0010948	109	0.018	Human
regulation of localization	GO:0032879	275	0.018
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.018
ribonucleotide catabolic process	GO:0009261	109	0.018
camera type eye development	GO:0043010	4	0.018
rna localization	GO:0006403	115	0.018
negative regulation of programmed cell death	GO:0043069	72	0.018
aromatic compound catabolic process	GO:0019439	166	0.018
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.018	Human
regulation of chromosome segregation	GO:0051983	32	0.017
karyosome formation	GO:0030717	22	0.017
dorsal ventral pattern formation	GO:0009953	133	0.017
internal peptidyl lysine acetylation	GO:0018393	38	0.017
regulation of meiosis	GO:0040020	3	0.017
mitotic g2 dna damage checkpoint	GO:0007095	69	0.017
chromosome condensation	GO:0030261	41	0.017
cellular protein catabolic process	GO:0044257	83	0.017
embryonic morphogenesis	GO:0048598	206	0.017
neurological system process	GO:0050877	358	0.016
embryonic development via the syncytial blastoderm	GO:0001700	148	0.016
cell division	GO:0051301	248	0.016
exocrine system development	GO:0035272	162	0.016
defense response to other organism	GO:0098542	225	0.016
dna conformation change	GO:0071103	105	0.016
posttranscriptional regulation of gene expression	GO:0010608	145	0.016
positive regulation of biosynthetic process	GO:0009891	316	0.016
meiotic cell cycle process	GO:1903046	132	0.016
internal protein amino acid acetylation	GO:0006475	38	0.016
cellular nitrogen compound catabolic process	GO:0044270	165	0.016
purine ribonucleoside metabolic process	GO:0046128	127	0.015
establishment of protein localization	GO:0045184	163	0.015
negative regulation of cell division	GO:0051782	17	0.015
meiotic nuclear division	GO:0007126	151	0.015	Mouse
regulation of cellular amine metabolic process	GO:0033238	3	0.015
cellular protein complex assembly	GO:0043623	71	0.015
negative regulation of signal transduction by p53 class mediator	GO:1901797	1	0.015
developmental programmed cell death	GO:0010623	138	0.015
ncrna metabolic process	GO:0034660	43	0.015
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.015
signal transduction by phosphorylation	GO:0023014	107	0.015
mrna metabolic process	GO:0016071	124	0.015
response to abiotic stimulus	GO:0009628	341	0.015	Human Worm
response to biotic stimulus	GO:0009607	294	0.015
protein phosphorylation	GO:0006468	169	0.015
chromosome separation	GO:0051304	42	0.014
appendage morphogenesis	GO:0035107	397	0.014
oocyte differentiation	GO:0009994	145	0.014
embryonic organ development	GO:0048568	50	0.014
negative regulation of developmental process	GO:0051093	201	0.014	Mouse
protein localization to organelle	GO:0033365	82	0.014
spinal cord development	GO:0021510	1	0.014
heart development	GO:0007507	82	0.014
negative regulation of apoptotic process	GO:0043066	63	0.014
ubiquitin dependent protein catabolic process	GO:0006511	78	0.014
peptidyl lysine modification	GO:0018205	57	0.014
positive regulation of intracellular signal transduction	GO:1902533	116	0.014
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.014
chaeta development	GO:0022416	97	0.014
protein dna complex subunit organization	GO:0071824	86	0.014
response to nitrogen compound	GO:1901698	90	0.014
carbohydrate derivative metabolic process	GO:1901135	217	0.014
prostaglandin biosynthetic process	GO:0001516	1	0.013
phagocytosis	GO:0006909	215	0.013
cytoplasmic transport	GO:0016482	130	0.013
actin filament based process	GO:0030029	220	0.013
circulatory system development	GO:0072359	82	0.013
synapse organization	GO:0050808	196	0.013
cell fate determination	GO:0001709	91	0.013
modification dependent macromolecule catabolic process	GO:0043632	79	0.013
cell migration	GO:0016477	238	0.013
immune response	GO:0006955	246	0.013
nucleus localization	GO:0051647	34	0.013
multi organism behavior	GO:0051705	175	0.013
cellular response to organic cyclic compound	GO:0071407	32	0.013
segmentation	GO:0035282	207	0.013
microtubule organizing center organization	GO:0031023	168	0.013
organophosphate catabolic process	GO:0046434	112	0.013
regulation of cellular response to stress	GO:0080135	89	0.013
nucleotide catabolic process	GO:0009166	109	0.012
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.012
positive regulation of protein metabolic process	GO:0051247	128	0.012
positive regulation of cell death	GO:0010942	69	0.012
locomotory behavior	GO:0007626	176	0.012
brain development	GO:0007420	120	0.012
regulation of transport	GO:0051049	181	0.012
regulation of growth	GO:0040008	233	0.012
regulation of organ morphogenesis	GO:2000027	78	0.012
regulation of neuron differentiation	GO:0045664	103	0.012
positive regulation of gliogenesis	GO:0014015	5	0.012
cellular macromolecule catabolic process	GO:0044265	136	0.012
dna methylation or demethylation	GO:0044728	4	0.012
purine ribonucleoside catabolic process	GO:0046130	112	0.012
nucleoside triphosphate catabolic process	GO:0009143	108	0.012
regulation of chitin based cuticle tanning	GO:0007564	14	0.012
regulation of cell projection organization	GO:0031344	92	0.012
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.012
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.012
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.012
anatomical structure homeostasis	GO:0060249	97	0.012
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.012	Human
dna repair	GO:0006281	54	0.012	Yeast
dna damage checkpoint	GO:0000077	78	0.011
organonitrogen compound catabolic process	GO:1901565	128	0.011
innate immune response	GO:0045087	144	0.011
positive regulation of cell differentiation	GO:0045597	64	0.011
germ line cyst formation	GO:0048134	44	0.011
regulation of dna metabolic process	GO:0051052	34	0.011	Human
purine nucleotide catabolic process	GO:0006195	109	0.011
centrosome cycle	GO:0007098	137	0.011
retina morphogenesis in camera type eye	GO:0060042	2	0.011
negative regulation of cellular metabolic process	GO:0031324	382	0.011	Human
regulation of nervous system development	GO:0051960	248	0.011
nucleosome mobilization	GO:0042766	9	0.011
regulation of mitosis	GO:0007088	56	0.011
autophagy	GO:0006914	108	0.011
receptor mediated endocytosis	GO:0006898	21	0.010	Worm
nucleoside metabolic process	GO:0009116	127	0.010
regulation of protein catabolic process	GO:0042176	55	0.010
dephosphorylation	GO:0016311	51	0.010
tissue death	GO:0016271	102	0.010
meiosis i	GO:0007127	59	0.010
regulation of microtubule based process	GO:0032886	49	0.010

SMC1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network