Drosophila melanogaster

23 known processes

skl (Dmel_CG13701)

sickle

(Aliases: BcDNA:RE14076,meph,veto,Dmel\CG13701,Skl,CG13701)

skl biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
salt aversionGO:003519930.145
sensory perception of chemical stimulusGO:00076061160.124
response to abiotic stimulusGO:00096283410.114
stem cell developmentGO:0048864790.113
respiratory system developmentGO:00605412130.104
connective tissue developmentGO:006144830.087
salivary gland morphogenesisGO:00074351450.085
gland morphogenesisGO:00226121450.078
response to organic substanceGO:00100332840.071
regulation of execution phase of apoptosisGO:190011750.069
notch signaling pathwayGO:00072191200.068
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280230.067
regulation of programmed cell deathGO:00430671520.063
exocrine system developmentGO:00352721620.063
positive regulation of endopeptidase activityGO:0010950260.062
salivary gland developmentGO:00074311620.061
regulation of cell deathGO:00109411730.061
regulation of endopeptidase activityGO:0052548360.056
transcription from rna polymerase ii promoterGO:00063663680.055
regulation of apoptotic processGO:00429811300.055
cell deathGO:00082192790.054
organonitrogen compound metabolic processGO:19015643180.054
proteolysisGO:00065081920.054
regulation of response to stressGO:00801342000.053
eye developmentGO:00016543230.053
localization of cellGO:00516742570.051
positive regulation of peptidase activityGO:0010952290.051
defense responseGO:00069523000.050
axon developmentGO:00615642970.050
positive regulation of cysteine type endopeptidase activityGO:2001056240.047
developmental programmed cell deathGO:00106231380.047
single organism behaviorGO:00447083910.046
synaptic transmissionGO:00072682880.046
cellular catabolic processGO:00442483720.045
negative regulation of macromolecule biosynthetic processGO:00105582700.045
negative regulation of programmed cell deathGO:0043069720.044
eye photoreceptor cell differentiationGO:00017541450.042
cell proliferationGO:00082832990.042
axonogenesisGO:00074092900.042
intracellular signal transductionGO:00355563000.041
protein localizationGO:00081042840.041
innate immune responseGO:00450871440.040
response to extracellular stimulusGO:00099911160.039
negative regulation of rna metabolic processGO:00512532510.037
response to hypoxiaGO:0001666530.036
negative regulation of cell deathGO:0060548810.035
positive regulation of proteolysisGO:0045862520.035
cellular response to chemical stimulusGO:00708871990.035
negative regulation of cellular metabolic processGO:00313243820.034
negative regulation of neuron deathGO:1901215180.034
response to alcoholGO:0097305950.033
catabolic processGO:00090564090.033
gland developmentGO:00487321910.033
phenol containing compound metabolic processGO:0018958570.033
negative regulation of biosynthetic processGO:00098902770.032
cell recognitionGO:00080371020.031
pigment metabolic processGO:0042440840.031
synapse organizationGO:00508081960.031
rhabdomere developmentGO:0042052380.031
feeding behaviorGO:0007631500.031
neuron deathGO:0070997270.031
execution phase of apoptosisGO:009719470.030
open tracheal system developmentGO:00074242040.030
regulation of transcription from rna polymerase ii promoterGO:00063573780.030
response to external biotic stimulusGO:00432072930.030
response to ionizing radiationGO:0010212320.030
regulation of cysteine type endopeptidase activityGO:2000116270.030
regulation of anatomical structure morphogenesisGO:00226032420.029
negative regulation of cell communicationGO:00106482230.029
neuron apoptotic processGO:0051402170.029
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.028
protein modification processGO:00362114380.028
central nervous system developmentGO:00074172010.028
organic substance transportGO:00717022570.028
deathGO:00162652840.028
autophagyGO:00069141080.028
response to bacteriumGO:00096171980.027
brain developmentGO:00074201200.027
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281250.027
regulation of cell proliferationGO:00421271630.027
positive regulation of protein metabolic processGO:00512471280.027
negative regulation of apoptotic processGO:0043066630.027
establishment or maintenance of cell polarityGO:00071631670.027
monocarboxylic acid transportGO:001571830.026
organic acid metabolic processGO:00060821030.026
nephron developmentGO:007200630.026
cell divisionGO:00513012480.026
eye morphogenesisGO:00485922600.026
regulation of response to extracellular stimulusGO:0032104180.026
regulation of neuron deathGO:1901214260.026
response to biotic stimulusGO:00096072940.025
stem cell differentiationGO:00488631170.025
humoral immune responseGO:00069591170.025
aromatic compound catabolic processGO:00194391660.025
secondary metabolic processGO:0019748750.025
intracellular transportGO:00469072280.025
regulation of cell cycleGO:00517262910.024
sensory perception of smellGO:0007608800.024
regulation of proteolysisGO:0030162870.024
endocytosisGO:00068973100.024
regulation of localizationGO:00328792750.024
positive regulation of response to stimulusGO:00485843230.024
regulation of intracellular signal transductionGO:19025312360.024
organic substance catabolic processGO:19015753080.024
peripheral nervous system developmentGO:0007422520.024
cell type specific apoptotic processGO:0097285380.024
larval behaviorGO:0030537420.023
melanization defense responseGO:0035006450.023
single organism carbohydrate metabolic processGO:0044723720.023
cellular response to starvationGO:0009267610.023
negative regulation of response to stimulusGO:00485852580.022
negative regulation of nucleic acid templated transcriptionGO:19035072400.022
regulation of peptidase activityGO:0052547390.022
methylationGO:0032259470.021
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.021
anatomical structure homeostasisGO:0060249970.021
negative regulation of rna biosynthetic processGO:19026792400.021
modification dependent protein catabolic processGO:0019941780.021
programmed cell deathGO:00125012570.021
peptide metabolic processGO:0006518800.021
response to lipopolysaccharideGO:003249640.021
sensory perception of salty tasteGO:005091430.021
negative regulation of transcription dna templatedGO:00458922370.021
compound eye developmentGO:00487493070.021
apoptotic processGO:00069151590.021
ion transportGO:00068111450.020
adult behaviorGO:00305341370.020
regulation of cellular amide metabolic processGO:0034248390.020
regulation of cellular component biogenesisGO:00440872010.020
neuromuscular junction developmentGO:00075281490.020
stem cell maintenanceGO:0019827670.020
regulation of protein metabolic processGO:00512462560.020
ectopic germ cell programmed cell deathGO:003523480.020
vesicle mediated transportGO:00161923810.020
single organism catabolic processGO:00447122280.020
negative regulation of signal transductionGO:00099682060.020
regulation of response to external stimulusGO:00321011150.020
cell cell adhesionGO:0098609260.020
negative regulation of gene expressionGO:00106293870.020
chromatin modificationGO:00165681470.019
positive regulation of cell communicationGO:00106472500.019
positive regulation of hydrolase activityGO:0051345780.019
synaptic target recognitionGO:0008039450.019
covalent chromatin modificationGO:00165691060.019
cellular response to organic substanceGO:00713101320.019
response to oxygen containing compoundGO:19017002000.019
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919160.019
macroautophagyGO:0016236420.019
regulation of cellular amine metabolic processGO:003323830.019
regulation of multicellular organismal developmentGO:20000264140.019
antimicrobial peptide productionGO:0002775460.018
regulation of organ morphogenesisGO:2000027780.018
regulation of developmental growthGO:00486381740.018
immune response regulating signaling pathwayGO:000276420.018
response to radiationGO:00093141550.018
positive regulation of defense response to bacteriumGO:1900426230.018
cellular protein modification processGO:00064644380.018
positive regulation of cellular protein metabolic processGO:00322701180.018
neuron recognitionGO:00080381010.018
production of molecular mediator of immune responseGO:0002440460.018
circadian rhythmGO:00076231050.018
defense response to gram negative bacteriumGO:0050829940.018
chaeta developmentGO:0022416970.018
regulation of synapse structure and activityGO:00508031280.018
biological adhesionGO:00226101380.018
retina development in camera type eyeGO:006004140.018
melanin metabolic processGO:0006582470.018
homeostatic processGO:00425921990.018
cellular amino acid metabolic processGO:0006520610.017
small molecule metabolic processGO:00442813050.017
organelle assemblyGO:00709251980.017
establishment of protein localizationGO:00451841630.017
kidney developmentGO:000182230.017
taxisGO:00423303040.017
r3 r4 cell differentiationGO:0048056120.017
tissue deathGO:00162711020.017
phagocytosisGO:00069092150.017
regulation of immune responseGO:00507761180.017
protein modification by small protein conjugation or removalGO:00706471060.017
regulation of cellular response to stressGO:0080135890.017
negative regulation of signalingGO:00230572190.017
positive regulation of cell migrationGO:003033520.017
cilium assemblyGO:0042384380.017
mesenchymal cell developmentGO:001403110.017
regulation of defense responseGO:00313471020.017
eye photoreceptor cell developmentGO:0042462810.017
positive regulation of nitrogen compound metabolic processGO:00511733540.017
nucleobase containing compound catabolic processGO:00346551650.017
intracellular protein transportGO:00068861040.017
compound eye photoreceptor cell differentiationGO:00017511400.017
immune system processGO:00023763470.016
regulation of neuron apoptotic processGO:0043523160.016
defense response to bacteriumGO:00427421780.016
positive regulation of macromolecule biosynthetic processGO:00105572830.016
response to oxygen levelsGO:0070482590.016
positive regulation of compound eye retinal cell programmed cell deathGO:004667290.016
regionalizationGO:00030024160.016
regulation of notch signaling pathwayGO:00085931000.016
chromosome organizationGO:00512763600.016
regulation of catabolic processGO:00098941700.016
synapse assemblyGO:00074161430.016
photoreceptor cell differentiationGO:00465301700.016
negative regulation of nitrogen compound metabolic processGO:00511722650.015
autophagic cell deathGO:0048102830.015
positive regulation of cell motilityGO:200014730.015
cellular protein catabolic processGO:0044257830.015
response to other organismGO:00517072930.015
larval locomotory behaviorGO:0008345270.015
hormone catabolic processGO:004244730.015
tube developmentGO:00352952440.015
positive regulation of cellular catabolic processGO:0031331950.015
developmental growthGO:00485892800.015
positive regulation of response to extracellular stimulusGO:003210680.015
pattern recognition receptor signaling pathwayGO:000222120.015
regulation of i kappab kinase nf kappab signalingGO:004312220.015
sensory organ morphogenesisGO:00905962600.015
mrna processingGO:00063971040.014
growthGO:00400073590.014
nuclear divisionGO:00002803320.014
regulation of hydrolase activityGO:0051336970.014
regulation of humoral immune responseGO:0002920510.014
positive regulation of autophagyGO:0010508210.014
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630110.014
regulation of growthGO:00400082330.014
negative regulation of cell differentiationGO:00455961430.014
defense response to other organismGO:00985422250.014
forebrain developmentGO:003090020.014
regulation of response to biotic stimulusGO:0002831630.014
organic hydroxy compound metabolic processGO:1901615830.014
positive regulation of retinal cell programmed cell deathGO:004667090.014
regulation of production of molecular mediator of immune responseGO:0002700440.014
establishment of localization in cellGO:00516494020.014
heterocycle catabolic processGO:00467001660.014
histone modificationGO:00165701060.014
positive regulation of macroautophagyGO:001623980.014
protein transportGO:00150311550.014
compound eye photoreceptor developmentGO:0042051780.014
neuromuscular synaptic transmissionGO:0007274670.014
camera type eye developmentGO:004301040.014
innate immune response activating signal transductionGO:000275820.014
cell migrationGO:00164772380.014
positive regulation of immune responseGO:0050778630.014
salivary gland histolysisGO:0035070880.014
mrna metabolic processGO:00160711240.014
mitotic spindle organizationGO:00070522200.014
single organism intracellular transportGO:19025822070.013
positive regulation of cell proliferationGO:0008284470.013
regulation of cell substrate adhesionGO:001081020.013
regulation of organ growthGO:0046620420.013
gene silencingGO:00164581380.013
regulation of multicellular organism growthGO:0040014400.013
immune effector processGO:0002252980.013
cellular ketone metabolic processGO:0042180240.013
multi organism reproductive behaviorGO:00447051210.013
carboxylic acid metabolic processGO:0019752920.013
extrinsic apoptotic signaling pathwayGO:009719110.013
molting cycle processGO:0022404290.013
response to endogenous stimulusGO:00097191190.013
oxoacid metabolic processGO:00434361030.013
spindle organizationGO:00070512530.013
sperm individualizationGO:0007291480.013
protein heterooligomerizationGO:005129140.013
organ growthGO:0035265560.013
mapk cascadeGO:00001651070.013
antimicrobial humoral responseGO:0019730990.013
apoptotic process involved in developmentGO:1902742200.013
limb developmentGO:006017310.013
histolysisGO:00075591020.013
behavioral response to ethanolGO:0048149490.013
endomembrane system organizationGO:00102561190.013
immune response activating signal transductionGO:000275720.013
negative regulation of notch signaling pathwayGO:0045746410.013
positive regulation of catalytic activityGO:00430851180.013
negative regulation of cellular biosynthetic processGO:00313272770.013
positive regulation of developmental processGO:00510941430.013
cell motilityGO:00488702510.013
cellularizationGO:0007349900.013
response to nutrient levelsGO:00316671140.013
regulation of retinal cell programmed cell deathGO:0046668180.013
cellular response to dna damage stimulusGO:00069742230.013
negative regulation of multicellular organismal processGO:00512411420.012
salivary gland cell autophagic cell deathGO:0035071830.012
spermatogenesisGO:00072832000.012
negative regulation of nucleobase containing compound metabolic processGO:00459342610.012
regulation of synapse assemblyGO:0051963940.012
positive regulation of nucleic acid templated transcriptionGO:19035082660.012
regulation of compound eye retinal cell programmed cell deathGO:0046669180.012
response to virusGO:0009615280.012
cell cycle phase transitionGO:00447701400.012
nucleobase containing small molecule metabolic processGO:00550861740.012
tripartite regional subdivisionGO:00073511030.012
positive regulation of response to nutrient levelsGO:003210980.012
regulation of cellular protein metabolic processGO:00322682430.012
amide biosynthetic processGO:0043604420.012
developmental maturationGO:00217001720.012
positive regulation of intracellular signal transductionGO:19025331160.012
response to starvationGO:0042594970.012
male gamete generationGO:00482322010.012
response to glucoseGO:000974920.012
organic cyclic compound catabolic processGO:19013611680.012
protein maturationGO:0051604710.012
cell maturationGO:00484691440.012
regulation of synaptic transmissionGO:0050804690.012
macromolecule methylationGO:0043414450.012
sensory perception of tasteGO:0050909250.012
regulation of immune effector processGO:0002697520.012
protein phosphorylationGO:00064681690.012
peripheral nervous system neuron developmentGO:004893580.012
nucleus organizationGO:0006997450.012
positive regulation of apoptotic signaling pathwayGO:200123540.012
dendrite morphogenesisGO:00488131990.012
negative regulation of neuron apoptotic processGO:0043524140.011
retinal cell programmed cell deathGO:0046666250.011
compound eye morphogenesisGO:00017452490.011
response to sterolGO:0036314340.011
spermatid developmentGO:0007286980.011
nitrogen compound transportGO:0071705850.011
compound eye retinal cell programmed cell deathGO:0046667230.011
cellular amide metabolic processGO:0043603800.011
lateral inhibitionGO:00463312060.011
imaginal disc derived appendage developmentGO:00487373990.011
serotonin receptor signaling pathwayGO:000721050.011
photoreceptor cell developmentGO:0042461960.011
regulation of mitotic cell cycleGO:00073461900.011
regulation of transportGO:00510491810.011
larval midgut histolysisGO:0035069220.011
regulation of tube architecture open tracheal systemGO:0035152680.011
circadian sleep wake cycleGO:0042745280.011
rna splicing via transesterification reactionsGO:0000375730.011
carbohydrate derivative metabolic processGO:19011352170.011
nephron epithelium developmentGO:007200930.011
positive regulation of phosphorus metabolic processGO:00105621390.011
amino sugar catabolic processGO:004634830.011
regulation of catalytic activityGO:00507901850.011
positive regulation of phosphate metabolic processGO:00459371390.011
circadian sleep wake cycle sleepGO:0050802230.011
regulation of cell motilityGO:2000145230.011
acid secretionGO:004671710.011
positive regulation of catabolic processGO:00098961050.011
cell adhesionGO:00071551360.011
regulation of circadian rhythmGO:0042752490.011
response to hexoseGO:000974630.011
hindbrain developmentGO:003090220.010
immune responseGO:00069552460.010
activation of cysteine type endopeptidase activityGO:0097202170.010
mitotic spindle elongationGO:0000022810.010
embryonic pattern specificationGO:00098801740.010
protein alkylationGO:0008213430.010
organonitrogen compound biosynthetic processGO:19015661170.010
positive regulation of multicellular organismal processGO:00512401430.010
signal transduction by phosphorylationGO:00230141070.010
positive regulation of humoral immune responseGO:0002922280.010
purine containing compound catabolic processGO:00725231120.010
vitamin biosynthetic processGO:000911010.010
macromolecule catabolic processGO:00090571610.010
alternative mrna splicing via spliceosomeGO:0000380600.010
cellular response to nutrient levelsGO:0031669620.010
molting cycle chitin based cuticleGO:0007591560.010

skl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:1700.076
disease of anatomical entityDOID:700.076
bone development diseaseDOID:008000600.057
bone diseaseDOID:008000100.057
connective tissue diseaseDOID:6500.057
nervous system diseaseDOID:86300.017
urinary system diseaseDOID:1800.015
sensory system diseaseDOID:005015500.011