IMP: Integrative Multi-species Prediction

Drosophila melanogaster

43 known processes

Tcp-1eta (Dmel_CG8351)

CG8351 gene product from transcript CG8351-RA

(Aliases: CG8351,Dmel\CG8351,Tcp-1-eta1,Cct7)

Entrez: 41054
FLYBASE: FBgn0037632
UniProtKB: Q9VHL2

Process Predictions
Disease Predictions

Tcp-1eta biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
cytoplasmic microtubule organization	GO:0031122	22	0.768
mitotic spindle organization	GO:0007052	220	0.694
spindle organization	GO:0007051	253	0.662
cell recognition	GO:0008037	102	0.638	Mouse
protein complex biogenesis	GO:0070271	201	0.516
spindle assembly involved in mitosis	GO:0090307	50	0.496
spindle assembly	GO:0051225	80	0.474
organelle fission	GO:0048285	340	0.461
negative regulation of gene expression	GO:0010629	387	0.400
protein complex assembly	GO:0006461	200	0.398
single fertilization	GO:0007338	24	0.366	Mouse
small molecule metabolic process	GO:0044281	305	0.360
cell death	GO:0008219	279	0.331	Worm
single organism catabolic process	GO:0044712	228	0.292
negative regulation of cellular metabolic process	GO:0031324	382	0.282
cellular macromolecular complex assembly	GO:0034622	153	0.276
larval development	GO:0002164	104	0.272	Worm
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.271
embryo development ending in birth or egg hatching	GO:0009792	152	0.263	Worm
organonitrogen compound metabolic process	GO:1901564	318	0.246
response to organic substance	GO:0010033	284	0.226
cellular macromolecule localization	GO:0070727	220	0.212
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.209
purine containing compound metabolic process	GO:0072521	155	0.209
death	GO:0016265	284	0.198	Worm
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.183
endocytosis	GO:0006897	310	0.174	Worm
fertilization	GO:0009566	26	0.169	Mouse
cell motility	GO:0048870	251	0.169
body morphogenesis	GO:0010171	2	0.168
aging	GO:0007568	143	0.166
gonad development	GO:0008406	50	0.162	Worm
programmed cell death	GO:0012501	257	0.160	Worm
nuclear division	GO:0000280	332	0.160
macromolecular complex assembly	GO:0065003	256	0.156
purine nucleotide metabolic process	GO:0006163	146	0.151
purine nucleotide catabolic process	GO:0006195	109	0.151
organelle assembly	GO:0070925	198	0.149
catabolic process	GO:0009056	409	0.149
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.149
ribonucleoside metabolic process	GO:0009119	127	0.146
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.141
nucleoside catabolic process	GO:0009164	112	0.137
response to abiotic stimulus	GO:0009628	341	0.135
centrosome duplication	GO:0051298	121	0.132
organophosphate catabolic process	GO:0046434	112	0.124
vesicle mediated transport	GO:0016192	381	0.115	Worm
ribose phosphate metabolic process	GO:0019693	145	0.114
negative regulation of biosynthetic process	GO:0009890	277	0.111
purine ribonucleoside metabolic process	GO:0046128	127	0.109
single organism cellular localization	GO:1902580	180	0.106
nucleoside triphosphate metabolic process	GO:0009141	120	0.106
organonitrogen compound catabolic process	GO:1901565	128	0.105
organophosphate metabolic process	GO:0019637	195	0.105
purine ribonucleoside catabolic process	GO:0046130	112	0.104
renal system development	GO:0072001	72	0.102
glycosyl compound catabolic process	GO:1901658	112	0.100
cellular catabolic process	GO:0044248	372	0.099
appendage morphogenesis	GO:0035107	397	0.098
regulation of multicellular organismal development	GO:2000026	414	0.097
nucleoside triphosphate catabolic process	GO:0009143	108	0.097
regulation of cell death	GO:0010941	173	0.091
localization of cell	GO:0051674	257	0.088
protein modification process	GO:0036211	438	0.088
cellular nitrogen compound catabolic process	GO:0044270	165	0.087
negative regulation of cellular biosynthetic process	GO:0031327	277	0.085
regulation of protein metabolic process	GO:0051246	256	0.085
sex differentiation	GO:0007548	81	0.084	Worm
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.083
carbohydrate derivative metabolic process	GO:1901135	217	0.083
nucleobase containing small molecule metabolic process	GO:0055086	174	0.082
multicellular organismal aging	GO:0010259	140	0.082
cell migration	GO:0016477	238	0.082
negative regulation of transcription dna templated	GO:0045892	237	0.082
regulation of transport	GO:0051049	181	0.081
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.081
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.080
regulation of immune response	GO:0050776	118	0.078
purine nucleoside metabolic process	GO:0042278	127	0.077
immune response	GO:0006955	246	0.077
protein transport	GO:0015031	155	0.077
carbohydrate derivative catabolic process	GO:1901136	118	0.077
nucleoside phosphate metabolic process	GO:0006753	162	0.077
negative regulation of rna biosynthetic process	GO:1902679	240	0.077
purine ribonucleotide catabolic process	GO:0009154	109	0.076
response to temperature stimulus	GO:0009266	106	0.076
aromatic compound catabolic process	GO:0019439	166	0.073
centrosome organization	GO:0051297	163	0.072
oxoacid metabolic process	GO:0043436	103	0.071
nucleotide metabolic process	GO:0009117	161	0.069
purine nucleoside catabolic process	GO:0006152	112	0.069
ribonucleoside catabolic process	GO:0042454	112	0.068
glycosyl compound metabolic process	GO:1901657	127	0.068
protein localization	GO:0008104	284	0.066
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.066
taxis	GO:0042330	304	0.066
establishment of localization in cell	GO:0051649	402	0.064
embryonic morphogenesis	GO:0048598	206	0.064
response to biotic stimulus	GO:0009607	294	0.064
intracellular protein transport	GO:0006886	104	0.063
development of primary sexual characteristics	GO:0045137	50	0.062	Worm
apoptotic process	GO:0006915	159	0.061	Worm
posttranscriptional regulation of gene expression	GO:0010608	145	0.061
phosphorylation	GO:0016310	294	0.060
nucleoside phosphate catabolic process	GO:1901292	110	0.060
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.059
organic substance transport	GO:0071702	257	0.059
sensory organ morphogenesis	GO:0090596	260	0.058
organic cyclic compound catabolic process	GO:1901361	168	0.057
eye morphogenesis	GO:0048592	260	0.056
positive regulation of multicellular organismal process	GO:0051240	143	0.056
reproductive structure development	GO:0048608	74	0.056	Worm
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.055
anterior posterior pattern specification	GO:0009952	136	0.054
purine ribonucleotide metabolic process	GO:0009150	145	0.053
cell proliferation	GO:0008283	299	0.053
nucleobase containing compound catabolic process	GO:0034655	165	0.053
regulation of phosphorus metabolic process	GO:0051174	210	0.053
atp metabolic process	GO:0046034	49	0.051
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.050
nucleotide catabolic process	GO:0009166	109	0.050
regulation of cellular protein metabolic process	GO:0032268	243	0.050
single organism intracellular transport	GO:1902582	207	0.049
regulation of response to stress	GO:0080134	200	0.049
establishment of protein localization	GO:0045184	163	0.049
urogenital system development	GO:0001655	72	0.049
regulation of catalytic activity	GO:0050790	185	0.049
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.049
cellular protein complex assembly	GO:0043623	71	0.048
determination of adult lifespan	GO:0008340	137	0.048
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.046
cellular protein localization	GO:0034613	160	0.046
negative regulation of multicellular organismal process	GO:0051241	142	0.046
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.045
regulation of phosphate metabolic process	GO:0019220	210	0.044
mitotic nuclear division	GO:0007067	213	0.043
imaginal disc derived appendage development	GO:0048737	399	0.043
response to oxygen containing compound	GO:1901700	200	0.043
ribonucleotide metabolic process	GO:0009259	145	0.043
regulation of defense response	GO:0031347	102	0.042
organic substance catabolic process	GO:1901575	308	0.041
regulation of response to biotic stimulus	GO:0002831	63	0.040
developmental growth	GO:0048589	280	0.039
negative regulation of rna metabolic process	GO:0051253	251	0.039
reproductive system development	GO:0061458	74	0.039	Worm
organic acid metabolic process	GO:0006082	103	0.039
regulation of programmed cell death	GO:0043067	152	0.039
regulation of anatomical structure morphogenesis	GO:0022603	242	0.038
autophagy	GO:0006914	108	0.038
intracellular signal transduction	GO:0035556	300	0.038
post embryonic appendage morphogenesis	GO:0035120	385	0.038
cellular protein modification process	GO:0006464	438	0.037
regulation of cellular catabolic process	GO:0031329	157	0.036
axon guidance	GO:0007411	233	0.035
carboxylic acid metabolic process	GO:0019752	92	0.035
single organism behavior	GO:0044708	391	0.035
ribonucleotide catabolic process	GO:0009261	109	0.034
cellular response to chemical stimulus	GO:0070887	199	0.033
regulation of apoptotic process	GO:0042981	130	0.033
kidney development	GO:0001822	3	0.033
regulation of response to external stimulus	GO:0032101	115	0.033
regulation of purine nucleotide catabolic process	GO:0033121	48	0.032
nucleoside monophosphate metabolic process	GO:0009123	52	0.032
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.032
chemotaxis	GO:0006935	249	0.032
imaginal disc derived wing morphogenesis	GO:0007476	337	0.032
cellular amino acid metabolic process	GO:0006520	61	0.032
protein targeting	GO:0006605	64	0.031
positive regulation of cellular component organization	GO:0051130	156	0.031
regulation of cell differentiation	GO:0045595	302	0.031
nucleoside metabolic process	GO:0009116	127	0.030
muscle structure development	GO:0061061	224	0.030
response to other organism	GO:0051707	293	0.030
camera type eye development	GO:0043010	4	0.030
regulation of molecular function	GO:0065009	217	0.029
response to extracellular stimulus	GO:0009991	116	0.028
negative regulation of cell communication	GO:0010648	223	0.028
dna metabolic process	GO:0006259	227	0.028
purine containing compound catabolic process	GO:0072523	112	0.028
pole plasm rna localization	GO:0007316	52	0.028
response to wounding	GO:0009611	94	0.028
genitalia development	GO:0048806	26	0.028	Worm
negative regulation of signaling	GO:0023057	219	0.027
connective tissue development	GO:0061448	3	0.027
gene silencing	GO:0016458	138	0.027
negative regulation of response to stimulus	GO:0048585	258	0.027
humoral immune response	GO:0006959	117	0.026
protein polymerization	GO:0051258	42	0.025
symbiosis encompassing mutualism through parasitism	GO:0044403	16	0.025
atp catabolic process	GO:0006200	38	0.025
establishment of protein localization to organelle	GO:0072594	62	0.025
regulation of developmental growth	GO:0048638	174	0.024
positive regulation of molecular function	GO:0044093	136	0.024
response to external biotic stimulus	GO:0043207	293	0.024
regulation of localization	GO:0032879	275	0.024
positive regulation of hydrolase activity	GO:0051345	78	0.024
positive regulation of developmental process	GO:0051094	143	0.023
appendage development	GO:0048736	401	0.023
receptor mediated endocytosis	GO:0006898	21	0.023	Worm
biological adhesion	GO:0022610	138	0.023
segmentation	GO:0035282	207	0.023
negative regulation of cell death	GO:0060548	81	0.023
negative regulation of phosphorus metabolic process	GO:0010563	45	0.023
myotube cell development	GO:0014904	3	0.023
response to nutrient levels	GO:0031667	114	0.022
positive regulation of catalytic activity	GO:0043085	118	0.022
intracellular transport	GO:0046907	228	0.022
regulation of catabolic process	GO:0009894	170	0.022
regulation of cellular component biogenesis	GO:0044087	201	0.021
negative regulation of developmental process	GO:0051093	201	0.021
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.021
head development	GO:0060322	135	0.021
chaperone mediated protein folding	GO:0061077	2	0.021
response to peptide hormone	GO:0043434	29	0.021
blastoderm segmentation	GO:0007350	159	0.021
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.020
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.020
positive regulation of cellular biosynthetic process	GO:0031328	316	0.020
phagocytosis	GO:0006909	215	0.020
anterior posterior axis specification	GO:0009948	109	0.020
heterocycle catabolic process	GO:0046700	166	0.020
regulation of vesicle mediated transport	GO:0060627	59	0.020
endomembrane system organization	GO:0010256	119	0.020
cellular response to external stimulus	GO:0071496	66	0.020
regulation of nucleoside metabolic process	GO:0009118	50	0.019
positive regulation of protein metabolic process	GO:0051247	128	0.019
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.019
cellular response to organic substance	GO:0071310	132	0.018
protein catabolic process	GO:0030163	101	0.018
positive regulation of cellular catabolic process	GO:0031331	95	0.018
cellular response to oxygen containing compound	GO:1901701	79	0.018
microtubule organizing center organization	GO:0031023	168	0.018
regulation of growth	GO:0040008	233	0.018
cytoplasmic transport	GO:0016482	130	0.018
immune system process	GO:0002376	347	0.017
cellular response to extracellular stimulus	GO:0031668	64	0.017
axis specification	GO:0009798	167	0.017
response to light stimulus	GO:0009416	124	0.017
eye development	GO:0001654	323	0.017
cation transport	GO:0006812	110	0.017
circulatory system development	GO:0072359	82	0.017
negative regulation of programmed cell death	GO:0043069	72	0.017
growth	GO:0040007	359	0.017
positive regulation of catabolic process	GO:0009896	105	0.017
negative regulation of cell differentiation	GO:0045596	143	0.017
regulation of cell development	GO:0060284	215	0.017
membrane organization	GO:0061024	112	0.016
meiotic cell cycle	GO:0051321	171	0.016
protein transmembrane transport	GO:0071806	4	0.016
regulation of proteolysis	GO:0030162	87	0.016
regulation of cellular ketone metabolic process	GO:0010565	3	0.016
translational elongation	GO:0006414	4	0.016
activation of innate immune response	GO:0002218	4	0.015
negative regulation of catalytic activity	GO:0043086	42	0.015
ion transport	GO:0006811	145	0.015
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.015
interspecies interaction between organisms	GO:0044419	16	0.015
chromatin organization	GO:0006325	207	0.015
regulation of intracellular signal transduction	GO:1902531	236	0.015
mitochondrion organization	GO:0007005	65	0.015
negative regulation of molecular function	GO:0044092	51	0.015
regulation of hydrolase activity	GO:0051336	97	0.015
ncrna metabolic process	GO:0034660	43	0.015
single organism membrane organization	GO:0044802	93	0.014
response to hormone	GO:0009725	45	0.014
translation	GO:0006412	69	0.014
spermatogenesis	GO:0007283	200	0.014
positive regulation of macromolecule metabolic process	GO:0010604	405	0.014
response to radiation	GO:0009314	155	0.014
response to nitrogen compound	GO:1901698	90	0.014
positive regulation of gene expression	GO:0010628	290	0.013
transmembrane transport	GO:0055085	139	0.013
embryonic organ development	GO:0048568	50	0.013
regulation of innate immune response	GO:0045088	71	0.013
protein localization to organelle	GO:0033365	82	0.013
chromatin modification	GO:0016568	147	0.013
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.013
proteolysis	GO:0006508	192	0.013
mitotic spindle elongation	GO:0000022	81	0.013
protein import	GO:0017038	55	0.013
positive regulation of cell migration	GO:0030335	2	0.013
positive regulation of intracellular signal transduction	GO:1902533	116	0.013
mitotic cell cycle phase transition	GO:0044772	138	0.013
generation of precursor metabolites and energy	GO:0006091	42	0.013
cell cycle phase transition	GO:0044770	140	0.013
positive regulation of developmental growth	GO:0048639	62	0.012
negative regulation of phosphate metabolic process	GO:0045936	45	0.012
regulation of organelle organization	GO:0033043	196	0.012
anterior posterior axis specification embryo	GO:0008595	103	0.012
negative regulation of microtubule polymerization or depolymerization	GO:0031111	21	0.012
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.012
rna splicing	GO:0008380	83	0.012
defense response	GO:0006952	300	0.012
centrosome cycle	GO:0007098	137	0.012
antimicrobial humoral response	GO:0019730	99	0.012
wound healing	GO:0042060	75	0.012
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.012
protein targeting to mitochondrion	GO:0006626	1	0.012
positive regulation of synapse assembly	GO:0051965	29	0.012
embryonic pattern specification	GO:0009880	174	0.012
tripartite regional subdivision	GO:0007351	103	0.012
adult behavior	GO:0030534	137	0.012
cellular macromolecule catabolic process	GO:0044265	136	0.012
microtubule polymerization or depolymerization	GO:0031109	39	0.012
multicellular organismal reproductive behavior	GO:0033057	110	0.012
negative regulation of apoptotic process	GO:0043066	63	0.011
embryonic axis specification	GO:0000578	107	0.011
single organism biosynthetic process	GO:0044711	206	0.011
negative regulation of cell proliferation	GO:0008285	69	0.011
positive regulation of cellular protein metabolic process	GO:0032270	118	0.011
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.011
negative regulation of signal transduction	GO:0009968	206	0.011
regulation of purine nucleotide metabolic process	GO:1900542	62	0.011
epithelial cell differentiation	GO:0030855	322	0.011
positive regulation of biosynthetic process	GO:0009891	316	0.011
chromatin silencing	GO:0006342	76	0.011
cytoplasm organization	GO:0007028	64	0.011
regulation of mrna splicing via spliceosome	GO:0048024	64	0.011
rna processing	GO:0006396	147	0.011
oocyte development	GO:0048599	124	0.011
male gamete generation	GO:0048232	201	0.011
energy derivation by oxidation of organic compounds	GO:0015980	32	0.010
positive regulation of immune response	GO:0050778	63	0.010
positive regulation of cell motility	GO:2000147	3	0.010
response to decreased oxygen levels	GO:0036293	58	0.010
positive regulation of phosphorus metabolic process	GO:0010562	139	0.010
regulation of protein complex disassembly	GO:0043244	29	0.010
oocyte anterior posterior axis specification	GO:0007314	72	0.010

Tcp-1eta disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.091
disease of cellular proliferation	DOID:14566	0.017
disease of metabolism	DOID:0014667	0.014
organ system cancer	DOID:0050686	0.012
cancer	DOID:162	0.012
central nervous system disease	DOID:331	0.012
nervous system disease	DOID:863	0.012

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network