IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Vha100-2 (Dmel_CG18617)

CG18617 gene product from transcript CG18617-RB

(Aliases: vha100-2,CG7679,anon-WO0118547.296,BcDNA:LD21735,Dmel\CG18617,CG18617,V-ATPase)

Entrez: 42216
FLYBASE: FBgn0028670
UniProtKB: Q9VE75

Process Predictions
Disease Predictions

Vha100-2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
ph reduction	GO:0045851	7	0.481
regulation of ph	GO:0006885	7	0.248	Human
cation homeostasis	GO:0055080	51	0.169	Human
regionalization	GO:0003002	416	0.158
organelle assembly	GO:0070925	198	0.153
monovalent inorganic cation homeostasis	GO:0055067	7	0.137	Human
intracellular ph reduction	GO:0051452	7	0.137
single organism biosynthetic process	GO:0044711	206	0.106
cellular chemical homeostasis	GO:0055082	40	0.101
response to light stimulus	GO:0009416	124	0.093
death	GO:0016265	284	0.090
embryonic morphogenesis	GO:0048598	206	0.086
pigment granule organization	GO:0048753	12	0.080
vesicle mediated transport	GO:0016192	381	0.078
retina development in camera type eye	GO:0060041	4	0.076
mitotic spindle organization	GO:0007052	220	0.075
homeostatic process	GO:0042592	199	0.074	Human
regulation of cellular ph	GO:0030641	7	0.070
sodium dependent phosphate transport	GO:0044341	2	0.069
spindle organization	GO:0007051	253	0.066
response to wounding	GO:0009611	94	0.064
endocytosis	GO:0006897	310	0.060
growth	GO:0040007	359	0.058
cellular homeostasis	GO:0019725	80	0.058
digestive system development	GO:0055123	149	0.056
establishment of localization in cell	GO:0051649	402	0.056
kidney epithelium development	GO:0072073	3	0.053
tissue morphogenesis	GO:0048729	297	0.052
ion transmembrane transport	GO:0034220	122	0.050
phosphate ion transport	GO:0006817	4	0.050
vacuolar acidification	GO:0007035	4	0.050
kidney development	GO:0001822	3	0.050
regulation of immune system process	GO:0002682	176	0.047
response to abiotic stimulus	GO:0009628	341	0.044
organonitrogen compound metabolic process	GO:1901564	318	0.041
cilium organization	GO:0044782	41	0.041
circulatory system development	GO:0072359	82	0.040
lipid biosynthetic process	GO:0008610	46	0.039
phagocytosis	GO:0006909	215	0.039
ion transport	GO:0006811	145	0.038	Human
cell death	GO:0008219	279	0.038
camera type eye development	GO:0043010	4	0.037
vesicle organization	GO:0016050	44	0.036
anion transport	GO:0006820	41	0.036
connective tissue development	GO:0061448	3	0.035
regulation of mitotic cell cycle	GO:0007346	190	0.035
cardiovascular system development	GO:0072358	82	0.034
single organism intracellular transport	GO:1902582	207	0.034
intracellular transport	GO:0046907	228	0.034
gland development	GO:0048732	191	0.034
morphogenesis of an epithelium	GO:0002009	276	0.033
developmental growth	GO:0048589	280	0.033
wound healing	GO:0042060	75	0.032
ion homeostasis	GO:0050801	55	0.032	Human
digestive tract morphogenesis	GO:0048546	127	0.032
inorganic cation transmembrane transport	GO:0098662	61	0.032
organic substance transport	GO:0071702	257	0.031
gastrulation with mouth forming first	GO:0001703	36	0.031
cellular cation homeostasis	GO:0030003	38	0.031
chemical homeostasis	GO:0048878	92	0.030	Human
body morphogenesis	GO:0010171	2	0.030
negative regulation of cellular metabolic process	GO:0031324	382	0.030
digestive tract development	GO:0048565	149	0.030
cellular monovalent inorganic cation homeostasis	GO:0030004	7	0.029
response to external biotic stimulus	GO:0043207	293	0.029
regulation of multicellular organismal development	GO:2000026	414	0.029
cellular ketone metabolic process	GO:0042180	24	0.029
wing disc morphogenesis	GO:0007472	344	0.029
inorganic ion transmembrane transport	GO:0098660	73	0.029
cellular component assembly involved in morphogenesis	GO:0010927	151	0.028
regulation of anatomical structure size	GO:0090066	163	0.028
neurological system process	GO:0050877	358	0.028	Human
cilium assembly	GO:0042384	38	0.028
stem cell development	GO:0048864	79	0.028
cellular ion homeostasis	GO:0006873	39	0.026
lateral inhibition	GO:0046331	206	0.026
tube development	GO:0035295	244	0.026
regulation of cell cycle	GO:0051726	291	0.026
neuron recognition	GO:0008038	101	0.026
embryonic development via the syncytial blastoderm	GO:0001700	148	0.026
renal system development	GO:0072001	72	0.026
alpha amino acid metabolic process	GO:1901605	20	0.025
small molecule metabolic process	GO:0044281	305	0.025
anion transmembrane transport	GO:0098656	26	0.024
cellular lipid metabolic process	GO:0044255	83	0.024
immune response	GO:0006955	246	0.024
phosphate ion transmembrane transport	GO:0035435	4	0.024
purine ribonucleotide metabolic process	GO:0009150	145	0.023
regulation of multi organism process	GO:0043900	131	0.023
taxis	GO:0042330	304	0.023
defense response	GO:0006952	300	0.022
response to radiation	GO:0009314	155	0.022
response to hexose	GO:0009746	3	0.022
response to glucose	GO:0009749	2	0.021
cell proliferation	GO:0008283	299	0.021
negative regulation of cellular biosynthetic process	GO:0031327	277	0.021
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.021
cell motility	GO:0048870	251	0.021
triglyceride biosynthetic process	GO:0019432	2	0.020
stem cell differentiation	GO:0048863	117	0.020
anion homeostasis	GO:0055081	3	0.020
cell recognition	GO:0008037	102	0.020
hormone metabolic process	GO:0042445	33	0.020
muscle cell differentiation	GO:0042692	103	0.019
defense response to bacterium	GO:0042742	178	0.019
immune system process	GO:0002376	347	0.019
cellular protein localization	GO:0034613	160	0.019
l amino acid import	GO:0043092	2	0.019
regulation of intracellular ph	GO:0051453	7	0.019
axis specification	GO:0009798	167	0.019
open tracheal system development	GO:0007424	204	0.019
negative regulation of developmental process	GO:0051093	201	0.018
organonitrogen compound catabolic process	GO:1901565	128	0.018
purine nucleoside metabolic process	GO:0042278	127	0.018
appendage development	GO:0048736	401	0.018
intracellular signal transduction	GO:0035556	300	0.018
transmembrane transport	GO:0055085	139	0.018
imaginal disc derived wing morphogenesis	GO:0007476	337	0.018
negative regulation of cell differentiation	GO:0045596	143	0.018
developmental pigmentation	GO:0048066	68	0.017
biological adhesion	GO:0022610	138	0.017
striated muscle myosin thick filament assembly	GO:0071688	3	0.017
embryo development ending in birth or egg hatching	GO:0009792	152	0.017
gastrulation involving germ band extension	GO:0010004	36	0.017
single organism membrane organization	GO:0044802	93	0.017
l glutamate import	GO:0051938	1	0.017
endomembrane system organization	GO:0010256	119	0.016
regulation of response to external stimulus	GO:0032101	115	0.016
tube morphogenesis	GO:0035239	191	0.016
heart development	GO:0007507	82	0.016
aromatic compound catabolic process	GO:0019439	166	0.016
cellular response to monosaccharide stimulus	GO:0071326	2	0.016
larval development	GO:0002164	104	0.016
cellular nitrogen compound catabolic process	GO:0044270	165	0.016
metal ion homeostasis	GO:0055065	44	0.016
nad metabolic process	GO:0019674	1	0.016
respiratory system development	GO:0060541	213	0.016
regulation of immune response	GO:0050776	118	0.015
thioester metabolic process	GO:0035383	3	0.015
eye development	GO:0001654	323	0.015
cuticle development	GO:0042335	86	0.015
negative regulation of cell development	GO:0010721	62	0.015
programmed cell death	GO:0012501	257	0.015
urogenital system development	GO:0001655	72	0.015
developmental programmed cell death	GO:0010623	138	0.015
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.015
spermatid differentiation	GO:0048515	114	0.015
nucleobase containing compound catabolic process	GO:0034655	165	0.015
cilium morphogenesis	GO:0060271	39	0.015
negative regulation of rna metabolic process	GO:0051253	251	0.015
regulation of hormone levels	GO:0010817	40	0.015
regulation of proteolysis	GO:0030162	87	0.015
negative regulation of neurogenesis	GO:0050768	53	0.015
negative regulation of multicellular organismal process	GO:0051241	142	0.015
gastrulation	GO:0007369	70	0.015
pigmentation	GO:0043473	75	0.014
regulation of transport	GO:0051049	181	0.014
positive regulation of response to stimulus	GO:0048584	323	0.014
dorsal ventral pattern formation	GO:0009953	133	0.014
nucleoside phosphate metabolic process	GO:0006753	162	0.014
carboxylic acid transport	GO:0046942	18	0.014
response to copper ion	GO:0046688	4	0.014
inorganic anion transmembrane transport	GO:0098661	14	0.014
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.014
cation transport	GO:0006812	110	0.014	Human
head development	GO:0060322	135	0.014
cellular protein modification process	GO:0006464	438	0.014
positive regulation of cell communication	GO:0010647	250	0.014
negative regulation of nervous system development	GO:0051961	92	0.013
phosphorylation	GO:0016310	294	0.013
positive regulation of signaling	GO:0023056	243	0.013
nephron epithelium development	GO:0072009	3	0.013
cellular metal ion homeostasis	GO:0006875	31	0.013
heterocycle catabolic process	GO:0046700	166	0.013
cellular response to chemical stimulus	GO:0070887	199	0.013
salivary gland cell autophagic cell death	GO:0035071	83	0.013
ribonucleoside catabolic process	GO:0042454	112	0.013
nephron development	GO:0072006	3	0.013
nucleobase containing small molecule metabolic process	GO:0055086	174	0.013
localization of cell	GO:0051674	257	0.013
regulation of cell cycle process	GO:0010564	181	0.013
response to monosaccharide	GO:0034284	4	0.013
forebrain development	GO:0030900	2	0.013
cell cell junction organization	GO:0045216	55	0.012
regulation of epithelial cell proliferation	GO:0050678	4	0.012
carbohydrate biosynthetic process	GO:0016051	17	0.012
segmentation	GO:0035282	207	0.012
response to nutrient levels	GO:0031667	114	0.012
purine ribonucleoside catabolic process	GO:0046130	112	0.012
negative regulation of response to stimulus	GO:0048585	258	0.012
central nervous system development	GO:0007417	201	0.012
response to extracellular stimulus	GO:0009991	116	0.012
positive regulation of cell motility	GO:2000147	3	0.012
membrane organization	GO:0061024	112	0.012
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.012
response to organic cyclic compound	GO:0014070	89	0.012
protein modification process	GO:0036211	438	0.012
regulation of cell death	GO:0010941	173	0.012
imaginal disc derived appendage development	GO:0048737	399	0.011
purine ribonucleoside metabolic process	GO:0046128	127	0.011
cellular catabolic process	GO:0044248	372	0.011
regulation of localization	GO:0032879	275	0.011
single organism catabolic process	GO:0044712	228	0.011
mesenchymal cell development	GO:0014031	1	0.011
macromolecular complex assembly	GO:0065003	256	0.011
ecdysteroid metabolic process	GO:0045455	19	0.011
regulation of cellular response to stress	GO:0080135	89	0.011
negative regulation of signaling	GO:0023057	219	0.011
cellular response to oxygen containing compound	GO:1901701	79	0.011
androgen metabolic process	GO:0008209	1	0.011
negative regulation of gene expression	GO:0010629	387	0.011
single organism carbohydrate metabolic process	GO:0044723	72	0.011
appendage morphogenesis	GO:0035107	397	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.011
ribonucleoside metabolic process	GO:0009119	127	0.011
apoptotic process	GO:0006915	159	0.011
water homeostasis	GO:0030104	3	0.011
salivary gland histolysis	GO:0035070	88	0.011
post embryonic appendage morphogenesis	GO:0035120	385	0.011
generation of precursor metabolites and energy	GO:0006091	42	0.011
multicellular organismal aging	GO:0010259	140	0.011
atp metabolic process	GO:0046034	49	0.011
organic cyclic compound catabolic process	GO:1901361	168	0.011
regulation of circadian rhythm	GO:0042752	49	0.011
axonogenesis	GO:0007409	290	0.010
cell migration	GO:0016477	238	0.010
regulation of defense response	GO:0031347	102	0.010
histolysis	GO:0007559	102	0.010
positive regulation of neurotransmitter transport	GO:0051590	2	0.010
negative regulation of biosynthetic process	GO:0009890	277	0.010
cell projection assembly	GO:0030031	94	0.010
positive regulation of cell migration	GO:0030335	2	0.010
regulation of programmed cell death	GO:0043067	152	0.010
regulation of molecular function	GO:0065009	217	0.010
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.010
regulation of cell projection organization	GO:0031344	92	0.010
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.010
purine ribonucleoside biosynthetic process	GO:0046129	3	0.010

Vha100-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.036	Human
renal tubular transport disease	DOID:447	0.028	Human
urinary system disease	DOID:18	0.028	Human
kidney disease	DOID:557	0.028	Human
disease of metabolism	DOID:0014667	0.025
inherited metabolic disorder	DOID:655	0.022
cancer	DOID:162	0.011
disease of cellular proliferation	DOID:14566	0.011
organ system cancer	DOID:0050686	0.011
musculoskeletal system disease	DOID:17	0.010

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