IMP: Integrative Multi-species Prediction

Drosophila melanogaster

76 known processes

tilB (Dmel_CG14620)

touch insensitive larva B

(Aliases: Dmel\CG14620,CG14620)

Entrez: 33130
FLYBASE: FBgn0014395
UniProtKB: Q9VR52

Process Predictions
Disease Predictions

tilB biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cilium assembly	GO:0042384	38	0.999
axoneme assembly	GO:0035082	18	0.989
cilium morphogenesis	GO:0060271	39	0.983
cilium organization	GO:0044782	41	0.976
sensory perception of mechanical stimulus	GO:0050954	72	0.954
male courtship behavior	GO:0008049	63	0.941
courtship behavior	GO:0007619	68	0.904
neurological system process	GO:0050877	358	0.863
mating behavior	GO:0007617	106	0.851
multi organism behavior	GO:0051705	175	0.851
sensory perception	GO:0007600	196	0.849
sensory perception of sound	GO:0007605	56	0.841
reproductive behavior	GO:0019098	122	0.823
single organism behavior	GO:0044708	391	0.817
microtubule bundle formation	GO:0001578	27	0.807
locomotory behavior	GO:0007626	176	0.744
cellular component assembly involved in morphogenesis	GO:0010927	151	0.718
mating	GO:0007618	120	0.713
intraciliary transport	GO:0042073	8	0.520
cell projection assembly	GO:0030031	94	0.507
multi multicellular organism process	GO:0044706	123	0.496
multicellular organismal reproductive behavior	GO:0033057	110	0.477
male courtship behavior veined wing extension	GO:0048065	22	0.408
male gamete generation	GO:0048232	201	0.390
organelle assembly	GO:0070925	198	0.385
multi organism reproductive behavior	GO:0044705	121	0.383
male mating behavior	GO:0060179	70	0.381
microtubule based transport	GO:0010970	42	0.381
locomotor rhythm	GO:0045475	56	0.344
sperm axoneme assembly	GO:0007288	13	0.330
response to mechanical stimulus	GO:0009612	28	0.288
nonmotile primary cilium assembly	GO:0035058	8	0.243
male courtship behavior veined wing vibration	GO:0016545	21	0.232
spermatid differentiation	GO:0048515	114	0.219
positive regulation of signal transduction	GO:0009967	223	0.210
male courtship behavior veined wing generated song production	GO:0045433	20	0.196
positive regulation of response to stimulus	GO:0048584	323	0.193
spermatogenesis	GO:0007283	200	0.181
adult locomotory behavior	GO:0008344	76	0.168
response to abiotic stimulus	GO:0009628	341	0.168
circadian rhythm	GO:0007623	105	0.159
regionalization	GO:0003002	416	0.152	Zebrafish
spermatid development	GO:0007286	98	0.142
cellular response to organic substance	GO:0071310	132	0.141
response to auditory stimulus	GO:0010996	5	0.131
adult behavior	GO:0030534	137	0.129
auditory behavior	GO:0031223	1	0.122
cellular response to chemical stimulus	GO:0070887	199	0.119
response to organic substance	GO:0010033	284	0.116
cellular response to acid chemical	GO:0071229	8	0.113
response to oxygen containing compound	GO:1901700	200	0.106
regulation of anatomical structure morphogenesis	GO:0022603	242	0.102
positive regulation of signaling	GO:0023056	243	0.100
circadian behavior	GO:0048512	76	0.100
negative regulation of transcription dna templated	GO:0045892	237	0.099
response to endogenous stimulus	GO:0009719	119	0.097
eye development	GO:0001654	323	0.091
rhythmic process	GO:0048511	106	0.086
rhythmic behavior	GO:0007622	76	0.085
antennal morphogenesis	GO:0048800	14	0.085
cellular response to endogenous stimulus	GO:0071495	80	0.083
kidney development	GO:0001822	3	0.082	Zebrafish
protein maturation	GO:0051604	71	0.078
eye morphogenesis	GO:0048592	260	0.077
intracellular signal transduction	GO:0035556	300	0.074
cognition	GO:0050890	141	0.073
protein processing	GO:0016485	68	0.068
startle response	GO:0001964	16	0.068
response to acid chemical	GO:0001101	25	0.066
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.066
mechanosensory behavior	GO:0007638	12	0.066
regulation of localization	GO:0032879	275	0.064
cellular response to organonitrogen compound	GO:0071417	36	0.063
sensory organ morphogenesis	GO:0090596	260	0.061
appendage development	GO:0048736	401	0.060
actin filament based movement	GO:0030048	26	0.059
positive regulation of intracellular signal transduction	GO:1902533	116	0.056
dendrite development	GO:0016358	204	0.054
apical constriction	GO:0003383	18	0.053
localization of cell	GO:0051674	257	0.053
dorsal ventral pattern formation	GO:0009953	133	0.053	Zebrafish
appendage morphogenesis	GO:0035107	397	0.051
regulation of transport	GO:0051049	181	0.050
negative regulation of signaling	GO:0023057	219	0.050
organonitrogen compound metabolic process	GO:1901564	318	0.049
response to organonitrogen compound	GO:0010243	75	0.047
sensory perception of touch	GO:0050975	11	0.046
compound eye development	GO:0048749	307	0.045
response to radiation	GO:0009314	155	0.044
segmentation	GO:0035282	207	0.043
forebrain development	GO:0030900	2	0.043
cellular response to oxygen containing compound	GO:1901701	79	0.042
endocytosis	GO:0006897	310	0.042
negative regulation of cellular metabolic process	GO:0031324	382	0.042
negative regulation of signal transduction	GO:0009968	206	0.040
embryonic morphogenesis	GO:0048598	206	0.040	Zebrafish
negative regulation of gene expression	GO:0010629	387	0.039
synaptic transmission	GO:0007268	288	0.039
detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	2	0.039
smoothened signaling pathway	GO:0007224	49	0.038
dendrite morphogenesis	GO:0048813	199	0.037
negative regulation of cell communication	GO:0010648	223	0.037
spermatid nucleus elongation	GO:0007290	4	0.037
homeostatic process	GO:0042592	199	0.036
intraspecies interaction between organisms	GO:0051703	4	0.036
regulation of cell differentiation	GO:0045595	302	0.036
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.036
establishment of localization in cell	GO:0051649	402	0.035
regulation of intracellular signal transduction	GO:1902531	236	0.035
limb morphogenesis	GO:0035108	1	0.034
intracellular transport	GO:0046907	228	0.034
epithelial cell development	GO:0002064	274	0.034
phagocytosis	GO:0006909	215	0.034
detection of stimulus	GO:0051606	156	0.034
ion transport	GO:0006811	145	0.033
macromolecule catabolic process	GO:0009057	161	0.033
epidermis development	GO:0008544	65	0.033
negative regulation of rna biosynthetic process	GO:1902679	240	0.033
sensory perception of salty taste	GO:0050914	3	0.032
brain development	GO:0007420	120	0.032
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.032
limb development	GO:0060173	1	0.032
regulation of organ morphogenesis	GO:2000027	78	0.032
organic substance catabolic process	GO:1901575	308	0.031
chemotaxis	GO:0006935	249	0.031
negative regulation of rna metabolic process	GO:0051253	251	0.031
protein localization	GO:0008104	284	0.030
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.030
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.030
flight behavior	GO:0007629	26	0.030
peripheral nervous system development	GO:0007422	52	0.030
nucleobase containing small molecule metabolic process	GO:0055086	174	0.030
mitotic spindle organization	GO:0007052	220	0.029
response to nutrient levels	GO:0031667	114	0.029
cell motility	GO:0048870	251	0.029
regulation of neurogenesis	GO:0050767	158	0.028
negative regulation of biosynthetic process	GO:0009890	277	0.028
transcription from rna polymerase ii promoter	GO:0006366	368	0.028
signal transduction by phosphorylation	GO:0023014	107	0.028
cellular catabolic process	GO:0044248	372	0.028
regulation of multicellular organismal development	GO:2000026	414	0.028
actin mediated cell contraction	GO:0070252	21	0.027
regulation of cell morphogenesis	GO:0022604	163	0.027
epithelial cell differentiation	GO:0030855	322	0.027
small molecule metabolic process	GO:0044281	305	0.026
oxoacid metabolic process	GO:0043436	103	0.026
growth	GO:0040007	359	0.026
phosphorylation	GO:0016310	294	0.026
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.026
peptide metabolic process	GO:0006518	80	0.025
axon development	GO:0061564	297	0.025
glycosyl compound metabolic process	GO:1901657	127	0.025
learning or memory	GO:0007611	141	0.025
behavioral response to pain	GO:0048266	3	0.024
compound eye morphogenesis	GO:0001745	249	0.024
eye antennal disc development	GO:0035214	60	0.024
regulation of tor signaling	GO:0032006	21	0.024
cellular response to nitrogen compound	GO:1901699	51	0.024
entrainment of circadian clock	GO:0009649	16	0.024
regulation of cell development	GO:0060284	215	0.024
negative regulation of response to stimulus	GO:0048585	258	0.023
spinal cord development	GO:0021510	1	0.023
regulation of synaptic activity	GO:0060025	9	0.023
cellular response to starvation	GO:0009267	61	0.023
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.022
cellular macromolecule catabolic process	GO:0044265	136	0.022
retina development in camera type eye	GO:0060041	4	0.022
negative regulation of cellular biosynthetic process	GO:0031327	277	0.022
renal system development	GO:0072001	72	0.022	Zebrafish
cranial nerve development	GO:0021545	1	0.022
catabolic process	GO:0009056	409	0.022
response to nitrogen compound	GO:1901698	90	0.022
regulation of protein metabolic process	GO:0051246	256	0.022
single organism catabolic process	GO:0044712	228	0.021
vesicle mediated transport	GO:0016192	381	0.021
organic acid metabolic process	GO:0006082	103	0.021
synapse assembly	GO:0007416	143	0.021
carboxylic acid metabolic process	GO:0019752	92	0.021
cellular response to external stimulus	GO:0071496	66	0.021
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.021
aggressive behavior	GO:0002118	63	0.020
cellular homeostasis	GO:0019725	80	0.020
response to organophosphorus	GO:0046683	2	0.020
ribose phosphate metabolic process	GO:0019693	145	0.020
gland development	GO:0048732	191	0.020
regulation of retinal cell programmed cell death	GO:0046668	18	0.020
response to pain	GO:0048265	3	0.020
nucleoside phosphate metabolic process	GO:0006753	162	0.019
axon guidance	GO:0007411	233	0.019
compound eye photoreceptor development	GO:0042051	78	0.019
regulation of intracellular transport	GO:0032386	64	0.019
taxis	GO:0042330	304	0.018
cell death	GO:0008219	279	0.018
tissue morphogenesis	GO:0048729	297	0.018	Zebrafish
regulation of cellular localization	GO:0060341	136	0.018
regulation of programmed cell death	GO:0043067	152	0.018
proteolysis	GO:0006508	192	0.018
inorganic cation transmembrane transport	GO:0098662	61	0.018
cellular amide metabolic process	GO:0043603	80	0.018
cellularization	GO:0007349	90	0.018
respiratory system development	GO:0060541	213	0.018
organelle fission	GO:0048285	340	0.017
regulation of cellular response to growth factor stimulus	GO:0090287	13	0.017
cellular macromolecule localization	GO:0070727	220	0.017
imaginal disc derived appendage development	GO:0048737	399	0.017
single organism intracellular transport	GO:1902582	207	0.017
neuromuscular process	GO:0050905	21	0.017
nucleotide metabolic process	GO:0009117	161	0.017
metal ion homeostasis	GO:0055065	44	0.017
ion transmembrane transport	GO:0034220	122	0.017
microtubule based movement	GO:0007018	51	0.016	Zebrafish
detection of stimulus involved in sensory perception	GO:0050906	92	0.016
purine ribonucleotide metabolic process	GO:0009150	145	0.016
protein complex assembly	GO:0006461	200	0.016
sperm individualization	GO:0007291	48	0.016
autophagy	GO:0006914	108	0.016
regulation of embryonic development	GO:0045995	68	0.016
embryonic pattern specification	GO:0009880	174	0.016
regulation of cell cycle	GO:0051726	291	0.016
regulation of microtubule based process	GO:0032886	49	0.016
eye antennal disc morphogenesis	GO:0007455	34	0.016
wound healing spreading of epidermal cells	GO:0035313	1	0.016
cellular response to nutrient levels	GO:0031669	62	0.016
response to glucose	GO:0009749	2	0.016
eye photoreceptor cell differentiation	GO:0001754	145	0.016
regulation of circadian rhythm	GO:0042752	49	0.015
positive regulation of ion transmembrane transporter activity	GO:0032414	4	0.015
regulation of smoothened signaling pathway	GO:0008589	28	0.015
non sensory hair organization	GO:0035316	47	0.015
positive regulation of biosynthetic process	GO:0009891	316	0.015
wing disc morphogenesis	GO:0007472	344	0.015
molting cycle chitin based cuticle	GO:0007591	56	0.015
cellular response to mechanical stimulus	GO:0071260	2	0.015
programmed cell death	GO:0012501	257	0.015
dna damage checkpoint	GO:0000077	78	0.015
immune effector process	GO:0002252	98	0.015
developmental maturation	GO:0021700	172	0.015
blastoderm segmentation	GO:0007350	159	0.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.015
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	4	0.014
monovalent inorganic cation transport	GO:0015672	40	0.014
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.014
regulation of cell cycle phase transition	GO:1901987	130	0.014
cytoskeleton dependent intracellular transport	GO:0030705	44	0.014
ion homeostasis	GO:0050801	55	0.014
camera type eye development	GO:0043010	4	0.014
regulation of cell death	GO:0010941	173	0.014
response to biotic stimulus	GO:0009607	294	0.014
response to wounding	GO:0009611	94	0.014
centriole replication	GO:0007099	24	0.014
centriole assembly	GO:0098534	24	0.014
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.014
negative regulation of programmed cell death	GO:0043069	72	0.014
regulation of response to external stimulus	GO:0032101	115	0.013
energy derivation by oxidation of organic compounds	GO:0015980	32	0.013
response to lipopolysaccharide	GO:0032496	4	0.013
exocrine system development	GO:0035272	162	0.013
central nervous system development	GO:0007417	201	0.013
single organism biosynthetic process	GO:0044711	206	0.013
spinal cord patterning	GO:0021511	1	0.013
regulation of nervous system development	GO:0051960	248	0.013
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.013
protein catabolic process	GO:0030163	101	0.013
cell cycle checkpoint	GO:0000075	95	0.013
protein modification process	GO:0036211	438	0.013
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.013
actin filament organization	GO:0007015	126	0.013
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.013
wing disc pattern formation	GO:0035222	66	0.013
cation homeostasis	GO:0055080	51	0.013
positive regulation of cell communication	GO:0010647	250	0.013
death	GO:0016265	284	0.013
specification of symmetry	GO:0009799	13	0.012	Zebrafish
purine nucleotide metabolic process	GO:0006163	146	0.012
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.012
negative regulation of cell differentiation	GO:0045596	143	0.012
cation transport	GO:0006812	110	0.012
cellular protein modification process	GO:0006464	438	0.012
carbohydrate derivative metabolic process	GO:1901135	217	0.012
negative regulation of cell cycle process	GO:0010948	109	0.012
lateral inhibition	GO:0046331	206	0.012
cellular amino acid metabolic process	GO:0006520	61	0.012
cellular protein localization	GO:0034613	160	0.012
nucleoside monophosphate metabolic process	GO:0009123	52	0.012
actin filament based process	GO:0030029	220	0.012
cellular chemical homeostasis	GO:0055082	40	0.012
epithelial cell morphogenesis	GO:0003382	25	0.012
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.012
compound eye retinal cell programmed cell death	GO:0046667	23	0.012
learning	GO:0007612	75	0.012
regulation of response to extracellular stimulus	GO:0032104	18	0.012
drinking behavior	GO:0042756	2	0.012
body morphogenesis	GO:0010171	2	0.012
associative learning	GO:0008306	65	0.012
atp metabolic process	GO:0046034	49	0.012
organic substance transport	GO:0071702	257	0.012
positive regulation of rna biosynthetic process	GO:1902680	266	0.012
positive regulation of axonogenesis	GO:0050772	2	0.012
cellular respiration	GO:0045333	26	0.011
posttranscriptional regulation of gene expression	GO:0010608	145	0.011
epiboly	GO:0090504	2	0.011
regulation of growth	GO:0040008	233	0.011
response to other organism	GO:0051707	293	0.011
photoreceptor cell development	GO:0042461	96	0.011
segment polarity determination	GO:0007367	25	0.011
regulation of response to nutrient levels	GO:0032107	18	0.011
membrane depolarization	GO:0051899	4	0.011
developmental programmed cell death	GO:0010623	138	0.011
post embryonic appendage morphogenesis	GO:0035120	385	0.011
oxidation reduction process	GO:0055114	123	0.011
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.011
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.011
response to extracellular stimulus	GO:0009991	116	0.011
regulation of response to stress	GO:0080134	200	0.011
neurotransmitter metabolic process	GO:0042133	2	0.011
imaginal disc derived wing hair organization	GO:0035317	45	0.011
regulation of cellular protein metabolic process	GO:0032268	243	0.011
neural retina development	GO:0003407	4	0.011
chaeta development	GO:0022416	97	0.011
mapk cascade	GO:0000165	107	0.011
response to external biotic stimulus	GO:0043207	293	0.010
developmental growth	GO:0048589	280	0.010
response to heat	GO:0009408	63	0.010
l amino acid import	GO:0043092	2	0.010
negative regulation of cell death	GO:0060548	81	0.010
proteasomal protein catabolic process	GO:0010498	59	0.010
regulation of catabolic process	GO:0009894	170	0.010
eye photoreceptor cell development	GO:0042462	81	0.010
regulation of cellular amino acid metabolic process	GO:0006521	0	0.010
cation transmembrane transport	GO:0098655	88	0.010

tilB disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
bronchial disease	DOID:1176	0.195
respiratory system disease	DOID:1579	0.195
disease of anatomical entity	DOID:7	0.195
lower respiratory tract disease	DOID:0050161	0.195
nervous system disease	DOID:863	0.054
kidney disease	DOID:557	0.035
urinary system disease	DOID:18	0.035
renal tubular transport disease	DOID:447	0.035
bronchiectasis	DOID:9563	0.024
sensory system disease	DOID:0050155	0.021
disease of metabolism	DOID:0014667	0.016
inherited metabolic disorder	DOID:655	0.016
auditory system disease	DOID:2742	0.013
liddle syndrome	DOID:0050477	0.011
organ system cancer	DOID:0050686	0.011
disease of cellular proliferation	DOID:14566	0.011
cancer	DOID:162	0.011
cardiovascular system disease	DOID:1287	0.011
heart conduction disease	DOID:10273	0.011
eye and adnexa disease	DOID:1492	0.010

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