IMP: Integrative Multi-species Prediction

Drosophila melanogaster

95 known processes

fbl (Dmel_CG5725)

fumble

(Aliases: PANK,Dmel\CG5725,dPANK,CG5725)

Entrez: 46234
FLYBASE: FBgn0011205
UniProtKB: Q9NHN2
UniProtKB: M9NDE0
UniProtKB: D8FT20
UniProtKB: Q9VPG5
UniProtKB: Q9VPG4
UniProtKB: Q8I0S6

Process Predictions
Disease Predictions

fbl biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
cell division	GO:0051301	248	0.863
organelle fission	GO:0048285	340	0.817
meiotic cell cycle	GO:0051321	171	0.597
meiotic cell cycle process	GO:1903046	132	0.440
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.428
meiotic nuclear division	GO:0007126	151	0.386
adult behavior	GO:0030534	137	0.380
cytoskeleton dependent cytokinesis	GO:0061640	81	0.374
imaginal disc derived appendage development	GO:0048737	399	0.353
response to abiotic stimulus	GO:0009628	341	0.351
organonitrogen compound metabolic process	GO:1901564	318	0.328	Mouse
oxoacid metabolic process	GO:0043436	103	0.319
cellular protein modification process	GO:0006464	438	0.316
cell migration	GO:0016477	238	0.286
spermatogenesis	GO:0007283	200	0.281
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.277
appendage development	GO:0048736	401	0.267
cellular lipid metabolic process	GO:0044255	83	0.266
adult locomotory behavior	GO:0008344	76	0.243
regulation of neurogenesis	GO:0050767	158	0.231
cellular catabolic process	GO:0044248	372	0.228
mitochondrion organization	GO:0007005	65	0.209	Mouse
nuclear division	GO:0000280	332	0.205
programmed cell death	GO:0012501	257	0.190	Worm
organic acid metabolic process	GO:0006082	103	0.190
central nervous system development	GO:0007417	201	0.188
organic substance catabolic process	GO:1901575	308	0.181
transmembrane transport	GO:0055085	139	0.181
modification dependent macromolecule catabolic process	GO:0043632	79	0.174
cell death	GO:0008219	279	0.162	Worm
organonitrogen compound catabolic process	GO:1901565	128	0.155
ion transmembrane transport	GO:0034220	122	0.146
homeostatic process	GO:0042592	199	0.139
regulation of multicellular organismal development	GO:2000026	414	0.139
intracellular transport	GO:0046907	228	0.134
aging	GO:0007568	143	0.134	Worm
head development	GO:0060322	135	0.134
catabolic process	GO:0009056	409	0.134
single organism intracellular transport	GO:1902582	207	0.129
meiotic cytokinesis	GO:0033206	33	0.125
cytoplasmic transport	GO:0016482	130	0.125
appendage morphogenesis	GO:0035107	397	0.124
muscle structure development	GO:0061061	224	0.118
macromolecule catabolic process	GO:0009057	161	0.111
proteolysis	GO:0006508	192	0.104
defense response	GO:0006952	300	0.103
brain development	GO:0007420	120	0.102
developmental growth	GO:0048589	280	0.101
regulation of localization	GO:0032879	275	0.101
small molecule metabolic process	GO:0044281	305	0.100	Mouse
regulation of organelle organization	GO:0033043	196	0.100
macromolecular complex disassembly	GO:0032984	37	0.096
regulation of cellular catabolic process	GO:0031329	157	0.091
nitrogen compound transport	GO:0071705	85	0.090
establishment of localization in cell	GO:0051649	402	0.089
imaginal disc derived wing morphogenesis	GO:0007476	337	0.084
modification dependent protein catabolic process	GO:0019941	78	0.083
organophosphate metabolic process	GO:0019637	195	0.079	Mouse
ubiquitin dependent protein catabolic process	GO:0006511	78	0.079
negative regulation of cellular metabolic process	GO:0031324	382	0.077
single organism behavior	GO:0044708	391	0.074
regulation of cell development	GO:0060284	215	0.073
locomotory behavior	GO:0007626	176	0.073
apoptotic process	GO:0006915	159	0.072	Worm
chromosome organization	GO:0051276	360	0.071
cytokinesis	GO:0000910	90	0.070
response to oxygen containing compound	GO:1901700	200	0.067
ion transport	GO:0006811	145	0.067
regulation of nervous system development	GO:0051960	248	0.067
eye development	GO:0001654	323	0.066
response to organic substance	GO:0010033	284	0.065
organic substance transport	GO:0071702	257	0.065
cellular response to organic substance	GO:0071310	132	0.065
multicellular organismal aging	GO:0010259	140	0.063	Worm
secretion	GO:0046903	109	0.061
regulation of catabolic process	GO:0009894	170	0.060
vesicle mediated transport	GO:0016192	381	0.059
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.058
positive regulation of cell communication	GO:0010647	250	0.058
purine containing compound metabolic process	GO:0072521	155	0.058	Mouse
carboxylic acid metabolic process	GO:0019752	92	0.058
epithelial cell migration	GO:0010631	148	0.057
regulation of transport	GO:0051049	181	0.057
immune system process	GO:0002376	347	0.056
regulation of protein metabolic process	GO:0051246	256	0.055
organic anion transport	GO:0015711	28	0.054
negative regulation of response to stimulus	GO:0048585	258	0.053
cellular macromolecule catabolic process	GO:0044265	136	0.053
mitotic nuclear division	GO:0007067	213	0.052
regulation of cell cycle	GO:0051726	291	0.052
forebrain development	GO:0030900	2	0.051
negative regulation of developmental process	GO:0051093	201	0.050
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.050
circadian sleep wake cycle sleep	GO:0050802	23	0.050
death	GO:0016265	284	0.049	Worm
single organism biosynthetic process	GO:0044711	206	0.049	Mouse
determination of adult lifespan	GO:0008340	137	0.049	Worm
carbohydrate derivative metabolic process	GO:1901135	217	0.049	Mouse
cell motility	GO:0048870	251	0.048
actin filament based process	GO:0030029	220	0.048
negative regulation of cell differentiation	GO:0045596	143	0.047
nucleobase containing compound catabolic process	GO:0034655	165	0.047
aromatic compound catabolic process	GO:0019439	166	0.046
positive regulation of multicellular organismal process	GO:0051240	143	0.045
localization of cell	GO:0051674	257	0.045
positive regulation of developmental process	GO:0051094	143	0.045
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.042
mitotic cytokinesis	GO:0000281	50	0.042
cellular amino acid metabolic process	GO:0006520	61	0.042
cellular protein catabolic process	GO:0044257	83	0.042
cellular amine metabolic process	GO:0044106	12	0.042
tissue migration	GO:0090130	155	0.040
sperm mitochondrion organization	GO:0030382	7	0.040
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.040
cognition	GO:0050890	141	0.039
sperm individualization	GO:0007291	48	0.039
nucleobase containing small molecule metabolic process	GO:0055086	174	0.038	Mouse
regulation of response to stress	GO:0080134	200	0.037
actin cytoskeleton organization	GO:0030036	206	0.037
oocyte development	GO:0048599	124	0.036
regulation of cell differentiation	GO:0045595	302	0.035
tube development	GO:0035295	244	0.035
regulation of phosphorus metabolic process	GO:0051174	210	0.035
spindle assembly	GO:0051225	80	0.034
body morphogenesis	GO:0010171	2	0.034
positive regulation of cellular protein metabolic process	GO:0032270	118	0.034
positive regulation of signal transduction	GO:0009967	223	0.033
spermatocyte division	GO:0048137	13	0.033
regulation of cellular protein catabolic process	GO:1903362	44	0.032
post embryonic appendage morphogenesis	GO:0035120	385	0.032
ribonucleotide catabolic process	GO:0009261	109	0.031
cytoskeleton dependent intracellular transport	GO:0030705	44	0.031
positive regulation of cellular catabolic process	GO:0031331	95	0.031
regulation of hemocyte proliferation	GO:0035206	37	0.031
cellular response to endogenous stimulus	GO:0071495	80	0.031
bmp signaling pathway	GO:0030509	27	0.030
male meiosis cytokinesis	GO:0007112	26	0.030
protein complex assembly	GO:0006461	200	0.030
male gamete generation	GO:0048232	201	0.029
ameboidal type cell migration	GO:0001667	151	0.029
meiosis ii	GO:0007135	23	0.029
positive regulation of signaling	GO:0023056	243	0.029
lipid metabolic process	GO:0006629	121	0.029
protein catabolic process	GO:0030163	101	0.028
nucleotide metabolic process	GO:0009117	161	0.028	Mouse
anion transport	GO:0006820	41	0.028
chaeta development	GO:0022416	97	0.028
positive regulation of catabolic process	GO:0009896	105	0.028
carbohydrate derivative biosynthetic process	GO:1901137	85	0.028	Mouse
purine nucleotide metabolic process	GO:0006163	146	0.028	Mouse
protein localization	GO:0008104	284	0.028
positive regulation of nervous system development	GO:0051962	69	0.027
negative regulation of cellular component organization	GO:0051129	108	0.027
protein modification by small protein conjugation or removal	GO:0070647	106	0.027
protein phosphorylation	GO:0006468	169	0.027
blastoderm segmentation	GO:0007350	159	0.027
monocarboxylic acid transport	GO:0015718	3	0.027
cardiovascular system development	GO:0072358	82	0.026
regulation of cellular response to oxidative stress	GO:1900407	4	0.026
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.026
regionalization	GO:0003002	416	0.026
purine ribonucleotide metabolic process	GO:0009150	145	0.026	Mouse
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.026
single organism cellular localization	GO:1902580	180	0.026
response to oxidative stress	GO:0006979	86	0.025
compound eye development	GO:0048749	307	0.025
axonogenesis	GO:0007409	290	0.025
regulation of developmental growth	GO:0048638	174	0.025
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.024
purine nucleotide catabolic process	GO:0006195	109	0.024
embryonic pattern specification	GO:0009880	174	0.024
embryonic development via the syncytial blastoderm	GO:0001700	148	0.024
regulation of cell cycle process	GO:0010564	181	0.024
organonitrogen compound biosynthetic process	GO:1901566	117	0.024	Mouse
nucleoside phosphate metabolic process	GO:0006753	162	0.023	Mouse
purine ribonucleotide catabolic process	GO:0009154	109	0.023
connective tissue development	GO:0061448	3	0.023
carbohydrate derivative catabolic process	GO:1901136	118	0.023
cellular response to chemical stimulus	GO:0070887	199	0.023
regulation of response to external stimulus	GO:0032101	115	0.023
positive regulation of cellular protein catabolic process	GO:1903364	24	0.023
immune system development	GO:0002520	57	0.022
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.022
regulation of cellular protein metabolic process	GO:0032268	243	0.022
inorganic cation transmembrane transport	GO:0098662	61	0.022
pigmentation	GO:0043473	75	0.021
regulation of autophagy	GO:0010506	62	0.021
neurological system process	GO:0050877	358	0.021
negative regulation of multicellular organismal process	GO:0051241	142	0.021
proteasomal protein catabolic process	GO:0010498	59	0.021
regulation of proteolysis	GO:0030162	87	0.021
positive regulation of macromolecule metabolic process	GO:0010604	405	0.020
regulation of cellular response to stress	GO:0080135	89	0.020
response to wounding	GO:0009611	94	0.020
mitochondrial fission	GO:0000266	8	0.020
response to other organism	GO:0051707	293	0.020
cytokinetic process	GO:0032506	27	0.019
positive regulation of protein metabolic process	GO:0051247	128	0.019
spermatid development	GO:0007286	98	0.019	Mouse
cellular respiration	GO:0045333	26	0.019	Mouse
cation transport	GO:0006812	110	0.019
response to symbiotic bacterium	GO:0009609	2	0.019
regulation of proteasomal protein catabolic process	GO:0061136	39	0.019
regulation of cell death	GO:0010941	173	0.019
microtubule organizing center organization	GO:0031023	168	0.018
centrosome organization	GO:0051297	163	0.018
developmental maturation	GO:0021700	172	0.018
synaptic transmission dopaminergic	GO:0001963	2	0.018
response to hypoxia	GO:0001666	53	0.018
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.018
protein modification by small protein conjugation	GO:0032446	79	0.018
protein complex disassembly	GO:0043241	36	0.018
organic cyclic compound catabolic process	GO:1901361	168	0.018
epithelial cell differentiation	GO:0030855	322	0.017
organelle fusion	GO:0048284	46	0.017
meiosis i	GO:0007127	59	0.017
cellular protein localization	GO:0034613	160	0.017
regulation of protein modification process	GO:0031399	112	0.017
reproductive system development	GO:0061458	74	0.017
positive regulation of cellular biosynthetic process	GO:0031328	316	0.017
regulation of programmed cell death	GO:0043067	152	0.017
growth	GO:0040007	359	0.017
purine nucleoside catabolic process	GO:0006152	112	0.017
response to alcohol	GO:0097305	95	0.016
endocytosis	GO:0006897	310	0.016
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.016
regulation of cellular component biogenesis	GO:0044087	201	0.016
axon development	GO:0061564	297	0.016
nucleus organization	GO:0006997	45	0.016
regulation of protein depolymerization	GO:1901879	27	0.016
regulation of cellular localization	GO:0060341	136	0.016
nucleoside monophosphate metabolic process	GO:0009123	52	0.016
nucleobase containing compound transport	GO:0015931	56	0.016
regulation of organ morphogenesis	GO:2000027	78	0.016
response to growth factor	GO:0070848	31	0.015
lipid biosynthetic process	GO:0008610	46	0.015
response to endogenous stimulus	GO:0009719	119	0.015
peptidyl lysine acetylation	GO:0018394	39	0.015
negative regulation of signaling	GO:0023057	219	0.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.015
regulation of protein catabolic process	GO:0042176	55	0.015
developmental cell growth	GO:0048588	52	0.015
regulation of circadian sleep wake cycle sleep	GO:0045187	21	0.015
circulatory system development	GO:0072359	82	0.015
gland morphogenesis	GO:0022612	145	0.015
protein modification process	GO:0036211	438	0.015
amine metabolic process	GO:0009308	12	0.015
ribonucleoside metabolic process	GO:0009119	127	0.015	Mouse
mitochondrial fusion	GO:0008053	7	0.015
positive regulation of response to stimulus	GO:0048584	323	0.014
wing disc morphogenesis	GO:0007472	344	0.014
stem cell development	GO:0048864	79	0.014
stem cell proliferation	GO:0072089	88	0.014
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.014
cellular nitrogen compound catabolic process	GO:0044270	165	0.014
secretion by cell	GO:0032940	101	0.014
single organism catabolic process	GO:0044712	228	0.014
cellular response to metal ion	GO:0071248	6	0.014
biological adhesion	GO:0022610	138	0.014
histone modification	GO:0016570	106	0.014
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.014
cellular macromolecule localization	GO:0070727	220	0.014
embryonic organ development	GO:0048568	50	0.013
ribose phosphate metabolic process	GO:0019693	145	0.013	Mouse
protein ubiquitination	GO:0016567	70	0.013
negative regulation of homeostatic process	GO:0032845	2	0.013
positive regulation of organelle organization	GO:0010638	65	0.013
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.013
establishment of protein localization	GO:0045184	163	0.013
cellular protein complex disassembly	GO:0043624	35	0.013
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.013
autophagy	GO:0006914	108	0.013
heterocycle catabolic process	GO:0046700	166	0.013
organic hydroxy compound metabolic process	GO:1901615	83	0.013
nucleoside triphosphate metabolic process	GO:0009141	120	0.013
negative regulation of cellular response to oxidative stress	GO:1900408	1	0.013
protein transport	GO:0015031	155	0.013
regulation of apoptotic process	GO:0042981	130	0.012
negative regulation of cytoskeleton organization	GO:0051494	30	0.012
purine ribonucleoside metabolic process	GO:0046128	127	0.012	Mouse
oocyte differentiation	GO:0009994	145	0.012
regulation of spindle organization	GO:0090224	17	0.012
cation transmembrane transport	GO:0098655	88	0.012
transcription from rna polymerase ii promoter	GO:0006366	368	0.012
sister chromatid segregation	GO:0000819	92	0.012
organic acid transport	GO:0015849	18	0.012
camera type eye development	GO:0043010	4	0.012
actin filament organization	GO:0007015	126	0.012
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.012
sensory perception of pain	GO:0019233	4	0.012
regulation of catalytic activity	GO:0050790	185	0.012
cellular response to oxidative stress	GO:0034599	28	0.012
single organism carbohydrate metabolic process	GO:0044723	72	0.012
regulation of cellular amine metabolic process	GO:0033238	3	0.011
telencephalon development	GO:0021537	2	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
positive regulation of protein modification process	GO:0031401	58	0.011
contractile ring contraction	GO:0036213	12	0.011
positive regulation of phosphate metabolic process	GO:0045937	139	0.011
electron transport chain	GO:0022900	14	0.011
regulation of bmp signaling pathway	GO:0030510	23	0.011
nucleoside metabolic process	GO:0009116	127	0.011	Mouse
response to organic cyclic compound	GO:0014070	89	0.011
cellular response to oxygen containing compound	GO:1901701	79	0.011
sex differentiation	GO:0007548	81	0.011
positive regulation of gene expression	GO:0010628	290	0.011
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.011
regulation of phosphatase activity	GO:0010921	3	0.011
response to oxygen levels	GO:0070482	59	0.011
muscle organ development	GO:0007517	127	0.011
atp metabolic process	GO:0046034	49	0.011
regulation of circadian rhythm	GO:0042752	49	0.011
hematopoietic or lymphoid organ development	GO:0048534	57	0.011
gland development	GO:0048732	191	0.011
protein complex biogenesis	GO:0070271	201	0.011
stem cell differentiation	GO:0048863	117	0.011
regulation of mitochondrial fission	GO:0090140	7	0.011
cellularization	GO:0007349	90	0.011
microtubule based transport	GO:0010970	42	0.010
developmental growth involved in morphogenesis	GO:0060560	65	0.010
positive regulation of cell development	GO:0010720	61	0.010
regulation of cellular ketone metabolic process	GO:0010565	3	0.010
small molecule biosynthetic process	GO:0044283	37	0.010
cellular response to hexose stimulus	GO:0071331	1	0.010
purine containing compound catabolic process	GO:0072523	112	0.010
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.010
rna localization	GO:0006403	115	0.010
circadian rhythm	GO:0007623	105	0.010
centrosome cycle	GO:0007098	137	0.010
regulation of response to oxidative stress	GO:1902882	4	0.010
acid secretion	GO:0046717	1	0.010
response to copper ion	GO:0046688	4	0.010

fbl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.147
nervous system disease	DOID:863	0.109
central nervous system disease	DOID:331	0.044
neurodegenerative disease	DOID:1289	0.044
parkinson s disease	DOID:14330	0.014
synucleinopathy	DOID:0050890	0.014

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network