Drosophila melanogaster

95 known processes

fbl (Dmel_CG5725)

fumble

(Aliases: PANK,Dmel\CG5725,dPANK,CG5725)

fbl biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cell divisionGO:00513012480.863
organelle fissionGO:00482853400.817
meiotic cell cycleGO:00513211710.597
meiotic cell cycle processGO:19030461320.440
cytoplasmic transport nurse cell to oocyteGO:0007303120.428
meiotic nuclear divisionGO:00071261510.386
adult behaviorGO:00305341370.380
cytoskeleton dependent cytokinesisGO:0061640810.374
imaginal disc derived appendage developmentGO:00487373990.353
response to abiotic stimulusGO:00096283410.351
organonitrogen compound metabolic processGO:19015643180.328
Mouse
oxoacid metabolic processGO:00434361030.319
cellular protein modification processGO:00064644380.316
cell migrationGO:00164772380.286
spermatogenesisGO:00072832000.281
imaginal disc derived appendage morphogenesisGO:00351143950.277
appendage developmentGO:00487364010.267
cellular lipid metabolic processGO:0044255830.266
adult locomotory behaviorGO:0008344760.243
regulation of neurogenesisGO:00507671580.231
cellular catabolic processGO:00442483720.228
mitochondrion organizationGO:0007005650.209
Mouse
nuclear divisionGO:00002803320.205
programmed cell deathGO:00125012570.190
Worm
organic acid metabolic processGO:00060821030.190
central nervous system developmentGO:00074172010.188
organic substance catabolic processGO:19015753080.181
transmembrane transportGO:00550851390.181
modification dependent macromolecule catabolic processGO:0043632790.174
cell deathGO:00082192790.162
Worm
organonitrogen compound catabolic processGO:19015651280.155
ion transmembrane transportGO:00342201220.146
homeostatic processGO:00425921990.139
regulation of multicellular organismal developmentGO:20000264140.139
intracellular transportGO:00469072280.134
agingGO:00075681430.134
Worm
head developmentGO:00603221350.134
catabolic processGO:00090564090.134
single organism intracellular transportGO:19025822070.129
meiotic cytokinesisGO:0033206330.125
cytoplasmic transportGO:00164821300.125
appendage morphogenesisGO:00351073970.124
muscle structure developmentGO:00610612240.118
macromolecule catabolic processGO:00090571610.111
proteolysisGO:00065081920.104
defense responseGO:00069523000.103
brain developmentGO:00074201200.102
developmental growthGO:00485892800.101
regulation of localizationGO:00328792750.101
small molecule metabolic processGO:00442813050.100
Mouse
regulation of organelle organizationGO:00330431960.100
macromolecular complex disassemblyGO:0032984370.096
regulation of cellular catabolic processGO:00313291570.091
nitrogen compound transportGO:0071705850.090
establishment of localization in cellGO:00516494020.089
imaginal disc derived wing morphogenesisGO:00074763370.084
modification dependent protein catabolic processGO:0019941780.083
organophosphate metabolic processGO:00196371950.079
Mouse
ubiquitin dependent protein catabolic processGO:0006511780.079
negative regulation of cellular metabolic processGO:00313243820.077
single organism behaviorGO:00447083910.074
regulation of cell developmentGO:00602842150.073
locomotory behaviorGO:00076261760.073
apoptotic processGO:00069151590.072
Worm
chromosome organizationGO:00512763600.071
cytokinesisGO:0000910900.070
response to oxygen containing compoundGO:19017002000.067
ion transportGO:00068111450.067
regulation of nervous system developmentGO:00519602480.067
eye developmentGO:00016543230.066
response to organic substanceGO:00100332840.065
organic substance transportGO:00717022570.065
cellular response to organic substanceGO:00713101320.065
multicellular organismal agingGO:00102591400.063
Worm
secretionGO:00469031090.061
regulation of catabolic processGO:00098941700.060
vesicle mediated transportGO:00161923810.059
positive regulation of nitrogen compound metabolic processGO:00511733540.058
positive regulation of cell communicationGO:00106472500.058
purine containing compound metabolic processGO:00725211550.058
Mouse
carboxylic acid metabolic processGO:0019752920.058
epithelial cell migrationGO:00106311480.057
regulation of transportGO:00510491810.057
immune system processGO:00023763470.056
regulation of protein metabolic processGO:00512462560.055
organic anion transportGO:0015711280.054
negative regulation of response to stimulusGO:00485852580.053
cellular macromolecule catabolic processGO:00442651360.053
mitotic nuclear divisionGO:00070672130.052
regulation of cell cycleGO:00517262910.052
forebrain developmentGO:003090020.051
negative regulation of developmental processGO:00510932010.050
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434370.050
circadian sleep wake cycle sleepGO:0050802230.050
deathGO:00162652840.049
Worm
single organism biosynthetic processGO:00447112060.049
Mouse
determination of adult lifespanGO:00083401370.049
Worm
carbohydrate derivative metabolic processGO:19011352170.049
Mouse
cell motilityGO:00488702510.048
actin filament based processGO:00300292200.048
negative regulation of cell differentiationGO:00455961430.047
nucleobase containing compound catabolic processGO:00346551650.047
aromatic compound catabolic processGO:00194391660.046
positive regulation of multicellular organismal processGO:00512401430.045
localization of cellGO:00516742570.045
positive regulation of developmental processGO:00510941430.045
proteolysis involved in cellular protein catabolic processGO:0051603830.042
mitotic cytokinesisGO:0000281500.042
cellular amino acid metabolic processGO:0006520610.042
cellular protein catabolic processGO:0044257830.042
cellular amine metabolic processGO:0044106120.042
tissue migrationGO:00901301550.040
sperm mitochondrion organizationGO:003038270.040
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.040
cognitionGO:00508901410.039
sperm individualizationGO:0007291480.039
nucleobase containing small molecule metabolic processGO:00550861740.038
Mouse
regulation of response to stressGO:00801342000.037
actin cytoskeleton organizationGO:00300362060.037
oocyte developmentGO:00485991240.036
regulation of cell differentiationGO:00455953020.035
tube developmentGO:00352952440.035
regulation of phosphorus metabolic processGO:00511742100.035
spindle assemblyGO:0051225800.034
body morphogenesisGO:001017120.034
positive regulation of cellular protein metabolic processGO:00322701180.034
positive regulation of signal transductionGO:00099672230.033
spermatocyte divisionGO:0048137130.033
regulation of cellular protein catabolic processGO:1903362440.032
post embryonic appendage morphogenesisGO:00351203850.032
ribonucleotide catabolic processGO:00092611090.031
cytoskeleton dependent intracellular transportGO:0030705440.031
positive regulation of cellular catabolic processGO:0031331950.031
regulation of hemocyte proliferationGO:0035206370.031
cellular response to endogenous stimulusGO:0071495800.031
bmp signaling pathwayGO:0030509270.030
male meiosis cytokinesisGO:0007112260.030
protein complex assemblyGO:00064612000.030
male gamete generationGO:00482322010.029
ameboidal type cell migrationGO:00016671510.029
meiosis iiGO:0007135230.029
positive regulation of signalingGO:00230562430.029
lipid metabolic processGO:00066291210.029
protein catabolic processGO:00301631010.028
nucleotide metabolic processGO:00091171610.028
Mouse
anion transportGO:0006820410.028
chaeta developmentGO:0022416970.028
positive regulation of catabolic processGO:00098961050.028
carbohydrate derivative biosynthetic processGO:1901137850.028
Mouse
purine nucleotide metabolic processGO:00061631460.028
Mouse
protein localizationGO:00081042840.028
positive regulation of nervous system developmentGO:0051962690.027
negative regulation of cellular component organizationGO:00511291080.027
protein modification by small protein conjugation or removalGO:00706471060.027
protein phosphorylationGO:00064681690.027
blastoderm segmentationGO:00073501590.027
monocarboxylic acid transportGO:001571830.027
cardiovascular system developmentGO:0072358820.026
regulation of cellular response to oxidative stressGO:190040740.026
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.026
regionalizationGO:00030024160.026
purine ribonucleotide metabolic processGO:00091501450.026
Mouse
purine ribonucleoside triphosphate catabolic processGO:00092071080.026
single organism cellular localizationGO:19025801800.026
response to oxidative stressGO:0006979860.025
compound eye developmentGO:00487493070.025
axonogenesisGO:00074092900.025
regulation of developmental growthGO:00486381740.025
positive regulation of nucleobase containing compound metabolic processGO:00459353320.024
purine nucleotide catabolic processGO:00061951090.024
embryonic pattern specificationGO:00098801740.024
embryonic development via the syncytial blastodermGO:00017001480.024
regulation of cell cycle processGO:00105641810.024
organonitrogen compound biosynthetic processGO:19015661170.024
Mouse
nucleoside phosphate metabolic processGO:00067531620.023
Mouse
purine ribonucleotide catabolic processGO:00091541090.023
connective tissue developmentGO:006144830.023
carbohydrate derivative catabolic processGO:19011361180.023
cellular response to chemical stimulusGO:00708871990.023
regulation of response to external stimulusGO:00321011150.023
positive regulation of cellular protein catabolic processGO:1903364240.023
immune system developmentGO:0002520570.022
regulation of transcription from rna polymerase ii promoterGO:00063573780.022
regulation of cellular protein metabolic processGO:00322682430.022
inorganic cation transmembrane transportGO:0098662610.022
pigmentationGO:0043473750.021
regulation of autophagyGO:0010506620.021
neurological system processGO:00508773580.021
negative regulation of multicellular organismal processGO:00512411420.021
proteasomal protein catabolic processGO:0010498590.021
regulation of proteolysisGO:0030162870.021
positive regulation of macromolecule metabolic processGO:00106044050.020
regulation of cellular response to stressGO:0080135890.020
response to woundingGO:0009611940.020
mitochondrial fissionGO:000026680.020
response to other organismGO:00517072930.020
cytokinetic processGO:0032506270.019
positive regulation of protein metabolic processGO:00512471280.019
spermatid developmentGO:0007286980.019
Mouse
cellular respirationGO:0045333260.019
Mouse
cation transportGO:00068121100.019
response to symbiotic bacteriumGO:000960920.019
regulation of proteasomal protein catabolic processGO:0061136390.019
regulation of cell deathGO:00109411730.019
microtubule organizing center organizationGO:00310231680.018
centrosome organizationGO:00512971630.018
developmental maturationGO:00217001720.018
synaptic transmission dopaminergicGO:000196320.018
response to hypoxiaGO:0001666530.018
enzyme linked receptor protein signaling pathwayGO:00071671790.018
protein modification by small protein conjugationGO:0032446790.018
protein complex disassemblyGO:0043241360.018
organic cyclic compound catabolic processGO:19013611680.018
epithelial cell differentiationGO:00308553220.017
organelle fusionGO:0048284460.017
meiosis iGO:0007127590.017
cellular protein localizationGO:00346131600.017
regulation of protein modification processGO:00313991120.017
reproductive system developmentGO:0061458740.017
positive regulation of cellular biosynthetic processGO:00313283160.017
regulation of programmed cell deathGO:00430671520.017
growthGO:00400073590.017
purine nucleoside catabolic processGO:00061521120.017
response to alcoholGO:0097305950.016
endocytosisGO:00068973100.016
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052240.016
regulation of cellular component biogenesisGO:00440872010.016
axon developmentGO:00615642970.016
nucleus organizationGO:0006997450.016
regulation of protein depolymerizationGO:1901879270.016
regulation of cellular localizationGO:00603411360.016
nucleoside monophosphate metabolic processGO:0009123520.016
nucleobase containing compound transportGO:0015931560.016
regulation of organ morphogenesisGO:2000027780.016
response to growth factorGO:0070848310.015
lipid biosynthetic processGO:0008610460.015
response to endogenous stimulusGO:00097191190.015
peptidyl lysine acetylationGO:0018394390.015
negative regulation of signalingGO:00230572190.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092380.015
regulation of protein catabolic processGO:0042176550.015
developmental cell growthGO:0048588520.015
regulation of circadian sleep wake cycle sleepGO:0045187210.015
circulatory system developmentGO:0072359820.015
gland morphogenesisGO:00226121450.015
protein modification processGO:00362114380.015
amine metabolic processGO:0009308120.015
ribonucleoside metabolic processGO:00091191270.015
Mouse
mitochondrial fusionGO:000805370.015
positive regulation of response to stimulusGO:00485843230.014
wing disc morphogenesisGO:00074723440.014
stem cell developmentGO:0048864790.014
stem cell proliferationGO:0072089880.014
positive regulation of i kappab kinase nf kappab signalingGO:004312310.014
cellular nitrogen compound catabolic processGO:00442701650.014
secretion by cellGO:00329401010.014
single organism catabolic processGO:00447122280.014
cellular response to metal ionGO:007124860.014
biological adhesionGO:00226101380.014
histone modificationGO:00165701060.014
epidermal growth factor receptor signaling pathwayGO:0007173580.014
cellular macromolecule localizationGO:00707272200.014
embryonic organ developmentGO:0048568500.013
ribose phosphate metabolic processGO:00196931450.013
Mouse
protein ubiquitinationGO:0016567700.013
negative regulation of homeostatic processGO:003284520.013
positive regulation of organelle organizationGO:0010638650.013
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.013
establishment of protein localizationGO:00451841630.013
cellular protein complex disassemblyGO:0043624350.013
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.013
autophagyGO:00069141080.013
heterocycle catabolic processGO:00467001660.013
organic hydroxy compound metabolic processGO:1901615830.013
nucleoside triphosphate metabolic processGO:00091411200.013
negative regulation of cellular response to oxidative stressGO:190040810.013
protein transportGO:00150311550.013
regulation of apoptotic processGO:00429811300.012
negative regulation of cytoskeleton organizationGO:0051494300.012
purine ribonucleoside metabolic processGO:00461281270.012
Mouse
oocyte differentiationGO:00099941450.012
regulation of spindle organizationGO:0090224170.012
cation transmembrane transportGO:0098655880.012
transcription from rna polymerase ii promoterGO:00063663680.012
sister chromatid segregationGO:0000819920.012
organic acid transportGO:0015849180.012
camera type eye developmentGO:004301040.012
actin filament organizationGO:00070151260.012
positive regulation of apoptotic signaling pathwayGO:200123540.012
sensory perception of painGO:001923340.012
regulation of catalytic activityGO:00507901850.012
cellular response to oxidative stressGO:0034599280.012
single organism carbohydrate metabolic processGO:0044723720.012
regulation of cellular amine metabolic processGO:003323830.011
telencephalon developmentGO:002153720.011
regulation of cellular amino acid metabolic processGO:000652100.011
positive regulation of protein modification processGO:0031401580.011
contractile ring contractionGO:0036213120.011
positive regulation of phosphate metabolic processGO:00459371390.011
electron transport chainGO:0022900140.011
regulation of bmp signaling pathwayGO:0030510230.011
nucleoside metabolic processGO:00091161270.011
Mouse
response to organic cyclic compoundGO:0014070890.011
cellular response to oxygen containing compoundGO:1901701790.011
sex differentiationGO:0007548810.011
positive regulation of gene expressionGO:00106282900.011
purine nucleoside triphosphate catabolic processGO:00091461080.011
regulation of phosphatase activityGO:001092130.011
response to oxygen levelsGO:0070482590.011
muscle organ developmentGO:00075171270.011
atp metabolic processGO:0046034490.011
regulation of circadian rhythmGO:0042752490.011
hematopoietic or lymphoid organ developmentGO:0048534570.011
gland developmentGO:00487321910.011
protein complex biogenesisGO:00702712010.011
stem cell differentiationGO:00488631170.011
regulation of mitochondrial fissionGO:009014070.011
cellularizationGO:0007349900.011
microtubule based transportGO:0010970420.010
developmental growth involved in morphogenesisGO:0060560650.010
positive regulation of cell developmentGO:0010720610.010
regulation of cellular ketone metabolic processGO:001056530.010
small molecule biosynthetic processGO:0044283370.010
cellular response to hexose stimulusGO:007133110.010
purine containing compound catabolic processGO:00725231120.010
regulation of protein modification by small protein conjugation or removalGO:1903320250.010
rna localizationGO:00064031150.010
circadian rhythmGO:00076231050.010
centrosome cycleGO:00070981370.010
regulation of response to oxidative stressGO:190288240.010
acid secretionGO:004671710.010
response to copper ionGO:004668840.010

fbl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.147
nervous system diseaseDOID:86300.109
central nervous system diseaseDOID:33100.044
neurodegenerative diseaseDOID:128900.044
parkinson s diseaseDOID:1433000.014
synucleinopathyDOID:005089000.014