Drosophila melanogaster

129 known processes

SAK (Dmel_CG7186)

Sak kinase

(Aliases: Sak,sak,Dmel\CG7186,plk4,CG7186,PLK4,SAK/PLK)

SAK biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
neuroblast divisionGO:0055057350.970
neuronal stem cell divisionGO:0036445350.963
organelle fissionGO:00482853400.954
centrosome organizationGO:00512971630.941
neural precursor cell proliferationGO:0061351750.940
nuclear divisionGO:00002803320.903
male meiosisGO:0007140520.895
asymmetric neuroblast divisionGO:0055059330.876
spindle organizationGO:00070512530.863
stem cell proliferationGO:0072089880.858
cilium organizationGO:0044782410.851
neuroblast proliferationGO:0007405740.844
microtubule organizing center organizationGO:00310231680.839
centrosome duplicationGO:00512981210.821
meiotic nuclear divisionGO:00071261510.820
organelle assemblyGO:00709251980.775
somatic stem cell divisionGO:0048103370.760
spermatogenesisGO:00072832000.698
meiotic chromosome segregationGO:0045132590.679
meiotic cell cycleGO:00513211710.675
centrosome cycleGO:00070981370.664
centrosome separationGO:0051299200.660
negative regulation of nervous system developmentGO:0051961920.607
chromosome segregationGO:00070591570.583
regulation of cell cycle phase transitionGO:19019871300.564
meiotic cell cycle processGO:19030461320.524
centriole centriole cohesionGO:001045750.516
spermatid differentiationGO:00485151140.515
regulation of mitotic cell cycle phase transitionGO:19019901300.504
neuroblast differentiationGO:0014016290.497
regulation of microtubule based processGO:0032886490.488
sperm axoneme assemblyGO:0007288130.487
asymmetric cell divisionGO:0008356370.479
mitotic spindle organizationGO:00070522200.470
glial cell developmentGO:0021782270.426
protein modification processGO:00362114380.415
cellular component assembly involved in morphogenesisGO:00109271510.408
sister chromatid segregationGO:0000819920.398
microtubule based transportGO:0010970420.398
mitotic cell cycle embryonicGO:0045448380.387
establishment of localization in cellGO:00516494020.367
centriole assemblyGO:0098534240.360
organic substance transportGO:00717022570.342
peripheral nervous system developmentGO:0007422520.335
chromosome separationGO:0051304420.321
regulation of synapse structure and activityGO:00508031280.313
asymmetric stem cell divisionGO:0098722490.290
macromolecule catabolic processGO:00090571610.287
pigment metabolic processGO:0042440840.277
negative regulation of mitotic cell cycle phase transitionGO:19019911030.275
protein modification by small protein conjugationGO:0032446790.272
positive regulation of programmed cell deathGO:0043068620.271
spermatid developmentGO:0007286980.269
mitotic cell cycle phase transitionGO:00447721380.264
forebrain developmentGO:003090020.248
brain developmentGO:00074201200.247
regulation of synapse organizationGO:00508071100.243
regulation of nervous system developmentGO:00519602480.242
regionalizationGO:00030024160.236
synapse assemblyGO:00074161430.233
axon developmentGO:00615642970.226
synaptic growth at neuromuscular junctionGO:00511241190.222
centriole replicationGO:0007099240.210
regulation of neurogenesisGO:00507671580.207
synaptic vesicle localizationGO:0097479530.206
segmentationGO:00352822070.198
regulation of microtubule cytoskeleton organizationGO:0070507410.198
male gamete generationGO:00482322010.197
regulation of multicellular organismal developmentGO:20000264140.196
mitotic nuclear divisionGO:00070672130.196
spindle assemblyGO:0051225800.196
mitotic cell cycle checkpointGO:0007093880.194
axis specificationGO:00097981670.184
regulation of cellular localizationGO:00603411360.182
peripheral nervous system neuron differentiationGO:004893480.177
secretion by cellGO:00329401010.176
negative regulation of neurogenesisGO:0050768530.174
organic substance catabolic processGO:19015753080.167
positive regulation of g2 m transition of mitotic cell cycleGO:001097120.167
dna recombinationGO:0006310320.166
proteolysisGO:00065081920.165
cell motilityGO:00488702510.163
negative regulation of cell cycle phase transitionGO:19019881030.155
cell cycle checkpointGO:0000075950.150
positive regulation of cell cycle g2 m phase transitionGO:190275120.147
regulation of transportGO:00510491810.141
negative regulation of neural precursor cell proliferationGO:2000178270.137
regulation of mitotic metaphase anaphase transitionGO:0030071260.137
endomembrane system organizationGO:00102561190.137
synapse organizationGO:00508081960.129
synaptic transmissionGO:00072682880.129
negative regulation of cell cycleGO:00457861160.126
post embryonic appendage morphogenesisGO:00351203850.126
multicellular organismal reproductive behaviorGO:00330571100.124
central nervous system developmentGO:00074172010.124
cell divisionGO:00513012480.120
negative regulation of gene expressionGO:00106293870.119
positive regulation of nitrogen compound metabolic processGO:00511733540.114
camera type eye morphogenesisGO:004859320.113
regulation of synaptic growth at neuromuscular junctionGO:0008582890.113
mitotic dna damage checkpointGO:0044773740.112
catabolic processGO:00090564090.111
nucleus localizationGO:0051647340.111
apoptotic processGO:00069151590.109
anterior posterior axis specification embryoGO:00085951030.109
positive regulation of cell deathGO:0010942690.109
male meiosis cytokinesisGO:0007112260.108
cell cycle arrestGO:000705040.105
regulation of synapse assemblyGO:0051963940.103
signal transduction by phosphorylationGO:00230141070.103
development of primary sexual characteristicsGO:0045137500.099
chromosome organizationGO:00512763600.099
phosphorylation of rna polymerase ii c terminal domainGO:007081610.099
cell proliferationGO:00082832990.097
immune system processGO:00023763470.096
telencephalon developmentGO:002153720.096
proteasomal protein catabolic processGO:0010498590.096
regulation of dendrite morphogenesisGO:0048814280.094
regulation of nurse cell apoptotic processGO:004547790.093
stem cell divisionGO:0017145690.093
reproductive system developmentGO:0061458740.092
Mouse
embryonic axis specificationGO:00005781070.091
regulation of cysteine type endopeptidase activityGO:2000116270.087
establishment of protein localizationGO:00451841630.086
hematopoietic or lymphoid organ developmentGO:0048534570.086
protein localizationGO:00081042840.085
meiosis iGO:0007127590.084
axoneme assemblyGO:0035082180.082
synaptic vesicle recyclingGO:0036465280.081
mapk cascadeGO:00001651070.079
negative regulation of cell cycle processGO:00109481090.079
regulation of proteolysisGO:0030162870.078
negative regulation of mitotic cell cycleGO:00459301090.078
negative regulation of multicellular organismal processGO:00512411420.076
embryonic pattern specificationGO:00098801740.075
cellular protein modification processGO:00064644380.075
regulation of mitotic cell cycleGO:00073461900.074
negative regulation of cellular metabolic processGO:00313243820.071
cell cycle phase transitionGO:00447701400.071
vesicle localizationGO:0051648550.071
negative regulation of response to stimulusGO:00485852580.071
microtubule based movementGO:0007018510.070
proteolysis involved in cellular protein catabolic processGO:0051603830.069
regulation of catalytic activityGO:00507901850.068
cell cell signaling involved in cell fate commitmentGO:00451682100.068
gliogenesisGO:0042063800.068
determination of adult lifespanGO:00083401370.068
localization of cellGO:00516742570.068
regulation of molecular functionGO:00650092170.067
establishment of synaptic vesicle localizationGO:0097480500.067
regulation of cell cycle g1 s phase transitionGO:1902806230.067
macromolecular complex assemblyGO:00650032560.067
regulation of cell cycleGO:00517262910.066
regulation of cell differentiationGO:00455953020.066
mitotic sister chromatid separationGO:0051306300.066
epithelial cell developmentGO:00020642740.066
negative regulation of synapse assemblyGO:0051964390.066
microtubule polymerizationGO:0046785150.064
protein maturationGO:0051604710.064
mitotic spindle assembly checkpointGO:0007094110.062
melanin metabolic processGO:0006582470.062
axon guidanceGO:00074112330.061
establishment of organelle localizationGO:00516561220.061
protein processingGO:0016485680.061
organelle localizationGO:00516401480.060
anterior posterior pattern specificationGO:00099521360.060
response to ionizing radiationGO:0010212320.059
neuromuscular junction developmentGO:00075281490.056
negative regulation of rna metabolic processGO:00512532510.055
syncytial blastoderm mitotic cell cycleGO:0035186210.055
protein catabolic processGO:00301631010.055
cell cycle comprising mitosis without cytokinesisGO:0033301250.055
establishment of vesicle localizationGO:0051650510.054
cell migrationGO:00164772380.054
regulation of neural precursor cell proliferationGO:2000177350.054
secondary metabolic processGO:0019748750.053
fertilizationGO:0009566260.053
negative regulation of developmental processGO:00510932010.052
mitotic g2 m transition checkpointGO:0044818700.051
rhythmic processGO:00485111060.051
digestive tract developmentGO:00485651490.051
response to woundingGO:0009611940.050
developmental maturationGO:00217001720.049
dendrite morphogenesisGO:00488131990.049
neuron projection guidanceGO:00974852410.049
positive regulation of macromolecule metabolic processGO:00106044050.049
regulation of protein localizationGO:0032880760.048
regulation of cell developmentGO:00602842150.047
metaphase anaphase transition of mitotic cell cycleGO:0007091280.047
chemotaxisGO:00069352490.046
positive regulation of neuron apoptotic processGO:004352510.046
ubiquitin dependent protein catabolic processGO:0006511780.046
positive regulation of transportGO:0051050920.046
cell cycle g1 s phase transitionGO:0044843310.045
protein transportGO:00150311550.045
axon choice point recognitionGO:0016198260.045
regulation of mitotic sister chromatid separationGO:0010965280.045
mitotic centrosome separationGO:000710080.045
rna splicingGO:0008380830.045
response to decreased oxygen levelsGO:0036293580.045
negative regulation of cellular component organizationGO:00511291080.044
protein modification by small protein conjugation or removalGO:00706471060.044
neuron remodelingGO:0016322290.043
dna damage checkpointGO:0000077780.043
single organism intracellular transportGO:19025822070.043
g1 s transition of mitotic cell cycleGO:0000082310.042
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281250.042
dorsal ventral axis specificationGO:0009950660.042
secretionGO:00469031090.042
regulation of wnt signaling pathwayGO:0030111680.041
regulation of proteasomal protein catabolic processGO:0061136390.041
cellular macromolecular complex assemblyGO:00346221530.040
retina morphogenesis in camera type eyeGO:006004220.040
columnar cuboidal epithelial cell developmentGO:00020662490.040
protein complex assemblyGO:00064612000.039
tripartite regional subdivisionGO:00073511030.039
regulation of circadian rhythmGO:0042752490.039
negative regulation of metaphase anaphase transition of cell cycleGO:1902100130.039
phosphorylationGO:00163102940.038
female meiotic divisionGO:0007143700.038
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434370.038
regulation of transcription from rna polymerase ii promoterGO:00063573780.038
male mating behaviorGO:0060179700.037
metaphase anaphase transition of cell cycleGO:0044784280.037
rna processingGO:00063961470.037
intracellular signal transductionGO:00355563000.036
protein ubiquitinationGO:0016567700.036
response to inorganic substanceGO:0010035440.036
purine nucleoside metabolic processGO:00422781270.036
axonogenesisGO:00074092900.035
immune responseGO:00069552460.035
positive regulation of apoptotic processGO:0043065470.035
female meiosis chromosome segregationGO:0016321330.034
cilium morphogenesisGO:0060271390.034
positive regulation of behaviorGO:0048520190.034
dendrite developmentGO:00163582040.034
small molecule metabolic processGO:00442813050.034
intracellular mrna localizationGO:0008298660.033
ion transportGO:00068111450.033
spindle assembly involved in mitosisGO:0090307500.033
regulation of hydrolase activityGO:0051336970.033
single organism cellular localizationGO:19025801800.032
positive regulation of lipid catabolic processGO:005099610.032
phenol containing compound metabolic processGO:0018958570.032
negative regulation of proteolysisGO:0045861310.032
transcription from rna polymerase ii promoterGO:00063663680.032
regulation of phosphorylationGO:00423251470.032
neuroblast fate determinationGO:0007400120.031
blastoderm segmentationGO:00073501590.031
regulation of chromosome segregationGO:0051983320.031
vesicle mediated transportGO:00161923810.031
protein localization to organelleGO:0033365820.031
anterior posterior axis specificationGO:00099481090.031
central nervous system neuron developmentGO:002195480.031
oocyte differentiationGO:00099941450.031
negative regulation of growthGO:0045926840.031
negative regulation of synaptic growth at neuromuscular junctionGO:0045886390.031
regulation of intracellular signal transductionGO:19025312360.031
peripheral nervous system neuron developmentGO:004893580.031
synaptic vesicle transportGO:0048489500.030
cellular protein localizationGO:00346131600.030
positive regulation of gene expressionGO:00106282900.029
regulation of dendrite developmentGO:0050773370.029
cellular catabolic processGO:00442483720.029
cell maturationGO:00484691440.028
positive regulation of endopeptidase activityGO:0010950260.028
taxisGO:00423303040.028
membrane organizationGO:00610241120.028
establishment of protein localization to organelleGO:0072594620.028
nucleoside triphosphate metabolic processGO:00091411200.028
positive regulation of transcription dna templatedGO:00458932660.027
negative regulation of nucleobase containing compound metabolic processGO:00459342610.027
negative regulation of protein processingGO:0010955310.027
regulation of growthGO:00400082330.027
regulation of anatomical structure morphogenesisGO:00226032420.027
regulation of cell proliferationGO:00421271630.026
adult locomotory behaviorGO:0008344760.026
mitotic dna integrity checkpointGO:0044774750.026
dorsal closureGO:0007391790.026
neuron projection extensionGO:1990138320.025
purine ribonucleoside metabolic processGO:00461281270.025
motor neuron axon guidanceGO:0008045580.025
regulation of mrna metabolic processGO:1903311720.025
regulation of phosphorus metabolic processGO:00511742100.025
regulation of protein metabolic processGO:00512462560.025
programmed cell deathGO:00125012570.024
meiotic spindle organizationGO:0000212360.024
positive regulation of cellular biosynthetic processGO:00313283160.024
regulation of cellular response to stressGO:0080135890.024
regulation of programmed cell deathGO:00430671520.023
positive regulation of secretionGO:0051047220.023
intracellular protein transportGO:00068861040.023
cellular macromolecule localizationGO:00707272200.023
protein localization to membraneGO:0072657190.023
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919160.023
positive regulation of molecular functionGO:00440931360.023
cellular protein complex assemblyGO:0043623710.023
stem cell differentiationGO:00488631170.022
regulation of neuron differentiationGO:00456641030.022
regulation of cell cycle processGO:00105641810.022
regulation of metaphase anaphase transition of cell cycleGO:1902099260.022
protein polymerizationGO:0051258420.022
regulation of protein processingGO:0070613320.022
regulation of establishment of protein localizationGO:0070201610.022
chromatin modificationGO:00165681470.021
regulation of exit from mitosisGO:000709670.021
negative regulation of mitotic sister chromatid segregationGO:0033048130.021
neuroblast fate commitmentGO:0014017190.021
regulation of cellular catabolic processGO:00313291570.021
nuclear envelope organizationGO:000699870.021
spermatocyte divisionGO:0048137130.021
cytoplasmic transportGO:00164821300.021
negative regulation of axon extensionGO:003051730.021
intercellular bridge organizationGO:0043063140.021
ribonucleoside triphosphate metabolic processGO:00091991190.021
establishment of nucleus localizationGO:0040023260.021
cellular protein catabolic processGO:0044257830.021
cytoplasmic transport nurse cell to oocyteGO:0007303120.020
synaptic transmission dopaminergicGO:000196320.020
regulation of cellular protein catabolic processGO:1903362440.020
mitotic sister chromatid segregationGO:0000070870.020
single organism membrane organizationGO:0044802930.020
regulation of immune responseGO:00507761180.020
embryo development ending in birth or egg hatchingGO:00097921520.020
Mouse
oocyte dorsal ventral axis specificationGO:0007310340.020
negative regulation of developmental growthGO:0048640640.020
regulation of localizationGO:00328792750.019
modification dependent protein catabolic processGO:0019941780.019
protein complex biogenesisGO:00702712010.019
maintenance of locationGO:0051235730.019
protein phosphorylationGO:00064681690.019
developmental pigmentationGO:0048066680.019
cortical actin cytoskeleton organizationGO:0030866240.018
oocyte nucleus localization involved in oocyte dorsal ventral axis specificationGO:0051663120.018
neural retina developmentGO:000340740.018
leg disc developmentGO:0035218920.018
embryonic development via the syncytial blastodermGO:00017001480.018
response to radiationGO:00093141550.018
negative regulation of nucleic acid templated transcriptionGO:19035072400.018
negative regulation of mitotic sister chromatid separationGO:2000816130.018
regulation of developmental growthGO:00486381740.017
midgut developmentGO:0007494230.017
sperm individualizationGO:0007291480.017
membrane depolarizationGO:005189940.017
regulation of mitotic sister chromatid segregationGO:0033047280.017
membrane disassemblyGO:003039740.017
negative regulation of macromolecule biosynthetic processGO:00105582700.017
mrna metabolic processGO:00160711240.017
reproductive structure developmentGO:0048608740.017
Mouse
protein targetingGO:0006605640.017
protein secretionGO:0009306450.017
positive regulation of catalytic activityGO:00430851180.017
regulation of secretion by cellGO:1903530390.017
single fertilizationGO:0007338240.016
negative regulation of protein maturationGO:1903318310.016
regulation of proteolysis involved in cellular protein catabolic processGO:1903050440.016
covalent chromatin modificationGO:00165691060.016
axon extension involved in axon guidanceGO:0048846100.016
negative regulation of catabolic processGO:0009895360.016
cell growthGO:00160491080.015
cellular amino acid metabolic processGO:0006520610.015
striated muscle cell differentiationGO:0051146900.015
pigmentationGO:0043473750.015
regulation of hormone levelsGO:0010817400.015
appendage developmentGO:00487364010.015
mrna processingGO:00063971040.015
cortical cytoskeleton organizationGO:0030865290.015
epithelial cell differentiationGO:00308553220.015
single organism biosynthetic processGO:00447112060.015
small gtpase mediated signal transductionGO:0007264880.014
sex differentiationGO:0007548810.014
single organism catabolic processGO:00447122280.014
columnar cuboidal epithelial cell differentiationGO:00020652560.014
circadian regulation of gene expressionGO:003292250.014
mitotic g2 dna damage checkpointGO:0007095690.014
hindbrain developmentGO:003090220.014
neurological system processGO:00508773580.014
oocyte constructionGO:00073081120.014
regulation of peptidase activityGO:0052547390.014
negative regulation of proteasomal protein catabolic processGO:1901799160.013
negative regulation of chromosome segregationGO:0051985140.013
aromatic compound catabolic processGO:00194391660.013
chaeta developmentGO:0022416970.013
regulation of cell sizeGO:0008361630.013
meiotic cell cycle phase transitionGO:004477140.013
microtubule polymerization or depolymerizationGO:0031109390.013
negative regulation of molecular functionGO:0044092510.013
regulation of cellular response to oxidative stressGO:190040740.013
appendage morphogenesisGO:00351073970.013
positive regulation of cellular protein metabolic processGO:00322701180.013
positive regulation of cysteine type endopeptidase activityGO:2001056240.012
sensory perception of mechanical stimulusGO:0050954720.012
positive regulation of nitric oxide biosynthetic processGO:004542910.012
regulation of neuron apoptotic processGO:0043523160.012
mitochondrion organizationGO:0007005650.012
neuron migrationGO:000176450.012
microtubule cytoskeleton organization involved in mitosisGO:1902850520.012
mitotic spindle checkpointGO:0071174110.012
camera type eye developmentGO:004301040.012
neuron fate commitmentGO:0048663500.012
nuclear migrationGO:0007097200.012
digestive system developmentGO:00551231490.012
multi multicellular organism processGO:00447061230.012
embryonic organ developmentGO:0048568500.012
Mouse
negative regulation of cell cycle g1 s phase transitionGO:1902807130.012
regulation of reproductive processGO:2000241540.011
negative regulation of neuron apoptotic processGO:0043524140.011
nuclear importGO:0051170510.011
regulation of axonogenesisGO:0050770320.011
response to temperature stimulusGO:00092661060.011
positive regulation of signalingGO:00230562430.011
positive regulation of axonogenesisGO:005077220.011
cognitionGO:00508901410.011
regulation of nuclear transcribed mrna poly a tail shorteningGO:006021140.011
cellular response to hexose stimulusGO:007133110.011
ribonucleoside catabolic processGO:00424541120.011
heterocycle catabolic processGO:00467001660.011
regulation of cell deathGO:00109411730.011
positive regulation of response to stimulusGO:00485843230.011
negative regulation of stem cell proliferationGO:2000647300.011
regulation of photoreceptor cell differentiationGO:0046532340.011
retina development in camera type eyeGO:006004140.011
spindle assembly involved in male meiosisGO:000705350.011
negative regulation of cell developmentGO:0010721620.011
positive regulation of cellular catabolic processGO:0031331950.011
apoptotic process involved in developmentGO:1902742200.011
protein kinase b signalingGO:004349110.011
cellular macromolecule catabolic processGO:00442651360.011
response to extracellular stimulusGO:00099911160.011
g2 dna damage checkpointGO:0031572690.010
regulation of epithelial cell proliferationGO:005067840.010
pigment biosynthetic processGO:0046148360.010
ovarian follicle cell developmentGO:00307072480.010
regulation of transferase activityGO:0051338580.010
cell junction organizationGO:0034330570.010
modification dependent macromolecule catabolic processGO:0043632790.010
photoreceptor cell axon guidanceGO:0072499230.010
negative regulation of neuron differentiationGO:0045665160.010

SAK disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.060
cancerDOID:16200.048
organ system cancerDOID:005068600.045
gastrointestinal system cancerDOID:311900.039
large intestine cancerDOID:567200.039
intestinal cancerDOID:1015500.039
colorectal cancerDOID:925600.039
disease of metabolismDOID:001466700.036
colon cancerDOID:21900.021
physical disorderDOID:008001500.017
congenital nervous system abnormalityDOID:249000.017
carbohydrate metabolism diseaseDOID:005001300.012
acquired metabolic diseaseDOID:006015800.012