IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

MED15 (Dmel_CG4184)

Mediator complex subunit 15

(Aliases: med15,BcDNA:GH03922,Arc105,dARC105,Med15,Dmel\CG4184,CG4184,Med9/ARC105)

Entrez: 33223
FLYBASE: FBgn0027592
UniProtKB: Q9Y149

Process Predictions
Disease Predictions

MED15 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.998
positive regulation of gene expression	GO:0010628	290	0.988
positive regulation of rna metabolic process	GO:0051254	271	0.973
transcription from rna polymerase ii promoter	GO:0006366	368	0.970
positive regulation of cellular biosynthetic process	GO:0031328	316	0.968
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.929
positive regulation of biosynthetic process	GO:0009891	316	0.905
positive regulation of macromolecule metabolic process	GO:0010604	405	0.873
positive regulation of rna biosynthetic process	GO:1902680	266	0.845
positive regulation of transcription dna templated	GO:0045893	266	0.800
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.754
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.713
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.629
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.518
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.518
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.499
negative regulation of gene expression	GO:0010629	387	0.479
localization of cell	GO:0051674	257	0.477
protein modification process	GO:0036211	438	0.441
negative regulation of cellular biosynthetic process	GO:0031327	277	0.434
embryo development ending in birth or egg hatching	GO:0009792	152	0.424
negative regulation of rna metabolic process	GO:0051253	251	0.369
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.365
negative regulation of biosynthetic process	GO:0009890	277	0.334
regulation of cell cycle process	GO:0010564	181	0.330
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.326
negative regulation of cell cycle	GO:0045786	116	0.324
cellular macromolecule catabolic process	GO:0044265	136	0.295
negative regulation of rna biosynthetic process	GO:1902679	240	0.283
regulation of cell cycle	GO:0051726	291	0.281
embryonic morphogenesis	GO:0048598	206	0.278
negative regulation of cell proliferation	GO:0008285	69	0.273
posttranscriptional gene silencing by rna	GO:0035194	45	0.230
imaginal disc derived appendage development	GO:0048737	399	0.224
positive regulation of signaling	GO:0023056	243	0.222
antimicrobial humoral response	GO:0019730	99	0.211
muscle structure development	GO:0061061	224	0.204
protein complex assembly	GO:0006461	200	0.200
macromolecule catabolic process	GO:0009057	161	0.198
larval development	GO:0002164	104	0.197
regionalization	GO:0003002	416	0.193
chromatin modification	GO:0016568	147	0.192
negative regulation of cell cycle process	GO:0010948	109	0.190
organic substance catabolic process	GO:1901575	308	0.182
regulation of programmed cell death	GO:0043067	152	0.180
regulation of catabolic process	GO:0009894	170	0.178
negative regulation of transcription dna templated	GO:0045892	237	0.173
regulation of response to external stimulus	GO:0032101	115	0.168
regulation of cellular protein metabolic process	GO:0032268	243	0.164
regulation of nervous system development	GO:0051960	248	0.158
meiotic cell cycle	GO:0051321	171	0.155
response to other organism	GO:0051707	293	0.154
cell migration	GO:0016477	238	0.151
appendage development	GO:0048736	401	0.150
negative regulation of cellular metabolic process	GO:0031324	382	0.149
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.149
phosphorylation	GO:0016310	294	0.147
regulation of cell proliferation	GO:0042127	163	0.144
vesicle mediated transport	GO:0016192	381	0.136
regulation of mitotic cell cycle	GO:0007346	190	0.136
negative regulation of response to stimulus	GO:0048585	258	0.136
cellular catabolic process	GO:0044248	372	0.136
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.135
cell motility	GO:0048870	251	0.130
positive regulation of cell communication	GO:0010647	250	0.127
cell death	GO:0008219	279	0.126
positive regulation of mrna metabolic process	GO:1903313	5	0.121
catabolic process	GO:0009056	409	0.120
gene silencing by rna	GO:0031047	57	0.117
regulation of cell differentiation	GO:0045595	302	0.115
chromatin organization	GO:0006325	207	0.115
regulation of multi organism process	GO:0043900	131	0.114
mitotic spindle organization	GO:0007052	220	0.110
response to biotic stimulus	GO:0009607	294	0.108
organelle fission	GO:0048285	340	0.108
mitotic cell cycle phase transition	GO:0044772	138	0.107
forebrain development	GO:0030900	2	0.107
negative regulation of mitotic cell cycle	GO:0045930	109	0.105
posttranscriptional regulation of gene expression	GO:0010608	145	0.103
regulation of dna recombination	GO:0000018	4	0.103
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.102
positive regulation of signal transduction	GO:0009967	223	0.102
protein complex disassembly	GO:0043241	36	0.102
histone h3 k4 methylation	GO:0051568	16	0.101
response to external biotic stimulus	GO:0043207	293	0.100
cell proliferation	GO:0008283	299	0.098
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.097
nuclear division	GO:0000280	332	0.096
cellular protein modification process	GO:0006464	438	0.092
regulation of neurogenesis	GO:0050767	158	0.092
protein phosphorylation	GO:0006468	169	0.089
macromolecular complex assembly	GO:0065003	256	0.089
protein complex biogenesis	GO:0070271	201	0.088
body morphogenesis	GO:0010171	2	0.088
regulation of immune response	GO:0050776	118	0.086
death	GO:0016265	284	0.083
immune system process	GO:0002376	347	0.083
immune response	GO:0006955	246	0.080
ameboidal type cell migration	GO:0001667	151	0.080
ubiquitin dependent protein catabolic process	GO:0006511	78	0.079
production of molecular mediator of immune response	GO:0002440	46	0.079
regulation of multicellular organismal development	GO:2000026	414	0.078
response to abiotic stimulus	GO:0009628	341	0.077
endocytosis	GO:0006897	310	0.076
negative regulation of apoptotic process	GO:0043066	63	0.070
dna damage checkpoint	GO:0000077	78	0.069
posttranscriptional gene silencing	GO:0016441	46	0.069
regulation of protein modification process	GO:0031399	112	0.069
stem cell differentiation	GO:0048863	117	0.068
modification dependent protein catabolic process	GO:0019941	78	0.067
single organism intracellular transport	GO:1902582	207	0.066
protein catabolic process	GO:0030163	101	0.064
positive regulation of response to stimulus	GO:0048584	323	0.064
proteasomal protein catabolic process	GO:0010498	59	0.063
regulation of immune system process	GO:0002682	176	0.063
negative regulation of developmental process	GO:0051093	201	0.063
head development	GO:0060322	135	0.061
intracellular transport	GO:0046907	228	0.061
negative regulation of multicellular organismal process	GO:0051241	142	0.061
response to organic substance	GO:0010033	284	0.060
regulation of secretion by cell	GO:1903530	39	0.059
regulation of cellular localization	GO:0060341	136	0.058
cell cycle checkpoint	GO:0000075	95	0.057
regulation of cell cycle phase transition	GO:1901987	130	0.055
proteolysis	GO:0006508	192	0.054
camera type eye development	GO:0043010	4	0.054
tissue morphogenesis	GO:0048729	297	0.053
wnt signaling pathway	GO:0016055	98	0.053
gene silencing	GO:0016458	138	0.052
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.049
programmed cell death	GO:0012501	257	0.048
apoptotic process	GO:0006915	159	0.047
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.047
cell type specific apoptotic process	GO:0097285	38	0.046
modification dependent macromolecule catabolic process	GO:0043632	79	0.045
regulation of phosphorus metabolic process	GO:0051174	210	0.044
response to radiation	GO:0009314	155	0.043
oxoacid metabolic process	GO:0043436	103	0.043
anterior posterior pattern specification	GO:0009952	136	0.043
histone lysine demethylation	GO:0070076	6	0.043
cell fate specification	GO:0001708	71	0.043
establishment of localization in cell	GO:0051649	402	0.043
positive regulation of cellular component organization	GO:0051130	156	0.042
regulation of humoral immune response	GO:0002920	51	0.040
regulation of cell projection organization	GO:0031344	92	0.040
mitotic g2 dna damage checkpoint	GO:0007095	69	0.040
spindle organization	GO:0007051	253	0.039
erbb signaling pathway	GO:0038127	58	0.039
regulation of erbb signaling pathway	GO:1901184	42	0.039
regulation of response to stress	GO:0080134	200	0.039
regulation of response to biotic stimulus	GO:0002831	63	0.038
embryonic development via the syncytial blastoderm	GO:0001700	148	0.037
positive regulation of catabolic process	GO:0009896	105	0.037
notch signaling pathway	GO:0007219	120	0.036
small molecule metabolic process	GO:0044281	305	0.036
protein localization	GO:0008104	284	0.036
regulation of defense response	GO:0031347	102	0.035
negative regulation of cell cycle phase transition	GO:1901988	103	0.035
organonitrogen compound metabolic process	GO:1901564	318	0.035
negative regulation of signaling	GO:0023057	219	0.034
positive regulation of immune response	GO:0050778	63	0.034
protein acylation	GO:0043543	42	0.034
regulation of phosphorylation	GO:0042325	147	0.034
rna 3 end processing	GO:0031123	45	0.033
negative regulation of programmed cell death	GO:0043069	72	0.033
regulation of notch signaling pathway	GO:0008593	100	0.033
cellular amino acid metabolic process	GO:0006520	61	0.032
intracellular signal transduction	GO:0035556	300	0.031
organonitrogen compound biosynthetic process	GO:1901566	117	0.031
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.031
secondary metabolic process	GO:0019748	75	0.031
regulation of cellular catabolic process	GO:0031329	157	0.031
regulation of localization	GO:0032879	275	0.031
secretion by cell	GO:0032940	101	0.030
carboxylic acid metabolic process	GO:0019752	92	0.030
cellular component disassembly	GO:0022411	46	0.030
imaginal disc derived leg morphogenesis	GO:0007480	80	0.030
regulation of cellular amino acid metabolic process	GO:0006521	0	0.029
mrna 3 end processing	GO:0031124	28	0.029
phagocytosis	GO:0006909	215	0.029
mitotic g2 m transition checkpoint	GO:0044818	70	0.029
cell cycle phase transition	GO:0044770	140	0.029
regulation of cellular ketone metabolic process	GO:0010565	3	0.028
negative regulation of cell differentiation	GO:0045596	143	0.028
imaginal disc derived leg segmentation	GO:0036011	26	0.028
cellular protein catabolic process	GO:0044257	83	0.028
regulation of protein metabolic process	GO:0051246	256	0.028
development of primary sexual characteristics	GO:0045137	50	0.028
antimicrobial peptide production	GO:0002775	46	0.028
positive regulation of developmental process	GO:0051094	143	0.027
wing disc morphogenesis	GO:0007472	344	0.027
growth	GO:0040007	359	0.027
protein modification by small protein removal	GO:0070646	28	0.027
regulation of protein catabolic process	GO:0042176	55	0.027
regulation of cell development	GO:0060284	215	0.027
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.027
epithelial cell development	GO:0002064	274	0.027
inositol lipid mediated signaling	GO:0048017	4	0.026
protein modification by small protein conjugation	GO:0032446	79	0.026
translation	GO:0006412	69	0.026
regulation of secretion	GO:0051046	44	0.026
protein import into nucleus	GO:0006606	51	0.025
regulation of production of molecular mediator of immune response	GO:0002700	44	0.025
post embryonic appendage morphogenesis	GO:0035120	385	0.025
reproductive system development	GO:0061458	74	0.025
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.025
regulation of protein phosphorylation	GO:0001932	64	0.025
signal transduction by phosphorylation	GO:0023014	107	0.024
rna interference	GO:0016246	27	0.024
chemotaxis	GO:0006935	249	0.024
cytoplasmic transport	GO:0016482	130	0.024
cellular protein localization	GO:0034613	160	0.024
regulation of antimicrobial humoral response	GO:0002759	50	0.023
regulation of locomotion	GO:0040012	42	0.023
mitotic nuclear division	GO:0007067	213	0.023
chromatin assembly or disassembly	GO:0006333	52	0.023
cellular response to chemical stimulus	GO:0070887	199	0.022
positive regulation of multi organism process	GO:0043902	40	0.022
immune effector process	GO:0002252	98	0.022
regulation of cellular component movement	GO:0051270	42	0.021
regulation of antimicrobial peptide production	GO:0002784	44	0.021
sex differentiation	GO:0007548	81	0.021
signal release	GO:0023061	49	0.021
gonad development	GO:0008406	50	0.021
amine metabolic process	GO:0009308	12	0.021
cellular macromolecular complex assembly	GO:0034622	153	0.021
regulation of cellular amine metabolic process	GO:0033238	3	0.021
tube development	GO:0035295	244	0.021
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.020
mitotic dna damage checkpoint	GO:0044773	74	0.020
mitotic dna integrity checkpoint	GO:0044774	75	0.020
apoptotic cell clearance	GO:0043277	14	0.020
regulation of immune effector process	GO:0002697	52	0.020
imaginal disc derived wing morphogenesis	GO:0007476	337	0.020
synaptic transmission	GO:0007268	288	0.020
macromolecular complex disassembly	GO:0032984	37	0.020
intracellular protein transport	GO:0006886	104	0.020
centrosome organization	GO:0051297	163	0.020
organic acid metabolic process	GO:0006082	103	0.019
cellular ketone metabolic process	GO:0042180	24	0.019
chaeta development	GO:0022416	97	0.019
mrna processing	GO:0006397	104	0.019
g2 dna damage checkpoint	GO:0031572	69	0.018
establishment of protein localization	GO:0045184	163	0.018
regulation of molecular function	GO:0065009	217	0.018
cell division	GO:0051301	248	0.018
regulation of gene expression epigenetic	GO:0040029	128	0.018
convergent extension	GO:0060026	2	0.018
endomembrane system organization	GO:0010256	119	0.018
positive regulation of secretion by cell	GO:1903532	20	0.018
regulation of transport	GO:0051049	181	0.018
membrane organization	GO:0061024	112	0.018
single organism cellular localization	GO:1902580	180	0.018
protein transport	GO:0015031	155	0.017
negative regulation of protein metabolic process	GO:0051248	85	0.017
innate immune response	GO:0045087	144	0.017
regulation of phosphate metabolic process	GO:0019220	210	0.017
mitotic cell cycle checkpoint	GO:0007093	88	0.017
response to extracellular stimulus	GO:0009991	116	0.017
negative regulation of stem cell proliferation	GO:2000647	30	0.017
regulation of cellular component biogenesis	GO:0044087	201	0.017
response to light stimulus	GO:0009416	124	0.016
neuron projection guidance	GO:0097485	241	0.016
protein modification by small protein conjugation or removal	GO:0070647	106	0.016
positive regulation of cellular amine metabolic process	GO:0033240	0	0.016
protein maturation	GO:0051604	71	0.016
regulation of apoptotic process	GO:0042981	130	0.016
asymmetric cell division	GO:0008356	37	0.016
spermatid differentiation	GO:0048515	114	0.016
response to wounding	GO:0009611	94	0.016
response to oxygen containing compound	GO:1901700	200	0.016
covalent chromatin modification	GO:0016569	106	0.015
histone modification	GO:0016570	106	0.015
positive regulation of transport	GO:0051050	92	0.015
positive regulation of protein metabolic process	GO:0051247	128	0.015
positive regulation of mrna processing	GO:0050685	4	0.015
cell cycle arrest	GO:0007050	4	0.015
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.015
response to organic cyclic compound	GO:0014070	89	0.015
regulation of cell motility	GO:2000145	23	0.015
centrosome duplication	GO:0051298	121	0.014
extrinsic apoptotic signaling pathway	GO:0097191	1	0.014
positive regulation of molecular function	GO:0044093	136	0.014
glial cell differentiation	GO:0010001	35	0.014
peptide biosynthetic process	GO:0043043	42	0.014
organic substance transport	GO:0071702	257	0.014
negative regulation of signal transduction	GO:0009968	206	0.014
regulation of cell death	GO:0010941	173	0.014
regulation of mapk cascade	GO:0043408	92	0.014
gland morphogenesis	GO:0022612	145	0.014
multicellular organismal homeostasis	GO:0048871	41	0.014
negative regulation of cell communication	GO:0010648	223	0.014
positive regulation of cell differentiation	GO:0045597	64	0.013
neural precursor cell proliferation	GO:0061351	75	0.013
response to nutrient levels	GO:0031667	114	0.013
secretion	GO:0046903	109	0.013
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.013
salivary gland morphogenesis	GO:0007435	145	0.013
dna integrity checkpoint	GO:0031570	81	0.013
defense response to other organism	GO:0098542	225	0.013
regulation of protein localization	GO:0032880	76	0.013
regulation of mrna 3 end processing	GO:0031440	7	0.013
centrosome cycle	GO:0007098	137	0.012
organelle assembly	GO:0070925	198	0.012
histone lysine methylation	GO:0034968	32	0.012
appendage morphogenesis	GO:0035107	397	0.012
negative regulation of cell death	GO:0060548	81	0.012
rna processing	GO:0006396	147	0.012
regulation of transferase activity	GO:0051338	58	0.012
dorsal ventral axis specification	GO:0009950	66	0.012
chromosome organization	GO:0051276	360	0.012
regulation of kinase activity	GO:0043549	53	0.011
cellular protein complex assembly	GO:0043623	71	0.011
aromatic compound catabolic process	GO:0019439	166	0.011
head involution	GO:0008258	35	0.011
cellular response to dna damage stimulus	GO:0006974	223	0.011
central nervous system development	GO:0007417	201	0.011
axon development	GO:0061564	297	0.011
gland development	GO:0048732	191	0.011
regulation of intracellular signal transduction	GO:1902531	236	0.011
connective tissue development	GO:0061448	3	0.011
negative regulation of cellular component organization	GO:0051129	108	0.011
microtubule organizing center organization	GO:0031023	168	0.011
spinal cord development	GO:0021510	1	0.011
chromosome segregation	GO:0007059	157	0.011
regulation of cellular protein catabolic process	GO:1903362	44	0.011
positive regulation of cell migration	GO:0030335	2	0.011
response to dsrna	GO:0043331	15	0.011
regulation of proteasomal protein catabolic process	GO:0061136	39	0.011
nuclear import	GO:0051170	51	0.011
methylation	GO:0032259	47	0.011
axis specification	GO:0009798	167	0.010
regulation of cell migration	GO:0030334	22	0.010
protein ubiquitination	GO:0016567	70	0.010
spermatid development	GO:0007286	98	0.010
morphogenesis of an epithelium	GO:0002009	276	0.010
dorsal closure	GO:0007391	79	0.010

MED15 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.019
cancer	DOID:162	0.019
organ system cancer	DOID:0050686	0.019

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