Drosophila melanogaster

7 known processes

Nep2 (Dmel_CG9761)

Neprilysin 2

(Aliases: Dmel\CG9761,nep2,CG9761,BcDNA:GH07643,DmNEP2,dNEP2)

Nep2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to abiotic stimulusGO:00096283410.050
appendage developmentGO:00487364010.047
endocytosisGO:00068973100.047
regionalizationGO:00030024160.045
establishment of localization in cellGO:00516494020.045
response to external biotic stimulusGO:00432072930.043
small molecule metabolic processGO:00442813050.043
neurological system processGO:00508773580.042
intracellular signal transductionGO:00355563000.042
vesicle mediated transportGO:00161923810.041
catabolic processGO:00090564090.040
organonitrogen compound metabolic processGO:19015643180.040
Rat
carboxylic acid metabolic processGO:0019752920.040
cellular catabolic processGO:00442483720.039
positive regulation of macromolecule metabolic processGO:00106044050.039
positive regulation of response to stimulusGO:00485843230.038
organic acid metabolic processGO:00060821030.037
appendage morphogenesisGO:00351073970.036
single organism behaviorGO:00447083910.036
xenobiotic catabolic processGO:004217810.036
oxoacid metabolic processGO:00434361030.035
regulation of multicellular organismal developmentGO:20000264140.034
positive regulation of cell communicationGO:00106472500.034
response to lipopolysaccharideGO:003249640.033
positive regulation of nitrogen compound metabolic processGO:00511733540.033
imaginal disc derived appendage developmentGO:00487373990.033
epithelial cell developmentGO:00020642740.032
kidney developmentGO:000182230.032
phagocytosisGO:00069092150.031
organic substance transportGO:00717022570.031
positive regulation of signalingGO:00230562430.031
single organism biosynthetic processGO:00447112060.031
regulation of response to stressGO:00801342000.031
forebrain developmentGO:003090020.031
response to other organismGO:00517072930.030
imaginal disc derived appendage morphogenesisGO:00351143950.030
autophagyGO:00069141080.030
single organism intracellular transportGO:19025822070.030
regulation of localizationGO:00328792750.029
negative regulation of cellular metabolic processGO:00313243820.029
response to oxygen containing compoundGO:19017002000.029
regulation of epithelial cell proliferationGO:005067840.029
central nervous system developmentGO:00074172010.029
response to organic substanceGO:00100332840.029
brain developmentGO:00074201200.028
sensory perceptionGO:00076001960.028
localization of cellGO:00516742570.027
chaeta developmentGO:0022416970.027
response to biotic stimulusGO:00096072940.027
intracellular transportGO:00469072280.026
cellular amino acid metabolic processGO:0006520610.026
segmentationGO:00352822070.026
organic substance catabolic processGO:19015753080.026
imaginal disc derived wing morphogenesisGO:00074763370.026
cellular protein modification processGO:00064644380.026
body morphogenesisGO:001017120.025
reproductive behaviorGO:00190981220.025
Fly
androgen metabolic processGO:000820910.025
limb developmentGO:006017310.025
single organism catabolic processGO:00447122280.025
peptide metabolic processGO:0006518800.025
Rat
regulation of intracellular signal transductionGO:19025312360.025
positive regulation of signal transductionGO:00099672230.024
response to radiationGO:00093141550.024
homeostatic processGO:00425921990.024
cell motilityGO:00488702510.024
regulation of cell cycleGO:00517262910.024
wing disc morphogenesisGO:00074723440.024
multi multicellular organism processGO:00447061230.024
Fly
steroid catabolic processGO:000670610.024
response to bacteriumGO:00096171980.023
negative regulation of cell communicationGO:00106482230.023
epithelial cell differentiationGO:00308553220.023
response to monosaccharideGO:003428440.023
protein modification processGO:00362114380.023
camera type eye developmentGO:004301040.023
regulation of cellular protein metabolic processGO:00322682430.023
neuron projection guidanceGO:00974852410.023
multi organism behaviorGO:00517051750.023
Fly
eye developmentGO:00016543230.023
Fly
spindle organizationGO:00070512530.023
regulation of phosphorus metabolic processGO:00511742100.023
post embryonic appendage morphogenesisGO:00351203850.023
regulation of multi organism processGO:00439001310.022
response to hexoseGO:000974630.022
hormone catabolic processGO:004244730.022
regulation of cellular catabolic processGO:00313291570.022
open tracheal system developmentGO:00074242040.022
positive regulation of cellular biosynthetic processGO:00313283160.022
cell projection assemblyGO:0030031940.021
positive regulation of nucleobase containing compound metabolic processGO:00459353320.021
defense responseGO:00069523000.021
response to nutrient levelsGO:00316671140.021
cellular component assembly involved in morphogenesisGO:00109271510.021
negative regulation of response to stimulusGO:00485852580.021
deathGO:00162652840.021
nucleotide metabolic processGO:00091171610.020
phosphorylationGO:00163102940.020
cation transportGO:00068121100.020
response to starvationGO:0042594970.020
dorsal ventral pattern formationGO:00099531330.020
antimicrobial humoral responseGO:0019730990.020
programmed cell deathGO:00125012570.020
response to glucoseGO:000974920.020
cellular response to chemical stimulusGO:00708871990.020
positive regulation of cell motilityGO:200014730.020
regulation of transportGO:00510491810.020
negative regulation of signalingGO:00230572190.020
negative regulation of multicellular organismal processGO:00512411420.020
regulation of molecular functionGO:00650092170.019
taxisGO:00423303040.019
regulation of protein metabolic processGO:00512462560.019
protein localizationGO:00081042840.019
estrogen metabolic processGO:000821010.019
locomotory behaviorGO:00076261760.019
lipid metabolic processGO:00066291210.019
organonitrogen compound biosynthetic processGO:19015661170.019
positive regulation of cell migrationGO:003033520.019
connective tissue developmentGO:006144830.019
sensory perception of chemical stimulusGO:00076061160.019
limb morphogenesisGO:003510810.019
axon guidanceGO:00074112330.019
salivary gland developmentGO:00074311620.018
multicellular organismal agingGO:00102591400.018
negative regulation of signal transductionGO:00099682060.018
regulation of cellular ketone metabolic processGO:001056530.018
regulation of autophagyGO:0010506620.018
regulation of cell differentiationGO:00455953020.018
multi organism reproductive behaviorGO:00447051210.018
Fly
protein phosphorylationGO:00064681690.018
nucleoside phosphate metabolic processGO:00067531620.018
positive regulation of programmed cell deathGO:0043068620.018
maintenance of locationGO:0051235730.018
actin cytoskeleton organizationGO:00300362060.018
regulation of developmental growthGO:00486381740.018
regulation of catalytic activityGO:00507901850.018
developmental growthGO:00485892800.018
telencephalon developmentGO:002153720.018
gland developmentGO:00487321910.018
exocrine system developmentGO:00352721620.018
nuclear divisionGO:00002803320.018
response to light stimulusGO:00094161240.018
negative regulation of gene expressionGO:00106293870.018
head developmentGO:00603221350.018
epithelium migrationGO:00901321480.018
ion transmembrane transportGO:00342201220.018
anion homeostasisGO:005508130.017
defense response to other organismGO:00985422250.017
immune system processGO:00023763470.017
tissue migrationGO:00901301550.017
cell migrationGO:00164772380.017
cell deathGO:00082192790.017
regulation of phosphate metabolic processGO:00192202100.017
regulation of programmed cell deathGO:00430671520.017
organophosphate metabolic processGO:00196371950.017
carbohydrate derivative metabolic processGO:19011352170.017
signal transduction by phosphorylationGO:00230141070.017
positive regulation of lipid storageGO:001088440.017
cellular response to ethanolGO:007136140.017
cellular response to molecule of bacterial originGO:007121930.017
chemotaxisGO:00069352490.017
cation transmembrane transportGO:0098655880.017
ion transportGO:00068111450.017
positive regulation of gene expressionGO:00106282900.017
negative regulation of homeostatic processGO:003284520.017
transmembrane transportGO:00550851390.016
morphogenesis of an epitheliumGO:00020092760.016
positive regulation of rna biosynthetic processGO:19026802660.016
positive regulation of macromolecule biosynthetic processGO:00105572830.016
transcription from rna polymerase ii promoterGO:00063663680.016
pigment biosynthetic processGO:0046148360.016
developmental pigmentationGO:0048066680.016
regulation of behaviorGO:0050795750.016
small gtpase mediated signal transductionGO:0007264880.016
amine metabolic processGO:0009308120.016
spermatid developmentGO:0007286980.016
proteolysisGO:00065081920.016
apoptotic processGO:00069151590.016
positive regulation of cellular catabolic processGO:0031331950.016
eye pigmentationGO:0048069430.016
regulation of immune system processGO:00026821760.016
positive regulation of biosynthetic processGO:00098913160.016
respiratory system developmentGO:00605412130.016
regulation of apoptotic processGO:00429811300.016
developmental maturationGO:00217001720.016
embryonic morphogenesisGO:00485982060.016
regulation of catabolic processGO:00098941700.016
agingGO:00075681430.016
blastoderm segmentationGO:00073501590.016
ras protein signal transductionGO:0007265880.016
cellular response to lipopolysaccharideGO:007122230.015
regulation of cellular amino acid metabolic processGO:000652100.015
growthGO:00400073590.015
cilium morphogenesisGO:0060271390.015
carbohydrate metabolic processGO:0005975820.015
regulation of anatomical structure sizeGO:00900661630.015
cell proliferationGO:00082832990.015
organelle assemblyGO:00709251980.015
regulation of anatomical structure morphogenesisGO:00226032420.015
cytoplasmic transportGO:00164821300.014
axon developmentGO:00615642970.014
positive regulation of nucleic acid templated transcriptionGO:19035082660.014
lateral inhibitionGO:00463312060.014
regulation of cellular response to stressGO:0080135890.014
multicellular organismal reproductive behaviorGO:00330571100.014
Fly
embryonic pattern specificationGO:00098801740.014
lipid localizationGO:0010876540.014
determination of adult lifespanGO:00083401370.014
posttranscriptional regulation of gene expressionGO:00106081450.014
developmental programmed cell deathGO:00106231380.014
spermatogenesisGO:00072832000.014
renal system developmentGO:0072001720.014
positive regulation of phosphorus metabolic processGO:00105621390.014
cellular ketone metabolic processGO:0042180240.014
epithelial cell migrationGO:00106311480.014
cuticle developmentGO:0042335860.014
actin filament based processGO:00300292200.014
response to extracellular stimulusGO:00099911160.014
regulation of cellular amine metabolic processGO:003323830.014
inorganic cation transmembrane transportGO:0098662610.014
organic cyclic compound catabolic processGO:19013611680.014
organelle fissionGO:00482853400.014
negative regulation of epithelial cell proliferationGO:005068040.014
regulation of i kappab kinase nf kappab signalingGO:004312220.014
mesenchymal cell differentiationGO:004876210.014
cellular response to organic substanceGO:00713101320.014
cellular macromolecule catabolic processGO:00442651360.014
regulation of phosphorylationGO:00423251470.014
regulation of nervous system developmentGO:00519602480.014
actin filament organizationGO:00070151260.014
regulation of transcription from rna polymerase ii promoterGO:00063573780.013
notch signaling pathwayGO:00072191200.013
cholesterol transportGO:003030120.013
positive regulation of transcription dna templatedGO:00458932660.013
mitotic spindle organizationGO:00070522200.013
hindbrain developmentGO:003090220.013
detection of abiotic stimulusGO:0009582660.013
spermatid differentiationGO:00485151140.013
immune responseGO:00069552460.013
salivary gland histolysisGO:0035070880.013
response to organic cyclic compoundGO:0014070890.013
compound eye developmentGO:00487493070.013
Fly
cell cycle phase transitionGO:00447701400.013
heterocycle catabolic processGO:00467001660.013
negative regulation of nitrogen compound metabolic processGO:00511722650.013
axonogenesisGO:00074092900.013
cellular response to biotic stimulusGO:007121640.013
gland morphogenesisGO:00226121450.013
nucleobase containing small molecule metabolic processGO:00550861740.013
benzene containing compound metabolic processGO:004253730.013
spinal cord developmentGO:002151010.013
columnar cuboidal epithelial cell differentiationGO:00020652560.013
male gamete generationGO:00482322010.013
chemosensory behaviorGO:00076351060.013
chemical homeostasisGO:0048878920.013
embryonic development via the syncytial blastodermGO:00017001480.013
positive regulation of intracellular signal transductionGO:19025331160.013
positive regulation of catabolic processGO:00098961050.013
negative regulation of nervous system developmentGO:0051961920.013
nitrogen compound transportGO:0071705850.013
regulation of cellular component biogenesisGO:00440872010.012
inorganic ion transmembrane transportGO:0098660730.012
positive regulation of molecular functionGO:00440931360.012
macromolecule catabolic processGO:00090571610.012
nephron developmentGO:007200630.012
sterol homeostasisGO:005509240.012
tube morphogenesisGO:00352391910.012
positive regulation of catalytic activityGO:00430851180.012
immune response regulating signaling pathwayGO:000276420.012
regulation of mitotic cell cycleGO:00073461900.012
lipid storageGO:0019915380.012
regulation of proteolysisGO:0030162870.012
negative regulation of cellular component organizationGO:00511291080.012
cellular protein catabolic processGO:0044257830.012
regulation of cell projection organizationGO:0031344920.012
purine nucleotide metabolic processGO:00061631460.012
single organism cellular localizationGO:19025801800.012
mitotic nuclear divisionGO:00070672130.012
single organism carbohydrate metabolic processGO:0044723720.012
lipopolysaccharide mediated signaling pathwayGO:003166310.012
regulation of growthGO:00400082330.012
ameboidal type cell migrationGO:00016671510.012
negative regulation of developmental processGO:00510932010.012
heart developmentGO:0007507820.012
chromosome organizationGO:00512763600.012
retina development in camera type eyeGO:006004140.012
detection of stimulusGO:00516061560.012
protein processingGO:0016485680.012
cell adhesionGO:00071551360.012
cilium assemblyGO:0042384380.012
imaginal disc derived leg morphogenesisGO:0007480800.012
response to endogenous stimulusGO:00097191190.012
adult behaviorGO:00305341370.012
tube developmentGO:00352952440.012
axis specificationGO:00097981670.012
regulation of neurogenesisGO:00507671580.012
monocarboxylic acid transportGO:001571830.012
innate immune response activating signal transductionGO:000275820.012
regulation of mapk cascadeGO:0043408920.012
mitotic cell cycle phase transitionGO:00447721380.012
establishment of protein localizationGO:00451841630.012
regulation of cell deathGO:00109411730.012
regulation of synapse organizationGO:00508071100.012
pyridine containing compound metabolic processGO:007252430.011
response to alcoholGO:0097305950.011
regulation of cell developmentGO:00602842150.011
enzyme linked receptor protein signaling pathwayGO:00071671790.011
cell cell signaling involved in cell fate commitmentGO:00451682100.011
detection of external stimulusGO:0009581660.011
digestive system developmentGO:00551231490.011
defense response to bacteriumGO:00427421780.011
nucleoside catabolic processGO:00091641120.011
tissue morphogenesisGO:00487292970.011
defense response to gram negative bacteriumGO:0050829940.011
response to organophosphorusGO:004668320.011
mapk cascadeGO:00001651070.011
cellular amide metabolic processGO:0043603800.011
Rat
salivary gland morphogenesisGO:00074351450.011
organonitrogen compound catabolic processGO:19015651280.011
regulation of cell cycle processGO:00105641810.011
ribose phosphate metabolic processGO:00196931450.011
negative regulation of protein metabolic processGO:0051248850.011
leg disc developmentGO:0035218920.011
aggressive behaviorGO:0002118630.011
response to copper ionGO:004668840.011
purine containing compound metabolic processGO:00725211550.011
pigment metabolic processGO:0042440840.011
mesenchymal cell developmentGO:001403110.011
negative regulation of cell cycle processGO:00109481090.011
regulation of cell proliferationGO:00421271630.011
rna localizationGO:00064031150.011
cellular homeostasisGO:0019725800.011
regulation of response to external stimulusGO:00321011150.011
positive regulation of multicellular organismal processGO:00512401430.011
gene silencingGO:00164581380.011
dendrite morphogenesisGO:00488131990.011
positive regulation of cellular protein metabolic processGO:00322701180.011
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.011
rna processingGO:00063961470.011
nucleoside metabolic processGO:00091161270.011
membrane organizationGO:00610241120.011
vitamin metabolic processGO:000676620.011
aromatic compound catabolic processGO:00194391660.011
positive regulation of developmental processGO:00510941430.011
regulation of hormone levelsGO:0010817400.011
molting cycle chitin based cuticleGO:0007591560.011
centrosome organizationGO:00512971630.011
cellular response to light stimulusGO:0071482370.011
camera type eye morphogenesisGO:004859320.011
cellular protein localizationGO:00346131600.011
cell divisionGO:00513012480.011
carbohydrate derivative catabolic processGO:19011361180.011
regulation of protein modification processGO:00313991120.011
matingGO:00076181200.011
Fly
cellular response to nutrient levelsGO:0031669620.011
negative regulation of cell differentiationGO:00455961430.011
chromatin modificationGO:00165681470.011
sensory perception of smellGO:0007608800.010
secondary metabolic processGO:0019748750.010
nucleoside phosphate catabolic processGO:19012921100.010
microtubule organizing center organizationGO:00310231680.010
positive regulation of calcium ion transportGO:005192840.010
positive regulation of cell deathGO:0010942690.010
cholesterol homeostasisGO:004263230.010
regulation of mitotic cell cycle phase transitionGO:19019901300.010
protein modification by small protein conjugation or removalGO:00706471060.010
sensory perception of soundGO:0007605560.010
ribonucleoside triphosphate metabolic processGO:00091991190.010
digestive tract morphogenesisGO:00485461270.010
regulation of cellular localizationGO:00603411360.010
cellular response to hexose stimulusGO:007133110.010
synaptic transmissionGO:00072682880.010
negative regulation of sequence specific dna binding transcription factor activityGO:004343340.010
water homeostasisGO:003010430.010
humoral immune responseGO:00069591170.010
secretionGO:00469031090.010
microtubule based transportGO:0010970420.010
purine containing compound catabolic processGO:00725231120.010
single organism membrane organizationGO:0044802930.010
regulation of locomotionGO:0040012420.010
kidney epithelium developmentGO:007207330.010
eye morphogenesisGO:00485922600.010
Fly
positive regulation of rna metabolic processGO:00512542710.010
sensory perception of mechanical stimulusGO:0050954720.010
columnar cuboidal epithelial cell developmentGO:00020662490.010
imaginal disc pattern formationGO:0007447910.010
neutral lipid biosynthetic processGO:004646020.010

Nep2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.033
Human
disease of anatomical entityDOID:700.028
inherited metabolic disorderDOID:65500.028
Human
nervous system diseaseDOID:86300.019
urinary system diseaseDOID:1800.013
sensory system diseaseDOID:005015500.013
musculoskeletal system diseaseDOID:1700.010