Drosophila melanogaster

15 known processes

Npc2c (Dmel_CG3934)

Niemann-Pick type C-2c

(Aliases: Dmel\CG3934,npc2c,DmML5A,CG3934)

Npc2c biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
gland developmentGO:00487321910.100
response to biotic stimulusGO:00096072940.095
Fly
response to external biotic stimulusGO:00432072930.084
Fly
imaginal disc derived appendage morphogenesisGO:00351143950.081
phosphatidylethanolamine metabolic processGO:004633710.079
defense responseGO:00069523000.079
Fly
organic acid metabolic processGO:00060821030.078
wing disc morphogenesisGO:00074723440.078
imaginal disc derived appendage developmentGO:00487373990.070
benzene containing compound metabolic processGO:004253730.069
appendage developmentGO:00487364010.068
post embryonic appendage morphogenesisGO:00351203850.067
small molecule metabolic processGO:00442813050.065
Fly
imaginal disc derived wing morphogenesisGO:00074763370.062
appendage morphogenesisGO:00351073970.061
response to organic substanceGO:00100332840.060
negative regulation of gene expressionGO:00106293870.060
salivary gland developmentGO:00074311620.060
gland morphogenesisGO:00226121450.058
oxoacid metabolic processGO:00434361030.058
organonitrogen compound metabolic processGO:19015643180.057
deathGO:00162652840.055
endocytosisGO:00068973100.054
vesicle mediated transportGO:00161923810.053
acylglycerol catabolic processGO:004646430.051
positive regulation of response to stimulusGO:00485843230.050
response to other organismGO:00517072930.049
Fly
catabolic processGO:00090564090.048
regulation of localizationGO:00328792750.048
cellular catabolic processGO:00442483720.048
carboxylic acid metabolic processGO:0019752920.047
organic substance catabolic processGO:19015753080.046
cell deathGO:00082192790.046
regulation of sequestering of triglycerideGO:001088930.045
developmental programmed cell deathGO:00106231380.044
response to bacteriumGO:00096171980.044
Fly
ethanolamine containing compound metabolic processGO:004243940.043
axon developmentGO:00615642970.042
response to lipopolysaccharideGO:003249640.042
exocrine system developmentGO:00352721620.041
acylglycerol biosynthetic processGO:004646320.041
single organism biosynthetic processGO:00447112060.041
Fly
salivary gland morphogenesisGO:00074351450.041
dendrite developmentGO:00163582040.041
positive regulation of lipid storageGO:001088440.040
morphogenesis of an epitheliumGO:00020092760.039
cellular amine metabolic processGO:0044106120.039
phagocytosisGO:00069092150.039
positive regulation of cell communicationGO:00106472500.038
secondary metabolic processGO:0019748750.038
triglyceride biosynthetic processGO:001943220.038
multi organism behaviorGO:00517051750.038
phospholipid homeostasisGO:005509110.038
tissue deathGO:00162711020.038
cellular response to organic substanceGO:00713101320.037
histolysisGO:00075591020.036
cellular protein modification processGO:00064644380.035
axonogenesisGO:00074092900.035
cholesterol homeostasisGO:004263230.035
triglyceride catabolic processGO:001943330.035
negative regulation of cellular metabolic processGO:00313243820.035
positive regulation of signal transductionGO:00099672230.035
matingGO:00076181200.034
cell proliferationGO:00082832990.034
neurological system processGO:00508773580.034
ommochrome metabolic processGO:0046152190.034
cellular ketone metabolic processGO:0042180240.034
Fly
amine metabolic processGO:0009308120.033
neuron recognitionGO:00080381010.033
Fly
salivary gland cell autophagic cell deathGO:0035071830.033
protein modification processGO:00362114380.033
cellular amino acid metabolic processGO:0006520610.033
tissue morphogenesisGO:00487292970.032
regionalizationGO:00030024160.032
organelle fissionGO:00482853400.032
forebrain developmentGO:003090020.032
response to abiotic stimulusGO:00096283410.031
response to endogenous stimulusGO:00097191190.031
positive regulation of signalingGO:00230562430.031
sterol homeostasisGO:005509240.031
Fly
positive regulation of cellular biosynthetic processGO:00313283160.030
cellular response to chemical stimulusGO:00708871990.030
salivary gland histolysisGO:0035070880.030
epithelial cell differentiationGO:00308553220.030
nuclear divisionGO:00002803320.030
response to copper ionGO:004668840.030
single organism behaviorGO:00447083910.030
ovarian follicle cell developmentGO:00307072480.030
phosphorylationGO:00163102940.030
immune system processGO:00023763470.029
Fly
neutral lipid catabolic processGO:004646130.029
phosphatidic acid metabolic processGO:004647310.029
epithelial cell developmentGO:00020642740.029
positive regulation of nitrogen compound metabolic processGO:00511733540.029
programmed cell deathGO:00125012570.029
columnar cuboidal epithelial cell differentiationGO:00020652560.029
cellular response to endogenous stimulusGO:0071495800.029
gene silencingGO:00164581380.028
response to oxygen containing compoundGO:19017002000.028
positive regulation of gene expressionGO:00106282900.028
glycerolipid catabolic processGO:004650330.028
response to extracellular stimulusGO:00099911160.027
positive regulation of transcription dna templatedGO:00458932660.027
protein complex biogenesisGO:00702712010.027
single organism catabolic processGO:00447122280.027
secondary metabolite biosynthetic processGO:0044550240.027
negative regulation of nitrogen compound metabolic processGO:00511722650.027
cellular modified amino acid metabolic processGO:0006575450.027
autophagic cell deathGO:0048102830.027
regulation of transcription from rna polymerase ii promoterGO:00063573780.026
positive regulation of rna biosynthetic processGO:19026802660.026
carbohydrate derivative metabolic processGO:19011352170.026
positive regulation of biosynthetic processGO:00098913160.026
hormone catabolic processGO:004244730.026
macromolecular complex assemblyGO:00650032560.026
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.026
reproductive behaviorGO:00190981220.026
pigmentationGO:0043473750.025
protein localizationGO:00081042840.025
regulation of neurogenesisGO:00507671580.025
transcription from rna polymerase ii promoterGO:00063663680.025
cellular macromolecule localizationGO:00707272200.025
intracellular signal transductionGO:00355563000.025
growthGO:00400073590.025
negative regulation of cellular biosynthetic processGO:00313272770.025
chromosome organizationGO:00512763600.025
body morphogenesisGO:001017120.025
dendrite morphogenesisGO:00488131990.025
regulation of cell cycleGO:00517262910.025
taxisGO:00423303040.025
regulation of cellular amine metabolic processGO:003323830.025
neutral lipid biosynthetic processGO:004646020.024
regulation of transportGO:00510491810.024
proteolysisGO:00065081920.024
negative regulation of rna metabolic processGO:00512532510.024
columnar cuboidal epithelial cell developmentGO:00020662490.024
cellular response to dna damage stimulusGO:00069742230.024
negative regulation of transcription dna templatedGO:00458922370.024
ocellus pigmentationGO:0033060190.024
embryonic morphogenesisGO:00485982060.023
positive regulation of rna metabolic processGO:00512542710.023
immune responseGO:00069552460.023
Fly
defense response to other organismGO:00985422250.023
Fly
compound eye morphogenesisGO:00017452490.023
mating behaviorGO:00076171060.023
response to nutrient levelsGO:00316671140.023
anion homeostasisGO:005508130.023
androgen metabolic processGO:000820910.023
negative regulation of biosynthetic processGO:00098902770.023
transmembrane transportGO:00550851390.022
positive regulation of nucleobase containing compound metabolic processGO:00459353320.022
defense response to bacteriumGO:00427421780.022
Fly
innate immune responseGO:00450871440.022
Fly
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.022
negative regulation of response to stimulusGO:00485852580.022
negative regulation of macromolecule biosynthetic processGO:00105582700.022
ion transmembrane transportGO:00342201220.022
regulation of immune system processGO:00026821760.022
regulation of mitotic cell cycleGO:00073461900.022
maintenance of locationGO:0051235730.022
xenobiotic catabolic processGO:004217810.022
regulation of multicellular organismal developmentGO:20000264140.022
regulation of cellular ketone metabolic processGO:001056530.021
cholesterol transportGO:003030120.021
organic substance transportGO:00717022570.021
Fly
steroid catabolic processGO:000670610.021
estrogen metabolic processGO:000821010.021
regulation of cellular amino acid metabolic processGO:000652100.021
courtship behaviorGO:0007619680.021
chorion containing eggshell formationGO:00073041050.021
carbohydrate derivative biosynthetic processGO:1901137850.020
mitotic nuclear divisionGO:00070672130.020
camera type eye developmentGO:004301040.020
negative regulation of signalingGO:00230572190.020
positive regulation of macromolecule metabolic processGO:00106044050.020
regulation of cell deathGO:00109411730.020
chemical homeostasisGO:0048878920.020
Fly
dna metabolic processGO:00062592270.020
gene silencing by rnaGO:0031047570.020
response to nitrogen compoundGO:1901698900.020
regulation of lipid storageGO:0010883220.020
negative regulation of signal transductionGO:00099682060.020
photoreceptor cell differentiationGO:00465301700.020
imaginal disc pattern formationGO:0007447910.020
developmental growthGO:00485892800.020
regulation of cellular protein metabolic processGO:00322682430.020
protein heterooligomerizationGO:005129140.019
ion transportGO:00068111450.019
pigment metabolic process involved in pigmentationGO:0043474330.019
compound eye photoreceptor cell differentiationGO:00017511400.019
sulfur compound metabolic processGO:0006790590.019
lipid storageGO:0019915380.019
response to alcoholGO:0097305950.019
regulation of phosphorus metabolic processGO:00511742100.019
response to organophosphorusGO:004668320.019
neuron projection guidanceGO:00974852410.019
compound eye developmentGO:00487493070.019
mitotic spindle organizationGO:00070522200.019
establishment of localization in cellGO:00516494020.019
lateral inhibitionGO:00463312060.019
synaptic transmissionGO:00072682880.019
immune response activating signal transductionGO:000275720.019
negative regulation of nucleic acid templated transcriptionGO:19035072400.019
negative regulation of nucleobase containing compound metabolic processGO:00459342610.019
lipid metabolic processGO:00066291210.018
Fly
eggshell formationGO:00307031050.018
wound healingGO:0042060750.018
Fly
negative regulation of developmental processGO:00510932010.018
cell recognitionGO:00080371020.018
Fly
response to woundingGO:0009611940.018
Fly
organophosphate metabolic processGO:00196371950.018
positive regulation of sequestering of triglycerideGO:001089010.018
lipid localizationGO:0010876540.018
Fly
dorsal ventral pattern formationGO:00099531330.018
regulation of synapse structure and activityGO:00508031280.018
single organism intracellular transportGO:19025822070.018
negative regulation of cell cycle processGO:00109481090.018
response to organic cyclic compoundGO:0014070890.018
negative regulation of rna biosynthetic processGO:19026792400.018
alditol phosphate metabolic processGO:005264620.018
adult behaviorGO:00305341370.017
negative regulation of multicellular organismal processGO:00512411420.017
axon guidanceGO:00074112330.017
aggressive behaviorGO:0002118630.017
cellular response to hormone stimulusGO:0032870440.017
positive regulation of macromolecule biosynthetic processGO:00105572830.017
synapse organizationGO:00508081960.017
positive regulation of nucleic acid templated transcriptionGO:19035082660.017
regulation of intracellular signal transductionGO:19025312360.017
humoral immune responseGO:00069591170.017
Fly
sensory organ morphogenesisGO:00905962600.017
regulation of epithelial cell differentiationGO:003085640.017
regulation of neuron differentiationGO:00456641030.017
long chain fatty acid metabolic processGO:000167630.017
tube morphogenesisGO:00352391910.017
protein complex assemblyGO:00064612000.017
intracellular transportGO:00469072280.017
synapse assemblyGO:00074161430.017
regulation of nervous system developmentGO:00519602480.017
central nervous system developmentGO:00074172010.017
gliogenesisGO:0042063800.017
regulation of organelle organizationGO:00330431960.017
negative regulation of cell communicationGO:00106482230.017
non sensory hair organizationGO:0035316470.016
regulation of sterol transportGO:003237110.016
regulation of mitotic cell cycle phase transitionGO:19019901300.016
regulation of cell cycle processGO:00105641810.016
immune response regulating signaling pathwayGO:000276420.016
ocellus pigment biosynthetic processGO:0008055190.016
chaeta developmentGO:0022416970.016
phosphatidylcholine metabolic processGO:004647030.016
protein maturationGO:0051604710.016
mitotic cell cycle phase transitionGO:00447721380.016
circadian rhythmGO:00076231050.016
regulation of multi organism processGO:00439001310.016
eye photoreceptor cell differentiationGO:00017541450.016
respiratory system developmentGO:00605412130.016
developmental maturationGO:00217001720.016
regulation of protein metabolic processGO:00512462560.016
regulation of response to stressGO:00801342000.016
chromatin modificationGO:00165681470.016
neurotransmitter metabolic processGO:004213320.016
eye morphogenesisGO:00485922600.016
cell cycle checkpointGO:0000075950.016
cellular component assembly involved in morphogenesisGO:00109271510.016
cell motilityGO:00488702510.016
heterocycle catabolic processGO:00467001660.016
mitotic dna integrity checkpointGO:0044774750.016
anterior posterior pattern specificationGO:00099521360.016
wnt signaling pathwayGO:0016055980.016
axis specificationGO:00097981670.015
chromatin organizationGO:00063252070.015
establishment of tissue polarityGO:0007164870.015
retina development in camera type eyeGO:006004140.015
nephron tubule morphogenesisGO:007207830.015
regulation of gene expression epigeneticGO:00400291280.015
regulation of lipid transportGO:003236830.015
acetylcholine catabolic processGO:000658110.015
organophosphate catabolic processGO:00464341120.015
meiotic cell cycleGO:00513211710.015
negative regulation of cell cycle phase transitionGO:19019881030.015
organelle localizationGO:00516401480.015
homeostatic processGO:00425921990.015
Fly
defense response to gram negative bacteriumGO:0050829940.015
mitotic g2 m transition checkpointGO:0044818700.015
regulation of cell cycle phase transitionGO:19019871300.015
mitotic cell cycle checkpointGO:0007093880.015
hindbrain developmentGO:003090220.015
nephron tubule developmentGO:007208030.015
mitotic dna damage checkpointGO:0044773740.015
photoreceptor cell developmentGO:0042461960.015
ameboidal type cell migrationGO:00016671510.015
secretion by cellGO:00329401010.015
chromosome segregationGO:00070591570.015
multi multicellular organism processGO:00447061230.015
cellular protein localizationGO:00346131600.015
positive regulation of cellular amino acid metabolic processGO:004576400.015
limb morphogenesisGO:003510810.015
limb developmentGO:006017310.014
aromatic compound catabolic processGO:00194391660.014
telencephalon developmentGO:002153720.014
dna integrity checkpointGO:0031570810.014
regulation of cell differentiationGO:00455953020.014
eye developmentGO:00016543230.014
stem cell differentiationGO:00488631170.014
cellular response to carbohydrate stimulusGO:007132240.014
eye photoreceptor cell developmentGO:0042462810.014
protein processingGO:0016485680.014
single organism cellular localizationGO:19025801800.014
connective tissue developmentGO:006144830.014
genital disc developmentGO:0035215440.014
nephron epithelium developmentGO:007200930.014
cell cycle phase transitionGO:00447701400.014
actin filament based processGO:00300292200.014
signal transduction by phosphorylationGO:00230141070.014
negative regulation of cell cycleGO:00457861160.014
imaginal disc derived wing hair organizationGO:0035317450.014
regulation of phosphorylationGO:00423251470.014
regulation of excitatory postsynaptic membrane potentialGO:006007930.014
negative regulation of mitotic cell cycle phase transitionGO:19019911030.014
cell divisionGO:00513012480.014
autophagyGO:00069141080.014
cellular response to ethanolGO:007136140.014
kidney developmentGO:000182230.014
nucleobase containing small molecule metabolic processGO:00550861740.014
negative regulation of cellular protein metabolic processGO:0032269850.014
negative regulation of mitotic cell cycleGO:00459301090.014
multicellular organismal reproductive behaviorGO:00330571100.014
response to hormoneGO:0009725450.014
apoptotic processGO:00069151590.014
negative regulation of protein metabolic processGO:0051248850.014
positive regulation of transportGO:0051050920.014
segmentationGO:00352822070.014
imaginal disc derived leg morphogenesisGO:0007480800.013
posttranscriptional regulation of gene expressionGO:00106081450.013
male mating behaviorGO:0060179700.013
mapk cascadeGO:00001651070.013
embryonic development via the syncytial blastodermGO:00017001480.013
small gtpase mediated signal transductionGO:0007264880.013
regulation of molecular functionGO:00650092170.013
g2 dna damage checkpointGO:0031572690.013
camera type eye morphogenesisGO:004859320.013
nephron developmentGO:007200630.013
localization of cellGO:00516742570.013
tube developmentGO:00352952440.013
small molecule biosynthetic processGO:0044283370.013
Fly
regulation of apoptotic processGO:00429811300.013
spindle organizationGO:00070512530.013
brain developmentGO:00074201200.013
innate immune response activating signal transductionGO:000275820.013
response to organonitrogen compoundGO:0010243750.013
positive regulation of cellular amine metabolic processGO:003324000.013
nephron epithelium morphogenesisGO:007208830.013
dna damage checkpointGO:0000077780.013
open tracheal system developmentGO:00074242040.013
cellular response to lipopolysaccharideGO:007122230.013
kidney morphogenesisGO:006099330.013
positive regulation of intracellular signal transductionGO:19025331160.013
regulation of cell proliferationGO:00421271630.013
mitotic cytokinesisGO:0000281500.013
positive regulation of cell migrationGO:003033520.013
peptidyl amino acid modificationGO:00181931050.013
response to hexoseGO:000974630.013
cytokinesisGO:0000910900.013
positive regulation of cell deathGO:0010942690.013
regulation of mapk cascadeGO:0043408920.013
protein phosphorylationGO:00064681690.013
membrane organizationGO:00610241120.013
peptide metabolic processGO:0006518800.013
kidney epithelium developmentGO:007207330.013
anterior posterior axis specificationGO:00099481090.013
organic cyclic compound catabolic processGO:19013611680.012
chemotaxisGO:00069352490.012
antimicrobial humoral responseGO:0019730990.012
cognitionGO:00508901410.012
g protein coupled receptor signaling pathwayGO:00071861360.012
macromolecule catabolic processGO:00090571610.012
cellular biogenic amine catabolic processGO:004240210.012
response to oxygen levelsGO:0070482590.012
morphogenesis of a polarized epitheliumGO:0001738930.012
membrane depolarizationGO:005189940.012
adult locomotory behaviorGO:0008344760.012
positive regulation of cell motilityGO:200014730.012
regulation of programmed cell deathGO:00430671520.012
locomotory behaviorGO:00076261760.012
regulation of epithelial cell proliferationGO:005067840.012
positive regulation of exocytosisGO:004592140.012
inorganic ion transmembrane transportGO:0098660730.012
meiotic chromosome segregationGO:0045132590.012
embryonic axis specificationGO:00005781070.012
rna localizationGO:00064031150.012
nephron morphogenesisGO:007202830.012
cellular lipid metabolic processGO:0044255830.012
mitotic g2 dna damage checkpointGO:0007095690.012
cytoplasmic transportGO:00164821300.012
l glutamate importGO:005193810.012
cellular macromolecule catabolic processGO:00442651360.012
regulation of cellular component biogenesisGO:00440872010.012
cellular amide metabolic processGO:0043603800.012
regulation of wnt signaling pathwayGO:0030111680.012
amine catabolic processGO:000931010.012
organonitrogen compound biosynthetic processGO:19015661170.012
long chain fatty acid biosynthetic processGO:004275910.012
organonitrogen compound catabolic processGO:19015651280.012
response to light stimulusGO:00094161240.012
embryo development ending in birth or egg hatchingGO:00097921520.012
regulation of hormone levelsGO:0010817400.012
Fly
eye pigment metabolic processGO:0042441330.012
pheromone biosynthetic processGO:004281130.012
regulation of cell developmentGO:00602842150.012
inter male aggressive behaviorGO:0002121600.012
cell projection assemblyGO:0030031940.012
eye pigmentationGO:0048069430.012
cell adhesionGO:00071551360.012
positive regulation of cellular component organizationGO:00511301560.012
tripartite regional subdivisionGO:00073511030.012
regulation of cellular localizationGO:00603411360.012
pattern recognition receptor signaling pathwayGO:000222120.012
male gamete generationGO:00482322010.012
regulation of cellular response to stressGO:0080135890.012
ras protein signal transductionGO:0007265880.012
protein transportGO:00150311550.012
cellular response to monosaccharide stimulusGO:007132620.011
negative regulation of cellular component organizationGO:00511291080.011
regulation of catalytic activityGO:00507901850.011
nucleotide metabolic processGO:00091171610.011
pigment biosynthetic processGO:0046148360.011
ocellus pigment metabolic processGO:0046158190.011
meiotic nuclear divisionGO:00071261510.011
regulation of immune responseGO:00507761180.011
hindgut morphogenesisGO:0007442580.011
synaptic growth at neuromuscular junctionGO:00511241190.011
peripheral nervous system developmentGO:0007422520.011
cellular response to molecule of bacterial originGO:007121930.011
establishment of protein localizationGO:00451841630.011
organelle fusionGO:0048284460.011
olfactory behaviorGO:0042048970.011
cell maturationGO:00484691440.011
regulation of phosphate metabolic processGO:00192202100.011
response to temperature stimulusGO:00092661060.011
regulation of i kappab kinase nf kappab signalingGO:004312220.011
covalent chromatin modificationGO:00165691060.011
endomembrane system organizationGO:00102561190.011
rrna processingGO:000636430.011
nucleoside phosphate metabolic processGO:00067531620.011
single organism carbohydrate metabolic processGO:0044723720.011
carbohydrate metabolic processGO:0005975820.011
anterior posterior axis specification embryoGO:00085951030.011
establishment of planar polarityGO:0001736870.011
regulation of synapse organizationGO:00508071100.011
acetate ester metabolic processGO:190061920.011
peptidyl lysine modificationGO:0018205570.011
response to radiationGO:00093141550.011
embryonic pattern specificationGO:00098801740.011
negative regulation of insulin secretionGO:004667610.011
spindle elongationGO:0051231830.011
compound eye photoreceptor developmentGO:0042051780.011
photoreceptor cell fate commitmentGO:0046552410.011
negative regulation of homeostatic processGO:003284520.011
dorsal ventral axis specificationGO:0009950660.011
anatomical structure homeostasisGO:0060249970.011
purine ribonucleotide metabolic processGO:00091501450.011
cellular response to biotic stimulusGO:007121640.011
response to decreased oxygen levelsGO:0036293580.011
glycosyl compound metabolic processGO:19016571270.011
vitamin metabolic processGO:000676620.011
lipid biosynthetic processGO:0008610460.011
Fly
rna processingGO:00063961470.011
hair cell differentiationGO:0035315470.011
acetylcholine metabolic processGO:000829120.011
neuropeptide signaling pathwayGO:0007218450.011
glycoprotein biosynthetic processGO:0009101410.011
leg disc developmentGO:0035218920.011
protein modification by small protein conjugation or removalGO:00706471060.010

Npc2c disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
inherited metabolic disorderDOID:65500.077
lipid metabolism disorderDOID:314600.077
familial hyperlipidemiaDOID:116800.077
disease of metabolismDOID:001466700.077
familial combined hyperlipidemiaDOID:1380900.077
familial hypertriglyceridemiaDOID:005052700.075
acquired metabolic diseaseDOID:006015800.071
disease of anatomical entityDOID:700.054
familial lipoprotein lipase deficiencyDOID:1411800.052
hair diseaseDOID:42100.052
hypotrichosisDOID:453500.052
integumentary system diseaseDOID:1600.052
carbohydrate metabolism diseaseDOID:005001300.027
glucose metabolism diseaseDOID:419400.027
diabetes mellitusDOID:935100.022
type 2 diabetes mellitusDOID:935200.022
hypophosphatasiaDOID:1421300.019
nervous system diseaseDOID:86300.016
cardiovascular system diseaseDOID:128700.015
sensory system diseaseDOID:005015500.015
musculoskeletal system diseaseDOID:1700.013