IMP: Integrative Multi-species Prediction

Drosophila melanogaster

37 known processes

emp (Dmel_CG2727)

epithelial membrane protein

(Aliases: Dmel\CG2727,CG2727)

Entrez: 37999
FLYBASE: FBgn0010435
UniProtKB: Q9W0X0
UniProtKB: Q7KVF1

Process Predictions
Disease Predictions

emp biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
response to abiotic stimulus	GO:0009628	341	0.163	Fly
carboxylic acid metabolic process	GO:0019752	92	0.121
response to radiation	GO:0009314	155	0.090	Fly
lipid metabolic process	GO:0006629	121	0.081	Rat Fly
phagocytosis	GO:0006909	215	0.081	Human Rat
long chain fatty acid metabolic process	GO:0001676	3	0.078
very long chain fatty acid metabolic process	GO:0000038	4	0.076
organic acid metabolic process	GO:0006082	103	0.072
appendage morphogenesis	GO:0035107	397	0.063
cell death	GO:0008219	279	0.063
cellular protein modification process	GO:0006464	438	0.061
regulation of hormone levels	GO:0010817	40	0.061	Rat
very long chain fatty acid biosynthetic process	GO:0042761	2	0.058
response to external biotic stimulus	GO:0043207	293	0.057	Human
organonitrogen compound metabolic process	GO:1901564	318	0.056
detection of stimulus	GO:0051606	156	0.056	Human Fly
appendage development	GO:0048736	401	0.055
single organism biosynthetic process	GO:0044711	206	0.051	Rat Fly
imaginal disc derived wing morphogenesis	GO:0007476	337	0.049
post embryonic appendage morphogenesis	GO:0035120	385	0.049
homeostatic process	GO:0042592	199	0.046
defense response to other organism	GO:0098542	225	0.046
negative regulation of gene expression	GO:0010629	387	0.046
cellular lipid metabolic process	GO:0044255	83	0.045	Fly
organonitrogen compound biosynthetic process	GO:1901566	117	0.043
small molecule biosynthetic process	GO:0044283	37	0.042
ovarian follicle cell development	GO:0030707	248	0.042
regulation of protein metabolic process	GO:0051246	256	0.042
long chain fatty acid biosynthetic process	GO:0042759	1	0.040
microtubule organizing center organization	GO:0031023	168	0.040
vitamin metabolic process	GO:0006766	2	0.039
regulation of cell death	GO:0010941	173	0.038
tube morphogenesis	GO:0035239	191	0.038
immune system process	GO:0002376	347	0.036	Human
regulation of molecular function	GO:0065009	217	0.035	Human
wing disc morphogenesis	GO:0007472	344	0.035
monocarboxylic acid metabolic process	GO:0032787	29	0.035
connective tissue development	GO:0061448	3	0.034
regulation of cellular protein metabolic process	GO:0032268	243	0.034
neuron recognition	GO:0008038	101	0.034
apoptotic process	GO:0006915	159	0.034
regulation of cell cycle	GO:0051726	291	0.034
regulation of localization	GO:0032879	275	0.034	Human Rat
small molecule metabolic process	GO:0044281	305	0.033
regulation of catalytic activity	GO:0050790	185	0.032	Human
intracellular signal transduction	GO:0035556	300	0.032
response to bacterium	GO:0009617	198	0.030	Human
positive regulation of response to stimulus	GO:0048584	323	0.030	Human
spindle organization	GO:0007051	253	0.030
lipid biosynthetic process	GO:0008610	46	0.029	Rat
kidney development	GO:0001822	3	0.029
detection of external stimulus	GO:0009581	66	0.027	Fly
mating behavior	GO:0007617	106	0.027
cellular response to radiation	GO:0071478	52	0.027	Fly
protein modification process	GO:0036211	438	0.027
phosphorylation	GO:0016310	294	0.027
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.027
fatty acid elongation unsaturated fatty acid	GO:0019368	1	0.026
imaginal disc derived appendage development	GO:0048737	399	0.026
organic substance transport	GO:0071702	257	0.026	Human Rat Fly
single organism catabolic process	GO:0044712	228	0.026
neurological system process	GO:0050877	358	0.026
catabolic process	GO:0009056	409	0.026
secondary metabolite biosynthetic process	GO:0044550	24	0.025
regulation of multicellular organismal development	GO:2000026	414	0.025
cell proliferation	GO:0008283	299	0.025
open tracheal system development	GO:0007424	204	0.025
regulation of transport	GO:0051049	181	0.025	Rat
positive regulation of signal transduction	GO:0009967	223	0.024
response to biotic stimulus	GO:0009607	294	0.023	Human
organic substance catabolic process	GO:1901575	308	0.023
programmed cell death	GO:0012501	257	0.023
phototransduction	GO:0007602	52	0.022	Fly
cellular catabolic process	GO:0044248	372	0.022
defense response to bacterium	GO:0042742	178	0.021
oxoacid metabolic process	GO:0043436	103	0.021
endocytosis	GO:0006897	310	0.021	Human Rat Fly
death	GO:0016265	284	0.021
negative regulation of response to stimulus	GO:0048585	258	0.021
regulation of intracellular signal transduction	GO:1902531	236	0.021
renal system development	GO:0072001	72	0.021
carboxylic acid biosynthetic process	GO:0046394	15	0.021
cellular response to chemical stimulus	GO:0070887	199	0.020	Human
response to other organism	GO:0051707	293	0.020	Human
cellular protein localization	GO:0034613	160	0.020
chemical homeostasis	GO:0048878	92	0.020
negative regulation of cell death	GO:0060548	81	0.020
ras protein signal transduction	GO:0007265	88	0.020
sensory organ morphogenesis	GO:0090596	260	0.020
cellular macromolecule localization	GO:0070727	220	0.020
cell migration	GO:0016477	238	0.020
response to organic substance	GO:0010033	284	0.020	Human
vesicle mediated transport	GO:0016192	381	0.020	Human Rat Fly
lipid localization	GO:0010876	54	0.020	Human Rat Fly
respiratory system development	GO:0060541	213	0.020
positive regulation of cell communication	GO:0010647	250	0.020
spindle assembly	GO:0051225	80	0.020
cell division	GO:0051301	248	0.020
positive regulation of macromolecule metabolic process	GO:0010604	405	0.019
secondary metabolic process	GO:0019748	75	0.019
synaptic target recognition	GO:0008039	45	0.019
regulation of cell differentiation	GO:0045595	302	0.019
negative regulation of extracellular matrix disassembly	GO:0010716	1	0.019
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.019
organelle assembly	GO:0070925	198	0.019
positive regulation of molecular function	GO:0044093	136	0.019	Human
organelle fission	GO:0048285	340	0.019
aging	GO:0007568	143	0.019
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.018
epithelial cell differentiation	GO:0030855	322	0.018
positive regulation of multicellular organismal process	GO:0051240	143	0.018
meiotic nuclear division	GO:0007126	151	0.018
macromolecular complex assembly	GO:0065003	256	0.018
regulation of cell development	GO:0060284	215	0.017
defense response	GO:0006952	300	0.017
regulation of programmed cell death	GO:0043067	152	0.017
rhodopsin metabolic process	GO:0046154	10	0.017	Fly
single organism cellular localization	GO:1902580	180	0.017
response to oxygen containing compound	GO:1901700	200	0.017	Human
cell motility	GO:0048870	251	0.017
mesoderm development	GO:0007498	78	0.017
eye morphogenesis	GO:0048592	260	0.017
response to extracellular stimulus	GO:0009991	116	0.017
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.017
actin cytoskeleton organization	GO:0030036	206	0.017
regulation of phosphorus metabolic process	GO:0051174	210	0.017
negative regulation of cellular metabolic process	GO:0031324	382	0.017
epithelium migration	GO:0090132	148	0.016
centrosome organization	GO:0051297	163	0.016
positive regulation of signaling	GO:0023056	243	0.016
sterol homeostasis	GO:0055092	4	0.016
actin filament based process	GO:0030029	220	0.016
mating	GO:0007618	120	0.016
biological adhesion	GO:0022610	138	0.016	Human
segmentation	GO:0035282	207	0.016
fatty acid elongation	GO:0030497	3	0.016
meiotic cell cycle	GO:0051321	171	0.016
regulation of mitotic cell cycle	GO:0007346	190	0.015
regionalization	GO:0003002	416	0.015
defense response to gram negative bacterium	GO:0050829	94	0.015
nuclear division	GO:0000280	332	0.015
ovarian follicle cell migration	GO:0007297	121	0.015
response to reactive oxygen species	GO:0000302	24	0.015
single organism intracellular transport	GO:1902582	207	0.015
protein phosphorylation	GO:0006468	169	0.015
aromatic compound catabolic process	GO:0019439	166	0.015
regulation of hydrolase activity	GO:0051336	97	0.015
regulation of tube architecture open tracheal system	GO:0035152	68	0.015
taxis	GO:0042330	304	0.015	Fly
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.015
positive regulation of phosphorus metabolic process	GO:0010562	139	0.015
epithelial cell development	GO:0002064	274	0.015
regulation of apoptotic process	GO:0042981	130	0.014
maintenance of location	GO:0051235	73	0.014	Human
negative regulation of cell communication	GO:0010648	223	0.014
axonogenesis	GO:0007409	290	0.014
response to nutrient levels	GO:0031667	114	0.014
organic acid biosynthetic process	GO:0016053	15	0.014
negative regulation of cell cycle phase transition	GO:1901988	103	0.014
response to ionizing radiation	GO:0010212	32	0.014
heart development	GO:0007507	82	0.014
cellular amine metabolic process	GO:0044106	12	0.014
body morphogenesis	GO:0010171	2	0.014
response to lipopolysaccharide	GO:0032496	4	0.014	Human
response to oxidative stress	GO:0006979	86	0.014
organonitrogen compound catabolic process	GO:1901565	128	0.013
tissue migration	GO:0090130	155	0.013
axis specification	GO:0009798	167	0.013
detection of abiotic stimulus	GO:0009582	66	0.013	Fly
regulation of neuron differentiation	GO:0045664	103	0.013
cellular response to abiotic stimulus	GO:0071214	58	0.013	Fly
tissue morphogenesis	GO:0048729	297	0.013
camera type eye development	GO:0043010	4	0.013
xenobiotic catabolic process	GO:0042178	1	0.013
posttranscriptional regulation of gene expression	GO:0010608	145	0.013
regulation of intracellular transport	GO:0032386	64	0.013
synaptic transmission	GO:0007268	288	0.013
regulation of nervous system development	GO:0051960	248	0.013
male gamete generation	GO:0048232	201	0.013
transcription from rna polymerase ii promoter	GO:0006366	368	0.013
cytoskeleton dependent cytokinesis	GO:0061640	81	0.013
stem cell differentiation	GO:0048863	117	0.013
amine metabolic process	GO:0009308	12	0.013
lateral inhibition	GO:0046331	206	0.013
neuron projection guidance	GO:0097485	241	0.012
regulation of phosphate metabolic process	GO:0019220	210	0.012
cellular amino acid metabolic process	GO:0006520	61	0.012
tube formation	GO:0035148	21	0.012
positive regulation of cellular protein metabolic process	GO:0032270	118	0.012
fatty acid metabolic process	GO:0006631	20	0.012
positive regulation of phosphate metabolic process	GO:0045937	139	0.012
negative regulation of protein metabolic process	GO:0051248	85	0.012
regulation of response to stress	GO:0080134	200	0.012	Human
protein localization	GO:0008104	284	0.012
forebrain development	GO:0030900	2	0.012
immune effector process	GO:0002252	98	0.012
reproductive behavior	GO:0019098	122	0.012
compound eye morphogenesis	GO:0001745	249	0.012
cytokinesis	GO:0000910	90	0.012
response to organophosphorus	GO:0046683	2	0.012
positive regulation of protein metabolic process	GO:0051247	128	0.012
negative regulation of extracellular matrix organization	GO:1903054	1	0.012
cell recognition	GO:0008037	102	0.012	Human Rat
protein complex assembly	GO:0006461	200	0.012
multi organism reproductive behavior	GO:0044705	121	0.012
gland development	GO:0048732	191	0.012
cellular response to dna damage stimulus	GO:0006974	223	0.012
regulation of defense response	GO:0031347	102	0.011	Human
positive regulation of lipid storage	GO:0010884	4	0.011	Human
skin development	GO:0043588	65	0.011
positive regulation of catalytic activity	GO:0043085	118	0.011	Human
axon development	GO:0061564	297	0.011
antimicrobial humoral response	GO:0019730	99	0.011
pigmentation	GO:0043473	75	0.011	Fly
carbohydrate derivative metabolic process	GO:1901135	217	0.011
hematopoietic progenitor cell differentiation	GO:0002244	1	0.011
androgen metabolic process	GO:0008209	1	0.011	Rat
response to glucose	GO:0009749	2	0.011
negative regulation of rna metabolic process	GO:0051253	251	0.011
small gtpase mediated signal transduction	GO:0007264	88	0.011
cellular ketone metabolic process	GO:0042180	24	0.011
protein localization to organelle	GO:0033365	82	0.011
response to alcohol	GO:0097305	95	0.011
protein complex biogenesis	GO:0070271	201	0.011
positive regulation of phosphorylation	GO:0042327	87	0.011
regulation of cellular component biogenesis	GO:0044087	201	0.011
cell adhesion	GO:0007155	136	0.011
epithelial cell migration	GO:0010631	148	0.010
regulation of cellular ketone metabolic process	GO:0010565	3	0.010
negative regulation of mitotic cell cycle	GO:0045930	109	0.010
eye development	GO:0001654	323	0.010
cytoplasmic transport	GO:0016482	130	0.010
spermatogenesis	GO:0007283	200	0.010
localization of cell	GO:0051674	257	0.010
positive regulation of cellular biosynthetic process	GO:0031328	316	0.010
regulation of neurogenesis	GO:0050767	158	0.010
synapse assembly	GO:0007416	143	0.010
cellular nitrogen compound catabolic process	GO:0044270	165	0.010
regulation of proteolysis	GO:0030162	87	0.010
blastoderm segmentation	GO:0007350	159	0.010
regulation of cellular catabolic process	GO:0031329	157	0.010
ribonucleotide catabolic process	GO:0009261	109	0.010
negative regulation of developmental process	GO:0051093	201	0.010
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.010

emp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.129
nervous system disease	DOID:863	0.041
sensory system disease	DOID:0050155	0.015
eye disease	DOID:5614	0.015
eye and adnexa disease	DOID:1492	0.015
musculoskeletal system disease	DOID:17	0.013
neurodegenerative disease	DOID:1289	0.011
central nervous system disease	DOID:331	0.011

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