IMP: Integrative Multi-species Prediction

Drosophila melanogaster

87 known processes

CG6116 (Dmel_CG6116)

CG6116 gene product from transcript CG6116-RA

(Aliases: Dmel\CG6116,UVRAG)

Entrez: 34735
FLYBASE: FBgn0032499
UniProtKB: M9PD33
UniProtKB: Q9VK07

Process Predictions
Disease Predictions

CG6116 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
autophagic vacuole fusion	GO:0000046	15	0.968
macroautophagy	GO:0016236	42	0.863
organelle membrane fusion	GO:0090174	16	0.862
single organism membrane fusion	GO:0044801	42	0.693
lysosomal transport	GO:0007041	13	0.525
organelle fusion	GO:0048284	46	0.491
single organism catabolic process	GO:0044712	228	0.473
autophagy	GO:0006914	108	0.420
homeostatic process	GO:0042592	199	0.370
membrane fusion	GO:0061025	42	0.344
regulation of protein modification process	GO:0031399	112	0.310
nucleotide metabolic process	GO:0009117	161	0.293
regulation of localization	GO:0032879	275	0.270
regulation of phosphorylation	GO:0042325	147	0.247
protein modification process	GO:0036211	438	0.235
vacuolar transport	GO:0007034	13	0.225
larval midgut histolysis	GO:0035069	22	0.213
notch signaling pathway	GO:0007219	120	0.208
catabolic process	GO:0009056	409	0.203
compound eye development	GO:0048749	307	0.194
cell death	GO:0008219	279	0.181
immune system process	GO:0002376	347	0.177
positive regulation of macromolecule metabolic process	GO:0010604	405	0.168
cellular protein modification process	GO:0006464	438	0.160
cellular catabolic process	GO:0044248	372	0.159
regulation of catabolic process	GO:0009894	170	0.151
regulation of cell development	GO:0060284	215	0.150
organophosphate metabolic process	GO:0019637	195	0.147
cellular response to starvation	GO:0009267	61	0.145
appendage development	GO:0048736	401	0.135
positive regulation of response to stimulus	GO:0048584	323	0.134
ribose phosphate metabolic process	GO:0019693	145	0.127
phosphorylation	GO:0016310	294	0.124
regulation of cell projection organization	GO:0031344	92	0.124
intracellular signal transduction	GO:0035556	300	0.123
immune response regulating signaling pathway	GO:0002764	2	0.112
regulation of cellular protein metabolic process	GO:0032268	243	0.112
regulation of hydrolase activity	GO:0051336	97	0.112
protein modification by small protein conjugation	GO:0032446	79	0.105
regulation of notch signaling pathway	GO:0008593	100	0.102
regulation of intracellular signal transduction	GO:1902531	236	0.101
purine nucleoside metabolic process	GO:0042278	127	0.099
organic substance catabolic process	GO:1901575	308	0.098
eye development	GO:0001654	323	0.097
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.096
larval midgut cell programmed cell death	GO:0035096	19	0.093
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.093
regulation of nervous system development	GO:0051960	248	0.091
positive regulation of cellular component organization	GO:0051130	156	0.091
negative regulation of response to stimulus	GO:0048585	258	0.091
nucleobase containing small molecule metabolic process	GO:0055086	174	0.087
negative regulation of signaling	GO:0023057	219	0.086
death	GO:0016265	284	0.085
regulation of protein metabolic process	GO:0051246	256	0.084
protein transport	GO:0015031	155	0.083
regulation of anatomical structure morphogenesis	GO:0022603	242	0.079
regulation of chromosome organization	GO:0033044	64	0.077
protein acylation	GO:0043543	42	0.072
regulation of response to external stimulus	GO:0032101	115	0.072
regulation of programmed cell death	GO:0043067	152	0.071
proteolysis	GO:0006508	192	0.071
nucleoside phosphate metabolic process	GO:0006753	162	0.069
organonitrogen compound catabolic process	GO:1901565	128	0.067
response to starvation	GO:0042594	97	0.066
regulation of apoptotic process	GO:0042981	130	0.066
cellular pigmentation	GO:0033059	12	0.065
organonitrogen compound metabolic process	GO:1901564	318	0.064
post embryonic appendage morphogenesis	GO:0035120	385	0.064
protein modification by small protein conjugation or removal	GO:0070647	106	0.063
single organism membrane organization	GO:0044802	93	0.063
protein localization	GO:0008104	284	0.063
carbohydrate derivative metabolic process	GO:1901135	217	0.061
regulation of phosphorus metabolic process	GO:0051174	210	0.056
positive regulation of signaling	GO:0023056	243	0.054
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.054
regulation of cell morphogenesis	GO:0022604	163	0.053
actin filament based process	GO:0030029	220	0.052
regulation of cellular localization	GO:0060341	136	0.052
ribonucleotide catabolic process	GO:0009261	109	0.050
cell junction organization	GO:0034330	57	0.050
macromolecule catabolic process	GO:0009057	161	0.050
regulation of vesicle mediated transport	GO:0060627	59	0.050
regulation of autophagy	GO:0010506	62	0.048
cellular homeostasis	GO:0019725	80	0.048
positive regulation of signal transduction	GO:0009967	223	0.048
nucleotide catabolic process	GO:0009166	109	0.047
small molecule metabolic process	GO:0044281	305	0.047
response to nutrient levels	GO:0031667	114	0.047
ribonucleoside metabolic process	GO:0009119	127	0.047
autophagic vacuole assembly	GO:0000045	2	0.046
developmental programmed cell death	GO:0010623	138	0.045
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.045
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.045
purine ribonucleoside catabolic process	GO:0046130	112	0.045
intracellular transport	GO:0046907	228	0.045
tissue morphogenesis	GO:0048729	297	0.044
single organism cellular localization	GO:1902580	180	0.044
actin filament organization	GO:0007015	126	0.043
regulation of response to stress	GO:0080134	200	0.043
purine containing compound metabolic process	GO:0072521	155	0.042
purine nucleotide metabolic process	GO:0006163	146	0.042
nucleoside triphosphate catabolic process	GO:0009143	108	0.042
establishment of localization in cell	GO:0051649	402	0.042
purine ribonucleotide catabolic process	GO:0009154	109	0.041
cellular response to external stimulus	GO:0071496	66	0.041
positive regulation of developmental process	GO:0051094	143	0.041
autophagic cell death	GO:0048102	83	0.041
positive regulation of phosphate metabolic process	GO:0045937	139	0.040
purine containing compound catabolic process	GO:0072523	112	0.040
purine nucleoside catabolic process	GO:0006152	112	0.038
sensory organ morphogenesis	GO:0090596	260	0.038
chromosome segregation	GO:0007059	157	0.037
single organism behavior	GO:0044708	391	0.037
actin cytoskeleton organization	GO:0030036	206	0.037
programmed cell death	GO:0012501	257	0.037
protein catabolic process	GO:0030163	101	0.037
endocytosis	GO:0006897	310	0.036
ovarian follicle cell development	GO:0030707	248	0.035
establishment or maintenance of cell polarity	GO:0007163	167	0.035
organelle localization	GO:0051640	148	0.035
nucleoside phosphate catabolic process	GO:1901292	110	0.035
regulation of neuron differentiation	GO:0045664	103	0.035
vesicle organization	GO:0016050	44	0.035
positive regulation of cellular catabolic process	GO:0031331	95	0.035
purine ribonucleotide metabolic process	GO:0009150	145	0.034
protein maturation	GO:0051604	71	0.034
organophosphate catabolic process	GO:0046434	112	0.033
eye morphogenesis	GO:0048592	260	0.032
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.032
regulation of cell differentiation	GO:0045595	302	0.032
purine ribonucleoside metabolic process	GO:0046128	127	0.032
single organism intracellular transport	GO:1902582	207	0.032
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.031
organelle fission	GO:0048285	340	0.031
gland morphogenesis	GO:0022612	145	0.030
epithelial cell development	GO:0002064	274	0.030
endosomal transport	GO:0016197	44	0.030
cell projection assembly	GO:0030031	94	0.030
tissue death	GO:0016271	102	0.030
negative regulation of cellular component organization	GO:0051129	108	0.030
morphogenesis of a branching epithelium	GO:0061138	45	0.029
histone h4 acetylation	GO:0043967	13	0.028
photoreceptor cell maintenance	GO:0045494	11	0.028
regulation of phosphate metabolic process	GO:0019220	210	0.028
protein ubiquitination	GO:0016567	70	0.028
protein acetylation	GO:0006473	39	0.027
nucleoside catabolic process	GO:0009164	112	0.027
morphogenesis of an epithelium	GO:0002009	276	0.027
chromatin organization	GO:0006325	207	0.027
membrane organization	GO:0061024	112	0.027
open tracheal system development	GO:0007424	204	0.026
wing disc morphogenesis	GO:0007472	344	0.026
guanosine containing compound catabolic process	GO:1901069	74	0.026
immune response activating signal transduction	GO:0002757	2	0.026
vesicle mediated transport	GO:0016192	381	0.026
regulation of epithelial cell proliferation	GO:0050678	4	0.026
histolysis	GO:0007559	102	0.026
notch receptor processing	GO:0007220	13	0.025
imaginal disc derived appendage development	GO:0048737	399	0.025
regulation of cell death	GO:0010941	173	0.025
regulation of ras protein signal transduction	GO:0046578	93	0.025
negative regulation of cellular metabolic process	GO:0031324	382	0.025
retina development in camera type eye	GO:0060041	4	0.024
regulation of cellular catabolic process	GO:0031329	157	0.024
positive regulation of catabolic process	GO:0009896	105	0.024
imaginal disc derived wing morphogenesis	GO:0007476	337	0.023
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.023
immune response	GO:0006955	246	0.023
ras protein signal transduction	GO:0007265	88	0.023
small gtpase mediated signal transduction	GO:0007264	88	0.023
positive regulation of phosphorus metabolic process	GO:0010562	139	0.023
adult behavior	GO:0030534	137	0.022
cytoskeleton dependent cytokinesis	GO:0061640	81	0.022
glycosyl compound metabolic process	GO:1901657	127	0.022
chemical homeostasis	GO:0048878	92	0.022
respiratory system development	GO:0060541	213	0.022
positive regulation of catalytic activity	GO:0043085	118	0.022
axon development	GO:0061564	297	0.022
regulation of immune system process	GO:0002682	176	0.022
pigment metabolic process	GO:0042440	84	0.022
intracellular protein transport	GO:0006886	104	0.021
positive regulation of organelle organization	GO:0010638	65	0.021
ribonucleotide metabolic process	GO:0009259	145	0.021
response to extracellular stimulus	GO:0009991	116	0.021
positive regulation of nervous system development	GO:0051962	69	0.021
stem cell development	GO:0048864	79	0.021
morphogenesis of follicular epithelium	GO:0016333	36	0.020
positive regulation of response to external stimulus	GO:0032103	44	0.020
regulation of neuron projection development	GO:0010975	69	0.020
organic cyclic compound catabolic process	GO:1901361	168	0.019
gland development	GO:0048732	191	0.019
signal transduction by phosphorylation	GO:0023014	107	0.019
macromolecular complex disassembly	GO:0032984	37	0.019
chromatin modification	GO:0016568	147	0.019
anatomical structure homeostasis	GO:0060249	97	0.019
regulation of nucleotide catabolic process	GO:0030811	48	0.019
regulation of cell shape	GO:0008360	113	0.019
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.019
cellular protein localization	GO:0034613	160	0.019
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.019
covalent chromatin modification	GO:0016569	106	0.019
salivary gland histolysis	GO:0035070	88	0.018
chromatin mediated maintenance of transcription	GO:0048096	7	0.018
regulation of catalytic activity	GO:0050790	185	0.018
compound eye morphogenesis	GO:0001745	249	0.018
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.018
taxis	GO:0042330	304	0.018
establishment or maintenance of epithelial cell apical basal polarity	GO:0045197	24	0.018
regulation of purine nucleotide metabolic process	GO:1900542	62	0.018
positive regulation of cellular biosynthetic process	GO:0031328	316	0.017
purine nucleotide catabolic process	GO:0006195	109	0.017
epithelium migration	GO:0090132	148	0.017
apoptotic process	GO:0006915	159	0.017
regulation of endocytosis	GO:0030100	37	0.017
adherens junction organization	GO:0034332	27	0.017
salivary gland development	GO:0007431	162	0.017
localization of cell	GO:0051674	257	0.017
regulation of protein localization	GO:0032880	76	0.017
protein targeting	GO:0006605	64	0.017
regulation of molecular function	GO:0065009	217	0.016
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.016
negative regulation of growth	GO:0045926	84	0.016
dephosphorylation	GO:0016311	51	0.016
endosome to lysosome transport	GO:0008333	7	0.016
negative regulation of epithelial cell proliferation	GO:0050680	4	0.016
growth	GO:0040007	359	0.016
photoreceptor cell development	GO:0042461	96	0.016
camera type eye development	GO:0043010	4	0.016
atp metabolic process	GO:0046034	49	0.016
ameboidal type cell migration	GO:0001667	151	0.015
positive regulation of protein metabolic process	GO:0051247	128	0.015
positive regulation of intracellular signal transduction	GO:1902533	116	0.015
negative regulation of signal transduction	GO:0009968	206	0.015
epithelial tube morphogenesis	GO:0060562	88	0.015
positive regulation of molecular function	GO:0044093	136	0.015
cellular protein catabolic process	GO:0044257	83	0.015
mitotic nuclear division	GO:0007067	213	0.015
regulation of hemocyte proliferation	GO:0035206	37	0.015
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.015
regulation of transport	GO:0051049	181	0.015
establishment of protein localization	GO:0045184	163	0.015
regulation of nucleoside metabolic process	GO:0009118	50	0.014
actin filament based movement	GO:0030048	26	0.014
tube morphogenesis	GO:0035239	191	0.014
appendage morphogenesis	GO:0035107	397	0.014
nucleoside metabolic process	GO:0009116	127	0.014
modification dependent macromolecule catabolic process	GO:0043632	79	0.014
protein complex disassembly	GO:0043241	36	0.014
negative regulation of apoptotic process	GO:0043066	63	0.014
regulation of cellular amino acid metabolic process	GO:0006521	0	0.014
post golgi vesicle mediated transport	GO:0006892	11	0.014
positive regulation of programmed cell death	GO:0043068	62	0.014
inositol lipid mediated signaling	GO:0048017	4	0.014
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.014
glycerophospholipid metabolic process	GO:0006650	23	0.014
regulation of defense response	GO:0031347	102	0.014
response to oxidative stress	GO:0006979	86	0.013
heterocycle catabolic process	GO:0046700	166	0.013
salivary gland cell autophagic cell death	GO:0035071	83	0.013
positive regulation of hydrolase activity	GO:0051345	78	0.013
cellular ketone metabolic process	GO:0042180	24	0.013
positive regulation of cell development	GO:0010720	61	0.013
regulation of nucleotide metabolic process	GO:0006140	62	0.013
positive regulation of exocytosis	GO:0045921	4	0.013
lipid modification	GO:0030258	24	0.013
response to radiation	GO:0009314	155	0.013
negative regulation of cell communication	GO:0010648	223	0.013
stem cell differentiation	GO:0048863	117	0.013
defense response	GO:0006952	300	0.013
regulation of cellular component movement	GO:0051270	42	0.013
organophosphate biosynthetic process	GO:0090407	46	0.012
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.012
regulation of cellular response to stress	GO:0080135	89	0.012
positive regulation of apoptotic process	GO:0043065	47	0.012
histone modification	GO:0016570	106	0.012
carboxylic acid metabolic process	GO:0019752	92	0.012
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.012
regulation of mitosis	GO:0007088	56	0.012
cellular amine metabolic process	GO:0044106	12	0.012
establishment of protein localization to organelle	GO:0072594	62	0.012
hippo signaling	GO:0035329	20	0.012
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.012
negative regulation of cell death	GO:0060548	81	0.011
pigment granule organization	GO:0048753	12	0.011
cellular lipid metabolic process	GO:0044255	83	0.011
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.011
exocrine system development	GO:0035272	162	0.011
negative regulation of phosphorus metabolic process	GO:0010563	45	0.011
synaptic vesicle recycling	GO:0036465	28	0.011
cellular nitrogen compound catabolic process	GO:0044270	165	0.011
regulation of rab protein signal transduction	GO:0032483	7	0.011
hindbrain development	GO:0030902	2	0.011
regulation of cellular amine metabolic process	GO:0033238	3	0.011
protein heterooligomerization	GO:0051291	4	0.011
positive regulation of nucleoside metabolic process	GO:0045979	47	0.011
endomembrane system organization	GO:0010256	119	0.011
regulation of erbb signaling pathway	GO:1901184	42	0.011
carbohydrate derivative catabolic process	GO:1901136	118	0.011
positive regulation of cell differentiation	GO:0045597	64	0.011
sensory perception of sound	GO:0007605	56	0.011
regulation of immune response	GO:0050776	118	0.011
positive regulation of cellular amine metabolic process	GO:0033240	0	0.011
protein phosphorylation	GO:0006468	169	0.011
positive regulation of multicellular organismal process	GO:0051240	143	0.011
regulation of mapk cascade	GO:0043408	92	0.011
positive regulation of binding	GO:0051099	4	0.011
sensory perception	GO:0007600	196	0.011
response to organic substance	GO:0010033	284	0.011
phosphatidylinositol phosphorylation	GO:0046854	10	0.011
endosome organization	GO:0007032	9	0.011
aromatic compound catabolic process	GO:0019439	166	0.011
negative regulation of programmed cell death	GO:0043069	72	0.010
positive regulation of cell death	GO:0010942	69	0.010
cellularization	GO:0007349	90	0.010
cellular amino acid metabolic process	GO:0006520	61	0.010
regulation of cellular component size	GO:0032535	98	0.010
cellular response to extracellular stimulus	GO:0031668	64	0.010
positive regulation of transcription dna templated	GO:0045893	266	0.010
innate immune response	GO:0045087	144	0.010
positive regulation of rna metabolic process	GO:0051254	271	0.010
negative regulation of intracellular signal transduction	GO:1902532	57	0.010
regulation of gtp catabolic process	GO:0033124	44	0.010
lysosome localization	GO:0032418	1	0.010
skin development	GO:0043588	65	0.010
ion transport	GO:0006811	145	0.010
cellular macromolecule localization	GO:0070727	220	0.010
protein localization to organelle	GO:0033365	82	0.010
salivary gland morphogenesis	GO:0007435	145	0.010

CG6116 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.028
disease of cellular proliferation	DOID:14566	0.024
nervous system disease	DOID:863	0.017

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