Drosophila melanogaster

119 known processes

Ire1 (Dmel_CG4583)

Inositol-requiring enzyme-1

(Aliases: dIRE1,Dmel\CG4583,dire-1,ire-1,CG4583,IRE1,Ire-1,IRE-like,Ire)

Ire1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
growthGO:00400073590.119
autophagyGO:00069141080.081
regulation of developmental growthGO:00486381740.066
small molecule metabolic processGO:00442813050.062
regionalizationGO:00030024160.061
organonitrogen compound metabolic processGO:19015643180.058
eye morphogenesisGO:00485922600.055
compound eye developmentGO:00487493070.055
negative regulation of developmental growthGO:0048640640.051
homeostatic processGO:00425921990.050
cellular catabolic processGO:00442483720.048
compound eye morphogenesisGO:00017452490.044
sensory organ morphogenesisGO:00905962600.043
negative regulation of growthGO:0045926840.041
positive regulation of signalingGO:00230562430.040
eye developmentGO:00016543230.040
deathGO:00162652840.040
nucleobase containing compound catabolic processGO:00346551650.039
organic substance transportGO:00717022570.037
ion transmembrane transportGO:00342201220.036
organelle assemblyGO:00709251980.035
cellular macromolecular complex assemblyGO:00346221530.034
macromolecular complex assemblyGO:00650032560.034
ribonucleoside triphosphate metabolic processGO:00091991190.034
cell deathGO:00082192790.033
spindle organizationGO:00070512530.033
regulation of phosphorus metabolic processGO:00511742100.033
negative regulation of developmental processGO:00510932010.032
catabolic processGO:00090564090.032
developmental growthGO:00485892800.032
connective tissue developmentGO:006144830.032
positive regulation of response to stimulusGO:00485843230.031
vesicle mediated transportGO:00161923810.031
regulation of multicellular organismal developmentGO:20000264140.030
regulation of response to stressGO:00801342000.030
camera type eye developmentGO:004301040.030
response to bacteriumGO:00096171980.030
ribonucleoside triphosphate catabolic processGO:00092031080.030
protein complex assemblyGO:00064612000.029
single organism biosynthetic processGO:00447112060.029
organic cyclic compound catabolic processGO:19013611680.029
positive regulation of cell communicationGO:00106472500.028
positive regulation of signal transductionGO:00099672230.028
phagocytosisGO:00069092150.027
enzyme linked receptor protein signaling pathwayGO:00071671790.027
regulation of catabolic processGO:00098941700.026
heterocycle catabolic processGO:00467001660.026
cellular nitrogen compound catabolic processGO:00442701650.026
positive regulation of catabolic processGO:00098961050.026
regulation of intracellular signal transductionGO:19025312360.025
nucleobase containing small molecule metabolic processGO:00550861740.025
ribonucleotide metabolic processGO:00092591450.025
cation homeostasisGO:0055080510.025
carboxylic acid metabolic processGO:0019752920.025
glycosyl compound catabolic processGO:19016581120.025
adult behaviorGO:00305341370.025
intracellular signal transductionGO:00355563000.024
programmed cell deathGO:00125012570.024
negative regulation of multicellular organismal processGO:00512411420.023
positive regulation of cellular biosynthetic processGO:00313283160.023
neurological system processGO:00508773580.023
organic acid metabolic processGO:00060821030.022
multicellular organismal agingGO:00102591400.022
regulation of neurogenesisGO:00507671580.022
organophosphate metabolic processGO:00196371950.022
single organism behaviorGO:00447083910.022
defense response to gram negative bacteriumGO:0050829940.022
endomembrane system organizationGO:00102561190.022
transmembrane transportGO:00550851390.022
cholesterol transportGO:003030120.022
regulation of cellular catabolic processGO:00313291570.022
regulation of notch signaling pathwayGO:00085931000.022
regulation of growthGO:00400082330.022
nitrogen compound transportGO:0071705850.022
immune responseGO:00069552460.022
regulation of stress activated mapk cascadeGO:0032872410.021
nucleoside phosphate metabolic processGO:00067531620.021
lateral inhibitionGO:00463312060.021
small gtpase mediated signal transductionGO:0007264880.020
apoptotic processGO:00069151590.020
regulation of phosphate metabolic processGO:00192202100.020
response to monosaccharideGO:003428440.020
body morphogenesisGO:001017120.020
rna processingGO:00063961470.020
ribonucleoside metabolic processGO:00091191270.020
positive regulation of macromolecule biosynthetic processGO:00105572830.020
aromatic compound catabolic processGO:00194391660.020
single organism catabolic processGO:00447122280.020
regulation of molecular functionGO:00650092170.020
regulation of localizationGO:00328792750.020
ras protein signal transductionGO:0007265880.020
positive regulation of intracellular signal transductionGO:19025331160.020
ribonucleotide catabolic processGO:00092611090.020
mitotic g2 m transition checkpointGO:0044818700.020
positive regulation of molecular functionGO:00440931360.019
segmentationGO:00352822070.019
response to external biotic stimulusGO:00432072930.019
purine ribonucleoside triphosphate catabolic processGO:00092071080.019
protein complex biogenesisGO:00702712010.019
cellular lipid metabolic processGO:0044255830.019
cell proliferationGO:00082832990.019
epithelial cell developmentGO:00020642740.019
regulation of programmed cell deathGO:00430671520.019
oxoacid metabolic processGO:00434361030.018
biological adhesionGO:00226101380.018
ribose phosphate metabolic processGO:00196931450.018
embryonic morphogenesisGO:00485982060.018
negative regulation of nervous system developmentGO:0051961920.018
regulation of phosphorylationGO:00423251470.018
purine nucleoside triphosphate catabolic processGO:00091461080.018
regulation of cell cycle phase transitionGO:19019871300.018
camera type eye morphogenesisGO:004859320.018
lipid metabolic processGO:00066291210.018
nucleoside metabolic processGO:00091161270.018
defense response to bacteriumGO:00427421780.017
glycosyl compound metabolic processGO:19016571270.017
nucleoside catabolic processGO:00091641120.017
positive regulation of phosphate metabolic processGO:00459371390.017
regulation of i kappab kinase nf kappab signalingGO:004312220.017
positive regulation of phosphorus metabolic processGO:00105621390.017
developmental maturationGO:00217001720.017
agingGO:00075681430.017
male gamete generationGO:00482322010.017
ion transportGO:00068111450.017
positive regulation of transcription dna templatedGO:00458932660.017
regulation of synapse assemblyGO:0051963940.017
anterior posterior pattern specificationGO:00099521360.017
establishment of localization in cellGO:00516494020.017
ovarian follicle cell developmentGO:00307072480.017
regulation of transportGO:00510491810.016
purine ribonucleotide metabolic processGO:00091501450.016
single organism intracellular transportGO:19025822070.016
muscle organ developmentGO:00075171270.016
carbohydrate derivative catabolic processGO:19011361180.016
blastoderm segmentationGO:00073501590.016
cation transportGO:00068121100.016
monocarboxylic acid transportGO:001571830.016
multi multicellular organism processGO:00447061230.016
nucleoside phosphate catabolic processGO:19012921100.016
mrna metabolic processGO:00160711240.016
stress activated mapk cascadeGO:0051403520.016
cell adhesionGO:00071551360.016
positive regulation of biosynthetic processGO:00098913160.016
cellular component assembly involved in morphogenesisGO:00109271510.016
imaginal disc derived wing morphogenesisGO:00074763370.015
defense response to other organismGO:00985422250.015
open tracheal system developmentGO:00074242040.015
nucleotide catabolic processGO:00091661090.015
regulation of cell proliferationGO:00421271630.015
establishment of protein localizationGO:00451841630.015
imaginal disc derived appendage developmentGO:00487373990.015
membrane organizationGO:00610241120.015
purine nucleotide metabolic processGO:00061631460.015
positive regulation of cellular catabolic processGO:0031331950.015
response to extracellular stimulusGO:00099911160.015
positive regulation of mapk cascadeGO:0043410630.015
mesenchymal cell differentiationGO:004876210.015
morphogenesis of a polarized epitheliumGO:0001738930.015
regulation of defense responseGO:00313471020.015
single organism cell adhesionGO:0098602470.015
purine nucleoside catabolic processGO:00061521120.015
purine nucleotide catabolic processGO:00061951090.015
phosphorylationGO:00163102940.015
notch signaling pathwayGO:00072191200.015
regulation of stress activated protein kinase signaling cascadeGO:0070302420.015
columnar cuboidal epithelial cell developmentGO:00020662490.015
regulation of cellular component sizeGO:0032535980.014
purine ribonucleoside triphosphate metabolic processGO:00092051190.014
synaptic growth at neuromuscular junctionGO:00511241190.014
mitotic spindle organizationGO:00070522200.014
muscle structure developmentGO:00610612240.014
developmental programmed cell deathGO:00106231380.014
histolysisGO:00075591020.014
neuromuscular junction developmentGO:00075281490.014
positive regulation of macromolecule metabolic processGO:00106044050.014
protein localizationGO:00081042840.014
regulation of cellular response to stressGO:0080135890.014
establishment of rna localizationGO:0051236470.014
endocytosisGO:00068973100.014
carbohydrate derivative metabolic processGO:19011352170.014
regulation of jnk cascadeGO:0046328400.014
organic substance catabolic processGO:19015753080.014
spermatogenesisGO:00072832000.014
cellular macromolecule localizationGO:00707272200.014
g2 dna damage checkpointGO:0031572690.014
mesenchymal cell developmentGO:001403110.014
organonitrogen compound catabolic processGO:19015651280.014
purine containing compound metabolic processGO:00725211550.014
locomotory behaviorGO:00076261760.014
cellular protein complex assemblyGO:0043623710.014
ameboidal type cell migrationGO:00016671510.014
regulation of apoptotic processGO:00429811300.014
positive regulation of phosphorylationGO:0042327870.014
positive regulation of rna biosynthetic processGO:19026802660.014
proteolysisGO:00065081920.014
mrna processingGO:00063971040.014
positive regulation of stem cell differentiationGO:200073830.013
cytoplasmic transportGO:00164821300.013
protein transportGO:00150311550.013
organophosphate catabolic processGO:00464341120.013
regulation of hydrolase activityGO:0051336970.013
columnar cuboidal epithelial cell differentiationGO:00020652560.013
positive regulation of multicellular organismal processGO:00512401430.013
regulation of cellular localizationGO:00603411360.013
chromosome organizationGO:00512763600.013
regulation of epithelial cell proliferationGO:005067840.013
regulation of cell cycleGO:00517262910.013
response to nutrient levelsGO:00316671140.013
imaginal disc growthGO:0007446370.013
purine ribonucleoside metabolic processGO:00461281270.013
regulation of rna splicingGO:0043484690.013
purine ribonucleotide catabolic processGO:00091541090.013
axis specificationGO:00097981670.013
regulation of autophagyGO:0010506620.013
salivary gland cell autophagic cell deathGO:0035071830.013
purine nucleoside metabolic processGO:00422781270.013
regulation of anatomical structure morphogenesisGO:00226032420.013
mushroom body developmentGO:0016319700.013
negative regulation of epithelial cell proliferationGO:005068040.013
appendage morphogenesisGO:00351073970.013
regulation of catalytic activityGO:00507901850.013
mitotic g2 dna damage checkpointGO:0007095690.013
regulation of organ growthGO:0046620420.013
autophagic cell deathGO:0048102830.013
wing disc morphogenesisGO:00074723440.012
actin filament organizationGO:00070151260.012
regulation of cellular ketone metabolic processGO:001056530.012
organ growthGO:0035265560.012
cellular cation homeostasisGO:0030003380.012
golgi vesicle transportGO:0048193270.012
purine nucleoside triphosphate metabolic processGO:00091441190.012
purine containing compound catabolic processGO:00725231120.012
telencephalon developmentGO:002153720.012
regulation of ras protein signal transductionGO:0046578930.012
retina development in camera type eyeGO:006004140.012
gland developmentGO:00487321910.012
water homeostasisGO:003010430.012
cellular response to dna damage stimulusGO:00069742230.012
anterior posterior axis specification embryoGO:00085951030.012
positive regulation of transportGO:0051050920.012
regulation of synapse organizationGO:00508071100.012
stress activated protein kinase signaling cascadeGO:0031098550.012
nucleoside triphosphate catabolic processGO:00091431080.012
post embryonic appendage morphogenesisGO:00351203850.012
innate immune responseGO:00450871440.012
response to glucoseGO:000974920.012
reproductive behaviorGO:00190981220.012
nucleoside triphosphate metabolic processGO:00091411200.012
organonitrogen compound biosynthetic processGO:19015661170.012
positive regulation of nucleobase containing compound metabolic processGO:00459353320.012
regulation of lipid transportGO:003236830.012
jnk cascadeGO:0007254500.012
embryonic pattern specificationGO:00098801740.012
cell cell junction organizationGO:0045216550.012
oocyte axis specificationGO:00073091080.012
response to lipopolysaccharideGO:003249640.012
cellular chemical homeostasisGO:0055082400.011
regulation of purine nucleotide metabolic processGO:1900542620.011
nucleobase containing compound transportGO:0015931560.011
cytoplasm organizationGO:0007028640.011
adult locomotory behaviorGO:0008344760.011
purine ribonucleoside catabolic processGO:00461301120.011
morphogenesis of embryonic epitheliumGO:0016331940.011
epithelial cell differentiationGO:00308553220.011
anterior posterior axis specificationGO:00099481090.011
spindle assemblyGO:0051225800.011
cell agingGO:000756920.011
determination of adult lifespanGO:00083401370.011
nucleotide metabolic processGO:00091171610.011
guanosine containing compound metabolic processGO:1901068740.011
regulation of cell substrate adhesionGO:001081020.011
imaginal disc pattern formationGO:0007447910.011
transcription from rna polymerase ii promoterGO:00063663680.011
establishment of planar polarityGO:0001736870.011
compound eye photoreceptor cell differentiationGO:00017511400.011
wing disc pattern formationGO:0035222660.011
cell cell signaling involved in cell fate commitmentGO:00451682100.011
tripartite regional subdivisionGO:00073511030.011
germ line stem cell maintenanceGO:0030718500.011
protein dna complex subunit organizationGO:0071824860.011
positive regulation of developmental growthGO:0048639620.011
synaptic transmissionGO:00072682880.011
epithelial cell migrationGO:00106311480.011
stem cell differentiationGO:00488631170.010
actin cytoskeleton organizationGO:00300362060.010
actin filament based processGO:00300292200.010
vesicle organizationGO:0016050440.010
eye photoreceptor cell developmentGO:0042462810.010
response to starvationGO:0042594970.010
positive regulation of synaptic growth at neuromuscular junctionGO:0045887260.010
mitotic dna damage checkpointGO:0044773740.010
regulation of mitotic cell cycle phase transitionGO:19019901300.010
regulation of mrna processingGO:0050684710.010
regulation of purine nucleotide catabolic processGO:0033121480.010
rna localizationGO:00064031150.010
positive regulation of catalytic activityGO:00430851180.010
regulation of organelle organizationGO:00330431960.010
adherens junction organizationGO:0034332270.010
atp metabolic processGO:0046034490.010
compound eye photoreceptor developmentGO:0042051780.010
embryonic axis specificationGO:00005781070.010

Ire1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.018
nervous system diseaseDOID:86300.018
cancerDOID:16200.014
disease of cellular proliferationDOID:1456600.014
disease of metabolismDOID:001466700.013
cardiovascular system diseaseDOID:128700.012
vascular diseaseDOID:17800.012
organ system cancerDOID:005068600.011
inherited metabolic disorderDOID:65500.010