Drosophila melanogaster

0 known processes

Bace (Dmel_CG13095)

beta-site APP-cleaving enzyme

(Aliases: CG13095,anon-WO0140519.142,dBACE,Dmel\CG13095)

Bace biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of response to stimulusGO:00485852580.090
kidney developmentGO:000182230.086
immune system processGO:00023763470.081
Human Rat
regulation of localizationGO:00328792750.080
response to bacteriumGO:00096171980.079
Fly
regulation of response to stressGO:00801342000.071
response to biotic stimulusGO:00096072940.066
Fly
defense response to gram negative bacteriumGO:0050829940.063
Fly
deathGO:00162652840.062
Fly
sterol homeostasisGO:005509240.059
regulation of immune system processGO:00026821760.059
response to organic substanceGO:00100332840.059
Yeast
response to temperature stimulusGO:00092661060.054
lateral inhibitionGO:00463312060.053
phospholipid homeostasisGO:005509110.051
gland developmentGO:00487321910.049
Fly
response to external biotic stimulusGO:00432072930.048
Fly
imaginal disc derived appendage morphogenesisGO:00351143950.048
Fly
homeostatic processGO:00425921990.047
regulation of transportGO:00510491810.047
gland morphogenesisGO:00226121450.046
Fly
macromolecular complex assemblyGO:00650032560.045
positive regulation of biosynthetic processGO:00098913160.045
epithelial cell differentiationGO:00308553220.044
Fly
regulation of defense responseGO:00313471020.043
camera type eye developmentGO:004301040.041
appendage developmentGO:00487364010.041
Fly
cellular component assembly involved in morphogenesisGO:00109271510.038
Fly
wing disc morphogenesisGO:00074723440.038
Fly
cell deathGO:00082192790.037
Fly
endomembrane system organizationGO:00102561190.037
kidney epithelium developmentGO:007207330.037
exocrine system developmentGO:00352721620.034
Fly
cellular response to organic substanceGO:00713101320.033
Yeast
vesicle mediated transportGO:00161923810.033
regulation of cellular amine metabolic processGO:003323830.032
organic acid metabolic processGO:00060821030.032
protein complex biogenesisGO:00702712010.032
cell cell signaling involved in cell fate commitmentGO:00451682100.032
defense response to other organismGO:00985422250.032
Fly
anatomical structure homeostasisGO:0060249970.031
imaginal disc derived appendage developmentGO:00487373990.031
Fly
programmed cell deathGO:00125012570.031
Fly
positive regulation of response to stimulusGO:00485843230.031
protein modification processGO:00362114380.031
developmental programmed cell deathGO:00106231380.030
Fly
autophagyGO:00069141080.030
response to oxygen containing compoundGO:19017002000.030
intracellular protein transportGO:00068861040.030
salivary gland morphogenesisGO:00074351450.030
Fly
positive regulation of nitrogen compound metabolic processGO:00511733540.029
proteolysisGO:00065081920.029
Human Yeast Rat
appendage morphogenesisGO:00351073970.029
Fly
regulation of anatomical structure morphogenesisGO:00226032420.029
very long chain fatty acid metabolic processGO:000003840.029
cell recognitionGO:00080371020.029
regulation of cellular localizationGO:00603411360.029
regulation of cellular component biogenesisGO:00440872010.028
cholesterol homeostasisGO:004263230.027
positive regulation of cellular biosynthetic processGO:00313283160.027
cellular protein modification processGO:00064644380.027
regulation of multicellular organismal developmentGO:20000264140.027
membrane organizationGO:00610241120.027
phagocytosisGO:00069092150.027
negative regulation of multicellular organismal processGO:00512411420.026
single organism cellular localizationGO:19025801800.026
endocytosisGO:00068973100.026
synaptic growth at neuromuscular junctionGO:00511241190.026
histolysisGO:00075591020.026
Fly
negative regulation of cell communicationGO:00106482230.026
sensory organ morphogenesisGO:00905962600.026
protein complex assemblyGO:00064612000.025
protein ubiquitinationGO:0016567700.025
eye developmentGO:00016543230.025
regulation of immune responseGO:00507761180.025
body morphogenesisGO:001017120.025
protein modification by small protein conjugationGO:0032446790.025
chemical homeostasisGO:0048878920.024
response to mechanical stimulusGO:0009612280.024
single organism behaviorGO:00447083910.024
connective tissue developmentGO:006144830.024
telencephalon developmentGO:002153720.023
response to organic cyclic compoundGO:0014070890.023
developmental maturationGO:00217001720.023
post embryonic appendage morphogenesisGO:00351203850.023
Fly
macromolecule catabolic processGO:00090571610.023
growthGO:00400073590.023
cellular macromolecule localizationGO:00707272200.023
salivary gland developmentGO:00074311620.022
Fly
regulation of autophagyGO:0010506620.022
catabolic processGO:00090564090.022
Yeast
cellular amine metabolic processGO:0044106120.022
establishment of localization in cellGO:00516494020.022
positive regulation of macromolecule metabolic processGO:00106044050.022
carboxylic acid metabolic processGO:0019752920.022
camera type eye morphogenesisGO:004859320.021
multicellular organismal homeostasisGO:0048871410.021
actin filament organizationGO:00070151260.021
compound eye morphogenesisGO:00017452490.021
cell proliferationGO:00082832990.021
anion transportGO:0006820410.021
single organism membrane organizationGO:0044802930.021
hindbrain developmentGO:003090220.021
protein modification by small protein conjugation or removalGO:00706471060.021
single organism biosynthetic processGO:00447112060.021
regulation of protein metabolic processGO:00512462560.021
regulation of intracellular signal transductionGO:19025312360.021
cellular protein complex assemblyGO:0043623710.021
ethanolamine containing compound metabolic processGO:004243940.021
positive regulation of rna biosynthetic processGO:19026802660.021
columnar cuboidal epithelial cell differentiationGO:00020652560.021
Fly
long chain fatty acid metabolic processGO:000167630.020
positive regulation of signal transductionGO:00099672230.020
positive regulation of protein transportGO:0051222370.020
positive regulation of multicellular organismal processGO:00512401430.020
response to other organismGO:00517072930.020
Fly
immune responseGO:00069552460.020
tissue homeostasisGO:0001894360.020
negative regulation of signal transductionGO:00099682060.020
positive regulation of signalingGO:00230562430.020
developmental inductionGO:003112830.020
mitotic spindle organizationGO:00070522200.020
regulation of developmental growthGO:00486381740.020
cell cycle phase transitionGO:00447701400.019
embryonic pattern specificationGO:00098801740.019
synapse organizationGO:00508081960.019
negative regulation of signalingGO:00230572190.019
cellular protein localizationGO:00346131600.019
acylglycerol biosynthetic processGO:004646320.019
activation of innate immune responseGO:000221840.019
cellular catabolic processGO:00442483720.019
Yeast
response to copper ionGO:004668840.019
oxoacid metabolic processGO:00434361030.019
protein transportGO:00150311550.019
proteolysis involved in cellular protein catabolic processGO:0051603830.019
developmental growthGO:00485892800.019
organic substance catabolic processGO:19015753080.019
Yeast
chromatin organizationGO:00063252070.019
response to endogenous stimulusGO:00097191190.019
positive regulation of transcription dna templatedGO:00458932660.018
axis specificationGO:00097981670.018
eye morphogenesisGO:00485922600.018
chromosome organizationGO:00512763600.018
apoptotic processGO:00069151590.018
Fly
regionalizationGO:00030024160.018
organic substance transportGO:00717022570.018
regulation of synapse structure and activityGO:00508031280.018
positive regulation of cell communicationGO:00106472500.018
developmental cell growthGO:0048588520.018
cellular macromolecule catabolic processGO:00442651360.018
columnar cuboidal epithelial cell developmentGO:00020662490.017
Fly
positive regulation of macromolecule biosynthetic processGO:00105572830.017
response to nitrogen compoundGO:1901698900.017
synaptic transmissionGO:00072682880.017
outflow tract morphogenesisGO:000315140.017
negative regulation of developmental processGO:00510932010.017
compound eye developmentGO:00487493070.017
learningGO:0007612750.017
forebrain developmentGO:003090020.017
chorion containing eggshell formationGO:00073041050.017
Fly
cellular amino acid metabolic processGO:0006520610.017
single organism intracellular transportGO:19025822070.017
adult behaviorGO:00305341370.017
positive regulation of transportGO:0051050920.017
regulation of protein transportGO:0051223570.016
negative regulation of defense responseGO:0031348350.016
regulation of cellular response to stressGO:0080135890.016
regulation of transcription from rna polymerase ii promoterGO:00063573780.016
cell migrationGO:00164772380.016
regulation of cellular response to oxidative stressGO:190040740.016
regulation of cellular amino acid metabolic processGO:000652100.016
innate immune responseGO:00450871440.016
rhythmic processGO:00485111060.016
renal system developmentGO:0072001720.016
eggshell formationGO:00307031050.016
Fly
epithelial cell developmentGO:00020642740.016
Fly
intracellular transportGO:00469072280.016
regulation of lipid storageGO:0010883220.016
intracellular signal transductionGO:00355563000.016
defense responseGO:00069523000.016
Fly
regulation of cellular protein metabolic processGO:00322682430.016
positive regulation of intracellular protein transportGO:0090316300.016
negative regulation of cell differentiationGO:00455961430.016
nephron epithelium developmentGO:007200930.016
positive regulation of intracellular transportGO:0032388420.016
anion homeostasisGO:005508130.016
positive regulation of axonogenesisGO:005077220.015
cell motilityGO:00488702510.015
cellular response to dna damage stimulusGO:00069742230.015
regulation of cellular catabolic processGO:00313291570.015
cell maturationGO:00484691440.015
positive regulation of nucleic acid templated transcriptionGO:19035082660.015
regulation of cell cycleGO:00517262910.015
regulation of molecular functionGO:00650092170.015
response to coldGO:0009409130.015
autophagic cell deathGO:0048102830.015
Fly
phosphorylationGO:00163102940.015
ovarian follicle cell developmentGO:00307072480.015
Fly
mitotic cell cycle phase transitionGO:00447721380.015
negative regulation of developmental growthGO:0048640640.015
regulation of innate immune responseGO:0045088710.015
circadian rhythmGO:00076231050.015
positive regulation of developmental processGO:00510941430.015
regulation of intracellular transportGO:0032386640.015
establishment of protein localizationGO:00451841630.015
protein catabolic processGO:00301631010.015
response to organonitrogen compoundGO:0010243750.014
notch signaling pathwayGO:00072191200.014
positive regulation of nucleobase containing compound metabolic processGO:00459353320.014
amine metabolic processGO:0009308120.014
cellular protein catabolic processGO:0044257830.014
cellular response to chemical stimulusGO:00708871990.014
Yeast
regulation of catabolic processGO:00098941700.014
cellular macromolecular complex assemblyGO:00346221530.014
regulation of cell cycle processGO:00105641810.014
kidney morphogenesisGO:006099330.014
enzyme linked receptor protein signaling pathwayGO:00071671790.014
localization of cellGO:00516742570.014
negative regulation of cellular component organizationGO:00511291080.014
negative regulation of gene expressionGO:00106293870.014
taxisGO:00423303040.014
fatty acid biosynthetic processGO:000663360.014
negative regulation of nervous system developmentGO:0051961920.014
phosphatidylethanolamine metabolic processGO:004633710.014
developmental pigmentationGO:0048066680.014
nephron tubule developmentGO:007208030.013
positive regulation of cell developmentGO:0010720610.013
positive regulation of cell migrationGO:003033520.013
regulation of gene expression epigeneticGO:00400291280.013
negative regulation of immune responseGO:0050777390.013
regulation of vesicle mediated transportGO:0060627590.013
cell projection assemblyGO:0030031940.013
regulation of cell differentiationGO:00455953020.013
blastoderm segmentationGO:00073501590.013
small molecule metabolic processGO:00442813050.013
tissue deathGO:00162711020.013
Fly
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.013
regulation of notch signaling pathwayGO:00085931000.013
cellular response to starvationGO:0009267610.013
positive regulation of protein metabolic processGO:00512471280.013
tripartite regional subdivisionGO:00073511030.013
segmentationGO:00352822070.013
regulation of cell deathGO:00109411730.013
triglyceride biosynthetic processGO:001943220.013
protein localizationGO:00081042840.013
signal transduction by phosphorylationGO:00230141070.013
modification dependent protein catabolic processGO:0019941780.013
salivary gland cell autophagic cell deathGO:0035071830.013
Fly
regulation of epithelial cell proliferationGO:005067840.013
cellular lipid metabolic processGO:0044255830.013
regulation of protein localizationGO:0032880760.013
oocyte maturationGO:000155630.013
negative regulation of immune system processGO:0002683500.013
positive regulation of intracellular signal transductionGO:19025331160.013
urogenital system developmentGO:0001655720.012
negative regulation of cellular response to oxidative stressGO:190040810.012
salivary gland histolysisGO:0035070880.012
Fly
chromatin modificationGO:00165681470.012
neuromuscular junction developmentGO:00075281490.012
extrinsic apoptotic signaling pathwayGO:009719110.012
tissue morphogenesisGO:00487292970.012
Fly
reproductive behaviorGO:00190981220.012
response to lipopolysaccharideGO:003249640.012
pyridine containing compound metabolic processGO:007252430.012
lipid metabolic processGO:00066291210.012
protein polymerizationGO:0051258420.012
ion transmembrane transportGO:00342201220.012
locomotory behaviorGO:00076261760.012
compound eye photoreceptor cell differentiationGO:00017511400.012
negative regulation of nitrogen compound metabolic processGO:00511722650.012
positive regulation of reactive oxygen species metabolic processGO:200037900.012
limb developmentGO:006017310.012
regulation of epithelial cell differentiationGO:003085640.012
regulation of cell morphogenesisGO:00226041630.012
positive regulation of i kappab kinase nf kappab signalingGO:004312310.012
nephron developmentGO:007200630.012
regulation of organelle organizationGO:00330431960.012
axon developmentGO:00615642970.012
embryonic axis specificationGO:00005781070.012
regulation of heart morphogenesisGO:200082630.012
posttranscriptional regulation of gene expressionGO:00106081450.012
regulation of cytoplasmic transportGO:1903649470.012
courtship behaviorGO:0007619680.012
regulation of cell substrate adhesionGO:001081020.012
epidermal cell differentiationGO:0009913510.012
Fly
protein localization to plasma membraneGO:0072659130.012
regulation of catalytic activityGO:00507901850.012
negative regulation of cell developmentGO:0010721620.012
ribonucleoside triphosphate metabolic processGO:00091991190.011
lipid storageGO:0019915380.011
positive regulation of cellular amine metabolic processGO:003324000.011
organophosphate catabolic processGO:00464341120.011
ion transportGO:00068111450.011
organelle fissionGO:00482853400.011
regulation of organ formationGO:000315630.011
monocarboxylic acid transportGO:001571830.011
eye photoreceptor cell developmentGO:0042462810.011
spinal cord developmentGO:002151010.011
limb morphogenesisGO:003510810.011
regulation of response to oxidative stressGO:190288240.011
cuticle developmentGO:0042335860.011
retina development in camera type eyeGO:006004140.011
anterior posterior pattern specificationGO:00099521360.011
gene silencingGO:00164581380.011
nucleus localizationGO:0051647340.011
somatic muscle developmentGO:0007525660.011
immune effector processGO:0002252980.011
rna processingGO:00063961470.011
cranial nerve developmentGO:002154510.011
multicellular organismal reproductive behaviorGO:00330571100.011
cytoplasmic transportGO:00164821300.011
mushroom body developmentGO:0016319700.011
pigmentationGO:0043473750.011
nephron epithelium morphogenesisGO:007208830.011
regulation of synapse assemblyGO:0051963940.011
imaginal disc derived wing morphogenesisGO:00074763370.011
Fly
chemosensory behaviorGO:00076351060.011
small molecule biosynthetic processGO:0044283370.011
endodermal cell fate commitmentGO:000171130.011
cellular response to mechanical stimulusGO:007126020.011
l amino acid importGO:004309220.010
brain developmentGO:00074201200.010
negative regulation of rna metabolic processGO:00512532510.010
maintenance of locationGO:0051235730.010
regulation of cellular ketone metabolic processGO:001056530.010
axis elongationGO:000340130.010
response to abiotic stimulusGO:00096283410.010
regulation of proteolysisGO:0030162870.010
ubiquitin dependent protein catabolic processGO:0006511780.010
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.010
social behaviorGO:003517640.010
regulation of mitotic cell cycle phase transitionGO:19019901300.010
dorsal appendage formationGO:0046843470.010
morphogenesis of an epitheliumGO:00020092760.010
Fly
cellular response to extracellular stimulusGO:0031668640.010
regulation of response to dna damage stimulusGO:2001020230.010
regulation of protein modification processGO:00313991120.010
cognitionGO:00508901410.010
response to alcoholGO:0097305950.010
regulation of protein modification by small protein conjugation or removalGO:1903320250.010
mitotic g2 dna damage checkpointGO:0007095690.010
developmental growth involved in morphogenesisGO:0060560650.010
eggshell chorion assemblyGO:0007306660.010
Fly

Bace disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
hypophosphatasiaDOID:1421300.178
disease of metabolismDOID:001466700.070
acquired metabolic diseaseDOID:006015800.065
disease of anatomical entityDOID:700.059
familial visceral amyloidosisDOID:005063600.027
amyloidosisDOID:912000.027
familial hyperlipidemiaDOID:116800.021
inherited metabolic disorderDOID:65500.021
lipid metabolism disorderDOID:314600.021
familial combined hyperlipidemiaDOID:1380900.021
nervous system diseaseDOID:86300.018
sensory system diseaseDOID:005015500.018
carbohydrate metabolism diseaseDOID:005001300.015
glucose metabolism diseaseDOID:419400.015
diabetes mellitusDOID:935100.014
disease of cellular proliferationDOID:1456600.013
type 2 diabetes mellitusDOID:935200.013
cancerDOID:16200.011
cardiovascular system diseaseDOID:128700.011
eye and adnexa diseaseDOID:149200.010
eye diseaseDOID:561400.010