IMP: Integrative Multi-species Prediction

Drosophila melanogaster

45 known processes

Optix (Dmel_CG18455)

CG18455 gene product from transcript CG18455-RA

(Aliases: opt,OPTIX,opx,D-Six3,Six3,optix,Dmel\CG18455,CG18455,Dsix3,anon-WO0153538.79)

Entrez: 44108
FLYBASE: FBgn0025360
UniProtKB: Q95RW8

Process Predictions
Disease Predictions

Optix biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.943	Human Mouse
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.924	Mouse Fly
negative regulation of rna metabolic process	GO:0051253	251	0.923	Human Mouse
negative regulation of rna biosynthetic process	GO:1902679	240	0.868	Human Mouse
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.832	Human Mouse
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.818	Human Mouse
positive regulation of transcription dna templated	GO:0045893	266	0.813	Mouse Fly
negative regulation of transcription dna templated	GO:0045892	237	0.803	Human Mouse
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.778	Mouse Fly
eye antennal disc development	GO:0035214	60	0.775
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.772	Mouse Fly
negative regulation of cellular metabolic process	GO:0031324	382	0.761	Human Mouse
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.753	Human Mouse
negative regulation of biosynthetic process	GO:0009890	277	0.732	Human Mouse
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.731	Mouse Fly
positive regulation of rna metabolic process	GO:0051254	271	0.719	Mouse Fly
dendrite morphogenesis	GO:0048813	199	0.715
transcription from rna polymerase ii promoter	GO:0006366	368	0.707	Mouse Fly
negative regulation of cellular biosynthetic process	GO:0031327	277	0.682	Human Mouse
dendrite development	GO:0016358	204	0.658
leg disc development	GO:0035218	92	0.620
positive regulation of gene expression	GO:0010628	290	0.612	Mouse Fly
negative regulation of gene expression	GO:0010629	387	0.541	Human Mouse
positive regulation of rna biosynthetic process	GO:1902680	266	0.520	Mouse Fly
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.519	Human Mouse
imaginal disc derived appendage development	GO:0048737	399	0.496
post embryonic appendage morphogenesis	GO:0035120	385	0.474
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.473	Mouse Fly
compound eye development	GO:0048749	307	0.468
blastoderm segmentation	GO:0007350	159	0.448
regionalization	GO:0003002	416	0.444	Human Mouse
tube development	GO:0035295	244	0.440
regulation of cell differentiation	GO:0045595	302	0.436	Mouse
embryonic pattern specification	GO:0009880	174	0.435
renal tubule development	GO:0061326	64	0.424
sensory organ morphogenesis	GO:0090596	260	0.399
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.391
appendage development	GO:0048736	401	0.391
wing disc morphogenesis	GO:0007472	344	0.383
positive regulation of cellular biosynthetic process	GO:0031328	316	0.369	Mouse Fly
morphogenesis of an epithelium	GO:0002009	276	0.365
positive regulation of biosynthetic process	GO:0009891	316	0.344	Mouse Fly
circadian rhythm	GO:0007623	105	0.339	Mouse Fly
segment specification	GO:0007379	33	0.329
regulation of neuron differentiation	GO:0045664	103	0.311	Mouse
appendage morphogenesis	GO:0035107	397	0.286
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.286
wnt signaling pathway	GO:0016055	98	0.280	Mouse
embryonic morphogenesis	GO:0048598	206	0.268	Zebrafish Mouse Fly
eye development	GO:0001654	323	0.265
digestive tract development	GO:0048565	149	0.258
muscle structure development	GO:0061061	224	0.257	Fly
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.252	Mouse Fly
anterior posterior pattern specification	GO:0009952	136	0.246	Mouse
positive regulation of macromolecule metabolic process	GO:0010604	405	0.244	Mouse Fly
embryonic organ development	GO:0048568	50	0.236	Zebrafish Mouse
kidney morphogenesis	GO:0060993	3	0.234
tissue morphogenesis	GO:0048729	297	0.234	Mouse
wing disc pattern formation	GO:0035222	66	0.200
sensory perception	GO:0007600	196	0.199
segmentation	GO:0035282	207	0.192
antennal development	GO:0007469	25	0.185
imaginal disc pattern formation	GO:0007447	91	0.184
kidney development	GO:0001822	3	0.183
proximal distal pattern formation	GO:0009954	15	0.168	Mouse
muscle tissue development	GO:0060537	30	0.165
head development	GO:0060322	135	0.154	Human Zebrafish Mouse
imaginal disc derived wing morphogenesis	GO:0007476	337	0.142
compound eye morphogenesis	GO:0001745	249	0.142
axonogenesis	GO:0007409	290	0.138
embryo development ending in birth or egg hatching	GO:0009792	152	0.135	Worm
urogenital system development	GO:0001655	72	0.128
negative regulation of cell differentiation	GO:0045596	143	0.123	Mouse
retinal cone cell differentiation	GO:0042670	2	0.121
epithelial cell differentiation	GO:0030855	322	0.120	Mouse
neuron projection guidance	GO:0097485	241	0.119
regulation of localization	GO:0032879	275	0.116
regulation of anatomical structure morphogenesis	GO:0022603	242	0.115
camera type eye photoreceptor cell differentiation	GO:0060219	2	0.112
axon development	GO:0061564	297	0.111
stem cell differentiation	GO:0048863	117	0.111	Mouse
epithelial cell development	GO:0002064	274	0.107	Mouse
midgut development	GO:0007494	23	0.105
renal system development	GO:0072001	72	0.104
muscle cell fate commitment	GO:0042693	14	0.101
muscle cell differentiation	GO:0042692	103	0.101	Fly
dorsal ventral pattern formation	GO:0009953	133	0.100	Human
digestive system development	GO:0055123	149	0.100
regulation of photoreceptor cell differentiation	GO:0046532	34	0.098
mesenchymal cell differentiation	GO:0048762	1	0.098
kidney epithelium development	GO:0072073	3	0.097
embryonic development via the syncytial blastoderm	GO:0001700	148	0.095
protein localization	GO:0008104	284	0.094	Mouse
camera type eye morphogenesis	GO:0048593	2	0.093	Zebrafish Mouse
regulation of r7 cell differentiation	GO:0045676	15	0.093
negative regulation of multicellular organismal process	GO:0051241	142	0.089	Mouse
larval development	GO:0002164	104	0.088	Worm
malpighian tubule development	GO:0072002	64	0.085
feeding behavior	GO:0007631	50	0.080
specification of segmental identity head	GO:0007380	11	0.076
rhythmic process	GO:0048511	106	0.076	Mouse Fly
head segmentation	GO:0035287	13	0.074
stem cell development	GO:0048864	79	0.073
mushroom body development	GO:0016319	70	0.072
localization of cell	GO:0051674	257	0.070	Mouse Fly
negative regulation of signal transduction	GO:0009968	206	0.069	Mouse
compound eye photoreceptor cell differentiation	GO:0001751	140	0.069
regulation of nervous system development	GO:0051960	248	0.068	Mouse
neuron fate specification	GO:0048665	12	0.065
eye photoreceptor cell development	GO:0042462	81	0.064
retina development in camera type eye	GO:0060041	4	0.061	Zebrafish Mouse
epidermis development	GO:0008544	65	0.061
peripheral nervous system development	GO:0007422	52	0.060
ocellus development	GO:0008056	4	0.060
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.060
spermatogenesis	GO:0007283	200	0.057	Fly
retina morphogenesis in camera type eye	GO:0060042	2	0.057
compound eye cone cell fate commitment	GO:0042676	5	0.057
establishment or maintenance of cell polarity	GO:0007163	167	0.057
neurological system process	GO:0050877	358	0.056
negative regulation of nervous system development	GO:0051961	92	0.056	Mouse
epithelial tube morphogenesis	GO:0060562	88	0.055
negative regulation of cell development	GO:0010721	62	0.054	Mouse
positive regulation of developmental process	GO:0051094	143	0.053
gliogenesis	GO:0042063	80	0.053	Fly
cell fate specification	GO:0001708	71	0.051
branching morphogenesis of an epithelial tube	GO:0048754	45	0.051
single organism behavior	GO:0044708	391	0.051
cellular protein modification process	GO:0006464	438	0.050
positive regulation of cell differentiation	GO:0045597	64	0.049
negative regulation of neurogenesis	GO:0050768	53	0.048	Mouse
regulation of multicellular organismal development	GO:2000026	414	0.048	Mouse
developmental maturation	GO:0021700	172	0.047	Mouse
photoreceptor cell differentiation	GO:0046530	170	0.046
stem cell maintenance	GO:0019827	67	0.046
central nervous system development	GO:0007417	201	0.046	Human Zebrafish Mouse
cell motility	GO:0048870	251	0.046	Mouse Fly
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.045
sensory perception of mechanical stimulus	GO:0050954	72	0.044
negative regulation of signaling	GO:0023057	219	0.044	Mouse
skin development	GO:0043588	65	0.044
negative regulation of developmental process	GO:0051093	201	0.042	Mouse
endocytosis	GO:0006897	310	0.042
negative regulation of response to stimulus	GO:0048585	258	0.042	Mouse
single organism intracellular transport	GO:1902582	207	0.041	Mouse
compound eye photoreceptor development	GO:0042051	78	0.040
outflow tract morphogenesis	GO:0003151	4	0.040
nephron morphogenesis	GO:0072028	3	0.040
cellular protein localization	GO:0034613	160	0.039	Mouse
connective tissue development	GO:0061448	3	0.039	Fly
ras protein signal transduction	GO:0007265	88	0.037
regulation of cell proliferation	GO:0042127	163	0.037	Mouse
sex differentiation	GO:0007548	81	0.037	Fly
equator specification	GO:0045317	4	0.036
leg disc proximal distal pattern formation	GO:0007479	9	0.036
axon guidance	GO:0007411	233	0.036
body morphogenesis	GO:0010171	2	0.036	Worm
camera type eye development	GO:0043010	4	0.035	Zebrafish Mouse
posttranscriptional regulation of gene expression	GO:0010608	145	0.034
notch signaling pathway	GO:0007219	120	0.034
molting cycle	GO:0042303	56	0.034
photoreceptor cell fate commitment	GO:0046552	41	0.034
protein modification process	GO:0036211	438	0.034
photoreceptor cell fate specification	GO:0043704	9	0.033
forebrain development	GO:0030900	2	0.033	Human Mouse
gland development	GO:0048732	191	0.033	Mouse Fly
neural retina development	GO:0003407	4	0.033	Zebrafish Mouse
proximal distal pattern formation imaginal disc	GO:0007449	11	0.033
developmental growth	GO:0048589	280	0.032	Zebrafish
eye morphogenesis	GO:0048592	260	0.032
photoreceptor cell development	GO:0042461	96	0.032
respiratory system development	GO:0060541	213	0.032
reproductive system development	GO:0061458	74	0.032	Fly
cell proliferation	GO:0008283	299	0.032	Zebrafish Mouse
notum cell fate specification	GO:0035310	5	0.031
establishment of ommatidial planar polarity	GO:0042067	49	0.031
ribonucleotide metabolic process	GO:0009259	145	0.031
regulation of organ morphogenesis	GO:2000027	78	0.031
cellular component assembly involved in morphogenesis	GO:0010927	151	0.031
regulation of muscle cell differentiation	GO:0051147	8	0.031
taxis	GO:0042330	304	0.031
regulation of compound eye cone cell fate specification	GO:0042682	4	0.031
phagocytosis	GO:0006909	215	0.030
leg disc pattern formation	GO:0035223	11	0.030
specification of segmental identity trunk	GO:0035292	7	0.029
regulation of neurogenesis	GO:0050767	158	0.029	Mouse
regulation of anatomical structure size	GO:0090066	163	0.028
male gamete generation	GO:0048232	201	0.028	Fly
sensory neuron axon guidance	GO:0097374	2	0.028
morphogenesis of a branching structure	GO:0001763	45	0.027
dendrite guidance	GO:0070983	21	0.027
neuron recognition	GO:0008038	101	0.027
chorion containing eggshell formation	GO:0007304	105	0.027
vesicle mediated transport	GO:0016192	381	0.027
negative regulation of cell communication	GO:0010648	223	0.026	Mouse
carbohydrate derivative metabolic process	GO:1901135	217	0.026
chemotaxis	GO:0006935	249	0.026
cell recognition	GO:0008037	102	0.026
organonitrogen compound metabolic process	GO:1901564	318	0.026
regulation of transport	GO:0051049	181	0.025
morphogenesis of a polarized epithelium	GO:0001738	93	0.025
reproductive structure development	GO:0048608	74	0.025	Fly
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.025
brain development	GO:0007420	120	0.025	Human Zebrafish Mouse
compound eye cone cell differentiation	GO:0042675	13	0.024
r7 cell differentiation	GO:0045466	43	0.024
hyperosmotic salinity response	GO:0042538	1	0.024
response to organic substance	GO:0010033	284	0.024
adult behavior	GO:0030534	137	0.024
organophosphate metabolic process	GO:0019637	195	0.023
spinal cord development	GO:0021510	1	0.023
response to alcohol	GO:0097305	95	0.023
homeostatic process	GO:0042592	199	0.023
regulation of cell development	GO:0060284	215	0.023	Mouse
regulation of phosphate metabolic process	GO:0019220	210	0.023
cell migration	GO:0016477	238	0.022	Mouse Fly
musculoskeletal movement	GO:0050881	3	0.022
eye photoreceptor cell differentiation	GO:0001754	145	0.022
regulation of protein modification process	GO:0031399	112	0.022
nephron tubule development	GO:0072080	3	0.022
chromatin organization	GO:0006325	207	0.022
response to biotic stimulus	GO:0009607	294	0.022
regulation of growth	GO:0040008	233	0.022
development of primary female sexual characteristics	GO:0046545	12	0.021
regulation of cellular protein metabolic process	GO:0032268	243	0.021
neuron maturation	GO:0042551	31	0.021
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.021
somatic muscle development	GO:0007525	66	0.021
small molecule metabolic process	GO:0044281	305	0.021
eggshell chorion assembly	GO:0007306	66	0.021
imaginal disc derived leg morphogenesis	GO:0007480	80	0.021
mesenchymal cell development	GO:0014031	1	0.021
positive regulation of response to stimulus	GO:0048584	323	0.020
antennal morphogenesis	GO:0048800	14	0.020
regulation of cell morphogenesis	GO:0022604	163	0.020
hindbrain development	GO:0030902	2	0.020
neuron fate commitment	GO:0048663	50	0.020
immune system development	GO:0002520	57	0.020
ectodermal placode formation	GO:0060788	4	0.020	Fly
regulation of notch signaling pathway	GO:0008593	100	0.019
regulation of cellular localization	GO:0060341	136	0.019
negative regulation of cellular component organization	GO:0051129	108	0.019
response to oxygen containing compound	GO:1901700	200	0.019
tube morphogenesis	GO:0035239	191	0.019
development of primary sexual characteristics	GO:0045137	50	0.019	Fly
cell division	GO:0051301	248	0.018
protein transport	GO:0015031	155	0.018	Mouse
regulation of intracellular signal transduction	GO:1902531	236	0.018
regulation of cellular component size	GO:0032535	98	0.018
synaptic transmission	GO:0007268	288	0.018
salivary gland development	GO:0007431	162	0.018
cell adhesion	GO:0007155	136	0.018
imaginal disc derived wing vein specification	GO:0007474	48	0.018
ribose phosphate metabolic process	GO:0019693	145	0.018
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.018	Mouse
cellular macromolecule localization	GO:0070727	220	0.017	Mouse
multicellular organism growth	GO:0035264	46	0.017
circulatory system development	GO:0072359	82	0.017
columnar cuboidal epithelial cell development	GO:0002066	249	0.017
intracellular signal transduction	GO:0035556	300	0.017
positive regulation of cellular component organization	GO:0051130	156	0.017
photoreceptor cell axon guidance	GO:0072499	23	0.017
head involution	GO:0008258	35	0.017
exocrine system development	GO:0035272	162	0.017
sensory perception of touch	GO:0050975	11	0.017
positive regulation of developmental growth	GO:0048639	62	0.017
establishment of tissue polarity	GO:0007164	87	0.017
telencephalon development	GO:0021537	2	0.017	Mouse
negative regulation of epithelial cell proliferation	GO:0050680	4	0.017
developmental induction	GO:0031128	3	0.016	Mouse
nephron tubule morphogenesis	GO:0072078	3	0.016
response to other organism	GO:0051707	293	0.016
regulation of epithelial cell proliferation	GO:0050678	4	0.016
hematopoietic or lymphoid organ development	GO:0048534	57	0.016
cell fate determination	GO:0001709	91	0.016
nephron development	GO:0072006	3	0.016
regulation of phosphorus metabolic process	GO:0051174	210	0.016
regulation of epithelial cell differentiation	GO:0030856	4	0.016
negative regulation of developmental growth	GO:0048640	64	0.016
positive regulation of neurogenesis	GO:0050769	41	0.016
regulation of molecular function	GO:0065009	217	0.015
dorsal ventral axis specification	GO:0009950	66	0.015
response to abiotic stimulus	GO:0009628	341	0.015
regulation of cellular component movement	GO:0051270	42	0.015
positive regulation of signaling	GO:0023056	243	0.015
skeletal muscle organ development	GO:0060538	48	0.015
eggshell formation	GO:0030703	105	0.015
formation of anatomical boundary	GO:0048859	37	0.014
nuclear transport	GO:0051169	72	0.014	Mouse
pigment cell differentiation	GO:0050931	3	0.014
gland morphogenesis	GO:0022612	145	0.014
cell death	GO:0008219	279	0.014	Mouse
gastrulation	GO:0007369	70	0.014
maintenance of location	GO:0051235	73	0.014
establishment of planar polarity	GO:0001736	87	0.014
ribonucleoside catabolic process	GO:0042454	112	0.014
cardiovascular system development	GO:0072358	82	0.014
establishment of protein localization	GO:0045184	163	0.014	Mouse
positive regulation of cell communication	GO:0010647	250	0.014
purine containing compound metabolic process	GO:0072521	155	0.014
nucleocytoplasmic transport	GO:0006913	72	0.014	Mouse
muscle contraction	GO:0006936	13	0.013
response to wounding	GO:0009611	94	0.013	Zebrafish
neuron remodeling	GO:0016322	29	0.013
embryonic axis specification	GO:0000578	107	0.013
regulation of translation	GO:0006417	56	0.013
central nervous system formation	GO:0021556	5	0.013
regulation of protein localization	GO:0032880	76	0.013
response to lipopolysaccharide	GO:0032496	4	0.013
positive regulation of epithelial cell differentiation	GO:0030858	1	0.013
multicellular organismal reproductive behavior	GO:0033057	110	0.013
cellular response to chemical stimulus	GO:0070887	199	0.013
regulation of phosphorylation	GO:0042325	147	0.013
catabolic process	GO:0009056	409	0.013
response to ethanol	GO:0045471	59	0.013
organelle assembly	GO:0070925	198	0.013
regulation of dendrite morphogenesis	GO:0048814	28	0.013
nucleoside phosphate metabolic process	GO:0006753	162	0.012
response to endogenous stimulus	GO:0009719	119	0.012
nucleotide metabolic process	GO:0009117	161	0.012
response to external biotic stimulus	GO:0043207	293	0.012
purine ribonucleotide catabolic process	GO:0009154	109	0.012
cellular catabolic process	GO:0044248	372	0.012
positive regulation of multicellular organismal process	GO:0051240	143	0.012
translation	GO:0006412	69	0.012
pharynx development	GO:0060465	1	0.012
chromosome organization	GO:0051276	360	0.012
gonad development	GO:0008406	50	0.012	Fly
regulation of organelle organization	GO:0033043	196	0.012
smoothened signaling pathway	GO:0007224	49	0.012
endomembrane system organization	GO:0010256	119	0.011
purine ribonucleoside catabolic process	GO:0046130	112	0.011
cellular response to organic substance	GO:0071310	132	0.011
regulation of wnt signaling pathway	GO:0030111	68	0.011	Mouse
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.011
protein localization to organelle	GO:0033365	82	0.011	Mouse
establishment of localization in cell	GO:0051649	402	0.011	Mouse
glial cell differentiation	GO:0010001	35	0.011
adult locomotory behavior	GO:0008344	76	0.011
multicellular organismal movement	GO:0050879	3	0.011
regulation of developmental growth	GO:0048638	174	0.011
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.011
phosphorylation	GO:0016310	294	0.011
positive regulation of protein metabolic process	GO:0051247	128	0.011
synaptic target recognition	GO:0008039	45	0.011
anatomical structure homeostasis	GO:0060249	97	0.011
cellular amino acid metabolic process	GO:0006520	61	0.011
pigmentation	GO:0043473	75	0.011
purine nucleotide metabolic process	GO:0006163	146	0.011
regulation of intracellular transport	GO:0032386	64	0.011
cell maturation	GO:0048469	144	0.011	Mouse
regulation of heart morphogenesis	GO:2000826	3	0.011
organ formation	GO:0048645	39	0.011
eye photoreceptor cell fate commitment	GO:0042706	37	0.011
negative regulation of cell death	GO:0060548	81	0.011
cell fate commitment involved in pattern specification	GO:0060581	31	0.011
defense response to fungus	GO:0050832	48	0.011
rna localization	GO:0006403	115	0.011
aromatic compound catabolic process	GO:0019439	166	0.011
glial cell migration	GO:0008347	31	0.011	Fly
cytoplasmic transport	GO:0016482	130	0.010	Mouse
response to glucose	GO:0009749	2	0.010
nucleobase containing small molecule metabolic process	GO:0055086	174	0.010
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.010
negative regulation of programmed cell death	GO:0043069	72	0.010
regulation of stem cell proliferation	GO:0072091	40	0.010	Mouse
organic substance catabolic process	GO:1901575	308	0.010
protein import	GO:0017038	55	0.010	Mouse
cell type specific apoptotic process	GO:0097285	38	0.010	Mouse
leg disc morphogenesis	GO:0007478	80	0.010
cranial nerve development	GO:0021545	1	0.010
dorsal appendage formation	GO:0046843	47	0.010
ribonucleotide catabolic process	GO:0009261	109	0.010
cellular homeostasis	GO:0019725	80	0.010

Optix disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.059
disease of cellular proliferation	DOID:14566	0.041
nervous system disease	DOID:863	0.033
sensory system disease	DOID:0050155	0.033
cancer	DOID:162	0.016
organ system cancer	DOID:0050686	0.016
eye and adnexa disease	DOID:1492	0.011
urinary system disease	DOID:18	0.011
eye disease	DOID:5614	0.010

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network