Drosophila melanogaster

45 known processes

Optix (Dmel_CG18455)

CG18455 gene product from transcript CG18455-RA

(Aliases: opt,OPTIX,opx,D-Six3,Six3,optix,Dmel\CG18455,CG18455,Dsix3,anon-WO0153538.79)

Optix biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of nucleobase containing compound metabolic processGO:00459342610.943
Human Mouse
regulation of transcription from rna polymerase ii promoterGO:00063573780.924
Mouse Fly
negative regulation of rna metabolic processGO:00512532510.923
Human Mouse
negative regulation of rna biosynthetic processGO:19026792400.868
Human Mouse
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.832
Human Mouse
negative regulation of macromolecule biosynthetic processGO:00105582700.818
Human Mouse
positive regulation of transcription dna templatedGO:00458932660.813
Mouse Fly
negative regulation of transcription dna templatedGO:00458922370.803
Human Mouse
positive regulation of nucleic acid templated transcriptionGO:19035082660.778
Mouse Fly
eye antennal disc developmentGO:0035214600.775
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.772
Mouse Fly
negative regulation of cellular metabolic processGO:00313243820.761
Human Mouse
negative regulation of nitrogen compound metabolic processGO:00511722650.753
Human Mouse
negative regulation of biosynthetic processGO:00098902770.732
Human Mouse
positive regulation of macromolecule biosynthetic processGO:00105572830.731
Mouse Fly
positive regulation of rna metabolic processGO:00512542710.719
Mouse Fly
dendrite morphogenesisGO:00488131990.715
transcription from rna polymerase ii promoterGO:00063663680.707
Mouse Fly
negative regulation of cellular biosynthetic processGO:00313272770.682
Human Mouse
dendrite developmentGO:00163582040.658
leg disc developmentGO:0035218920.620
positive regulation of gene expressionGO:00106282900.612
Mouse Fly
negative regulation of gene expressionGO:00106293870.541
Human Mouse
positive regulation of rna biosynthetic processGO:19026802660.520
Mouse Fly
negative regulation of nucleic acid templated transcriptionGO:19035072400.519
Human Mouse
imaginal disc derived appendage developmentGO:00487373990.496
post embryonic appendage morphogenesisGO:00351203850.474
positive regulation of nitrogen compound metabolic processGO:00511733540.473
Mouse Fly
compound eye developmentGO:00487493070.468
blastoderm segmentationGO:00073501590.448
regionalizationGO:00030024160.444
Human Mouse
tube developmentGO:00352952440.440
regulation of cell differentiationGO:00455953020.436
Mouse
embryonic pattern specificationGO:00098801740.435
renal tubule developmentGO:0061326640.424
sensory organ morphogenesisGO:00905962600.399
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.391
appendage developmentGO:00487364010.391
wing disc morphogenesisGO:00074723440.383
positive regulation of cellular biosynthetic processGO:00313283160.369
Mouse Fly
morphogenesis of an epitheliumGO:00020092760.365
positive regulation of biosynthetic processGO:00098913160.344
Mouse Fly
circadian rhythmGO:00076231050.339
Mouse Fly
segment specificationGO:0007379330.329
regulation of neuron differentiationGO:00456641030.311
Mouse
appendage morphogenesisGO:00351073970.286
imaginal disc derived appendage morphogenesisGO:00351143950.286
wnt signaling pathwayGO:0016055980.280
Mouse
embryonic morphogenesisGO:00485982060.268
Zebrafish Mouse Fly
eye developmentGO:00016543230.265
digestive tract developmentGO:00485651490.258
muscle structure developmentGO:00610612240.257
Fly
positive regulation of nucleobase containing compound metabolic processGO:00459353320.252
Mouse Fly
anterior posterior pattern specificationGO:00099521360.246
Mouse
positive regulation of macromolecule metabolic processGO:00106044050.244
Mouse Fly
embryonic organ developmentGO:0048568500.236
Zebrafish Mouse
kidney morphogenesisGO:006099330.234
tissue morphogenesisGO:00487292970.234
Mouse
wing disc pattern formationGO:0035222660.200
sensory perceptionGO:00076001960.199
segmentationGO:00352822070.192
antennal developmentGO:0007469250.185
imaginal disc pattern formationGO:0007447910.184
kidney developmentGO:000182230.183
proximal distal pattern formationGO:0009954150.168
Mouse
muscle tissue developmentGO:0060537300.165
head developmentGO:00603221350.154
Human Zebrafish Mouse
imaginal disc derived wing morphogenesisGO:00074763370.142
compound eye morphogenesisGO:00017452490.142
axonogenesisGO:00074092900.138
embryo development ending in birth or egg hatchingGO:00097921520.135
Worm
urogenital system developmentGO:0001655720.128
negative regulation of cell differentiationGO:00455961430.123
Mouse
retinal cone cell differentiationGO:004267020.121
epithelial cell differentiationGO:00308553220.120
Mouse
neuron projection guidanceGO:00974852410.119
regulation of localizationGO:00328792750.116
regulation of anatomical structure morphogenesisGO:00226032420.115
camera type eye photoreceptor cell differentiationGO:006021920.112
axon developmentGO:00615642970.111
stem cell differentiationGO:00488631170.111
Mouse
epithelial cell developmentGO:00020642740.107
Mouse
midgut developmentGO:0007494230.105
renal system developmentGO:0072001720.104
muscle cell fate commitmentGO:0042693140.101
muscle cell differentiationGO:00426921030.101
Fly
dorsal ventral pattern formationGO:00099531330.100
Human
digestive system developmentGO:00551231490.100
regulation of photoreceptor cell differentiationGO:0046532340.098
mesenchymal cell differentiationGO:004876210.098
kidney epithelium developmentGO:007207330.097
embryonic development via the syncytial blastodermGO:00017001480.095
protein localizationGO:00081042840.094
Mouse
camera type eye morphogenesisGO:004859320.093
Zebrafish Mouse
regulation of r7 cell differentiationGO:0045676150.093
negative regulation of multicellular organismal processGO:00512411420.089
Mouse
larval developmentGO:00021641040.088
Worm
malpighian tubule developmentGO:0072002640.085
feeding behaviorGO:0007631500.080
specification of segmental identity headGO:0007380110.076
rhythmic processGO:00485111060.076
Mouse Fly
head segmentationGO:0035287130.074
stem cell developmentGO:0048864790.073
mushroom body developmentGO:0016319700.072
localization of cellGO:00516742570.070
Mouse Fly
negative regulation of signal transductionGO:00099682060.069
Mouse
compound eye photoreceptor cell differentiationGO:00017511400.069
regulation of nervous system developmentGO:00519602480.068
Mouse
neuron fate specificationGO:0048665120.065
eye photoreceptor cell developmentGO:0042462810.064
retina development in camera type eyeGO:006004140.061
Zebrafish Mouse
epidermis developmentGO:0008544650.061
peripheral nervous system developmentGO:0007422520.060
ocellus developmentGO:000805640.060
regulation of cell morphogenesis involved in differentiationGO:0010769610.060
spermatogenesisGO:00072832000.057
Fly
retina morphogenesis in camera type eyeGO:006004220.057
compound eye cone cell fate commitmentGO:004267650.057
establishment or maintenance of cell polarityGO:00071631670.057
neurological system processGO:00508773580.056
negative regulation of nervous system developmentGO:0051961920.056
Mouse
epithelial tube morphogenesisGO:0060562880.055
negative regulation of cell developmentGO:0010721620.054
Mouse
positive regulation of developmental processGO:00510941430.053
gliogenesisGO:0042063800.053
Fly
cell fate specificationGO:0001708710.051
branching morphogenesis of an epithelial tubeGO:0048754450.051
single organism behaviorGO:00447083910.051
cellular protein modification processGO:00064644380.050
positive regulation of cell differentiationGO:0045597640.049
negative regulation of neurogenesisGO:0050768530.048
Mouse
regulation of multicellular organismal developmentGO:20000264140.048
Mouse
developmental maturationGO:00217001720.047
Mouse
photoreceptor cell differentiationGO:00465301700.046
stem cell maintenanceGO:0019827670.046
central nervous system developmentGO:00074172010.046
Human Zebrafish Mouse
cell motilityGO:00488702510.046
Mouse Fly
dorsal ventral pattern formation imaginal discGO:0007450510.045
sensory perception of mechanical stimulusGO:0050954720.044
negative regulation of signalingGO:00230572190.044
Mouse
skin developmentGO:0043588650.044
negative regulation of developmental processGO:00510932010.042
Mouse
endocytosisGO:00068973100.042
negative regulation of response to stimulusGO:00485852580.042
Mouse
single organism intracellular transportGO:19025822070.041
Mouse
compound eye photoreceptor developmentGO:0042051780.040
outflow tract morphogenesisGO:000315140.040
nephron morphogenesisGO:007202830.040
cellular protein localizationGO:00346131600.039
Mouse
connective tissue developmentGO:006144830.039
Fly
ras protein signal transductionGO:0007265880.037
regulation of cell proliferationGO:00421271630.037
Mouse
sex differentiationGO:0007548810.037
Fly
equator specificationGO:004531740.036
leg disc proximal distal pattern formationGO:000747990.036
axon guidanceGO:00074112330.036
body morphogenesisGO:001017120.036
Worm
camera type eye developmentGO:004301040.035
Zebrafish Mouse
posttranscriptional regulation of gene expressionGO:00106081450.034
notch signaling pathwayGO:00072191200.034
molting cycleGO:0042303560.034
photoreceptor cell fate commitmentGO:0046552410.034
protein modification processGO:00362114380.034
photoreceptor cell fate specificationGO:004370490.033
forebrain developmentGO:003090020.033
Human Mouse
gland developmentGO:00487321910.033
Mouse Fly
neural retina developmentGO:000340740.033
Zebrafish Mouse
proximal distal pattern formation imaginal discGO:0007449110.033
developmental growthGO:00485892800.032
Zebrafish
eye morphogenesisGO:00485922600.032
photoreceptor cell developmentGO:0042461960.032
respiratory system developmentGO:00605412130.032
reproductive system developmentGO:0061458740.032
Fly
cell proliferationGO:00082832990.032
Zebrafish Mouse
notum cell fate specificationGO:003531050.031
establishment of ommatidial planar polarityGO:0042067490.031
ribonucleotide metabolic processGO:00092591450.031
regulation of organ morphogenesisGO:2000027780.031
cellular component assembly involved in morphogenesisGO:00109271510.031
regulation of muscle cell differentiationGO:005114780.031
taxisGO:00423303040.031
regulation of compound eye cone cell fate specificationGO:004268240.031
phagocytosisGO:00069092150.030
leg disc pattern formationGO:0035223110.030
specification of segmental identity trunkGO:003529270.029
regulation of neurogenesisGO:00507671580.029
Mouse
regulation of anatomical structure sizeGO:00900661630.028
male gamete generationGO:00482322010.028
Fly
sensory neuron axon guidanceGO:009737420.028
morphogenesis of a branching structureGO:0001763450.027
dendrite guidanceGO:0070983210.027
neuron recognitionGO:00080381010.027
chorion containing eggshell formationGO:00073041050.027
vesicle mediated transportGO:00161923810.027
negative regulation of cell communicationGO:00106482230.026
Mouse
carbohydrate derivative metabolic processGO:19011352170.026
chemotaxisGO:00069352490.026
cell recognitionGO:00080371020.026
organonitrogen compound metabolic processGO:19015643180.026
regulation of transportGO:00510491810.025
morphogenesis of a polarized epitheliumGO:0001738930.025
reproductive structure developmentGO:0048608740.025
Fly
enzyme linked receptor protein signaling pathwayGO:00071671790.025
brain developmentGO:00074201200.025
Human Zebrafish Mouse
compound eye cone cell differentiationGO:0042675130.024
r7 cell differentiationGO:0045466430.024
hyperosmotic salinity responseGO:004253810.024
response to organic substanceGO:00100332840.024
adult behaviorGO:00305341370.024
organophosphate metabolic processGO:00196371950.023
spinal cord developmentGO:002151010.023
response to alcoholGO:0097305950.023
homeostatic processGO:00425921990.023
regulation of cell developmentGO:00602842150.023
Mouse
regulation of phosphate metabolic processGO:00192202100.023
cell migrationGO:00164772380.022
Mouse Fly
musculoskeletal movementGO:005088130.022
eye photoreceptor cell differentiationGO:00017541450.022
regulation of protein modification processGO:00313991120.022
nephron tubule developmentGO:007208030.022
chromatin organizationGO:00063252070.022
response to biotic stimulusGO:00096072940.022
regulation of growthGO:00400082330.022
development of primary female sexual characteristicsGO:0046545120.021
regulation of cellular protein metabolic processGO:00322682430.021
neuron maturationGO:0042551310.021
columnar cuboidal epithelial cell differentiationGO:00020652560.021
somatic muscle developmentGO:0007525660.021
small molecule metabolic processGO:00442813050.021
eggshell chorion assemblyGO:0007306660.021
imaginal disc derived leg morphogenesisGO:0007480800.021
mesenchymal cell developmentGO:001403110.021
positive regulation of response to stimulusGO:00485843230.020
antennal morphogenesisGO:0048800140.020
regulation of cell morphogenesisGO:00226041630.020
hindbrain developmentGO:003090220.020
neuron fate commitmentGO:0048663500.020
immune system developmentGO:0002520570.020
ectodermal placode formationGO:006078840.020
Fly
regulation of notch signaling pathwayGO:00085931000.019
regulation of cellular localizationGO:00603411360.019
negative regulation of cellular component organizationGO:00511291080.019
response to oxygen containing compoundGO:19017002000.019
tube morphogenesisGO:00352391910.019
development of primary sexual characteristicsGO:0045137500.019
Fly
cell divisionGO:00513012480.018
protein transportGO:00150311550.018
Mouse
regulation of intracellular signal transductionGO:19025312360.018
regulation of cellular component sizeGO:0032535980.018
synaptic transmissionGO:00072682880.018
salivary gland developmentGO:00074311620.018
cell adhesionGO:00071551360.018
imaginal disc derived wing vein specificationGO:0007474480.018
ribose phosphate metabolic processGO:00196931450.018
cell cell signaling involved in cell fate commitmentGO:00451682100.018
Mouse
cellular macromolecule localizationGO:00707272200.017
Mouse
multicellular organism growthGO:0035264460.017
circulatory system developmentGO:0072359820.017
columnar cuboidal epithelial cell developmentGO:00020662490.017
intracellular signal transductionGO:00355563000.017
positive regulation of cellular component organizationGO:00511301560.017
photoreceptor cell axon guidanceGO:0072499230.017
head involutionGO:0008258350.017
exocrine system developmentGO:00352721620.017
sensory perception of touchGO:0050975110.017
positive regulation of developmental growthGO:0048639620.017
establishment of tissue polarityGO:0007164870.017
telencephalon developmentGO:002153720.017
Mouse
negative regulation of epithelial cell proliferationGO:005068040.017
developmental inductionGO:003112830.016
Mouse
nephron tubule morphogenesisGO:007207830.016
response to other organismGO:00517072930.016
regulation of epithelial cell proliferationGO:005067840.016
hematopoietic or lymphoid organ developmentGO:0048534570.016
cell fate determinationGO:0001709910.016
nephron developmentGO:007200630.016
regulation of phosphorus metabolic processGO:00511742100.016
regulation of epithelial cell differentiationGO:003085640.016
negative regulation of developmental growthGO:0048640640.016
positive regulation of neurogenesisGO:0050769410.016
regulation of molecular functionGO:00650092170.015
dorsal ventral axis specificationGO:0009950660.015
response to abiotic stimulusGO:00096283410.015
regulation of cellular component movementGO:0051270420.015
positive regulation of signalingGO:00230562430.015
skeletal muscle organ developmentGO:0060538480.015
eggshell formationGO:00307031050.015
formation of anatomical boundaryGO:0048859370.014
nuclear transportGO:0051169720.014
Mouse
pigment cell differentiationGO:005093130.014
gland morphogenesisGO:00226121450.014
cell deathGO:00082192790.014
Mouse
gastrulationGO:0007369700.014
maintenance of locationGO:0051235730.014
establishment of planar polarityGO:0001736870.014
ribonucleoside catabolic processGO:00424541120.014
cardiovascular system developmentGO:0072358820.014
establishment of protein localizationGO:00451841630.014
Mouse
positive regulation of cell communicationGO:00106472500.014
purine containing compound metabolic processGO:00725211550.014
nucleocytoplasmic transportGO:0006913720.014
Mouse
muscle contractionGO:0006936130.013
response to woundingGO:0009611940.013
Zebrafish
neuron remodelingGO:0016322290.013
embryonic axis specificationGO:00005781070.013
regulation of translationGO:0006417560.013
central nervous system formationGO:002155650.013
regulation of protein localizationGO:0032880760.013
response to lipopolysaccharideGO:003249640.013
positive regulation of epithelial cell differentiationGO:003085810.013
multicellular organismal reproductive behaviorGO:00330571100.013
cellular response to chemical stimulusGO:00708871990.013
regulation of phosphorylationGO:00423251470.013
catabolic processGO:00090564090.013
response to ethanolGO:0045471590.013
organelle assemblyGO:00709251980.013
regulation of dendrite morphogenesisGO:0048814280.013
nucleoside phosphate metabolic processGO:00067531620.012
response to endogenous stimulusGO:00097191190.012
nucleotide metabolic processGO:00091171610.012
response to external biotic stimulusGO:00432072930.012
purine ribonucleotide catabolic processGO:00091541090.012
cellular catabolic processGO:00442483720.012
positive regulation of multicellular organismal processGO:00512401430.012
translationGO:0006412690.012
pharynx developmentGO:006046510.012
chromosome organizationGO:00512763600.012
gonad developmentGO:0008406500.012
Fly
regulation of organelle organizationGO:00330431960.012
smoothened signaling pathwayGO:0007224490.012
endomembrane system organizationGO:00102561190.011
purine ribonucleoside catabolic processGO:00461301120.011
cellular response to organic substanceGO:00713101320.011
regulation of wnt signaling pathwayGO:0030111680.011
Mouse
imaginal disc derived wing margin morphogenesisGO:0008587410.011
protein localization to organelleGO:0033365820.011
Mouse
establishment of localization in cellGO:00516494020.011
Mouse
glial cell differentiationGO:0010001350.011
adult locomotory behaviorGO:0008344760.011
multicellular organismal movementGO:005087930.011
regulation of developmental growthGO:00486381740.011
negative regulation of sequence specific dna binding transcription factor activityGO:004343340.011
phosphorylationGO:00163102940.011
positive regulation of protein metabolic processGO:00512471280.011
synaptic target recognitionGO:0008039450.011
anatomical structure homeostasisGO:0060249970.011
cellular amino acid metabolic processGO:0006520610.011
pigmentationGO:0043473750.011
purine nucleotide metabolic processGO:00061631460.011
regulation of intracellular transportGO:0032386640.011
cell maturationGO:00484691440.011
Mouse
regulation of heart morphogenesisGO:200082630.011
organ formationGO:0048645390.011
eye photoreceptor cell fate commitmentGO:0042706370.011
negative regulation of cell deathGO:0060548810.011
cell fate commitment involved in pattern specificationGO:0060581310.011
defense response to fungusGO:0050832480.011
rna localizationGO:00064031150.011
aromatic compound catabolic processGO:00194391660.011
glial cell migrationGO:0008347310.011
Fly
cytoplasmic transportGO:00164821300.010
Mouse
response to glucoseGO:000974920.010
nucleobase containing small molecule metabolic processGO:00550861740.010
regulation of small gtpase mediated signal transductionGO:0051056930.010
negative regulation of programmed cell deathGO:0043069720.010
regulation of stem cell proliferationGO:0072091400.010
Mouse
organic substance catabolic processGO:19015753080.010
protein importGO:0017038550.010
Mouse
cell type specific apoptotic processGO:0097285380.010
Mouse
leg disc morphogenesisGO:0007478800.010
cranial nerve developmentGO:002154510.010
dorsal appendage formationGO:0046843470.010
ribonucleotide catabolic processGO:00092611090.010
cellular homeostasisGO:0019725800.010

Optix disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.059
disease of cellular proliferationDOID:1456600.041
nervous system diseaseDOID:86300.033
sensory system diseaseDOID:005015500.033
cancerDOID:16200.016
organ system cancerDOID:005068600.016
eye and adnexa diseaseDOID:149200.011
urinary system diseaseDOID:1800.011
eye diseaseDOID:561400.010