Drosophila melanogaster

64 known processes

upd2 (Dmel_CG5988)

unpaired 2

(Aliases: Dmel\CG5988,CG5988,cg5988,UPD2,Upd2)

upd2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
defense responseGO:00069523000.215
post embryonic appendage morphogenesisGO:00351203850.215
positive regulation of nitrogen compound metabolic processGO:00511733540.200
positive regulation of biosynthetic processGO:00098913160.189
peptide metabolic processGO:0006518800.170
immune response regulating signaling pathwayGO:000276420.159
immune responseGO:00069552460.156
regulation of immune system processGO:00026821760.154
immune response activating signal transductionGO:000275720.148
regulation of multi organism processGO:00439001310.145
circadian behaviorGO:0048512760.143
immune effector processGO:0002252980.143
response to external biotic stimulusGO:00432072930.138
eye developmentGO:00016543230.138
immune system processGO:00023763470.135
positive regulation of response to stimulusGO:00485843230.132
innate immune responseGO:00450871440.123
regulation of multicellular organismal developmentGO:20000264140.122
negative regulation of response to stimulusGO:00485852580.121
regulation of response to biotic stimulusGO:0002831630.120
positive regulation of rna metabolic processGO:00512542710.119
regulation of immune responseGO:00507761180.116
regulation of transcription from rna polymerase ii promoterGO:00063573780.116
single organism behaviorGO:00447083910.112
negative regulation of cellular metabolic processGO:00313243820.111
negative regulation of signal transductionGO:00099682060.110
defense response to bacteriumGO:00427421780.108
positive regulation of nucleic acid templated transcriptionGO:19035082660.106
melanin metabolic processGO:0006582470.102
pattern recognition receptor signaling pathwayGO:000222120.100
defense response to virusGO:0051607230.100
catabolic processGO:00090564090.097
rhythmic processGO:00485111060.096
transcription from rna polymerase ii promoterGO:00063663680.094
defense response to other organismGO:00985422250.093
activation of innate immune responseGO:000221840.093
positive regulation of biosynthetic process of antibacterial peptides active against gram positive bacteriaGO:000696530.091
response to oxygen containing compoundGO:19017002000.090
phosphorylationGO:00163102940.090
positive regulation of response to biotic stimulusGO:0002833310.089
positive regulation of macromolecule metabolic processGO:00106044050.089
response to biotic stimulusGO:00096072940.088
organonitrogen compound metabolic processGO:19015643180.087
melanization defense responseGO:0035006450.086
innate immune response activating signal transductionGO:000275820.084
positive regulation of gene expressionGO:00106282900.083
positive regulation of rna biosynthetic processGO:19026802660.083
negative regulation of immune system processGO:0002683500.078
regulation of immune effector processGO:0002697520.078
eye morphogenesisGO:00485922600.078
wing disc morphogenesisGO:00074723440.077
negative regulation of cell communicationGO:00106482230.075
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.075
response to other organismGO:00517072930.075
regulation of defense responseGO:00313471020.075
positive regulation of macromolecule biosynthetic processGO:00105572830.075
circadian rhythmGO:00076231050.073
response to virusGO:0009615280.072
intracellular signal transductionGO:00355563000.072
positive regulation of cellular biosynthetic processGO:00313283160.068
imaginal disc derived wing morphogenesisGO:00074763370.067
imaginal disc derived appendage developmentGO:00487373990.067
mapk cascadeGO:00001651070.066
determination of adult lifespanGO:00083401370.066
agingGO:00075681430.066
positive regulation of production of molecular mediator of immune responseGO:0002702280.064
cellular amide metabolic processGO:0043603800.064
aminoglycan metabolic processGO:0006022180.064
regulation of cell differentiationGO:00455953020.063
peptide biosynthetic processGO:0043043420.063
positive regulation of defense responseGO:0031349590.063
sleepGO:0030431490.063
response to organic substanceGO:00100332840.062
phenol containing compound metabolic processGO:0018958570.062
organic acid metabolic processGO:00060821030.062
peptidoglycan catabolic processGO:000925330.062
positive regulation of immune responseGO:0050778630.062
negative regulation of cell differentiationGO:00455961430.062
regulation of phosphate metabolic processGO:00192202100.061
cellular response to lipopolysaccharideGO:007122230.061
establishment of localization in cellGO:00516494020.061
epithelium migrationGO:00901321480.060
regulation of innate immune responseGO:0045088710.060
appendage developmentGO:00487364010.057
vesicle mediated transportGO:00161923810.056
negative regulation of multicellular organismal processGO:00512411420.055
rhythmic behaviorGO:0007622760.055
positive regulation of transcription dna templatedGO:00458932660.055
regulation of intracellular signal transductionGO:19025312360.054
long term memoryGO:0007616620.054
negative regulation of nitrogen compound metabolic processGO:00511722650.054
small molecule metabolic processGO:00442813050.053
positive regulation of multi organism processGO:0043902400.053
response to lipopolysaccharideGO:003249640.053
embryonic morphogenesisGO:00485982060.053
response to bacteriumGO:00096171980.053
multicellular organismal agingGO:00102591400.052
photoreceptor cell differentiationGO:00465301700.052
cell proliferationGO:00082832990.052
tissue migrationGO:00901301550.051
localization of cellGO:00516742570.051
regulation of phosphorylationGO:00423251470.050
regulation of response to external stimulusGO:00321011150.050
macromolecule catabolic processGO:00090571610.050
organonitrogen compound biosynthetic processGO:19015661170.050
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteriaGO:000281630.050
signal transduction by phosphorylationGO:00230141070.049
digestive system developmentGO:00551231490.049
lipopolysaccharide mediated signaling pathwayGO:003166310.049
response to monosaccharideGO:003428440.049
positive regulation of immune system processGO:0002684680.049
cognitionGO:00508901410.048
epithelial cell migrationGO:00106311480.048
ameboidal type cell migrationGO:00016671510.047
carboxylic acid metabolic processGO:0019752920.046
cation transportGO:00068121100.046
regulation of humoral immune responseGO:0002920510.045
stem cell divisionGO:0017145690.045
hindgut morphogenesisGO:0007442580.044
detection of stimulusGO:00516061560.044
sensory organ morphogenesisGO:00905962600.044
oxoacid metabolic processGO:00434361030.044
positive regulation of antibacterial peptide productionGO:0002803200.044
positive regulation of nucleobase containing compound metabolic processGO:00459353320.043
regulation of response to stressGO:00801342000.043
positive regulation of immune effector processGO:0002699280.043
glycosaminoglycan catabolic processGO:000602730.043
imaginal disc derived appendage morphogenesisGO:00351143950.043
compound eye morphogenesisGO:00017452490.043
regulation of circadian sleep wake cycle sleepGO:0045187210.042
antibacterial peptide biosynthetic processGO:0002780220.042
compound eye developmentGO:00487493070.042
positive regulation of antimicrobial peptide biosynthetic processGO:0002807260.042
columnar cuboidal epithelial cell differentiationGO:00020652560.041
regulation of cellular amine metabolic processGO:003323830.041
ovarian follicle cell developmentGO:00307072480.041
homeostatic processGO:00425921990.041
body morphogenesisGO:001017120.040
regulation of antimicrobial peptide biosynthetic processGO:0002805380.040
regionalizationGO:00030024160.040
regulation of phosphorus metabolic processGO:00511742100.040
stress activated protein kinase signaling cascadeGO:0031098550.039
columnar cuboidal epithelial cell developmentGO:00020662490.039
response to nitrogen compoundGO:1901698900.039
organic substance catabolic processGO:19015753080.039
regulation of cellular amide metabolic processGO:0034248390.038
regulation of jnk cascadeGO:0046328400.038
negative regulation of nucleic acid templated transcriptionGO:19035072400.038
cellular amino acid metabolic processGO:0006520610.038
peptidoglycan metabolic processGO:000027030.038
negative regulation of signalingGO:00230572190.037
eye photoreceptor cell differentiationGO:00017541450.037
regulation of circadian rhythmGO:0042752490.037
negative regulation of intracellular signal transductionGO:1902532570.036
regulation of antimicrobial humoral responseGO:0002759500.036
tube developmentGO:00352952440.036
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.036
appendage morphogenesisGO:00351073970.035
humoral immune responseGO:00069591170.035
amide biosynthetic processGO:0043604420.035
cellular amine metabolic processGO:0044106120.035
single organism biosynthetic processGO:00447112060.035
regulation of nervous system developmentGO:00519602480.035
memoryGO:0007613940.035
pigment metabolic processGO:0042440840.034
dorsal ventral pattern formationGO:00099531330.034
protein modification processGO:00362114380.033
regulation of anatomical structure sizeGO:00900661630.033
positive regulation of response to external stimulusGO:0032103440.033
epithelial cell developmentGO:00020642740.033
biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0002812140.033
compound eye photoreceptor cell differentiationGO:00017511400.032
circadian sleep wake cycle processGO:0022410240.032
carbohydrate derivative metabolic processGO:19011352170.032
cell migrationGO:00164772380.032
cellular response to molecule of bacterial originGO:007121930.032
positive regulation of humoral immune responseGO:0002922280.032
antimicrobial humoral responseGO:0019730990.031
hindgut developmentGO:0061525580.031
regulation of cellular amino acid metabolic processGO:000652100.031
negative regulation of rna metabolic processGO:00512532510.031
regulation of antimicrobial peptide productionGO:0002784440.031
cellular response to biotic stimulusGO:007121640.030
positive regulation of antimicrobial humoral responseGO:0002760280.030
stress activated mapk cascadeGO:0051403520.030
learning or memoryGO:00076111410.030
production of molecular mediator of immune responseGO:0002440460.030
cuticle developmentGO:0042335860.030
chorion containing eggshell formationGO:00073041050.030
oocyte differentiationGO:00099941450.029
circadian sleep wake cycle sleepGO:0050802230.029
regulation of stress activated protein kinase signaling cascadeGO:0070302420.029
peptidoglycan recognition protein signaling pathwayGO:0061057160.029
digestive tract morphogenesisGO:00485461270.029
circadian sleep wake cycleGO:0042745280.029
regulation of antibacterial peptide biosynthetic processGO:0002808220.029
positive regulation of defense response to bacteriumGO:1900426230.029
cellular ketone metabolic processGO:0042180240.028
jnk cascadeGO:0007254500.028
negative regulation of defense responseGO:0031348350.028
l amino acid importGO:004309220.028
defense response to gram negative bacteriumGO:0050829940.028
response to organonitrogen compoundGO:0010243750.028
amine metabolic processGO:0009308120.028
negative regulation of nucleobase containing compound metabolic processGO:00459342610.028
dendrite developmentGO:00163582040.027
cellular protein modification processGO:00064644380.027
anatomical structure homeostasisGO:0060249970.027
antibacterial humoral responseGO:0019731440.027
gland developmentGO:00487321910.027
response to glucoseGO:000974920.027
positive regulation of signal transductionGO:00099672230.027
hematopoietic or lymphoid organ developmentGO:0048534570.027
urogenital system developmentGO:0001655720.027
female gonad developmentGO:0008585120.027
response to hexoseGO:000974630.027
negative regulation of rna biosynthetic processGO:19026792400.027
antimicrobial peptide biosynthetic processGO:0002777380.026
carbohydrate derivative catabolic processGO:19011361180.026
aminoglycan catabolic processGO:000602660.026
phagocytosisGO:00069092150.026
negative regulation of response to external stimulusGO:0032102220.026
enzyme linked receptor protein signaling pathwayGO:00071671790.026
axon guidanceGO:00074112330.025
stem cell differentiationGO:00488631170.025
regulation of localizationGO:00328792750.025
negative regulation of phosphorylationGO:0042326350.025
pigmentationGO:0043473750.025
negative regulation of transcription dna templatedGO:00458922370.025
regulation of programmed cell deathGO:00430671520.025
eye antennal disc morphogenesisGO:0007455340.025
gastrulationGO:0007369700.025
macromolecular complex assemblyGO:00650032560.024
regulation of defense response to bacteriumGO:1900424300.024
cell motilityGO:00488702510.024
cell cell signaling involved in cell fate commitmentGO:00451682100.024
dendrite morphogenesisGO:00488131990.024
positive regulation of cellular amide metabolic processGO:0034250260.024
regulation of cell proliferationGO:00421271630.024
gene silencingGO:00164581380.024
regulation of cellular catabolic processGO:00313291570.024
regulation of antibacterial peptide productionGO:0002786220.024
cell divisionGO:00513012480.024
forebrain developmentGO:003090020.024
regulation of anatomical structure morphogenesisGO:00226032420.023
developmental maturationGO:00217001720.023
camera type eye developmentGO:004301040.023
morphogenesis of an epitheliumGO:00020092760.023
imaginal disc pattern formationGO:0007447910.023
cellular response to oxygen containing compoundGO:1901701790.023
regulation of cellular ketone metabolic processGO:001056530.023
cell deathGO:00082192790.023
antimicrobial peptide productionGO:0002775460.023
deathGO:00162652840.023
cellular response to chemical stimulusGO:00708871990.023
regulation of protein metabolic processGO:00512462560.022
regulation of mapk cascadeGO:0043408920.022
regulation of stress activated mapk cascadeGO:0032872410.022
negative regulation of macromolecule biosynthetic processGO:00105582700.022
secretion by cellGO:00329401010.022
epithelial cell differentiationGO:00308553220.022
regulation of notch signaling pathwayGO:00085931000.022
negative regulation of developmental processGO:00510932010.022
apoptotic processGO:00069151590.022
peripheral nervous system developmentGO:0007422520.021
hemopoiesisGO:0030097460.021
tube morphogenesisGO:00352391910.021
organelle fissionGO:00482853400.021
positive regulation of signalingGO:00230562430.021
embryonic pattern specificationGO:00098801740.021
negative regulation of multi organism processGO:0043901290.021
actin filament based processGO:00300292200.021
establishment of planar polarityGO:0001736870.021
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.021
secretionGO:00469031090.021
oocyte developmentGO:00485991240.020
endocytosisGO:00068973100.020
organic substance transportGO:00717022570.020
axon developmentGO:00615642970.020
camera type eye morphogenesisGO:004859320.020
regulation of catalytic activityGO:00507901850.020
negative regulation of immune responseGO:0050777390.020
neurological system processGO:00508773580.020
eggshell formationGO:00307031050.020
response to light stimulusGO:00094161240.020
biosynthetic process of antibacterial peptides active against gram positive bacteriaGO:000281530.020
negative regulation of gene expressionGO:00106293870.020
cellular macromolecular complex assemblyGO:00346221530.020
organic hydroxy compound metabolic processGO:1901615830.020
positive regulation of cell proliferationGO:0008284470.020
tissue morphogenesisGO:00487292970.020
positive regulation of antimicrobial peptide productionGO:0002225280.020
positive regulation of innate immune responseGO:0045089380.020
secondary metabolic processGO:0019748750.019
telencephalon developmentGO:002153720.019
response to abiotic stimulusGO:00096283410.019
immune system developmentGO:0002520570.019
response to peptidoglycanGO:003249420.019
digestive tract developmentGO:00485651490.019
regulation of neurogenesisGO:00507671580.019
cell maturationGO:00484691440.019
regulation of cell deathGO:00109411730.019
positive regulation of cell communicationGO:00106472500.019
defense response to gram positive bacteriumGO:0050830410.018
regulation of cell morphogenesisGO:00226041630.018
response to radiationGO:00093141550.018
negative regulation of stress activated protein kinase signaling cascadeGO:0070303200.018
chemotaxisGO:00069352490.018
positive regulation of tor signalingGO:0032008130.018
eye photoreceptor cell developmentGO:0042462810.018
positive regulation of antibacterial peptide biosynthetic processGO:0006963200.017
antibacterial peptide productionGO:0002778220.017
response to temperature stimulusGO:00092661060.017
malpighian tubule morphogenesisGO:0007443440.017
regulation of developmental growthGO:00486381740.017
response to oxidative stressGO:0006979860.017
response to woundingGO:0009611940.017
response to endogenous stimulusGO:00097191190.017
chromosome segregationGO:00070591570.017
wing disc pattern formationGO:0035222660.017
chromosome organizationGO:00512763600.016
cellular catabolic processGO:00442483720.016
negative regulation of phosphate metabolic processGO:0045936450.016
spinal cord developmentGO:002151010.016
mitotic nuclear divisionGO:00070672130.016
response to heatGO:0009408630.016
regulation of mitotic cell cycleGO:00073461900.016
somatic muscle developmentGO:0007525660.015
programmed cell deathGO:00125012570.015
regulation of secondary metabolic processGO:004345570.015
positive regulation of phosphate metabolic processGO:00459371390.015
response to organophosphorusGO:004668320.015
glycosaminoglycan metabolic processGO:0030203110.015
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.015
regulation of cellular protein metabolic processGO:00322682430.015
regulation of cellular component sizeGO:0032535980.015
lateral inhibitionGO:00463312060.014
regulation of peptidoglycan recognition protein signaling pathwayGO:006105840.014
negative regulation of cellular biosynthetic processGO:00313272770.014
establishment or maintenance of cell polarityGO:00071631670.014
negative regulation of innate immune responseGO:0045824300.014
regulation of cellular response to stressGO:0080135890.014
regulation of cell developmentGO:00602842150.014
regulation of circadian sleep wake cycleGO:0042749250.014
positive regulation of intracellular signal transductionGO:19025331160.014
regulation of catabolic processGO:00098941700.014
positive regulation of developmental processGO:00510941430.014
negative regulation of peptidoglycan recognition protein signaling pathwayGO:006106030.014
chemical homeostasisGO:0048878920.014
dna metabolic processGO:00062592270.014
ribonucleoside metabolic processGO:00091191270.014
response to lipidGO:0033993380.014
gliogenesisGO:0042063800.013
negative regulation of protein metabolic processGO:0051248850.013
regulation of cell cycleGO:00517262910.013
cytoplasmic transportGO:00164821300.013
growthGO:00400073590.013
actin filament based movementGO:0030048260.013
instar larval developmentGO:0002168550.013
detection of external biotic stimulusGO:009858120.013
regulation of reproductive processGO:2000241540.013
larval developmentGO:00021641040.013
cell adhesionGO:00071551360.013
negative regulation of neurogenesisGO:0050768530.013
proteolysisGO:00065081920.013
positive regulation of cellular component organizationGO:00511301560.013
cellular response to organic substanceGO:00713101320.013
compound eye photoreceptor developmentGO:0042051780.013
positive regulation of cellular amino acid metabolic processGO:004576400.013
lipid metabolic processGO:00066291210.013
protein complex assemblyGO:00064612000.013
actin mediated cell contractionGO:0070252210.013
negative regulation of apoptotic processGO:0043066630.013
regulation of gene expression epigeneticGO:00400291280.013
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0002813140.013
regulation of embryonic developmentGO:0045995680.013
positive regulation of biosynthetic process of antibacterial peptides active against gram negative bacteriaGO:0006964120.013
developmental growthGO:00485892800.013
regulation of gene silencingGO:0060968630.013
chemosensory behaviorGO:00076351060.012
positive regulation of protein metabolic processGO:00512471280.012
epithelial cell morphogenesisGO:0003382250.012
peptidyl amino acid modificationGO:00181931050.012
actin cytoskeleton organizationGO:00300362060.012
response to alcoholGO:0097305950.012
trna modificationGO:000640020.012
synaptic target recognitionGO:0008039450.012
negative regulation of phosphorus metabolic processGO:0010563450.012
positive regulation of phosphorylationGO:0042327870.012
cellular response to lipidGO:0071396200.012
organophosphate metabolic processGO:00196371950.012
oocyte axis specificationGO:00073091080.012
wound healingGO:0042060750.012
cholesterol homeostasisGO:004263230.012
cell fate specificationGO:0001708710.012
regulation of organelle organizationGO:00330431960.012
salivary gland developmentGO:00074311620.012
regulation of cell sizeGO:0008361630.012
positive regulation of cellular protein metabolic processGO:00322701180.012
molting cycle chitin based cuticleGO:0007591560.012
response to decreased oxygen levelsGO:0036293580.012
endodermal cell differentiationGO:003598730.012
hindbrain developmentGO:003090220.012
dorsal ventral axis specificationGO:0009950660.012
malpighian tubule developmentGO:0072002640.011
positive regulation of organelle organizationGO:0010638650.011
response to ethanolGO:0045471590.011
mrna processingGO:00063971040.011
negative regulation of cell developmentGO:0010721620.011
notch signaling pathwayGO:00072191200.011
asymmetric stem cell divisionGO:0098722490.011
cell fate determinationGO:0001709910.011
blastoderm segmentationGO:00073501590.011
sterol homeostasisGO:005509240.011
cellularizationGO:0007349900.011
negative regulation of cell deathGO:0060548810.011
ion transportGO:00068111450.011
axis specificationGO:00097981670.011
positive regulation of phosphorus metabolic processGO:00105621390.011
regulation of apoptotic processGO:00429811300.011
convergent extensionGO:006002620.011
dna alkylationGO:000630540.011
sex determinationGO:0007530180.011
phosphatidylinositol mediated signalingGO:004801540.011
compound eye photoreceptor fate commitmentGO:0001752360.011
nucleoside metabolic processGO:00091161270.011
chitin based cuticle developmentGO:0040003490.011
purine nucleotide metabolic processGO:00061631460.011
endomembrane system organizationGO:00102561190.011
dorsal ventral pattern formation imaginal discGO:0007450510.011
anterior posterior pattern specificationGO:00099521360.011
molting cycle processGO:0022404290.011
oxidation reduction processGO:00551141230.011
metal ion homeostasisGO:0055065440.011
behavioral response to ethanolGO:0048149490.011
connective tissue developmentGO:006144830.011
regulation of cell fate commitmentGO:0010453290.011
interspecies interaction between organismsGO:0044419160.011
tripartite regional subdivisionGO:00073511030.011
r7 cell differentiationGO:0045466430.011
inositol lipid mediated signalingGO:004801740.011
cellular component assembly involved in morphogenesisGO:00109271510.010
intracellular transportGO:00469072280.010
organic cyclic compound catabolic processGO:19013611680.010
positive regulation of catalytic activityGO:00430851180.010
neuroblast proliferationGO:0007405740.010
organonitrogen compound catabolic processGO:19015651280.010
nitrogen compound transportGO:0071705850.010
histolysisGO:00075591020.010
cell recognitionGO:00080371020.010
positive regulation of protein modification processGO:0031401580.010
eye antennal disc developmentGO:0035214600.010
negative regulation of mapk cascadeGO:0043409230.010
erk1 and erk2 cascadeGO:0070371390.010
negative regulation of biosynthetic processGO:00098902770.010
positive regulation of cellular component biogenesisGO:0044089800.010
single organism catabolic processGO:00447122280.010
regulation of protein modification processGO:00313991120.010
regulation of growthGO:00400082330.010
regulation of kinase activityGO:0043549530.010
negative regulation of nervous system developmentGO:0051961920.010
golgi organizationGO:0007030660.010
regulation of cell fate specificationGO:0042659270.010
stem cell fate commitmentGO:0048865250.010
anterior posterior axis specification embryoGO:00085951030.010
chaeta morphogenesisGO:0008407420.010
anion transportGO:0006820410.010

upd2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.045
eye diseaseDOID:561400.019
eye and adnexa diseaseDOID:149200.019
nervous system diseaseDOID:86300.019
sensory system diseaseDOID:005015500.019
disease of metabolismDOID:001466700.016
inherited metabolic disorderDOID:65500.015
cardiovascular system diseaseDOID:128700.014
carbohydrate metabolism diseaseDOID:005001300.011
glucose metabolism diseaseDOID:419400.011
acquired metabolic diseaseDOID:006015800.011
diabetes mellitusDOID:935100.011
type 2 diabetes mellitusDOID:935200.011
disease of cellular proliferationDOID:1456600.011