IMP: Integrative Multi-species Prediction

Drosophila melanogaster

48 known processes

nito (Dmel_CG2910)

spenito

(Aliases: cg2910,Dmel\CG2910,Dm44A/spenito,dOTT,BcDNA:GH11110,CG2910,DmSSp)

Entrez: 35756
FLYBASE: FBgn0027548
UniProtKB: Q7KMJ6

Process Predictions
Disease Predictions

nito biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
eye development	GO:0001654	323	0.509
regulation of anatomical structure morphogenesis	GO:0022603	242	0.351
compound eye development	GO:0048749	307	0.316
compound eye morphogenesis	GO:0001745	249	0.278
eye photoreceptor cell development	GO:0042462	81	0.244
eye morphogenesis	GO:0048592	260	0.239
photoreceptor cell differentiation	GO:0046530	170	0.225
eye photoreceptor cell differentiation	GO:0001754	145	0.218
sensory organ morphogenesis	GO:0090596	260	0.173
tube morphogenesis	GO:0035239	191	0.145	Mouse
compound eye photoreceptor cell differentiation	GO:0001751	140	0.133
tube development	GO:0035295	244	0.132	Mouse
morphogenesis of a polarized epithelium	GO:0001738	93	0.127	Fly
regulation of multicellular organismal development	GO:2000026	414	0.120	Mouse
photoreceptor cell development	GO:0042461	96	0.118
compound eye photoreceptor development	GO:0042051	78	0.117
negative regulation of cellular metabolic process	GO:0031324	382	0.109	Mouse
epithelial cell differentiation	GO:0030855	322	0.103	Fly
establishment or maintenance of cell polarity	GO:0007163	167	0.091
regulation of organ morphogenesis	GO:2000027	78	0.079
death	GO:0016265	284	0.077
cell proliferation	GO:0008283	299	0.074
embryonic morphogenesis	GO:0048598	206	0.072
regionalization	GO:0003002	416	0.070
small gtpase mediated signal transduction	GO:0007264	88	0.070
positive regulation of signal transduction	GO:0009967	223	0.069
single organism behavior	GO:0044708	391	0.066
intracellular signal transduction	GO:0035556	300	0.066
positive regulation of response to stimulus	GO:0048584	323	0.064
digestive system development	GO:0055123	149	0.063
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.063	Mouse
regulation of cell differentiation	GO:0045595	302	0.060	Mouse
neural precursor cell proliferation	GO:0061351	75	0.058
tissue morphogenesis	GO:0048729	297	0.057	Mouse Fly
protein modification process	GO:0036211	438	0.056
regulation of mitotic cell cycle	GO:0007346	190	0.054
transcription from rna polymerase ii promoter	GO:0006366	368	0.053	Mouse
regulation of ras protein signal transduction	GO:0046578	93	0.053
morphogenesis of an epithelium	GO:0002009	276	0.053	Mouse Fly
establishment of tissue polarity	GO:0007164	87	0.053	Fly
cell division	GO:0051301	248	0.051
catabolic process	GO:0009056	409	0.051
regulation of cell morphogenesis	GO:0022604	163	0.049
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.048
retina development in camera type eye	GO:0060041	4	0.047
regulation of phosphorus metabolic process	GO:0051174	210	0.047
apoptotic process	GO:0006915	159	0.047
positive regulation of rna biosynthetic process	GO:1902680	266	0.047	Mouse
notch signaling pathway	GO:0007219	120	0.047	Mouse
nuclear division	GO:0000280	332	0.046
neuroblast proliferation	GO:0007405	74	0.045
ras protein signal transduction	GO:0007265	88	0.044
cellular catabolic process	GO:0044248	372	0.044
regulation of nervous system development	GO:0051960	248	0.044
cellular macromolecule catabolic process	GO:0044265	136	0.043
phosphorylation	GO:0016310	294	0.042
organonitrogen compound metabolic process	GO:1901564	318	0.042
negative regulation of developmental process	GO:0051093	201	0.041	Mouse
organelle fission	GO:0048285	340	0.041
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.040	Mouse
cell death	GO:0008219	279	0.040
neuronal stem cell division	GO:0036445	35	0.040
programmed cell death	GO:0012501	257	0.040
antimicrobial humoral response	GO:0019730	99	0.040
negative regulation of cellular biosynthetic process	GO:0031327	277	0.040	Mouse
regulation of cell death	GO:0010941	173	0.039
establishment of planar polarity	GO:0001736	87	0.039	Fly
regulation of neurogenesis	GO:0050767	158	0.039
mapk cascade	GO:0000165	107	0.039
kidney development	GO:0001822	3	0.039
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.039	Mouse
positive regulation of transcription dna templated	GO:0045893	266	0.038	Mouse
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.038
digestive tract morphogenesis	GO:0048546	127	0.037
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.037	Mouse
negative regulation of biosynthetic process	GO:0009890	277	0.037	Mouse
digestive tract development	GO:0048565	149	0.036
negative regulation of transcription dna templated	GO:0045892	237	0.036	Mouse
eye photoreceptor cell fate commitment	GO:0042706	37	0.036
establishment of ommatidial planar polarity	GO:0042067	49	0.035
negative regulation of signaling	GO:0023057	219	0.035
regulation of intracellular signal transduction	GO:1902531	236	0.035
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.034	Mouse
regulation of cell cycle phase transition	GO:1901987	130	0.034
purine ribonucleoside metabolic process	GO:0046128	127	0.033
organelle localization	GO:0051640	148	0.033
regulation of cell cycle	GO:0051726	291	0.032
cell cycle phase transition	GO:0044770	140	0.032
positive regulation of biosynthetic process	GO:0009891	316	0.031	Mouse
regulation of phosphate metabolic process	GO:0019220	210	0.031
negative regulation of signal transduction	GO:0009968	206	0.031
positive regulation of catabolic process	GO:0009896	105	0.031
regulation of localization	GO:0032879	275	0.029
regulation of apoptotic process	GO:0042981	130	0.029
embryonic pattern specification	GO:0009880	174	0.029
positive regulation of rna metabolic process	GO:0051254	271	0.029	Mouse
synapse assembly	GO:0007416	143	0.029
negative regulation of gene expression	GO:0010629	387	0.029	Mouse
positive regulation of signaling	GO:0023056	243	0.029
nucleobase containing compound catabolic process	GO:0034655	165	0.029
compound eye photoreceptor fate commitment	GO:0001752	36	0.028
chaeta development	GO:0022416	97	0.027	Fly
developmental programmed cell death	GO:0010623	138	0.027
establishment of localization in cell	GO:0051649	402	0.027
positive regulation of cellular catabolic process	GO:0031331	95	0.027
organic substance catabolic process	GO:1901575	308	0.026
camera type eye morphogenesis	GO:0048593	2	0.026
negative regulation of programmed cell death	GO:0043069	72	0.026
positive regulation of cell communication	GO:0010647	250	0.026
epithelial tube morphogenesis	GO:0060562	88	0.026	Mouse
regulation of phosphorylation	GO:0042325	147	0.025
single organism catabolic process	GO:0044712	228	0.025
neurological system process	GO:0050877	358	0.025
neuroblast division	GO:0055057	35	0.025
synaptic transmission	GO:0007268	288	0.025
endocytosis	GO:0006897	310	0.025
purine containing compound catabolic process	GO:0072523	112	0.025
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.025	Mouse
stem cell differentiation	GO:0048863	117	0.024	Fly
negative regulation of cell communication	GO:0010648	223	0.024
cognition	GO:0050890	141	0.024
rna splicing	GO:0008380	83	0.024	Human
compound eye cone cell fate commitment	GO:0042676	5	0.024
regulation of cellular component biogenesis	GO:0044087	201	0.023
spermatogenesis	GO:0007283	200	0.023
nucleobase containing small molecule metabolic process	GO:0055086	174	0.023
response to oxygen containing compound	GO:1901700	200	0.023
imaginal disc derived appendage development	GO:0048737	399	0.023	Fly
purine nucleoside metabolic process	GO:0042278	127	0.023
respiratory system development	GO:0060541	213	0.023
regulation of behavior	GO:0050795	75	0.023
adult behavior	GO:0030534	137	0.023
regulation of catabolic process	GO:0009894	170	0.023
proteolysis	GO:0006508	192	0.022
immune response	GO:0006955	246	0.022
negative regulation of erbb signaling pathway	GO:1901185	29	0.022
asymmetric stem cell division	GO:0098722	49	0.022
organelle fusion	GO:0048284	46	0.022
axis specification	GO:0009798	167	0.022
organelle membrane fusion	GO:0090174	16	0.022
establishment of organelle localization	GO:0051656	122	0.022
positive regulation of gtpase activity	GO:0043547	43	0.022
locomotory behavior	GO:0007626	176	0.022
anatomical structure homeostasis	GO:0060249	97	0.022
cellular response to external stimulus	GO:0071496	66	0.021
regulation of catalytic activity	GO:0050790	185	0.021
regulation of cell division	GO:0051302	72	0.021
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.021	Fly
purine nucleoside catabolic process	GO:0006152	112	0.021
erbb signaling pathway	GO:0038127	58	0.021	Fly
phagocytosis	GO:0006909	215	0.021
macromolecule catabolic process	GO:0009057	161	0.021
associative learning	GO:0008306	65	0.020
epithelial cell development	GO:0002064	274	0.020
protein localization	GO:0008104	284	0.020
appendage development	GO:0048736	401	0.020	Fly
glycosyl compound catabolic process	GO:1901658	112	0.020
positive regulation of phosphorus metabolic process	GO:0010562	139	0.020
camera type eye development	GO:0043010	4	0.020
cellular nitrogen compound catabolic process	GO:0044270	165	0.020
cellular response to extracellular stimulus	GO:0031668	64	0.019
glycosyl compound metabolic process	GO:1901657	127	0.019
signal transduction by phosphorylation	GO:0023014	107	0.019
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.019	Fly
nucleotide metabolic process	GO:0009117	161	0.019
regulation of embryonic development	GO:0045995	68	0.019
cellular response to nutrient levels	GO:0031669	62	0.019
dendrite morphogenesis	GO:0048813	199	0.019
somatic muscle development	GO:0007525	66	0.019
embryonic hindgut morphogenesis	GO:0048619	48	0.019
regulation of mapk cascade	GO:0043408	92	0.019
vesicle mediated transport	GO:0016192	381	0.018
appendage morphogenesis	GO:0035107	397	0.018	Fly
carbohydrate derivative metabolic process	GO:1901135	217	0.018
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.018	Mouse
positive regulation of macromolecule metabolic process	GO:0010604	405	0.018	Mouse
leg disc development	GO:0035218	92	0.018
negative regulation of cell death	GO:0060548	81	0.018
positive regulation of intracellular signal transduction	GO:1902533	116	0.018
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.018
regulation of multi organism process	GO:0043900	131	0.018
mitotic cell cycle phase transition	GO:0044772	138	0.018
cell fate specification	GO:0001708	71	0.018
cell migration	GO:0016477	238	0.018	Fly
retina morphogenesis in camera type eye	GO:0060042	2	0.018
regulation of erbb signaling pathway	GO:1901184	42	0.018
regulation of molecular function	GO:0065009	217	0.018
regulation of organelle organization	GO:0033043	196	0.017
regulation of epithelial cell differentiation	GO:0030856	4	0.017
asymmetric protein localization involved in cell fate determination	GO:0045167	9	0.017
regulation of notch signaling pathway	GO:0008593	100	0.017
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.017	Fly
regulation of photoreceptor cell differentiation	GO:0046532	34	0.017
neural retina development	GO:0003407	4	0.017
aromatic compound catabolic process	GO:0019439	166	0.017
rhabdomere development	GO:0042052	38	0.017
regulation of wnt signaling pathway	GO:0030111	68	0.017
regulation of establishment of planar polarity	GO:0090175	22	0.017
synapse organization	GO:0050808	196	0.017
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.016
learning	GO:0007612	75	0.016
positive regulation of cellular component organization	GO:0051130	156	0.016
regulation of rna splicing	GO:0043484	69	0.016	Human
renal system development	GO:0072001	72	0.016
stem cell proliferation	GO:0072089	88	0.016
nucleoside catabolic process	GO:0009164	112	0.016
response to extracellular stimulus	GO:0009991	116	0.016
compound eye cone cell differentiation	GO:0042675	13	0.016
innate immune response activating signal transduction	GO:0002758	2	0.016
eye antennal disc development	GO:0035214	60	0.016
gtp catabolic process	GO:0006184	72	0.016
regulation of programmed cell death	GO:0043067	152	0.016
mitotic nuclear division	GO:0007067	213	0.015
regulation of cellular response to stress	GO:0080135	89	0.015
gtp metabolic process	GO:0046039	72	0.015
positive regulation of gene expression	GO:0010628	290	0.015	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	316	0.015	Mouse
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.015
regulation of neuron differentiation	GO:0045664	103	0.015
asymmetric protein localization	GO:0008105	33	0.015
ion transport	GO:0006811	145	0.015
regulation of mrna processing	GO:0050684	71	0.015	Human
germarium derived egg chamber formation	GO:0007293	101	0.015
cell maturation	GO:0048469	144	0.015
negative regulation of neurogenesis	GO:0050768	53	0.015
negative regulation of nervous system development	GO:0051961	92	0.015
renal tubule development	GO:0061326	64	0.015
regulation of cellular amine metabolic process	GO:0033238	3	0.015
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.015	Mouse
regulation of cell development	GO:0060284	215	0.015
ribonucleoside metabolic process	GO:0009119	127	0.015
negative regulation of erk1 and erk2 cascade	GO:0070373	3	0.015
negative regulation of rna biosynthetic process	GO:1902679	240	0.014	Mouse
ribonucleotide catabolic process	GO:0009261	109	0.014
cellular protein modification process	GO:0006464	438	0.014
macroautophagy	GO:0016236	42	0.014
small molecule metabolic process	GO:0044281	305	0.014
regulation of transport	GO:0051049	181	0.014
ommatidial rotation	GO:0016318	20	0.014
positive regulation of phosphate metabolic process	GO:0045937	139	0.014
r3 r4 cell differentiation	GO:0048056	12	0.014
urogenital system development	GO:0001655	72	0.014
membrane fusion	GO:0061025	42	0.014
humoral immune response	GO:0006959	117	0.014
eggshell formation	GO:0030703	105	0.014
ribonucleotide metabolic process	GO:0009259	145	0.014
nephron epithelium development	GO:0072009	3	0.014
cell motility	GO:0048870	251	0.014	Fly
heterocycle catabolic process	GO:0046700	166	0.014
regulation of synapse structure and activity	GO:0050803	128	0.014
protein ubiquitination	GO:0016567	70	0.014
spermatid development	GO:0007286	98	0.014
cellular homeostasis	GO:0019725	80	0.014
negative regulation of protein metabolic process	GO:0051248	85	0.014
negative regulation of multicellular organismal process	GO:0051241	142	0.014	Mouse
regulation of mrna splicing via spliceosome	GO:0048024	64	0.014	Human
regulation of cellular protein metabolic process	GO:0032268	243	0.014
dendrite development	GO:0016358	204	0.014
positive regulation of ras gtpase activity	GO:0032320	36	0.014
positive regulation of hydrolase activity	GO:0051345	78	0.014
columnar cuboidal epithelial cell development	GO:0002066	249	0.014
purine ribonucleoside catabolic process	GO:0046130	112	0.013
regulation of cell shape	GO:0008360	113	0.013
nucleoside phosphate catabolic process	GO:1901292	110	0.013
nitrogen compound transport	GO:0071705	85	0.013
kidney epithelium development	GO:0072073	3	0.013
stem cell maintenance	GO:0019827	67	0.013
protein modification by small protein conjugation or removal	GO:0070647	106	0.013
positive regulation of gtp catabolic process	GO:0033126	43	0.013
mitotic dna integrity checkpoint	GO:0044774	75	0.013
positive regulation of nucleoside metabolic process	GO:0045979	47	0.013
olfactory behavior	GO:0042048	97	0.013
stem cell division	GO:0017145	69	0.013
pole plasm mrna localization	GO:0019094	49	0.013
peripheral nervous system development	GO:0007422	52	0.013	Fly
organic cyclic compound catabolic process	GO:1901361	168	0.013
positive regulation of catalytic activity	GO:0043085	118	0.013
protein phosphorylation	GO:0006468	169	0.013
positive regulation of nucleotide catabolic process	GO:0030813	46	0.013
imaginal disc derived leg morphogenesis	GO:0007480	80	0.013
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.013
dorsal ventral pattern formation	GO:0009953	133	0.013
purine containing compound metabolic process	GO:0072521	155	0.013
rna processing	GO:0006396	147	0.013	Human
mitotic sister chromatid segregation	GO:0000070	87	0.013
oocyte anterior posterior axis specification	GO:0007314	72	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.013
neuron fate commitment	GO:0048663	50	0.012
ovarian follicle cell development	GO:0030707	248	0.012
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.012
regulation of hydrolase activity	GO:0051336	97	0.012
ubiquitin dependent protein catabolic process	GO:0006511	78	0.012
gastrulation	GO:0007369	70	0.012
anterior posterior axis specification	GO:0009948	109	0.012
cellular response to carbohydrate stimulus	GO:0071322	4	0.012
nucleoside triphosphate metabolic process	GO:0009141	120	0.012
negative regulation of response to stimulus	GO:0048585	258	0.012
g2 dna damage checkpoint	GO:0031572	69	0.012
macromolecular complex assembly	GO:0065003	256	0.012
chromatin organization	GO:0006325	207	0.012
dna templated transcription initiation	GO:0006352	25	0.012
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.012
regulation of cellular catabolic process	GO:0031329	157	0.012
homeostatic process	GO:0042592	199	0.012
purine ribonucleotide catabolic process	GO:0009154	109	0.012
actin filament based process	GO:0030029	220	0.012
gastrulation with mouth forming first	GO:0001703	36	0.012
positive regulation of molecular function	GO:0044093	136	0.012
negative regulation of cell cycle	GO:0045786	116	0.012
chromosome organization	GO:0051276	360	0.012
purine nucleotide catabolic process	GO:0006195	109	0.012
nephron epithelium morphogenesis	GO:0072088	3	0.012
centrosome duplication	GO:0051298	121	0.012
asymmetric neuroblast division	GO:0055059	33	0.012
apical constriction	GO:0003383	18	0.012
mitotic g2 dna damage checkpoint	GO:0007095	69	0.012
dna metabolic process	GO:0006259	227	0.012
regulation of cell proliferation	GO:0042127	163	0.012
cellular pigmentation	GO:0033059	12	0.012
rhythmic behavior	GO:0007622	76	0.011
mitotic cytokinesis	GO:0000281	50	0.011
negative regulation of notch signaling pathway	GO:0045746	41	0.011
photoreceptor cell fate commitment	GO:0046552	41	0.011
malpighian tubule development	GO:0072002	64	0.011
nephron development	GO:0072006	3	0.011
mitotic spindle organization	GO:0007052	220	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.011
ribonucleoside catabolic process	GO:0042454	112	0.011
regulation of response to stress	GO:0080134	200	0.011
sister chromatid segregation	GO:0000819	92	0.011
glial cell differentiation	GO:0010001	35	0.011	Fly
guanosine containing compound metabolic process	GO:1901068	74	0.011
purine nucleotide metabolic process	GO:0006163	146	0.011
posttranscriptional regulation of gene expression	GO:0010608	145	0.011
negative regulation of cell cycle phase transition	GO:1901988	103	0.011
guanosine containing compound catabolic process	GO:1901069	74	0.011
regulation of mitosis	GO:0007088	56	0.011
regulation of synaptic transmission	GO:0050804	69	0.011
purine ribonucleotide metabolic process	GO:0009150	145	0.011
single organism membrane fusion	GO:0044801	42	0.011
oocyte differentiation	GO:0009994	145	0.011
positive regulation of response to external stimulus	GO:0032103	44	0.011
meiotic cell cycle	GO:0051321	171	0.011
carbohydrate derivative catabolic process	GO:1901136	118	0.011
antibacterial peptide biosynthetic process	GO:0002780	22	0.011
regulation of protein metabolic process	GO:0051246	256	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.011
gland morphogenesis	GO:0022612	145	0.011
cytoskeleton dependent cytokinesis	GO:0061640	81	0.011
salivary gland morphogenesis	GO:0007435	145	0.011
regulation of epithelial cell proliferation	GO:0050678	4	0.011
renal tubule morphogenesis	GO:0061333	44	0.011
cellular response to starvation	GO:0009267	61	0.011
negative regulation of apoptotic process	GO:0043066	63	0.011
axon development	GO:0061564	297	0.011	Fly
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.010	Mouse
meiotic nuclear division	GO:0007126	151	0.010
regulation of cellular amino acid metabolic process	GO:0006521	0	0.010
nucleotide catabolic process	GO:0009166	109	0.010
cell fate determination	GO:0001709	91	0.010	Fly
response to external biotic stimulus	GO:0043207	293	0.010	Fly
embryonic organ development	GO:0048568	50	0.010
germ line stem cell maintenance	GO:0030718	50	0.010
retinal cell programmed cell death	GO:0046666	25	0.010
organonitrogen compound catabolic process	GO:1901565	128	0.010
positive regulation of retinal cell programmed cell death	GO:0046670	9	0.010
morphogenesis of embryonic epithelium	GO:0016331	94	0.010
positive regulation of phosphorylation	GO:0042327	87	0.010
regulation of protein modification process	GO:0031399	112	0.010
mitotic dna damage checkpoint	GO:0044773	74	0.010
regulation of ras gtpase activity	GO:0032318	38	0.010
protein catabolic process	GO:0030163	101	0.010
regulation of cellular localization	GO:0060341	136	0.010
positive regulation of cell death	GO:0010942	69	0.010
regulation of cell cycle process	GO:0010564	181	0.010

nito disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.017
disease of cellular proliferation	DOID:14566	0.016
organ system cancer	DOID:0050686	0.010
cancer	DOID:162	0.010

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network