IMP: Integrative Multi-species Prediction

Drosophila melanogaster

102 known processes

Smox (Dmel_CG2262)

Smad on X

(Aliases: dsmad2,dSmad2,Dmel\CG2262,SMOX,dSMAD2,DSmad2,l(1)G0348,ted,SMAD2,Sad,DSMAD2,Smad2,smad2,sad,CG2262,tmp,smox)

FLYBASE: FBgn0025800
Entrez: 31738
UniProtKB: O96660

Process Predictions
Disease Predictions

Smox biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
embryonic morphogenesis	GO:0048598	206	0.991	Fly
axon guidance	GO:0007411	233	0.976
phosphorylation	GO:0016310	294	0.976	Fly
taxis	GO:0042330	304	0.974
stem cell differentiation	GO:0048863	117	0.972	Fly
regulation of intracellular signal transduction	GO:1902531	236	0.970
intracellular signal transduction	GO:0035556	300	0.966	Fly
growth	GO:0040007	359	0.954	Worm Fly
cell migration	GO:0016477	238	0.953	Fly
embryonic development via the syncytial blastoderm	GO:0001700	148	0.952
developmental growth	GO:0048589	280	0.939	Worm Fly
regulation of growth	GO:0040008	233	0.938	Worm Fly
muscle cell differentiation	GO:0042692	103	0.926
extracellular structure organization	GO:0043062	46	0.922
chemotaxis	GO:0006935	249	0.921
cell motility	GO:0048870	251	0.914	Fly
multicellular organismal aging	GO:0010259	140	0.899
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.890	Fly
determination of adult lifespan	GO:0008340	137	0.887
regulation of mitotic cell cycle	GO:0007346	190	0.880
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.880	Fly
regulation of developmental growth	GO:0048638	174	0.870	Worm Fly
eye development	GO:0001654	323	0.861	Fly
protein modification process	GO:0036211	438	0.858
regulation of localization	GO:0032879	275	0.854
regulation of cell differentiation	GO:0045595	302	0.849	Fly
positive regulation of cell communication	GO:0010647	250	0.847
ameboidal type cell migration	GO:0001667	151	0.845
actin filament based process	GO:0030029	220	0.829
oxoacid metabolic process	GO:0043436	103	0.827
regulation of multicellular organism growth	GO:0040014	40	0.818	Worm
positive regulation of response to stimulus	GO:0048584	323	0.817
epithelial cell migration	GO:0010631	148	0.817
cellular protein modification process	GO:0006464	438	0.814
response to organic substance	GO:0010033	284	0.806	Fly
embryo development ending in birth or egg hatching	GO:0009792	152	0.796
positive regulation of developmental process	GO:0051094	143	0.783	Worm Fly
regulation of gtpase activity	GO:0043087	44	0.780
stem cell division	GO:0017145	69	0.761	Fly
regulation of cellular amine metabolic process	GO:0033238	3	0.744
stem cell proliferation	GO:0072089	88	0.730
immune system process	GO:0002376	347	0.729
positive regulation of molecular function	GO:0044093	136	0.723
negative regulation of cell communication	GO:0010648	223	0.722	Fly
regulation of mapk cascade	GO:0043408	92	0.709
catabolic process	GO:0009056	409	0.697
regulation of cellular protein metabolic process	GO:0032268	243	0.697
regulation of phosphorylation	GO:0042325	147	0.670	Fly
regulation of adult chitin containing cuticle pigmentation	GO:0048082	13	0.660
positive regulation of multicellular organismal process	GO:0051240	143	0.657	Worm Fly
regulation of phosphorus metabolic process	GO:0051174	210	0.649	Fly
negative regulation of developmental process	GO:0051093	201	0.645	Fly
aging	GO:0007568	143	0.644
regulation of phosphate metabolic process	GO:0019220	210	0.621	Fly
positive regulation of macromolecule metabolic process	GO:0010604	405	0.615	Fly
cellular response to chemical stimulus	GO:0070887	199	0.610	Fly
cardiocyte differentiation	GO:0035051	29	0.608
regulation of catabolic process	GO:0009894	170	0.603
polysaccharide metabolic process	GO:0005976	11	0.601
digestive system development	GO:0055123	149	0.597	Fly
positive regulation of signaling	GO:0023056	243	0.592
regulation of cellular localization	GO:0060341	136	0.588
cell division	GO:0051301	248	0.588	Fly
morphogenesis of embryonic epithelium	GO:0016331	94	0.584
positive regulation of signal transduction	GO:0009967	223	0.583
regulation of imaginal disc growth	GO:0045570	26	0.581
axonogenesis	GO:0007409	290	0.577
regionalization	GO:0003002	416	0.553	Fly
negative regulation of signal transduction	GO:0009968	206	0.550	Fly
positive regulation of phosphorus metabolic process	GO:0010562	139	0.544
heart development	GO:0007507	82	0.537
extracellular matrix organization	GO:0030198	32	0.531
immune system development	GO:0002520	57	0.517
positive regulation of proteolysis	GO:0045862	52	0.512
negative regulation of cell cycle phase transition	GO:1901988	103	0.507	Fly
posttranscriptional regulation of gene expression	GO:0010608	145	0.500
regulation of protein metabolic process	GO:0051246	256	0.496
cell death	GO:0008219	279	0.493
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.491	Fly
transcription from rna polymerase ii promoter	GO:0006366	368	0.487	Fly
central nervous system development	GO:0007417	201	0.487
protein phosphorylation	GO:0006468	169	0.481
defense response	GO:0006952	300	0.466
positive regulation of transcription dna templated	GO:0045893	266	0.462	Fly
localization of cell	GO:0051674	257	0.461	Fly
digestive tract development	GO:0048565	149	0.450	Fly
regulation of cellular catabolic process	GO:0031329	157	0.446
embryonic organ development	GO:0048568	50	0.427
organic acid metabolic process	GO:0006082	103	0.427
organelle fission	GO:0048285	340	0.426
response to abiotic stimulus	GO:0009628	341	0.423
developmental pigmentation	GO:0048066	68	0.417
mitotic cell cycle phase transition	GO:0044772	138	0.400	Fly
gland development	GO:0048732	191	0.399
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.397	Fly
protein localization to nucleus	GO:0034504	55	0.397
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.396	Fly
cellular ketone metabolic process	GO:0042180	24	0.394
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.389	Fly
mesenchymal cell differentiation	GO:0048762	1	0.387
single organism catabolic process	GO:0044712	228	0.387
cellular response to organic substance	GO:0071310	132	0.384	Fly
neural precursor cell proliferation	GO:0061351	75	0.380
signal transduction by phosphorylation	GO:0023014	107	0.372
cell growth	GO:0016049	108	0.370	Fly
eye morphogenesis	GO:0048592	260	0.370	Fly
macromolecule catabolic process	GO:0009057	161	0.365
axon development	GO:0061564	297	0.365
positive regulation of cellular protein metabolic process	GO:0032270	118	0.362
cellular catabolic process	GO:0044248	372	0.362
cell projection assembly	GO:0030031	94	0.361
protein localization	GO:0008104	284	0.353
regulation of wnt signaling pathway	GO:0030111	68	0.352
dorsal ventral pattern formation	GO:0009953	133	0.347	Fly
positive regulation of lipid metabolic process	GO:0045834	4	0.343
tissue morphogenesis	GO:0048729	297	0.333	Fly
hemopoiesis	GO:0030097	46	0.325
regulation of cellular amino acid metabolic process	GO:0006521	0	0.321
regulation of cell growth	GO:0001558	43	0.321
pigmentation	GO:0043473	75	0.308
protein complex biogenesis	GO:0070271	201	0.306
cell adhesion	GO:0007155	136	0.300
cell junction organization	GO:0034330	57	0.296
hematopoietic progenitor cell differentiation	GO:0002244	1	0.294
developmental maturation	GO:0021700	172	0.286
cardiovascular system development	GO:0072358	82	0.285
positive regulation of multicellular organism growth	GO:0040018	21	0.281	Worm
muscle structure development	GO:0061061	224	0.278	Fly
brain development	GO:0007420	120	0.271
regulation of anatomical structure morphogenesis	GO:0022603	242	0.270
cellular response to dna damage stimulus	GO:0006974	223	0.269
regulation of gtp catabolic process	GO:0033124	44	0.266
negative regulation of catabolic process	GO:0009895	36	0.265
epithelium migration	GO:0090132	148	0.263
regulation of bmp signaling pathway	GO:0030510	23	0.263
negative regulation of growth	GO:0045926	84	0.262	Fly
anterior posterior pattern specification imaginal disc	GO:0007448	16	0.260	Fly
amine metabolic process	GO:0009308	12	0.260
stem cell maintenance	GO:0019827	67	0.258	Fly
camera type eye development	GO:0043010	4	0.256
positive regulation of protein metabolic process	GO:0051247	128	0.255
negative regulation of cell differentiation	GO:0045596	143	0.255	Fly
positive regulation of hydrolase activity	GO:0051345	78	0.252
positive regulation of intracellular signal transduction	GO:1902533	116	0.251
tissue migration	GO:0090130	155	0.248
segmentation	GO:0035282	207	0.246	Fly
regulation of cell cycle	GO:0051726	291	0.242
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.240
positive regulation of phosphate metabolic process	GO:0045937	139	0.239
cell fate determination	GO:0001709	91	0.238
regulation of protein localization	GO:0032880	76	0.236
circulatory system development	GO:0072359	82	0.234
cellular macromolecule localization	GO:0070727	220	0.232
retinal ganglion cell axon guidance	GO:0031290	12	0.227	Fly
exocrine system development	GO:0035272	162	0.226
larval development	GO:0002164	104	0.224	Fly
positive regulation of developmental growth	GO:0048639	62	0.223	Worm Fly
carboxylic acid metabolic process	GO:0019752	92	0.217
positive regulation of biosynthetic process	GO:0009891	316	0.215	Fly
positive regulation of cell development	GO:0010720	61	0.215
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.214
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.213
protein modification by small protein conjugation or removal	GO:0070647	106	0.209
regulation of innate immune response	GO:0045088	71	0.208
connective tissue development	GO:0061448	3	0.207
neuron projection guidance	GO:0097485	241	0.206
neuroblast proliferation	GO:0007405	74	0.206
regulation of intracellular protein transport	GO:0033157	46	0.206
stem cell development	GO:0048864	79	0.205	Fly
regulation of nucleotide catabolic process	GO:0030811	48	0.202
cellular amino acid metabolic process	GO:0006520	61	0.202
mapk cascade	GO:0000165	107	0.197
innate immune response	GO:0045087	144	0.195
proteolysis	GO:0006508	192	0.194
molting cycle process	GO:0022404	29	0.191
cell fate specification	GO:0001708	71	0.189	Fly
positive regulation of phosphorylation	GO:0042327	87	0.188
phenol containing compound metabolic process	GO:0018958	57	0.185
protein catabolic process	GO:0030163	101	0.185
regulation of synapse structure and activity	GO:0050803	128	0.184	Fly
biological adhesion	GO:0022610	138	0.184
gastrulation	GO:0007369	70	0.184	Fly
striated muscle cell differentiation	GO:0051146	90	0.184
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.183	Fly
molting cycle	GO:0042303	56	0.182
macromolecular complex assembly	GO:0065003	256	0.182
regulation of transferase activity	GO:0051338	58	0.178
gliogenesis	GO:0042063	80	0.178
immune response regulating signaling pathway	GO:0002764	2	0.172
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.172
organonitrogen compound metabolic process	GO:1901564	318	0.172
regulation of molecular function	GO:0065009	217	0.170
protein targeting to nucleus	GO:0044744	51	0.168
cell proliferation	GO:0008283	299	0.166
regulation of cell cycle phase transition	GO:1901987	130	0.166	Fly
camera type eye morphogenesis	GO:0048593	2	0.164
activin receptor signaling pathway	GO:0032924	6	0.164
extrinsic apoptotic signaling pathway	GO:0097191	1	0.163
positive regulation of cell adhesion	GO:0045785	10	0.163
actin cytoskeleton reorganization	GO:0031532	22	0.163
regulation of protein modification process	GO:0031399	112	0.162
negative regulation of phosphorylation	GO:0042326	35	0.160
negative regulation of signaling	GO:0023057	219	0.159	Fly
cellular protein catabolic process	GO:0044257	83	0.153
negative regulation of cellular protein metabolic process	GO:0032269	85	0.152
regulation of transport	GO:0051049	181	0.151
stress activated mapk cascade	GO:0051403	52	0.148
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.148
regulation of hydrolase activity	GO:0051336	97	0.146
positive regulation of bmp signaling pathway	GO:0030513	5	0.145
regulation of stress activated mapk cascade	GO:0032872	41	0.144
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.142	Fly
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.142
protein complex assembly	GO:0006461	200	0.142
immune response	GO:0006955	246	0.142
regulation of immune system process	GO:0002682	176	0.141
cellular amine metabolic process	GO:0044106	12	0.141
regulation of stem cell proliferation	GO:0072091	40	0.140
positive regulation of cellular component organization	GO:0051130	156	0.139	Fly
organic substance catabolic process	GO:1901575	308	0.138
establishment of nucleus localization	GO:0040023	26	0.137
polysaccharide biosynthetic process	GO:0000271	7	0.137
regulation of response to stress	GO:0080134	200	0.137
regulation of cell cycle process	GO:0010564	181	0.135	Fly
cell fate commitment involved in formation of primary germ layer	GO:0060795	10	0.134	Fly
regulation of cell proliferation	GO:0042127	163	0.133
regulation of neurogenesis	GO:0050767	158	0.132
regulation of organ morphogenesis	GO:2000027	78	0.131
nucleus localization	GO:0051647	34	0.130
stress activated protein kinase signaling cascade	GO:0031098	55	0.129
cellular response to growth factor stimulus	GO:0071363	30	0.129	Fly
regulation of protein serine threonine kinase activity	GO:0071900	25	0.128
ras protein signal transduction	GO:0007265	88	0.127
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.127
regulation of cellular response to stress	GO:0080135	89	0.127
secretion	GO:0046903	109	0.125
positive regulation of catabolic process	GO:0009896	105	0.125
protein import into nucleus	GO:0006606	51	0.124
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	9	0.124
cell cycle checkpoint	GO:0000075	95	0.124
negative regulation of epithelial cell proliferation	GO:0050680	4	0.123
chitin based cuticle sclerotization	GO:0007593	19	0.123
positive regulation of rna metabolic process	GO:0051254	271	0.122	Fly
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.122
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.122	Fly
positive regulation of catalytic activity	GO:0043085	118	0.120
positive regulation of cellular catabolic process	GO:0031331	95	0.119
pigment metabolic process	GO:0042440	84	0.119
tube development	GO:0035295	244	0.118	Fly
membrane organization	GO:0061024	112	0.117
positive regulation of growth	GO:0045927	75	0.116	Worm Fly
cell junction assembly	GO:0034329	42	0.115
cellular response to endogenous stimulus	GO:0071495	80	0.115	Fly
gtp catabolic process	GO:0006184	72	0.115
regulation of protein phosphorylation	GO:0001932	64	0.115
peptidyl threonine phosphorylation	GO:0018107	2	0.114
nucleoside phosphate catabolic process	GO:1901292	110	0.114
hindbrain development	GO:0030902	2	0.114
death	GO:0016265	284	0.111
dorsal closure	GO:0007391	79	0.110
response to lipopolysaccharide	GO:0032496	4	0.109
mitotic cell cycle checkpoint	GO:0007093	88	0.108
nephron development	GO:0072006	3	0.107
regulation of nucleoside metabolic process	GO:0009118	50	0.107
secretion by cell	GO:0032940	101	0.106
regulation of cellular response to insulin stimulus	GO:1900076	17	0.106
positive regulation of cell migration	GO:0030335	2	0.105
meiotic nuclear division	GO:0007126	151	0.105
hematopoietic or lymphoid organ development	GO:0048534	57	0.104
protein modification by small protein conjugation	GO:0032446	79	0.104
carbohydrate derivative catabolic process	GO:1901136	118	0.102
regulation of epithelial cell proliferation	GO:0050678	4	0.102
salivary gland development	GO:0007431	162	0.101
positive regulation of peptidase activity	GO:0010952	29	0.100
cellular lipid metabolic process	GO:0044255	83	0.100
positive regulation of jun kinase activity	GO:0043507	4	0.100
positive regulation of cell growth	GO:0030307	19	0.099
positive regulation of protein complex assembly	GO:0031334	22	0.099
purine nucleotide catabolic process	GO:0006195	109	0.098
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.097
mesenchymal cell development	GO:0014031	1	0.096
body morphogenesis	GO:0010171	2	0.094
activation of protein kinase activity	GO:0032147	12	0.094
regulation of programmed cell death	GO:0043067	152	0.094
gtp metabolic process	GO:0046039	72	0.093
single organism cellular localization	GO:1902580	180	0.093
organic hydroxy compound metabolic process	GO:1901615	83	0.092
guanosine containing compound catabolic process	GO:1901069	74	0.092
phagocytosis	GO:0006909	215	0.090
regulation of ras protein signal transduction	GO:0046578	93	0.090
response to organonitrogen compound	GO:0010243	75	0.089
small molecule metabolic process	GO:0044281	305	0.088
small gtpase mediated signal transduction	GO:0007264	88	0.088
actin cytoskeleton organization	GO:0030036	206	0.087
cellular carbohydrate metabolic process	GO:0044262	22	0.087
single organismal cell cell adhesion	GO:0016337	45	0.086
glycosyl compound metabolic process	GO:1901657	127	0.085
negative regulation of immune system process	GO:0002683	50	0.084
homeostatic process	GO:0042592	199	0.084
axis specification	GO:0009798	167	0.082	Fly
regulation of cell death	GO:0010941	173	0.082
response to nutrient levels	GO:0031667	114	0.082
kidney development	GO:0001822	3	0.081
regulation of kinase activity	GO:0043549	53	0.080
posttranscriptional gene silencing	GO:0016441	46	0.080
unidimensional cell growth	GO:0009826	15	0.080	Fly
regulation of nervous system development	GO:0051960	248	0.079	Fly
regulation of protein kinase activity	GO:0045859	51	0.078
regulation of catalytic activity	GO:0050790	185	0.078
response to glucose	GO:0009749	2	0.077
purine nucleoside catabolic process	GO:0006152	112	0.076
positive regulation of mapk cascade	GO:0043410	63	0.075
organelle localization	GO:0051640	148	0.074
negative regulation of autophagy	GO:0010507	16	0.073
cellular protein localization	GO:0034613	160	0.073
renal system development	GO:0072001	72	0.073	Fly
regulation of jnk cascade	GO:0046328	40	0.073
nucleoside metabolic process	GO:0009116	127	0.072
endomembrane system organization	GO:0010256	119	0.072
negative regulation of protein metabolic process	GO:0051248	85	0.072
cell cell junction organization	GO:0045216	55	0.072
peptidyl amino acid modification	GO:0018193	105	0.071
jak stat cascade	GO:0007259	49	0.071
gene silencing by mirna	GO:0035195	22	0.071
posttranscriptional gene silencing by rna	GO:0035194	45	0.071
oviposition	GO:0018991	19	0.071
regulation of peptidyl tyrosine phosphorylation	GO:0050730	10	0.071
chromosome organization	GO:0051276	360	0.070
compound eye development	GO:0048749	307	0.070	Fly
striated muscle tissue development	GO:0014706	27	0.070
regulation of neuron differentiation	GO:0045664	103	0.069
chromatin organization	GO:0006325	207	0.069
regulation of immune response	GO:0050776	118	0.069
regulation of cellular ketone metabolic process	GO:0010565	3	0.068
positive regulation of rna biosynthetic process	GO:1902680	266	0.068	Fly
positive regulation of gtpase activity	GO:0043547	43	0.067
regulation of histone acetylation	GO:0035065	7	0.067
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.067
negative regulation of phosphate metabolic process	GO:0045936	45	0.067
gene silencing by rna	GO:0031047	57	0.067
response to extracellular stimulus	GO:0009991	116	0.067
nuclear division	GO:0000280	332	0.066
regulation of cell development	GO:0060284	215	0.066
regulation of cytoplasmic transport	GO:1903649	47	0.066
digestive tract morphogenesis	GO:0048546	127	0.066	Fly
ribonucleoside metabolic process	GO:0009119	127	0.066
endocytosis	GO:0006897	310	0.066
compound eye photoreceptor cell differentiation	GO:0001751	140	0.065
bmp signaling pathway	GO:0030509	27	0.065	Fly
regulation of phosphatidylinositol 3 kinase activity	GO:0043551	2	0.065
mesoderm development	GO:0007498	78	0.064
carbohydrate derivative metabolic process	GO:1901135	217	0.064
regulation of vesicle mediated transport	GO:0060627	59	0.064
response to monosaccharide	GO:0034284	4	0.064
cellular protein complex assembly	GO:0043623	71	0.064
dendrite development	GO:0016358	204	0.061
regulation of intracellular transport	GO:0032386	64	0.061
retina development in camera type eye	GO:0060041	4	0.061
maintenance of protein location in cell	GO:0032507	26	0.060
negative regulation of mitotic cell cycle	GO:0045930	109	0.058	Worm Fly
endodermal cell fate commitment	GO:0001711	3	0.058	Fly
regulation of glial cell proliferation	GO:0060251	11	0.058
regulation of translation	GO:0006417	56	0.058
negative regulation of phosphorus metabolic process	GO:0010563	45	0.057
negative regulation of cell proliferation	GO:0008285	69	0.057
endodermal cell differentiation	GO:0035987	3	0.057	Fly
purine ribonucleotide metabolic process	GO:0009150	145	0.057
spinal cord development	GO:0021510	1	0.057
organophosphate metabolic process	GO:0019637	195	0.057
negative regulation of cell death	GO:0060548	81	0.057
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.056
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.055
regulation of epithelial cell differentiation	GO:0030856	4	0.055
positive regulation of cell motility	GO:2000147	3	0.055
positive regulation of cellular biosynthetic process	GO:0031328	316	0.054	Fly
regulation of carbohydrate metabolic process	GO:0006109	10	0.054
positive regulation of transport	GO:0051050	92	0.053
dorsal ventral axon guidance	GO:0033563	2	0.053
cardioblast differentiation	GO:0010002	20	0.053
ribonucleoside catabolic process	GO:0042454	112	0.052
regulation of epithelial cell migration	GO:0010632	12	0.051
regulation of gliogenesis	GO:0014013	11	0.051
vesicle mediated transport	GO:0016192	381	0.051
erk1 and erk2 cascade	GO:0070371	39	0.051
positive regulation of kinase activity	GO:0033674	25	0.051
nucleoside triphosphate metabolic process	GO:0009141	120	0.050
regulation of organelle organization	GO:0033043	196	0.050
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.050
negative regulation of protein modification process	GO:0031400	29	0.050
nucleoside catabolic process	GO:0009164	112	0.049
establishment of protein localization	GO:0045184	163	0.049
positive regulation of gtp catabolic process	GO:0033126	43	0.049
negative regulation of gene expression	GO:0010629	387	0.049	Fly
regulation of protein catabolic process	GO:0042176	55	0.048
aromatic compound catabolic process	GO:0019439	166	0.048
response to heat	GO:0009408	63	0.047
regulation of ras gtpase activity	GO:0032318	38	0.047
regulation of purine nucleotide catabolic process	GO:0033121	48	0.047
regulation of protein acetylation	GO:1901983	7	0.047
myotube differentiation	GO:0014902	46	0.046
smad protein import into nucleus	GO:0007184	11	0.046
multicellular organism growth	GO:0035264	46	0.046	Worm
regulation of apoptotic process	GO:0042981	130	0.046
glycosyl compound catabolic process	GO:1901658	112	0.045
positive regulation of cellular component biogenesis	GO:0044089	80	0.045	Fly
positive regulation of transferase activity	GO:0051347	26	0.045
single organism nuclear import	GO:1902593	51	0.045
cellular nitrogen compound catabolic process	GO:0044270	165	0.045
guanosine containing compound metabolic process	GO:1901068	74	0.045
response to radiation	GO:0009314	155	0.044
ubiquitin dependent protein catabolic process	GO:0006511	78	0.044
regulation of glial cell differentiation	GO:0045685	1	0.044
epithelial cell differentiation	GO:0030855	322	0.044	Fly
peptidyl tyrosine phosphorylation	GO:0018108	24	0.044
regulation of neuron death	GO:1901214	26	0.044
nucleocytoplasmic transport	GO:0006913	72	0.043
mitotic nuclear division	GO:0007067	213	0.043
positive regulation of protein phosphorylation	GO:0001934	34	0.043
heterocycle catabolic process	GO:0046700	166	0.043
programmed cell death	GO:0012501	257	0.043
regulation of activin receptor signaling pathway	GO:0032925	4	0.042
establishment of localization in cell	GO:0051649	402	0.042
regulation of defense response	GO:0031347	102	0.042
cell cycle phase transition	GO:0044770	140	0.042	Fly
salivary gland morphogenesis	GO:0007435	145	0.042
response to hormone	GO:0009725	45	0.041
positive regulation of rab gtpase activity	GO:0032851	7	0.041
defense response to bacterium	GO:0042742	178	0.041
negative regulation of neurogenesis	GO:0050768	53	0.041
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.041
positive regulation of protein kinase activity	GO:0045860	25	0.040
developmental growth involved in morphogenesis	GO:0060560	65	0.040	Fly
wing disc anterior posterior pattern formation	GO:0048100	5	0.040	Fly
positive regulation of cellular component movement	GO:0051272	11	0.039
regulation of developmental pigmentation	GO:0048070	24	0.039
adult chitin containing cuticle pigmentation	GO:0048085	16	0.038
adult behavior	GO:0030534	137	0.038
regulation of neuron apoptotic process	GO:0043523	16	0.038
cellular macromolecule catabolic process	GO:0044265	136	0.038
wnt signaling pathway	GO:0016055	98	0.038
cellular component disassembly	GO:0022411	46	0.037
carbohydrate metabolic process	GO:0005975	82	0.037
positive regulation of ras gtpase activity	GO:0032320	36	0.037
response to wounding	GO:0009611	94	0.036
response to growth factor	GO:0070848	31	0.036	Fly
nucleoside triphosphate catabolic process	GO:0009143	108	0.036
maintenance of location	GO:0051235	73	0.036
adherens junction assembly	GO:0034333	11	0.036
nerve development	GO:0021675	6	0.036
ribonucleotide catabolic process	GO:0009261	109	0.036
regulation of multicellular organismal development	GO:2000026	414	0.036
neuron projection extension	GO:1990138	32	0.035
anterior malpighian tubule development	GO:0061327	12	0.035
positive regulation of immune system process	GO:0002684	68	0.035
regulation of stem cell differentiation	GO:2000736	14	0.035
somatic stem cell division	GO:0048103	37	0.035
regulation of hemocyte proliferation	GO:0035206	37	0.035
positive regulation of mitotic cell cycle	GO:0045931	34	0.035
imaginal disc growth	GO:0007446	37	0.035
respiratory system development	GO:0060541	213	0.034
negative regulation of nervous system development	GO:0051961	92	0.034	Fly
regulation of membrane potential	GO:0042391	35	0.034
syncytium formation by plasma membrane fusion	GO:0000768	43	0.034
positive regulation of organelle organization	GO:0010638	65	0.034
chromatin modification	GO:0016568	147	0.034
nucleoside phosphate metabolic process	GO:0006753	162	0.034
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.034
protein acetylation	GO:0006473	39	0.033
mushroom body development	GO:0016319	70	0.033
locomotory behavior	GO:0007626	176	0.033
response to endogenous stimulus	GO:0009719	119	0.032	Fly
positive regulation of response to external stimulus	GO:0032103	44	0.032
modification dependent macromolecule catabolic process	GO:0043632	79	0.032
organ growth	GO:0035265	56	0.032
chromosome separation	GO:0051304	42	0.032
regulation of pathway restricted smad protein phosphorylation	GO:0060393	1	0.032
asymmetric stem cell division	GO:0098722	49	0.032
rho protein signal transduction	GO:0007266	14	0.031
regulation of insulin receptor signaling pathway	GO:0046626	17	0.031
embryonic digestive tract development	GO:0048566	5	0.031
purine containing compound metabolic process	GO:0072521	155	0.031
negative regulation of cell cycle process	GO:0010948	109	0.031	Fly
negative regulation of cellular metabolic process	GO:0031324	382	0.030
r7 cell differentiation	GO:0045466	43	0.030
reproductive behavior	GO:0019098	122	0.030
nitrogen compound transport	GO:0071705	85	0.030
kidney epithelium development	GO:0072073	3	0.030
negative regulation of molecular function	GO:0044092	51	0.030
reactive oxygen species metabolic process	GO:0072593	22	0.030
germ cell migration	GO:0008354	43	0.030
response to biotic stimulus	GO:0009607	294	0.030
filopodium assembly	GO:0046847	33	0.030
tube morphogenesis	GO:0035239	191	0.030	Fly
response to bacterium	GO:0009617	198	0.030
stress fiber assembly	GO:0043149	6	0.030
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.029
anterior posterior pattern specification	GO:0009952	136	0.029	Fly
dna replication	GO:0006260	48	0.029

Smox disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.047

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