IMP: Integrative Multi-species Prediction

Drosophila melanogaster

50 known processes

MED20 (Dmel_CG18780)

Mediator complex subunit 20

(Aliases: Trfp,Tmr,CG18780,Med20,dTrfp,Dmel\CG18780,TrfP,med20,Srb2/TRFP,CG18267,l(2)28DE,p29,dTrap26)

Entrez: 43952
FLYBASE: FBgn0013531
UniProtKB: M9PCC3
UniProtKB: P91641

Process Predictions
Disease Predictions

MED20 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
positive regulation of macromolecule metabolic process	GO:0010604	405	0.728
transcription from rna polymerase ii promoter	GO:0006366	368	0.684
positive regulation of rna metabolic process	GO:0051254	271	0.590
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.580
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.506
positive regulation of gene expression	GO:0010628	290	0.435
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.420
positive regulation of transcription dna templated	GO:0045893	266	0.420
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.413
mitotic g2 m transition checkpoint	GO:0044818	70	0.399
positive regulation of rna biosynthetic process	GO:1902680	266	0.387
mitotic dna integrity checkpoint	GO:0044774	75	0.356
cell cycle checkpoint	GO:0000075	95	0.351
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.343
positive regulation of cellular biosynthetic process	GO:0031328	316	0.308
nuclear division	GO:0000280	332	0.289
meiotic cell cycle	GO:0051321	171	0.285
g2 dna damage checkpoint	GO:0031572	69	0.282
negative regulation of cell cycle phase transition	GO:1901988	103	0.265
dna damage checkpoint	GO:0000077	78	0.265
mitotic g2 dna damage checkpoint	GO:0007095	69	0.235
positive regulation of biosynthetic process	GO:0009891	316	0.214
regulation of cell cycle	GO:0051726	291	0.214
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.200
negative regulation of mitotic cell cycle	GO:0045930	109	0.180
cell cycle phase transition	GO:0044770	140	0.156
regulation of organelle organization	GO:0033043	196	0.145
mitotic cell cycle checkpoint	GO:0007093	88	0.142
organelle assembly	GO:0070925	198	0.122
endocytosis	GO:0006897	310	0.113
organelle fission	GO:0048285	340	0.112
regulation of cell cycle process	GO:0010564	181	0.111
mitotic dna damage checkpoint	GO:0044773	74	0.101
regulation of multicellular organismal development	GO:2000026	414	0.101
vesicle mediated transport	GO:0016192	381	0.094
embryo development ending in birth or egg hatching	GO:0009792	152	0.093
negative regulation of developmental process	GO:0051093	201	0.091
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.091
cellular macromolecular complex assembly	GO:0034622	153	0.090
regulation of nervous system development	GO:0051960	248	0.085
negative regulation of cell differentiation	GO:0045596	143	0.080
cell division	GO:0051301	248	0.080
negative regulation of cell cycle	GO:0045786	116	0.079
dna integrity checkpoint	GO:0031570	81	0.078
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.077
regulation of cell proliferation	GO:0042127	163	0.075
growth	GO:0040007	359	0.074
dna templated transcription initiation	GO:0006352	25	0.069
regulation of cell differentiation	GO:0045595	302	0.068
mitotic nuclear division	GO:0007067	213	0.068
mitotic cell cycle phase transition	GO:0044772	138	0.067
positive regulation of cellular component biogenesis	GO:0044089	80	0.067
cellular nitrogen compound catabolic process	GO:0044270	165	0.064
transcription initiation from rna polymerase ii promoter	GO:0006367	25	0.063
cell proliferation	GO:0008283	299	0.062
stem cell proliferation	GO:0072089	88	0.058
nucleobase containing compound catabolic process	GO:0034655	165	0.058
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.057
protein complex biogenesis	GO:0070271	201	0.056
cellular catabolic process	GO:0044248	372	0.055
regulation of cell development	GO:0060284	215	0.054
regulation of mitotic cell cycle	GO:0007346	190	0.052
dna replication	GO:0006260	48	0.051
mrna catabolic process	GO:0006402	33	0.049
regulation of cell cycle phase transition	GO:1901987	130	0.049
macromolecular complex assembly	GO:0065003	256	0.049
organic cyclic compound catabolic process	GO:1901361	168	0.047
positive regulation of developmental growth	GO:0048639	62	0.046
organic substance catabolic process	GO:1901575	308	0.041
meiotic nuclear division	GO:0007126	151	0.040
macromolecule catabolic process	GO:0009057	161	0.039
neuroblast proliferation	GO:0007405	74	0.037
regulation of growth	GO:0040008	233	0.036
aromatic compound catabolic process	GO:0019439	166	0.035
phagocytosis	GO:0006909	215	0.034
heterocycle catabolic process	GO:0046700	166	0.034
regulation of meiosis	GO:0040020	3	0.033
cell death	GO:0008219	279	0.033
negative regulation of stem cell proliferation	GO:2000647	30	0.033
rna interference	GO:0016246	27	0.032
ribonucleoprotein complex disassembly	GO:0032988	1	0.032
cellular macromolecule catabolic process	GO:0044265	136	0.031
negative regulation of rna biosynthetic process	GO:1902679	240	0.031
phosphorylation	GO:0016310	294	0.031
regulation of multi organism process	GO:0043900	131	0.031
negative regulation of cell cycle process	GO:0010948	109	0.029
regulation of immune system process	GO:0002682	176	0.029
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.027
ribonucleoprotein complex biogenesis	GO:0022613	31	0.027
regulation of cellular component biogenesis	GO:0044087	201	0.027
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.026
negative regulation of biosynthetic process	GO:0009890	277	0.025
regulation of cell division	GO:0051302	72	0.025
negative regulation of multicellular organismal process	GO:0051241	142	0.025
negative regulation of cellular metabolic process	GO:0031324	382	0.024
trna transcription from rna polymerase iii promoter	GO:0042797	1	0.024
negative regulation of cellular biosynthetic process	GO:0031327	277	0.023
chromosome segregation	GO:0007059	157	0.023
intermediate filament cytoskeleton organization	GO:0045104	1	0.022
rna splicing via transesterification reactions	GO:0000375	73	0.021
positive regulation of cellular component organization	GO:0051130	156	0.020
regulation of developmental growth	GO:0048638	174	0.020
snrna 3 end processing	GO:0034472	14	0.020
apoptotic process	GO:0006915	159	0.020
catabolic process	GO:0009056	409	0.020
positive regulation of growth	GO:0045927	75	0.019
regulation of rac gtpase activity	GO:0032314	1	0.019
rna processing	GO:0006396	147	0.018
regulation of intracellular signal transduction	GO:1902531	236	0.018
mrna processing	GO:0006397	104	0.018
larval development	GO:0002164	104	0.018
camera type eye development	GO:0043010	4	0.018
cellular protein complex assembly	GO:0043623	71	0.018
cellular component assembly involved in morphogenesis	GO:0010927	151	0.018
intracellular steroid hormone receptor signaling pathway	GO:0030518	12	0.018
regulation of neuroblast proliferation	GO:1902692	34	0.018
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.017
dna dependent dna replication	GO:0006261	17	0.017
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.017
protein complex assembly	GO:0006461	200	0.017
death	GO:0016265	284	0.017
chromatin modification	GO:0016568	147	0.017
regulation of stem cell proliferation	GO:0072091	40	0.016
eye development	GO:0001654	323	0.016
positive regulation of lipid catabolic process	GO:0050996	1	0.016
negative regulation of nervous system development	GO:0051961	92	0.016
rna splicing	GO:0008380	83	0.015
rna catabolic process	GO:0006401	37	0.015
programmed cell death	GO:0012501	257	0.015
posttranscriptional gene silencing by rna	GO:0035194	45	0.015
protein localization to organelle	GO:0033365	82	0.014
sister chromatid segregation	GO:0000819	92	0.014
response to biotic stimulus	GO:0009607	294	0.014
developmental growth	GO:0048589	280	0.014
positive regulation of cell cycle	GO:0045787	43	0.014
establishment of localization in cell	GO:0051649	402	0.014
mrna splicing via spliceosome	GO:0000398	73	0.014
negative regulation of signaling	GO:0023057	219	0.014
posttranscriptional regulation of gene expression	GO:0010608	145	0.014
sensory organ morphogenesis	GO:0090596	260	0.014
negative regulation of transcription dna templated	GO:0045892	237	0.014
regulation of phosphate metabolic process	GO:0019220	210	0.013
telomere maintenance	GO:0000723	21	0.013
protein deubiquitination	GO:0016579	17	0.013
muscle structure development	GO:0061061	224	0.013
cellular response to dna damage stimulus	GO:0006974	223	0.013
regulation of neurogenesis	GO:0050767	158	0.013
positive regulation of neuron projection regeneration	GO:0070572	3	0.013
cellular response to nutrient	GO:0031670	1	0.012
regulation of nuclear division	GO:0051783	58	0.012
ribonucleoprotein complex assembly	GO:0022618	23	0.012
snrna processing	GO:0016180	14	0.011
positive regulation of protein complex assembly	GO:0031334	22	0.011
dna metabolic process	GO:0006259	227	0.011
cellular protein localization	GO:0034613	160	0.011
nuclear transcribed mrna catabolic process	GO:0000956	24	0.011
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.011
regionalization	GO:0003002	416	0.011
ribonucleoprotein complex subunit organization	GO:0071826	28	0.011
nucleoside phosphate metabolic process	GO:0006753	162	0.011
negative regulation of neurogenesis	GO:0050768	53	0.010
negative regulation of transcription factor import into nucleus	GO:0042992	4	0.010
chromatin organization	GO:0006325	207	0.010
mrna metabolic process	GO:0016071	124	0.010

MED20 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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