IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

ND42 (Dmel_CG6343)

NADH:ubiquinone reductase 42kD subunit precursor

(Aliases: Dmel\CG6343,CG6343)

Entrez: 42591
FLYBASE: FBgn0019957
UniProtKB: A4V383
UniProtKB: P91929

Process Predictions
Disease Predictions

ND42 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
determination of adult lifespan	GO:0008340	137	0.531	Worm
multicellular organismal aging	GO:0010259	140	0.510	Worm
oxidation reduction process	GO:0055114	123	0.505
nucleobase containing small molecule metabolic process	GO:0055086	174	0.266
oxidative phosphorylation	GO:0006119	9	0.259
embryo development ending in birth or egg hatching	GO:0009792	152	0.234	Worm
aging	GO:0007568	143	0.220	Worm
organonitrogen compound metabolic process	GO:1901564	318	0.219
small molecule metabolic process	GO:0044281	305	0.211
generation of precursor metabolites and energy	GO:0006091	42	0.211
purine ribonucleoside metabolic process	GO:0046128	127	0.207
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.192
nucleoside triphosphate metabolic process	GO:0009141	120	0.181
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.167
glycosyl compound metabolic process	GO:1901657	127	0.161
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.157
larval development	GO:0002164	104	0.154	Worm
energy derivation by oxidation of organic compounds	GO:0015980	32	0.152
atp synthesis coupled electron transport	GO:0042773	8	0.149
cellular respiration	GO:0045333	26	0.143
purine nucleoside metabolic process	GO:0042278	127	0.135
atp metabolic process	GO:0046034	49	0.123
inorganic cation transmembrane transport	GO:0098662	61	0.123
purine containing compound metabolic process	GO:0072521	155	0.119
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.117
carbohydrate derivative metabolic process	GO:1901135	217	0.115
regulation of protein metabolic process	GO:0051246	256	0.111
mitochondrial atp synthesis coupled electron transport	GO:0042775	8	0.111
brain development	GO:0007420	120	0.107
respiratory electron transport chain	GO:0022904	11	0.106
embryonic morphogenesis	GO:0048598	206	0.103
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.100
carboxylic acid metabolic process	GO:0019752	92	0.096
central nervous system development	GO:0007417	201	0.092
phosphorylation	GO:0016310	294	0.090
organic acid metabolic process	GO:0006082	103	0.089
regulation of cellular protein metabolic process	GO:0032268	243	0.083
nucleoside monophosphate metabolic process	GO:0009123	52	0.082
endocytosis	GO:0006897	310	0.081
ribonucleotide metabolic process	GO:0009259	145	0.081
growth	GO:0040007	359	0.080
ribonucleoside metabolic process	GO:0009119	127	0.074
ion transmembrane transport	GO:0034220	122	0.072
response to abiotic stimulus	GO:0009628	341	0.070
cellular catabolic process	GO:0044248	372	0.070
vesicle mediated transport	GO:0016192	381	0.067
protein complex assembly	GO:0006461	200	0.066
purine ribonucleotide metabolic process	GO:0009150	145	0.065
protein complex biogenesis	GO:0070271	201	0.064
nucleoside metabolic process	GO:0009116	127	0.064
cation transmembrane transport	GO:0098655	88	0.062
spermatid differentiation	GO:0048515	114	0.061
epithelial cell differentiation	GO:0030855	322	0.061
macromolecular complex assembly	GO:0065003	256	0.057
nucleotide metabolic process	GO:0009117	161	0.056
purine nucleotide metabolic process	GO:0006163	146	0.051
death	GO:0016265	284	0.051
mitochondrion organization	GO:0007005	65	0.050
electron transport chain	GO:0022900	14	0.050
response to oxidative stress	GO:0006979	86	0.050
citrate metabolic process	GO:0006101	0	0.049
head development	GO:0060322	135	0.047
digestive system development	GO:0055123	149	0.047
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.045
body morphogenesis	GO:0010171	2	0.044
cell death	GO:0008219	279	0.044
programmed cell death	GO:0012501	257	0.043
organophosphate metabolic process	GO:0019637	195	0.043
nad metabolic process	GO:0019674	1	0.043
single organism catabolic process	GO:0044712	228	0.043
oxoacid metabolic process	GO:0043436	103	0.042
organic substance catabolic process	GO:1901575	308	0.042
spermatogenesis	GO:0007283	200	0.042
organonitrogen compound catabolic process	GO:1901565	128	0.042
developmental maturation	GO:0021700	172	0.041
cellular protein complex assembly	GO:0043623	71	0.041
nucleoside phosphate metabolic process	GO:0006753	162	0.040
heart development	GO:0007507	82	0.039
developmental growth	GO:0048589	280	0.038
cellular amino acid metabolic process	GO:0006520	61	0.038
regulation of developmental growth	GO:0048638	174	0.038
male gamete generation	GO:0048232	201	0.038
cell maturation	GO:0048469	144	0.037
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.036
phagocytosis	GO:0006909	215	0.035
cellular homeostasis	GO:0019725	80	0.034
positive regulation of macromolecule metabolic process	GO:0010604	405	0.032
ion transport	GO:0006811	145	0.032
defense response	GO:0006952	300	0.031
regulation of growth	GO:0040008	233	0.031
paracrine signaling	GO:0038001	7	0.031
cellular component assembly involved in morphogenesis	GO:0010927	151	0.028
regulation of protein modification process	GO:0031399	112	0.027
organonitrogen compound biosynthetic process	GO:1901566	117	0.027
single organism biosynthetic process	GO:0044711	206	0.026
reproductive structure development	GO:0048608	74	0.026
regulation of multicellular organismal development	GO:2000026	414	0.026
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.026
inorganic ion transmembrane transport	GO:0098660	73	0.026
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.025
lipid storage	GO:0019915	38	0.024
cellular macromolecular complex assembly	GO:0034622	153	0.023
cellular protein modification process	GO:0006464	438	0.023
regulation of cell differentiation	GO:0045595	302	0.023
negative regulation of cellular protein metabolic process	GO:0032269	85	0.023
establishment of localization in cell	GO:0051649	402	0.023
gastrulation	GO:0007369	70	0.023
catabolic process	GO:0009056	409	0.023
response to oxygen containing compound	GO:1901700	200	0.022
tube morphogenesis	GO:0035239	191	0.022
ribose phosphate metabolic process	GO:0019693	145	0.022
heterocycle catabolic process	GO:0046700	166	0.022
purine nucleoside catabolic process	GO:0006152	112	0.022
regulation of neurogenesis	GO:0050767	158	0.022
cell proliferation	GO:0008283	299	0.022
spermatid development	GO:0007286	98	0.022
cellular response to dna damage stimulus	GO:0006974	223	0.021
maintenance of location	GO:0051235	73	0.020
negative regulation of cell differentiation	GO:0045596	143	0.020
regulation of cell cycle	GO:0051726	291	0.020
endomembrane system organization	GO:0010256	119	0.020
multicellular organismal reproductive behavior	GO:0033057	110	0.019
reproductive system development	GO:0061458	74	0.019
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.019
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.019
mitochondrial respiratory chain complex i assembly	GO:0032981	2	0.019
nucleoside triphosphate catabolic process	GO:0009143	108	0.019
tricarboxylic acid metabolic process	GO:0072350	1	0.019
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.018
stem cell proliferation	GO:0072089	88	0.018
positive regulation of developmental growth	GO:0048639	62	0.018
multi organism behavior	GO:0051705	175	0.018
glycosyl compound catabolic process	GO:1901658	112	0.018
positive regulation of viral process	GO:0048524	2	0.017
spinal cord development	GO:0021510	1	0.017
intracellular signal transduction	GO:0035556	300	0.017
organophosphate catabolic process	GO:0046434	112	0.017
purine containing compound catabolic process	GO:0072523	112	0.017
response to organic substance	GO:0010033	284	0.017
negative regulation of stem cell proliferation	GO:2000647	30	0.017
purine ribonucleoside monophosphate biosynthetic process	GO:0009168	3	0.017
regulation of cell cycle phase transition	GO:1901987	130	0.017
reactive oxygen species metabolic process	GO:0072593	22	0.017
apoptotic process	GO:0006915	159	0.017
ribonucleoside catabolic process	GO:0042454	112	0.016
regulation of translation	GO:0006417	56	0.016
nucleoside phosphate catabolic process	GO:1901292	110	0.016
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.016
purine ribonucleoside catabolic process	GO:0046130	112	0.016
posttranscriptional regulation of gene expression	GO:0010608	145	0.016
ribonucleotide catabolic process	GO:0009261	109	0.016
negative regulation of gene expression	GO:0010629	387	0.016
purine ribonucleotide catabolic process	GO:0009154	109	0.015
neuroblast proliferation	GO:0007405	74	0.015
innate immune response	GO:0045087	144	0.015
tube development	GO:0035295	244	0.015
cellular nitrogen compound catabolic process	GO:0044270	165	0.015
positive regulation of developmental process	GO:0051094	143	0.015
negative regulation of protein metabolic process	GO:0051248	85	0.015
neural precursor cell proliferation	GO:0061351	75	0.015
positive regulation of cellular protein metabolic process	GO:0032270	118	0.015
regulation of membrane potential	GO:0042391	35	0.014
sex differentiation	GO:0007548	81	0.014
immune response	GO:0006955	246	0.014
atp catabolic process	GO:0006200	38	0.014
gonad development	GO:0008406	50	0.014
cation transport	GO:0006812	110	0.014
nucleoside monophosphate catabolic process	GO:0009125	39	0.014
positive regulation of cell communication	GO:0010647	250	0.014
biological adhesion	GO:0022610	138	0.014
regulation of molecular function	GO:0065009	217	0.014
localization of cell	GO:0051674	257	0.014
response to heat	GO:0009408	63	0.013
digestive tract development	GO:0048565	149	0.013
circulatory system development	GO:0072359	82	0.013
ribonucleoside triphosphate biosynthetic process	GO:0009201	2	0.013
response to biotic stimulus	GO:0009607	294	0.013
single organism intracellular transport	GO:1902582	207	0.013
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.012
golgi organization	GO:0007030	66	0.012
multicellular organism growth	GO:0035264	46	0.012
transmembrane transport	GO:0055085	139	0.012
regulation of catalytic activity	GO:0050790	185	0.012
positive regulation of protein metabolic process	GO:0051247	128	0.012
ribonucleoside biosynthetic process	GO:0042455	3	0.012
negative regulation of developmental process	GO:0051093	201	0.012
regulation of nervous system development	GO:0051960	248	0.012
response to radiation	GO:0009314	155	0.012
positive regulation of cellular biosynthetic process	GO:0031328	316	0.012
monovalent inorganic cation transport	GO:0015672	40	0.012
purine nucleoside biosynthetic process	GO:0042451	3	0.012
response to other organism	GO:0051707	293	0.012
digestive tract morphogenesis	GO:0048546	127	0.012
response to external biotic stimulus	GO:0043207	293	0.012
regulation of proteolysis	GO:0030162	87	0.012
organic cyclic compound catabolic process	GO:1901361	168	0.012
response to organophosphorus	GO:0046683	2	0.012
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.012
lipid localization	GO:0010876	54	0.011
negative regulation of signal transduction	GO:0009968	206	0.011
mitochondrial respiratory chain complex assembly	GO:0033108	4	0.011
nucleoside catabolic process	GO:0009164	112	0.011
regulation of cell death	GO:0010941	173	0.011
negative regulation of nervous system development	GO:0051961	92	0.011
regulation of hydrolase activity	GO:0051336	97	0.011
regionalization	GO:0003002	416	0.011
ribonucleoside monophosphate biosynthetic process	GO:0009156	3	0.011
negative regulation of response to stimulus	GO:0048585	258	0.011
membrane organization	GO:0061024	112	0.011
regulation of cell proliferation	GO:0042127	163	0.010
nucleotide catabolic process	GO:0009166	109	0.010
protein homooligomerization	GO:0051260	7	0.010
negative regulation of cellular biosynthetic process	GO:0031327	277	0.010
regulation of localization	GO:0032879	275	0.010
regulation of phosphate metabolic process	GO:0019220	210	0.010
nucleobase containing compound catabolic process	GO:0034655	165	0.010
transcription from rna polymerase ii promoter	GO:0006366	368	0.010
regulation of apoptotic cell clearance	GO:2000425	2	0.010
response to oxygen levels	GO:0070482	59	0.010
lateral inhibition	GO:0046331	206	0.010
response to hypoxia	GO:0001666	53	0.010

ND42 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.054
inherited metabolic disorder	DOID:655	0.054
disease of anatomical entity	DOID:7	0.048
disease of cellular proliferation	DOID:14566	0.036
cancer	DOID:162	0.029
organ system cancer	DOID:0050686	0.020

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