IMP: Integrative Multi-species Prediction

Drosophila melanogaster

41 known processes

DNApol-alpha180 (Dmel_CG6349)

DNA polymerase alpha 180kD

(Aliases: DNA Pol-alpha180,CG6349,DNA polalpha,DNApol-alpha,POLA,E(mus304),pol alpha,DNApola,DNA-Polalpha,183 kDa pol alpha,DmPolalpha,Polalpha,AAB24152,DNApolalpha180,polalpha,DNApolalpha,Dmpol alpha,polalphap180,Dmel\CG6349,Pol,Pol alpha,DNApol)

FLYBASE: FBgn0259113
Entrez: 42553
UniProtKB: P26019

Process Predictions
Disease Predictions

DNApol-alpha180 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
mitotic spindle organization	GO:0007052	220	0.347
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.306
cellular macromolecule catabolic process	GO:0044265	136	0.304
chromosome separation	GO:0051304	42	0.281
cell cycle phase transition	GO:0044770	140	0.245
chromosome segregation	GO:0007059	157	0.237
mitotic cell cycle phase transition	GO:0044772	138	0.233
negative regulation of cell cycle phase transition	GO:1901988	103	0.224
chromosome organization	GO:0051276	360	0.216
catabolic process	GO:0009056	409	0.194
negative regulation of mitotic cell cycle	GO:0045930	109	0.169
meiotic nuclear division	GO:0007126	151	0.148
mitotic dna damage checkpoint	GO:0044773	74	0.144
cellular response to dna damage stimulus	GO:0006974	223	0.138
male gamete generation	GO:0048232	201	0.136
g2 dna damage checkpoint	GO:0031572	69	0.135
sister chromatid segregation	GO:0000819	92	0.131
protein modification process	GO:0036211	438	0.130
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.125
mitotic cell cycle checkpoint	GO:0007093	88	0.124
regulation of cell cycle phase transition	GO:1901987	130	0.116
mitotic g2 m transition checkpoint	GO:0044818	70	0.114
mitotic sister chromatid separation	GO:0051306	30	0.103
organic substance catabolic process	GO:1901575	308	0.100
ubiquitin dependent protein catabolic process	GO:0006511	78	0.099
dna integrity checkpoint	GO:0031570	81	0.098
mitotic dna integrity checkpoint	GO:0044774	75	0.097
mitotic sister chromatid segregation	GO:0000070	87	0.094
protein dna complex subunit organization	GO:0071824	86	0.093
negative regulation of cell cycle process	GO:0010948	109	0.091
macromolecule catabolic process	GO:0009057	161	0.091
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.088
cell cycle checkpoint	GO:0000075	95	0.085
protein dna complex assembly	GO:0065004	63	0.084
spermatogenesis	GO:0007283	200	0.083
proteolysis	GO:0006508	192	0.083
neuron recognition	GO:0008038	101	0.083
dendrite development	GO:0016358	204	0.082
regulation of intracellular signal transduction	GO:1902531	236	0.079
cellular protein modification process	GO:0006464	438	0.076
organelle fission	GO:0048285	340	0.075
growth	GO:0040007	359	0.074
intracellular signal transduction	GO:0035556	300	0.073
heterocycle catabolic process	GO:0046700	166	0.072
modification dependent macromolecule catabolic process	GO:0043632	79	0.071
axon development	GO:0061564	297	0.069
nucleoside catabolic process	GO:0009164	112	0.067
cellular protein catabolic process	GO:0044257	83	0.065
regulation of protein metabolic process	GO:0051246	256	0.059
regulation of cellular protein metabolic process	GO:0032268	243	0.057
meiotic cell cycle	GO:0051321	171	0.057
nucleobase containing compound catabolic process	GO:0034655	165	0.057
cellular catabolic process	GO:0044248	372	0.056
regulation of mitotic cell cycle	GO:0007346	190	0.056
regulation of neuron differentiation	GO:0045664	103	0.056
spindle organization	GO:0007051	253	0.056
regulation of chromosome organization	GO:0033044	64	0.055
protein catabolic process	GO:0030163	101	0.054
modification dependent protein catabolic process	GO:0019941	78	0.053
regulation of molecular function	GO:0065009	217	0.051
regionalization	GO:0003002	416	0.051
centrosome organization	GO:0051297	163	0.049
single organism catabolic process	GO:0044712	228	0.044
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.044
dna damage checkpoint	GO:0000077	78	0.044
ras protein signal transduction	GO:0007265	88	0.043
atp metabolic process	GO:0046034	49	0.042
organic cyclic compound catabolic process	GO:1901361	168	0.042
purine nucleoside metabolic process	GO:0042278	127	0.041
regulation of anatomical structure morphogenesis	GO:0022603	242	0.041
nucleotide catabolic process	GO:0009166	109	0.041
sensory organ morphogenesis	GO:0090596	260	0.041
regulation of neuron projection development	GO:0010975	69	0.040
regulation of cell cycle process	GO:0010564	181	0.040
small gtpase mediated signal transduction	GO:0007264	88	0.040
aromatic compound catabolic process	GO:0019439	166	0.040
regulation of developmental growth	GO:0048638	174	0.039
regulation of mitotic sister chromatid separation	GO:0010965	28	0.039
cellular nitrogen compound catabolic process	GO:0044270	165	0.039
female meiotic division	GO:0007143	70	0.039
imaginal disc derived appendage development	GO:0048737	399	0.039
purine containing compound metabolic process	GO:0072521	155	0.038
regulation of cell cycle	GO:0051726	291	0.038
body morphogenesis	GO:0010171	2	0.038
positive regulation of macromolecule metabolic process	GO:0010604	405	0.038
regulation of phosphorylation	GO:0042325	147	0.038
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.038
nucleoside phosphate metabolic process	GO:0006753	162	0.037
regulation of phosphate metabolic process	GO:0019220	210	0.037
organophosphate metabolic process	GO:0019637	195	0.036
ribonucleotide metabolic process	GO:0009259	145	0.034
mitotic g2 dna damage checkpoint	GO:0007095	69	0.034
snrna processing	GO:0016180	14	0.034
meiotic cell cycle process	GO:1903046	132	0.034
dendrite morphogenesis	GO:0048813	199	0.033
axonogenesis	GO:0007409	290	0.032
purine nucleotide metabolic process	GO:0006163	146	0.032
dna replication	GO:0006260	48	0.032
dna conformation change	GO:0071103	105	0.032
organelle assembly	GO:0070925	198	0.031
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.031
negative regulation of chromosome segregation	GO:0051985	14	0.030
mitotic spindle elongation	GO:0000022	81	0.030
negative regulation of cell cycle	GO:0045786	116	0.030
metaphase anaphase transition of cell cycle	GO:0044784	28	0.030
chromatin organization	GO:0006325	207	0.030
ribose phosphate metabolic process	GO:0019693	145	0.029
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.029
organophosphate catabolic process	GO:0046434	112	0.029
wing disc morphogenesis	GO:0007472	344	0.029
regulation of phosphorus metabolic process	GO:0051174	210	0.029
eye photoreceptor cell differentiation	GO:0001754	145	0.028
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.028
dna packaging	GO:0006323	91	0.028
photoreceptor cell differentiation	GO:0046530	170	0.028
carbohydrate derivative metabolic process	GO:1901135	217	0.028
microtubule based transport	GO:0010970	42	0.027
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.027
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.027
centrosome duplication	GO:0051298	121	0.027
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.027
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.027
organonitrogen compound metabolic process	GO:1901564	318	0.027
axon guidance	GO:0007411	233	0.026
histone mrna 3 end processing	GO:0006398	8	0.026
nucleotide metabolic process	GO:0009117	161	0.026
regulation of proteasomal protein catabolic process	GO:0061136	39	0.026
developmental growth	GO:0048589	280	0.026
positive regulation of response to stimulus	GO:0048584	323	0.025
purine containing compound catabolic process	GO:0072523	112	0.025
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.025
dna repair	GO:0006281	54	0.025
cytoskeleton dependent intracellular transport	GO:0030705	44	0.024
endocytosis	GO:0006897	310	0.024
negative regulation of cellular component organization	GO:0051129	108	0.024
phosphorylation	GO:0016310	294	0.024
nucleobase containing small molecule metabolic process	GO:0055086	174	0.024
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.024
proteasomal protein catabolic process	GO:0010498	59	0.023
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.023
cellular macromolecular complex assembly	GO:0034622	153	0.023
regulation of catabolic process	GO:0009894	170	0.023
compound eye development	GO:0048749	307	0.023
cell adhesion	GO:0007155	136	0.022
centrosome cycle	GO:0007098	137	0.022
reproductive system development	GO:0061458	74	0.022
imaginal disc derived wing morphogenesis	GO:0007476	337	0.022
regulation of protein catabolic process	GO:0042176	55	0.022
germ line cyst formation	GO:0048134	44	0.022
nucleoside triphosphate catabolic process	GO:0009143	108	0.022
glycosyl compound catabolic process	GO:1901658	112	0.021
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.021
dna metabolic process	GO:0006259	227	0.021
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.020
programmed cell death	GO:0012501	257	0.020
regulation of neurogenesis	GO:0050767	158	0.020
negative regulation of neuroblast proliferation	GO:0007406	27	0.020
phagocytosis	GO:0006909	215	0.020
cell proliferation	GO:0008283	299	0.020
compound eye morphogenesis	GO:0001745	249	0.020
non sensory hair organization	GO:0035316	47	0.020
photoreceptor cell development	GO:0042461	96	0.020
embryo development ending in birth or egg hatching	GO:0009792	152	0.020
positive regulation of phosphate metabolic process	GO:0045937	139	0.020
negative regulation of organelle organization	GO:0010639	56	0.020
purine ribonucleotide metabolic process	GO:0009150	145	0.020
mitotic nuclear division	GO:0007067	213	0.019
eye photoreceptor cell development	GO:0042462	81	0.019
muscle structure development	GO:0061061	224	0.019
purine nucleotide catabolic process	GO:0006195	109	0.019
ribonucleotide catabolic process	GO:0009261	109	0.019
imaginal disc derived wing vein specification	GO:0007474	48	0.019
positive regulation of cellular biosynthetic process	GO:0031328	316	0.019
molting cycle	GO:0042303	56	0.019
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.019
cellular component assembly involved in morphogenesis	GO:0010927	151	0.019
dna amplification	GO:0006277	11	0.019
appendage morphogenesis	GO:0035107	397	0.019
spindle elongation	GO:0051231	83	0.018
nuclear division	GO:0000280	332	0.018
meiotic chromosome segregation	GO:0045132	59	0.018
multicellular organism growth	GO:0035264	46	0.018
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.018
protein phosphorylation	GO:0006468	169	0.018
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.018
spermatid development	GO:0007286	98	0.017
positive regulation of phosphorus metabolic process	GO:0010562	139	0.017
purine ribonucleotide catabolic process	GO:0009154	109	0.017
nucleoside metabolic process	GO:0009116	127	0.017
carbohydrate derivative catabolic process	GO:1901136	118	0.017
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.017
imaginal disc derived wing hair organization	GO:0035317	45	0.017
ribonucleoside metabolic process	GO:0009119	127	0.017
germarium derived female germ line cyst formation	GO:0030727	42	0.017
positive regulation of catabolic process	GO:0009896	105	0.016
snrna 3 end processing	GO:0034472	14	0.016
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.016
nucleoside phosphate catabolic process	GO:1901292	110	0.016
regulation of protein modification process	GO:0031399	112	0.016
asymmetric cell division	GO:0008356	37	0.016
organonitrogen compound catabolic process	GO:1901565	128	0.016
microtubule based movement	GO:0007018	51	0.016
neuron projection guidance	GO:0097485	241	0.016
positive regulation of gene expression	GO:0010628	290	0.015
kinetochore organization	GO:0051383	9	0.015
nucleoside triphosphate metabolic process	GO:0009141	120	0.015
microtubule organizing center organization	GO:0031023	168	0.015
response to organic substance	GO:0010033	284	0.015
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.015
protein modification by small protein conjugation	GO:0032446	79	0.015
positive regulation of signaling	GO:0023056	243	0.015
negative regulation of microtubule polymerization or depolymerization	GO:0031111	21	0.014
rna 3 end processing	GO:0031123	45	0.014
purine ribonucleoside catabolic process	GO:0046130	112	0.014
eye morphogenesis	GO:0048592	260	0.014
positive regulation of molecular function	GO:0044093	136	0.014
immune system process	GO:0002376	347	0.014
actin cytoskeleton organization	GO:0030036	206	0.014
negative regulation of protein metabolic process	GO:0051248	85	0.014
regulation of chromosome segregation	GO:0051983	32	0.014
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.014
positive regulation of protein metabolic process	GO:0051247	128	0.014
regulation of ras protein signal transduction	GO:0046578	93	0.014
appendage development	GO:0048736	401	0.014
regulation of cell shape	GO:0008360	113	0.014
regulation of catalytic activity	GO:0050790	185	0.014
meiotic cytokinesis	GO:0033206	33	0.014
purine nucleoside catabolic process	GO:0006152	112	0.014
compound eye photoreceptor cell differentiation	GO:0001751	140	0.014
nuclear transcribed mrna catabolic process	GO:0000956	24	0.013
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.013
endomembrane system organization	GO:0010256	119	0.013
glycosyl compound metabolic process	GO:1901657	127	0.013
leg disc development	GO:0035218	92	0.013
membrane organization	GO:0061024	112	0.013
biological adhesion	GO:0022610	138	0.013
post embryonic appendage morphogenesis	GO:0035120	385	0.013
imaginal disc derived leg morphogenesis	GO:0007480	80	0.013
regulation of sister chromatid segregation	GO:0033045	28	0.013
cell death	GO:0008219	279	0.013
microtubule bundle formation	GO:0001578	27	0.013
spermatid differentiation	GO:0048515	114	0.013
positive regulation of biosynthetic process	GO:0009891	316	0.013
compound eye photoreceptor development	GO:0042051	78	0.013
positive regulation of signal transduction	GO:0009967	223	0.013
spindle midzone assembly	GO:0051255	4	0.013
larval development	GO:0002164	104	0.013
regulation of growth	GO:0040008	233	0.013
hair cell differentiation	GO:0035315	47	0.012
negative regulation of catabolic process	GO:0009895	36	0.012
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.012
regulation of protein processing	GO:0070613	32	0.012
response to fungus	GO:0009620	50	0.012
apoptotic process	GO:0006915	159	0.012
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.012
regulation of cellular protein catabolic process	GO:1903362	44	0.012
neuron remodeling	GO:0016322	29	0.012
metaphase plate congression	GO:0051310	19	0.012
signal transduction by phosphorylation	GO:0023014	107	0.012
negative regulation of homeostatic process	GO:0032845	2	0.012
chorion containing eggshell formation	GO:0007304	105	0.012
somatic muscle development	GO:0007525	66	0.012
regulation of proteolysis	GO:0030162	87	0.011
regulation of cell morphogenesis	GO:0022604	163	0.011
response to abiotic stimulus	GO:0009628	341	0.011
snrna metabolic process	GO:0016073	14	0.011
regulation of cellular catabolic process	GO:0031329	157	0.011
negative regulation of translation	GO:0017148	28	0.011
ribonucleoside catabolic process	GO:0042454	112	0.011
atp catabolic process	GO:0006200	38	0.011
forebrain development	GO:0030900	2	0.011
regulation of erk1 and erk2 cascade	GO:0070372	39	0.011
rna processing	GO:0006396	147	0.011
regulation of notch signaling pathway	GO:0008593	100	0.011
nucleoside monophosphate metabolic process	GO:0009123	52	0.011
protein localization	GO:0008104	284	0.011
single organism membrane organization	GO:0044802	93	0.011
positive regulation of cell communication	GO:0010647	250	0.010
establishment of tissue polarity	GO:0007164	87	0.010
death	GO:0016265	284	0.010
male meiosis	GO:0007140	52	0.010
neuroblast proliferation	GO:0007405	74	0.010
gonad development	GO:0008406	50	0.010
response to monosaccharide	GO:0034284	4	0.010
cellular protein localization	GO:0034613	160	0.010
negative regulation of protein depolymerization	GO:1901880	23	0.010
negative regulation of microtubule depolymerization	GO:0007026	21	0.010

DNApol-alpha180 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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