IMP: Integrative Multi-species Prediction

Drosophila melanogaster

81 known processes

HDAC4 (Dmel_CG1770)

CG1770 gene product from transcript CG1770-RE

(Aliases: GC1770,dmHDA405,HDAC4a,DHDAC4,Dmel\CG1770,HDAC,CG1770,dHDAC4)

Entrez: 32278
FLYBASE: FBgn0041210
UniProtKB: M9NEF2
UniProtKB: Q9VYF3
UniProtKB: M9PJM2
UniProtKB: M9PHQ2
UniProtKB: Q59E49
UniProtKB: Q8IR69

Process Predictions
Disease Predictions

HDAC4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
learning or memory	GO:0007611	141	0.990
long term memory	GO:0007616	62	0.812
memory	GO:0007613	94	0.697
olfactory learning	GO:0008355	56	0.675
associative learning	GO:0008306	65	0.652
cognition	GO:0050890	141	0.625
learning	GO:0007612	75	0.570
chemosensory behavior	GO:0007635	106	0.534
neurological system process	GO:0050877	358	0.456
single organism behavior	GO:0044708	391	0.377
olfactory behavior	GO:0042048	97	0.369
behavioral response to ethanol	GO:0048149	49	0.268
medium term memory	GO:0072375	8	0.187
small molecule metabolic process	GO:0044281	305	0.178	Mouse
taxis	GO:0042330	304	0.171
adult behavior	GO:0030534	137	0.151
response to organic substance	GO:0010033	284	0.132	Human Mouse Rat
response to alcohol	GO:0097305	95	0.127
regulation of wound healing	GO:0061041	13	0.101
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.094
regionalization	GO:0003002	416	0.086
axis specification	GO:0009798	167	0.080
response to ethanol	GO:0045471	59	0.077
locomotory behavior	GO:0007626	176	0.076
intracellular signal transduction	GO:0035556	300	0.076	Mouse
notch signaling pathway	GO:0007219	120	0.074
establishment of localization in cell	GO:0051649	402	0.074
regulation of catalytic activity	GO:0050790	185	0.073
neuron projection guidance	GO:0097485	241	0.072
regulation of molecular function	GO:0065009	217	0.072	Human
nucleobase containing compound catabolic process	GO:0034655	165	0.071
single organism biosynthetic process	GO:0044711	206	0.069
cellular macromolecule localization	GO:0070727	220	0.066
oocyte construction	GO:0007308	112	0.062
purine containing compound metabolic process	GO:0072521	155	0.062
regulation of growth	GO:0040008	233	0.062
nucleoside phosphate metabolic process	GO:0006753	162	0.060
chemotaxis	GO:0006935	249	0.059
purine ribonucleotide metabolic process	GO:0009150	145	0.058
regulation of cell proliferation	GO:0042127	163	0.057	Human Mouse Rat
ribose phosphate metabolic process	GO:0019693	145	0.056
organonitrogen compound metabolic process	GO:1901564	318	0.055
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.055
positive regulation of rna biosynthetic process	GO:1902680	266	0.055	Human Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.054	Human Mouse
regulation of intracellular signal transduction	GO:1902531	236	0.054
negative regulation of cellular biosynthetic process	GO:0031327	277	0.053	Human Mouse
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.052
negative regulation of biosynthetic process	GO:0009890	277	0.052	Human Mouse
negative regulation of cellular metabolic process	GO:0031324	382	0.052	Human Mouse
regulation of phosphorus metabolic process	GO:0051174	210	0.052
oocyte development	GO:0048599	124	0.051
regulation of cellular protein metabolic process	GO:0032268	243	0.050	Human
ras protein signal transduction	GO:0007265	88	0.050
nucleotide metabolic process	GO:0009117	161	0.050
protein modification process	GO:0036211	438	0.050
carbohydrate derivative metabolic process	GO:1901135	217	0.048
g protein coupled receptor signaling pathway	GO:0007186	136	0.048
anesthesia resistant memory	GO:0007615	6	0.048
response to oxygen containing compound	GO:1901700	200	0.048	Mouse Rat
negative regulation of cell proliferation	GO:0008285	69	0.047	Mouse
vesicle mediated transport	GO:0016192	381	0.047
organophosphate metabolic process	GO:0019637	195	0.047
homeostatic process	GO:0042592	199	0.046
organonitrogen compound biosynthetic process	GO:1901566	117	0.046
regulation of notch signaling pathway	GO:0008593	100	0.046
negative regulation of multicellular organismal process	GO:0051241	142	0.046	Human Mouse
protein localization	GO:0008104	284	0.045
protein phosphorylation	GO:0006468	169	0.045
imaginal disc derived appendage development	GO:0048737	399	0.045
heterocycle catabolic process	GO:0046700	166	0.044
positive regulation of biosynthetic process	GO:0009891	316	0.044	Human Mouse Rat
response to sterol	GO:0036314	34	0.044
regulation of protein metabolic process	GO:0051246	256	0.044	Human
purine containing compound biosynthetic process	GO:0072522	30	0.042
cellular response to organic substance	GO:0071310	132	0.042	Rat
negative regulation of cell communication	GO:0010648	223	0.041
growth	GO:0040007	359	0.041
germarium derived egg chamber formation	GO:0007293	101	0.041
developmental maturation	GO:0021700	172	0.041
cell projection assembly	GO:0030031	94	0.040	Rat
aromatic compound catabolic process	GO:0019439	166	0.040
axon guidance	GO:0007411	233	0.039
actin cytoskeleton organization	GO:0030036	206	0.039
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.039	Human Mouse
negative regulation of notch signaling pathway	GO:0045746	41	0.039
catabolic process	GO:0009056	409	0.039	Mouse
positive regulation of cell communication	GO:0010647	250	0.039
phosphorylation	GO:0016310	294	0.039
regulation of response to stress	GO:0080134	200	0.038
nucleobase containing small molecule metabolic process	GO:0055086	174	0.038
posttranscriptional regulation of gene expression	GO:0010608	145	0.037
positive regulation of signal transduction	GO:0009967	223	0.037
cell migration	GO:0016477	238	0.037	Human Zebrafish Rat
anterior posterior pattern specification	GO:0009952	136	0.037
positive regulation of response to stimulus	GO:0048584	323	0.037
positive regulation of gene expression	GO:0010628	290	0.036	Human Mouse
positive regulation of signaling	GO:0023056	243	0.036
cell maturation	GO:0048469	144	0.036
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.036
regulation of purine nucleotide metabolic process	GO:1900542	62	0.036
appendage morphogenesis	GO:0035107	397	0.036
neuroblast division	GO:0055057	35	0.035
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.035	Human Mouse
body morphogenesis	GO:0010171	2	0.035
axonogenesis	GO:0007409	290	0.035
tripartite regional subdivision	GO:0007351	103	0.035
post embryonic appendage morphogenesis	GO:0035120	385	0.034
cell proliferation	GO:0008283	299	0.034	Human Mouse Rat
oocyte differentiation	GO:0009994	145	0.034
imaginal disc derived wing morphogenesis	GO:0007476	337	0.034
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.034
organic substance catabolic process	GO:1901575	308	0.034	Mouse
nuclear division	GO:0000280	332	0.034
regulation of multicellular organismal development	GO:2000026	414	0.034	Human Zebrafish Mouse
cellular amine metabolic process	GO:0044106	12	0.034
eye morphogenesis	GO:0048592	260	0.034
cell fate determination	GO:0001709	91	0.034
endocytosis	GO:0006897	310	0.034
organic cyclic compound catabolic process	GO:1901361	168	0.034
chromosome organization	GO:0051276	360	0.034
localization of cell	GO:0051674	257	0.033	Human Zebrafish Rat
positive regulation of phosphate metabolic process	GO:0045937	139	0.033
purine ribonucleotide biosynthetic process	GO:0009152	28	0.033
synapse organization	GO:0050808	196	0.033
ribonucleotide metabolic process	GO:0009259	145	0.033
purine nucleotide metabolic process	GO:0006163	146	0.032
actin filament based process	GO:0030029	220	0.032
response to light stimulus	GO:0009416	124	0.032
cellular catabolic process	GO:0044248	372	0.032	Mouse
asymmetric protein localization	GO:0008105	33	0.032
organic substance transport	GO:0071702	257	0.031
negative regulation of cell differentiation	GO:0045596	143	0.031	Human Mouse
positive regulation of phosphorus metabolic process	GO:0010562	139	0.031
embryonic axis specification	GO:0000578	107	0.031
cell adhesion	GO:0007155	136	0.031
multi organism reproductive behavior	GO:0044705	121	0.030
transcription from rna polymerase ii promoter	GO:0006366	368	0.030	Human Mouse
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.030
forebrain development	GO:0030900	2	0.029
organophosphate catabolic process	GO:0046434	112	0.029
regulation of mapk cascade	GO:0043408	92	0.029
positive regulation of cell migration	GO:0030335	2	0.029	Human Rat
phagocytosis	GO:0006909	215	0.029
regulation of phosphate metabolic process	GO:0019220	210	0.029
cellular response to endogenous stimulus	GO:0071495	80	0.029	Rat
glycosyl compound metabolic process	GO:1901657	127	0.029
embryonic pattern specification	GO:0009880	174	0.028
oocyte axis specification	GO:0007309	108	0.028
regulation of cellular component size	GO:0032535	98	0.028
response to abiotic stimulus	GO:0009628	341	0.028	Rat
organelle assembly	GO:0070925	198	0.027
developmental growth	GO:0048589	280	0.027
cell division	GO:0051301	248	0.027
inter male aggressive behavior	GO:0002121	60	0.027
response to external biotic stimulus	GO:0043207	293	0.027	Rat
cellular nitrogen compound catabolic process	GO:0044270	165	0.027
positive regulation of cellular biosynthetic process	GO:0031328	316	0.026	Human Mouse
anterior posterior axis specification embryo	GO:0008595	103	0.026
small gtpase mediated signal transduction	GO:0007264	88	0.026
regulation of nervous system development	GO:0051960	248	0.026
biological adhesion	GO:0022610	138	0.026
tissue morphogenesis	GO:0048729	297	0.026	Mouse
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.026
lateral inhibition	GO:0046331	206	0.026
signal transduction by phosphorylation	GO:0023014	107	0.026
cyclic nucleotide metabolic process	GO:0009187	28	0.025
camera type eye development	GO:0043010	4	0.025
positive regulation of multicellular organismal process	GO:0051240	143	0.025	Human
intracellular transport	GO:0046907	228	0.025
response to organic cyclic compound	GO:0014070	89	0.025	Mouse
wing disc morphogenesis	GO:0007472	344	0.024
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.024	Human Mouse
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.024
regulation of cell substrate adhesion	GO:0010810	2	0.024
response to ketone	GO:1901654	34	0.024
male courtship behavior	GO:0008049	63	0.023
oxoacid metabolic process	GO:0043436	103	0.023	Mouse
cation homeostasis	GO:0055080	51	0.023
regulation of cell cycle phase transition	GO:1901987	130	0.023
regulation of cell differentiation	GO:0045595	302	0.023	Human Zebrafish Mouse
response to ecdysone	GO:0035075	34	0.023
negative regulation of peptide hormone secretion	GO:0090278	1	0.023
regulation of cell cycle process	GO:0010564	181	0.023
multi organism behavior	GO:0051705	175	0.023
regulation of cellular ketone metabolic process	GO:0010565	3	0.023
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.022
regulation of anatomical structure morphogenesis	GO:0022603	242	0.022	Human Zebrafish
regulation of cellular amine metabolic process	GO:0033238	3	0.022
negative regulation of rna metabolic process	GO:0051253	251	0.022	Human Mouse
response to other organism	GO:0051707	293	0.022	Rat
cell motility	GO:0048870	251	0.022	Human Zebrafish Rat
wound healing	GO:0042060	75	0.022
positive regulation of intracellular signal transduction	GO:1902533	116	0.022
epithelial cell differentiation	GO:0030855	322	0.022
nucleotide catabolic process	GO:0009166	109	0.022
regulation of cellular amino acid metabolic process	GO:0006521	0	0.022
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.022
positive regulation of transport	GO:0051050	92	0.022
cellular protein modification process	GO:0006464	438	0.022
camp biosynthetic process	GO:0006171	17	0.022
regulation of mitotic cell cycle	GO:0007346	190	0.022
regulation of cellular component biogenesis	GO:0044087	201	0.021	Rat
amine metabolic process	GO:0009308	12	0.021
synapse assembly	GO:0007416	143	0.021
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.021	Human Mouse
camp metabolic process	GO:0046058	19	0.021
ribonucleoside catabolic process	GO:0042454	112	0.021
regulation of reproductive process	GO:2000241	54	0.021
mitotic cell cycle phase transition	GO:0044772	138	0.021
cellular amino acid metabolic process	GO:0006520	61	0.021
carboxylic acid metabolic process	GO:0019752	92	0.021	Mouse
nitrogen compound transport	GO:0071705	85	0.021
axon development	GO:0061564	297	0.021
negative regulation of response to stimulus	GO:0048585	258	0.021
short term memory	GO:0007614	19	0.021
cyclic purine nucleotide metabolic process	GO:0052652	25	0.021
positive regulation of gtpase activity	GO:0043547	43	0.021
regulation of cell shape	GO:0008360	113	0.021
oocyte anterior posterior axis specification	GO:0007314	72	0.021
open tracheal system development	GO:0007424	204	0.020
regulation of nucleotide metabolic process	GO:0006140	62	0.020
purine ribonucleoside metabolic process	GO:0046128	127	0.020
regulation of multi organism process	GO:0043900	131	0.020
gene silencing	GO:0016458	138	0.020
organophosphate biosynthetic process	GO:0090407	46	0.020
morphogenesis of follicular epithelium	GO:0016333	36	0.020
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.020
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.020	Human Mouse
synaptic transmission	GO:0007268	288	0.020
anterior posterior axis specification	GO:0009948	109	0.020
reproductive behavior	GO:0019098	122	0.020
regulation of cell death	GO:0010941	173	0.020	Rat
ameboidal type cell migration	GO:0001667	151	0.019	Human Zebrafish
cellular component assembly involved in morphogenesis	GO:0010927	151	0.019
negative regulation of phosphate metabolic process	GO:0045936	45	0.019
organic acid metabolic process	GO:0006082	103	0.019	Mouse
purine nucleotide biosynthetic process	GO:0006164	29	0.019
immune system development	GO:0002520	57	0.019
skin development	GO:0043588	65	0.019
somatic stem cell division	GO:0048103	37	0.019
organelle fission	GO:0048285	340	0.019
nucleoside phosphate catabolic process	GO:1901292	110	0.019
nucleoside triphosphate metabolic process	GO:0009141	120	0.019
golgi organization	GO:0007030	66	0.019
secretion	GO:0046903	109	0.019
positive regulation of macromolecule metabolic process	GO:0010604	405	0.019	Human Mouse
epidermis development	GO:0008544	65	0.018
carbohydrate derivative biosynthetic process	GO:1901137	85	0.018
negative regulation of phosphorus metabolic process	GO:0010563	45	0.018
regulation of phosphorylation	GO:0042325	147	0.018
mushroom body development	GO:0016319	70	0.018
protein transport	GO:0015031	155	0.018
chorion containing eggshell formation	GO:0007304	105	0.018
autophagic cell death	GO:0048102	83	0.018
immune response regulating signaling pathway	GO:0002764	2	0.018
ribonucleotide catabolic process	GO:0009261	109	0.018
positive regulation of catalytic activity	GO:0043085	118	0.018
purine nucleotide catabolic process	GO:0006195	109	0.018
sensory organ morphogenesis	GO:0090596	260	0.018
purine nucleoside catabolic process	GO:0006152	112	0.018
appendage development	GO:0048736	401	0.018
cyclic nucleotide biosynthetic process	GO:0009190	25	0.018
ribose phosphate biosynthetic process	GO:0046390	28	0.018
response to wounding	GO:0009611	94	0.018
positive regulation of nucleotide metabolic process	GO:0045981	55	0.018
segmentation	GO:0035282	207	0.017
ovarian follicle cell development	GO:0030707	248	0.017
nucleoside phosphate biosynthetic process	GO:1901293	34	0.017
regulation of cell division	GO:0051302	72	0.017
positive regulation of programmed cell death	GO:0043068	62	0.017	Rat
regulation of purine nucleotide biosynthetic process	GO:1900371	14	0.017
single organism catabolic process	GO:0044712	228	0.017	Mouse
epithelium migration	GO:0090132	148	0.017	Human
positive regulation of rna metabolic process	GO:0051254	271	0.017	Human Mouse
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.017	Human Mouse
mitotic nuclear division	GO:0007067	213	0.017
regulation of response to wounding	GO:1903034	19	0.017
negative regulation of peptide secretion	GO:0002792	1	0.017
negative regulation of gene expression	GO:0010629	387	0.017	Human Mouse
immune system process	GO:0002376	347	0.017
eye development	GO:0001654	323	0.017
posttranscriptional gene silencing by rna	GO:0035194	45	0.017
pigmentation	GO:0043473	75	0.017
cellular response to growth factor stimulus	GO:0071363	30	0.016
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.016
salivary gland cell autophagic cell death	GO:0035071	83	0.016
pattern recognition receptor signaling pathway	GO:0002221	2	0.016
negative regulation of signaling	GO:0023057	219	0.016
negative regulation of cellular protein metabolic process	GO:0032269	85	0.016
activation of innate immune response	GO:0002218	4	0.016
chemical homeostasis	GO:0048878	92	0.016
positive regulation of molecular function	GO:0044093	136	0.016	Human
kidney development	GO:0001822	3	0.016
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.016	Human Mouse
single organism intracellular transport	GO:1902582	207	0.016
detection of visible light	GO:0009584	38	0.016
regulation of epithelial cell proliferation	GO:0050678	4	0.016
cytoskeleton dependent cytokinesis	GO:0061640	81	0.016
response to lipopolysaccharide	GO:0032496	4	0.016	Rat
negative regulation of gene expression epigenetic	GO:0045814	77	0.016
nucleoside metabolic process	GO:0009116	127	0.016
regulation of neuromuscular synaptic transmission	GO:1900073	15	0.016
glycosyl compound catabolic process	GO:1901658	112	0.016
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.015
negative regulation of neurogenesis	GO:0050768	53	0.015
purine containing compound catabolic process	GO:0072523	112	0.015
defense response	GO:0006952	300	0.015
regulation of proteolysis	GO:0030162	87	0.015
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.015
cell growth	GO:0016049	108	0.015
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.015	Human Mouse
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.015
negative regulation of signal transduction	GO:0009968	206	0.015
purine ribonucleoside catabolic process	GO:0046130	112	0.015
regulation of erbb signaling pathway	GO:1901184	42	0.015
regulation of cell morphogenesis	GO:0022604	163	0.015	Zebrafish
positive regulation of developmental process	GO:0051094	143	0.015	Human
regulation of synaptic transmission	GO:0050804	69	0.015
epithelial cell migration	GO:0010631	148	0.015	Human
phototransduction	GO:0007602	52	0.015
eye pigment granule organization	GO:0008057	12	0.015
endomembrane system organization	GO:0010256	119	0.015
regulation of kinase activity	GO:0043549	53	0.015
regulation of cellular localization	GO:0060341	136	0.015
cell cell junction assembly	GO:0007043	38	0.015
regulation of developmental growth	GO:0048638	174	0.015
blastoderm segmentation	GO:0007350	159	0.015
cellular protein localization	GO:0034613	160	0.015
regulation of epithelial cell differentiation	GO:0030856	4	0.015
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.015
photoreceptor cell differentiation	GO:0046530	170	0.015
innate immune response activating signal transduction	GO:0002758	2	0.015
negative regulation of nervous system development	GO:0051961	92	0.015
purine ribonucleotide catabolic process	GO:0009154	109	0.015
regulation of epidermal cell differentiation	GO:0045604	3	0.015
negative regulation of developmental process	GO:0051093	201	0.015	Human Mouse
cellular response to oxygen containing compound	GO:1901701	79	0.015	Rat
response to bacterium	GO:0009617	198	0.014	Rat
neuromuscular junction development	GO:0007528	149	0.014
regulation of gene expression epigenetic	GO:0040029	128	0.014	Human
response to growth factor	GO:0070848	31	0.014
positive regulation of transcription dna templated	GO:0045893	266	0.014	Human Mouse
cellular response to carbohydrate stimulus	GO:0071322	4	0.014
photoreceptor cell development	GO:0042461	96	0.014
cellular response to nitrogen compound	GO:1901699	51	0.014
ribonucleoside metabolic process	GO:0009119	127	0.014
epithelial cell development	GO:0002064	274	0.014
retina development in camera type eye	GO:0060041	4	0.014
rho protein signal transduction	GO:0007266	14	0.014
positive regulation of cell motility	GO:2000147	3	0.014	Human Rat
actin filament organization	GO:0007015	126	0.014
gland morphogenesis	GO:0022612	145	0.014
regulation of secretion by cell	GO:1903530	39	0.014
response to endogenous stimulus	GO:0009719	119	0.014	Mouse Rat
regulation of ras protein signal transduction	GO:0046578	93	0.014
mapk cascade	GO:0000165	107	0.014
carbohydrate derivative catabolic process	GO:1901136	118	0.014
positive regulation of epithelial cell differentiation	GO:0030858	1	0.014
gtp metabolic process	GO:0046039	72	0.014
purine nucleoside metabolic process	GO:0042278	127	0.014
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.014
negative regulation of cell cycle	GO:0045786	116	0.013
chromatin silencing	GO:0006342	76	0.013
response to biotic stimulus	GO:0009607	294	0.013	Rat
central nervous system development	GO:0007417	201	0.013
developmental programmed cell death	GO:0010623	138	0.013
negative regulation of immune system process	GO:0002683	50	0.013
head development	GO:0060322	135	0.013
gtp catabolic process	GO:0006184	72	0.013
negative regulation of protein metabolic process	GO:0051248	85	0.013
visual learning	GO:0008542	4	0.013
regulation of cellular catabolic process	GO:0031329	157	0.013	Mouse
regulation of cell matrix adhesion	GO:0001952	1	0.013
synaptic growth at neuromuscular junction	GO:0051124	119	0.013
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.013
mesodermal cell migration	GO:0008078	7	0.013
organelle localization	GO:0051640	148	0.013
asymmetric protein localization involved in cell fate determination	GO:0045167	9	0.013
dendrite morphogenesis	GO:0048813	199	0.013
immune response activating signal transduction	GO:0002757	2	0.013
regulation of camp metabolic process	GO:0030814	12	0.013
establishment or maintenance of cell polarity	GO:0007163	167	0.013
establishment of protein localization	GO:0045184	163	0.013
compound eye development	GO:0048749	307	0.013
molting cycle	GO:0042303	56	0.013
morphogenesis of an epithelium	GO:0002009	276	0.013	Mouse
eye photoreceptor cell differentiation	GO:0001754	145	0.013
guanosine containing compound metabolic process	GO:1901068	74	0.013
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.012
limb morphogenesis	GO:0035108	1	0.012
negative regulation of transcription dna templated	GO:0045892	237	0.012	Human Mouse
negative regulation of cellular component organization	GO:0051129	108	0.012
regulation of cell cycle	GO:0051726	291	0.012
regulation of gene silencing	GO:0060968	63	0.012
negative regulation of catalytic activity	GO:0043086	42	0.012
positive regulation of protein transport	GO:0051222	37	0.012
regulation of camp biosynthetic process	GO:0030817	12	0.012
cellular response to molecule of bacterial origin	GO:0071219	3	0.012	Rat
regulation of response to external stimulus	GO:0032101	115	0.012
death	GO:0016265	284	0.012	Rat
protein polymerization	GO:0051258	42	0.012
exocrine system development	GO:0035272	162	0.012
signal release	GO:0023061	49	0.012
positive regulation of cell death	GO:0010942	69	0.012	Rat
heart development	GO:0007507	82	0.012	Mouse
negative regulation of erbb signaling pathway	GO:1901185	29	0.012
regulation of cyclic nucleotide biosynthetic process	GO:0030802	13	0.012
secretion by cell	GO:0032940	101	0.012
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.012
negative regulation of epithelial cell proliferation	GO:0050680	4	0.012
cellular response to hormone stimulus	GO:0032870	44	0.012	Rat
regulation of cell development	GO:0060284	215	0.012	Zebrafish Mouse
dendrite development	GO:0016358	204	0.012
female gonad development	GO:0008585	12	0.012
microtubule polymerization or depolymerization	GO:0031109	39	0.012
mating	GO:0007618	120	0.012
response to temperature stimulus	GO:0009266	106	0.012
telencephalon development	GO:0021537	2	0.011
regulation of epidermal growth factor activated receptor activity	GO:0007176	4	0.011
molting cycle process	GO:0022404	29	0.011
regulation of lyase activity	GO:0051339	14	0.011
response to hexose	GO:0009746	3	0.011
gene silencing by rna	GO:0031047	57	0.011
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.011	Human Mouse
salivary gland development	GO:0007431	162	0.011
germ line cyst formation	GO:0048134	44	0.011
positive regulation of exocytosis	GO:0045921	4	0.011
positive regulation of cellular component biogenesis	GO:0044089	80	0.011	Rat
macromolecular complex assembly	GO:0065003	256	0.011
regulation of cytoskeleton organization	GO:0051493	89	0.011
asymmetric stem cell division	GO:0098722	49	0.011
response to monosaccharide	GO:0034284	4	0.011
brain development	GO:0007420	120	0.011
regulation of catabolic process	GO:0009894	170	0.011	Mouse
peptidyl amino acid modification	GO:0018193	105	0.011	Human
positive regulation of catabolic process	GO:0009896	105	0.011
nucleotide biosynthetic process	GO:0009165	34	0.011
negative regulation of cell death	GO:0060548	81	0.011
membrane organization	GO:0061024	112	0.011
positive regulation of mapk cascade	GO:0043410	63	0.011
germarium derived female germ line cyst formation	GO:0030727	42	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.011
nucleoside triphosphate catabolic process	GO:0009143	108	0.011
carbohydrate metabolic process	GO:0005975	82	0.011	Mouse
asymmetric neuroblast division	GO:0055059	33	0.011
larval development	GO:0002164	104	0.011
nucleoside catabolic process	GO:0009164	112	0.011
sensory perception of mechanical stimulus	GO:0050954	72	0.011
cellular ketone metabolic process	GO:0042180	24	0.011
cuticle pattern formation	GO:0035017	27	0.011
regulation of actin cytoskeleton organization	GO:0032956	42	0.011
macromolecule catabolic process	GO:0009057	161	0.011
regulation of chromatin silencing	GO:0031935	36	0.010
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.010
multi multicellular organism process	GO:0044706	123	0.010
developmental growth involved in morphogenesis	GO:0060560	65	0.010
regulation of meiosis	GO:0040020	3	0.010
dorsal ventral axis specification	GO:0009950	66	0.010
cellular macromolecular complex assembly	GO:0034622	153	0.010
spindle assembly involved in mitosis	GO:0090307	50	0.010
regulation of protein modification process	GO:0031399	112	0.010	Human
programmed cell death	GO:0012501	257	0.010	Rat
columnar cuboidal epithelial cell development	GO:0002066	249	0.010
positive regulation of lipid metabolic process	GO:0045834	4	0.010
neuropeptide signaling pathway	GO:0007218	45	0.010
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.010
negative regulation of cell cycle process	GO:0010948	109	0.010
cell death	GO:0008219	279	0.010	Rat
cellular response to biotic stimulus	GO:0071216	4	0.010	Rat
cytokinesis	GO:0000910	90	0.010

HDAC4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.031
disease of cellular proliferation	DOID:14566	0.019
cancer	DOID:162	0.019
organ system cancer	DOID:0050686	0.019
nervous system disease	DOID:863	0.013

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