IMP: Integrative Multi-species Prediction

Drosophila melanogaster

25 known processes

RpL21 (Dmel_CG12775)

Ribosomal protein L21

(Aliases: anon-EST:Posey18,anon-EST:Posey30,Dmel\CG12775,CG12775,M(2)39F,BcDNA:RH06526)

FLYBASE: FBgn0032987
Entrez: 35453
UniProtKB: Q9V9M7

Process Predictions
Disease Predictions

RpL21 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
mitotic spindle elongation	GO:0000022	81	0.989
spindle elongation	GO:0051231	83	0.865
mitotic spindle organization	GO:0007052	220	0.854
centrosome duplication	GO:0051298	121	0.822
centrosome organization	GO:0051297	163	0.652
centrosome cycle	GO:0007098	137	0.553
spindle organization	GO:0007051	253	0.468
microtubule organizing center organization	GO:0031023	168	0.446
translation	GO:0006412	69	0.308
cytoplasmic transport	GO:0016482	130	0.192
aging	GO:0007568	143	0.182
rrna processing	GO:0006364	3	0.180
gonad development	GO:0008406	50	0.168	Worm
multicellular organismal aging	GO:0010259	140	0.154
molting cycle	GO:0042303	56	0.147
organic substance transport	GO:0071702	257	0.136
sex differentiation	GO:0007548	81	0.136	Worm
larval development	GO:0002164	104	0.123	Worm
determination of adult lifespan	GO:0008340	137	0.120
nucleocytoplasmic transport	GO:0006913	72	0.109
nuclear export	GO:0051168	24	0.107
rna processing	GO:0006396	147	0.101
death	GO:0016265	284	0.095	Worm
developmental growth	GO:0048589	280	0.094
regulation of growth	GO:0040008	233	0.086
embryo development ending in birth or egg hatching	GO:0009792	152	0.085	Worm
nuclear transport	GO:0051169	72	0.082
cellular macromolecular complex assembly	GO:0034622	153	0.079
development of primary sexual characteristics	GO:0045137	50	0.075	Worm
head development	GO:0060322	135	0.067
body morphogenesis	GO:0010171	2	0.066
regulation of multicellular organism growth	GO:0040014	40	0.065
macromolecular complex assembly	GO:0065003	256	0.060
regulation of cell cycle	GO:0051726	291	0.058
positive regulation of developmental growth	GO:0048639	62	0.057
regulation of translation	GO:0006417	56	0.056
ribonucleoprotein complex biogenesis	GO:0022613	31	0.056
regulation of developmental growth	GO:0048638	174	0.052
organelle assembly	GO:0070925	198	0.052
reproductive system development	GO:0061458	74	0.052	Worm
ribosomal large subunit biogenesis	GO:0042273	1	0.049
endocytosis	GO:0006897	310	0.049
cell death	GO:0008219	279	0.048	Worm
organic substance catabolic process	GO:1901575	308	0.048
protein modification process	GO:0036211	438	0.047
response to temperature stimulus	GO:0009266	106	0.046
response to other organism	GO:0051707	293	0.045
regulation of cellular protein metabolic process	GO:0032268	243	0.043
positive regulation of growth	GO:0045927	75	0.042
ncrna metabolic process	GO:0034660	43	0.040
meiotic cell cycle process	GO:1903046	132	0.040
translational elongation	GO:0006414	4	0.039
single organism intracellular transport	GO:1902582	207	0.038
proteolysis	GO:0006508	192	0.036
intracellular transport	GO:0046907	228	0.036
apoptotic process	GO:0006915	159	0.034	Worm
multicellular organism growth	GO:0035264	46	0.034
positive regulation of response to stimulus	GO:0048584	323	0.033
exocrine system development	GO:0035272	162	0.033
positive regulation of gene expression	GO:0010628	290	0.032
response to abiotic stimulus	GO:0009628	341	0.031
tissue death	GO:0016271	102	0.031
establishment of localization in cell	GO:0051649	402	0.030
regulation of protein metabolic process	GO:0051246	256	0.030
ribonucleoprotein complex assembly	GO:0022618	23	0.028
reproductive structure development	GO:0048608	74	0.028	Worm
cellular protein modification process	GO:0006464	438	0.027
positive regulation of cellular protein metabolic process	GO:0032270	118	0.027
positive regulation of developmental process	GO:0051094	143	0.027
salivary gland morphogenesis	GO:0007435	145	0.027
response to bacterium	GO:0009617	198	0.026
regulation of molecular function	GO:0065009	217	0.026
positive regulation of multicellular organism growth	GO:0040018	21	0.025
ribonucleoprotein complex subunit organization	GO:0071826	28	0.025
cell migration	GO:0016477	238	0.025	Worm
protein localization	GO:0008104	284	0.024
genitalia development	GO:0048806	26	0.024
glycosyl compound metabolic process	GO:1901657	127	0.024
organelle localization	GO:0051640	148	0.024
programmed cell death	GO:0012501	257	0.023	Worm
organonitrogen compound metabolic process	GO:1901564	318	0.023
catabolic process	GO:0009056	409	0.023
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.022
protein modification by small protein conjugation or removal	GO:0070647	106	0.022
immune system development	GO:0002520	57	0.022
nucleoside triphosphate catabolic process	GO:0009143	108	0.022
rna export from nucleus	GO:0006405	12	0.021
nucleobase containing compound transport	GO:0015931	56	0.021
purine nucleotide metabolic process	GO:0006163	146	0.021
protein ubiquitination	GO:0016567	70	0.021
nucleobase containing compound catabolic process	GO:0034655	165	0.021
histolysis	GO:0007559	102	0.020
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.020
posttranscriptional regulation of gene expression	GO:0010608	145	0.020
cell motility	GO:0048870	251	0.020	Worm
regulation of catalytic activity	GO:0050790	185	0.020
central nervous system development	GO:0007417	201	0.020
hemopoiesis	GO:0030097	46	0.020
brain development	GO:0007420	120	0.019
localization of cell	GO:0051674	257	0.019	Worm
positive regulation of signaling	GO:0023056	243	0.018
salivary gland development	GO:0007431	162	0.018
growth	GO:0040007	359	0.018
positive regulation of cell communication	GO:0010647	250	0.018
cellular catabolic process	GO:0044248	372	0.018
phagocytosis	GO:0006909	215	0.018
positive regulation of biosynthetic process	GO:0009891	316	0.017
purine ribonucleoside metabolic process	GO:0046128	127	0.017
regulation of gene expression epigenetic	GO:0040029	128	0.017
rna localization	GO:0006403	115	0.017
response to external biotic stimulus	GO:0043207	293	0.017
mitotic dna damage checkpoint	GO:0044773	74	0.017
protein modification by small protein conjugation	GO:0032446	79	0.017
regulation of hydrolase activity	GO:0051336	97	0.017
regulation of proteolysis	GO:0030162	87	0.017
homeostatic process	GO:0042592	199	0.017
regulation of phosphorus metabolic process	GO:0051174	210	0.016
regulation of apoptotic process	GO:0042981	130	0.016
heterocycle catabolic process	GO:0046700	166	0.016
positive regulation of cellular catabolic process	GO:0031331	95	0.016
small molecule metabolic process	GO:0044281	305	0.016
male gamete generation	GO:0048232	201	0.016
response to heat	GO:0009408	63	0.015
ncrna processing	GO:0034470	30	0.015
nitrogen compound transport	GO:0071705	85	0.015
gene silencing	GO:0016458	138	0.015
negative regulation of cellular metabolic process	GO:0031324	382	0.015
protein complex biogenesis	GO:0070271	201	0.015
salivary gland cell autophagic cell death	GO:0035071	83	0.015
ribosome biogenesis	GO:0042254	8	0.015
protein processing	GO:0016485	68	0.015
purine containing compound metabolic process	GO:0072521	155	0.015
organic cyclic compound catabolic process	GO:1901361	168	0.014
positive regulation of catabolic process	GO:0009896	105	0.014
dna metabolic process	GO:0006259	227	0.014
positive regulation of catalytic activity	GO:0043085	118	0.014
positive regulation of multicellular organismal process	GO:0051240	143	0.014
gland morphogenesis	GO:0022612	145	0.014
cellular protein localization	GO:0034613	160	0.014
spermatogenesis	GO:0007283	200	0.014
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.013
nucleoside triphosphate metabolic process	GO:0009141	120	0.013
glycosyl compound catabolic process	GO:1901658	112	0.013
vesicle mediated transport	GO:0016192	381	0.013
establishment of organelle localization	GO:0051656	122	0.013
cellular nitrogen compound catabolic process	GO:0044270	165	0.013
positive regulation of gtp catabolic process	GO:0033126	43	0.013
salivary gland histolysis	GO:0035070	88	0.013
immune system process	GO:0002376	347	0.013
developmental programmed cell death	GO:0010623	138	0.012
protein dna complex subunit organization	GO:0071824	86	0.012
response to oxygen containing compound	GO:1901700	200	0.012
nucleoside metabolic process	GO:0009116	127	0.012
ribonucleoside metabolic process	GO:0009119	127	0.012
positive regulation of macromolecule metabolic process	GO:0010604	405	0.012
ribonucleotide metabolic process	GO:0009259	145	0.012
carbohydrate derivative catabolic process	GO:1901136	118	0.012
positive regulation of apoptotic process	GO:0043065	47	0.012
guanosine containing compound catabolic process	GO:1901069	74	0.012
dna packaging	GO:0006323	91	0.012
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.012
taxis	GO:0042330	304	0.012
negative regulation of gene expression	GO:0010629	387	0.012
phosphorylation	GO:0016310	294	0.012
positive regulation of hydrolase activity	GO:0051345	78	0.012
response to organic substance	GO:0010033	284	0.012
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.012
nuclear transcribed mrna catabolic process	GO:0000956	24	0.012
nucleoside phosphate metabolic process	GO:0006753	162	0.011
regulation of cell death	GO:0010941	173	0.011
axon guidance	GO:0007411	233	0.011
rna transport	GO:0050658	46	0.011
intracellular signal transduction	GO:0035556	300	0.011
regulation of gtpase activity	GO:0043087	44	0.011
hematopoietic or lymphoid organ development	GO:0048534	57	0.011
positive regulation of cellular biosynthetic process	GO:0031328	316	0.011
purine ribonucleoside catabolic process	GO:0046130	112	0.011
skin development	GO:0043588	65	0.011
ribose phosphate metabolic process	GO:0019693	145	0.011
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.011
regulation of nucleoside metabolic process	GO:0009118	50	0.011
purine containing compound catabolic process	GO:0072523	112	0.011
protein transport	GO:0015031	155	0.010
defense response to bacterium	GO:0042742	178	0.010
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.010
purine ribonucleotide metabolic process	GO:0009150	145	0.010

RpL21 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.071
congenital hypoplastic anemia	DOID:1342	0.021
anemia	DOID:2355	0.021
immune system disease	DOID:2914	0.021
aplastic anemia	DOID:12449	0.021
hematopoietic system disease	DOID:74	0.021
bone marrow disease	DOID:4961	0.021

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