IMP: Integrative Multi-species Prediction

Drosophila melanogaster

41 known processes

Clic (Dmel_CG10997)

Chloride intracellular channel

(Aliases: DmCLIC,l(1)G0053,CG10997,DCLIC,Dmel\CG10997,l(1)G0472)

FLYBASE: FBgn0030529
Entrez: 32349
UniProtKB: Q9VY78

Process Predictions
Disease Predictions

Clic biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
gravitaxis	GO:0042332	26	0.330
wing disc morphogenesis	GO:0007472	344	0.280
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.232
adult behavior	GO:0030534	137	0.210
intracellular transport	GO:0046907	228	0.187
post embryonic appendage morphogenesis	GO:0035120	385	0.186
imaginal disc derived appendage development	GO:0048737	399	0.145
cellular macromolecule localization	GO:0070727	220	0.139
appendage development	GO:0048736	401	0.121
taxis	GO:0042330	304	0.117
cellular protein modification process	GO:0006464	438	0.101
establishment of localization in cell	GO:0051649	402	0.098
vesicle mediated transport	GO:0016192	381	0.091
intracellular signal transduction	GO:0035556	300	0.090
locomotory behavior	GO:0007626	176	0.089
imaginal disc derived wing morphogenesis	GO:0007476	337	0.085
response to abiotic stimulus	GO:0009628	341	0.084
endocytosis	GO:0006897	310	0.075
cellular protein localization	GO:0034613	160	0.074
single organism intracellular transport	GO:1902582	207	0.072
appendage morphogenesis	GO:0035107	397	0.071
protein localization	GO:0008104	284	0.071	Mouse
synapse organization	GO:0050808	196	0.070
regulation of anatomical structure morphogenesis	GO:0022603	242	0.069
dorsal closure	GO:0007391	79	0.068
cuticle pigmentation	GO:0048067	22	0.067
organelle assembly	GO:0070925	198	0.066
tissue morphogenesis	GO:0048729	297	0.066	Mouse
single organism catabolic process	GO:0044712	228	0.065
actin filament based process	GO:0030029	220	0.065
morphogenesis of embryonic epithelium	GO:0016331	94	0.061
single organism cellular localization	GO:1902580	180	0.061
synaptic transmission	GO:0007268	288	0.060
cytoplasmic transport	GO:0016482	130	0.059
cell projection assembly	GO:0030031	94	0.058
positive regulation of phosphate metabolic process	GO:0045937	139	0.058
macromolecular complex assembly	GO:0065003	256	0.057
protein transport	GO:0015031	155	0.056
regulation of phosphate metabolic process	GO:0019220	210	0.055
regulation of phosphorus metabolic process	GO:0051174	210	0.054
open tracheal system development	GO:0007424	204	0.053
establishment of protein localization	GO:0045184	163	0.053
respiratory system development	GO:0060541	213	0.051
regulation of cell shape	GO:0008360	113	0.049
cellular catabolic process	GO:0044248	372	0.048
negative regulation of response to stimulus	GO:0048585	258	0.047
pigmentation	GO:0043473	75	0.047
organophosphate catabolic process	GO:0046434	112	0.046
developmental pigmentation	GO:0048066	68	0.045
adult chitin containing cuticle pigmentation	GO:0048085	16	0.045
positive regulation of phosphorus metabolic process	GO:0010562	139	0.044
microtubule based movement	GO:0007018	51	0.044
positive regulation of response to stimulus	GO:0048584	323	0.044
protein modification process	GO:0036211	438	0.044
regulation of anatomical structure size	GO:0090066	163	0.044
response to gravity	GO:0009629	26	0.043
regulation of localization	GO:0032879	275	0.042
defense response to other organism	GO:0098542	225	0.042
regulation of cell morphogenesis	GO:0022604	163	0.041
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.041
photoreceptor cell differentiation	GO:0046530	170	0.040
positive regulation of cell size	GO:0045793	21	0.040
adult locomotory behavior	GO:0008344	76	0.040
positive regulation of signaling	GO:0023056	243	0.039
ras protein signal transduction	GO:0007265	88	0.038
positive regulation of cell communication	GO:0010647	250	0.038
proteolysis	GO:0006508	192	0.037
small gtpase mediated signal transduction	GO:0007264	88	0.037
homeostatic process	GO:0042592	199	0.037	Mouse
organic substance transport	GO:0071702	257	0.037
cilium morphogenesis	GO:0060271	39	0.037
protein complex biogenesis	GO:0070271	201	0.036
immune system process	GO:0002376	347	0.036
embryonic morphogenesis	GO:0048598	206	0.035	Mouse
transcription from rna polymerase ii promoter	GO:0006366	368	0.035
regulation of mapk cascade	GO:0043408	92	0.035
response to bacterium	GO:0009617	198	0.034
eye development	GO:0001654	323	0.033	Mouse
organelle localization	GO:0051640	148	0.033
regulation of cellular protein metabolic process	GO:0032268	243	0.033
organophosphate metabolic process	GO:0019637	195	0.032
nucleoside phosphate catabolic process	GO:1901292	110	0.032
catabolic process	GO:0009056	409	0.032
negative regulation of cell communication	GO:0010648	223	0.032
regulation of catalytic activity	GO:0050790	185	0.032
regulation of phosphorylation	GO:0042325	147	0.032
regulation of notch signaling pathway	GO:0008593	100	0.032
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.031
head development	GO:0060322	135	0.031
positive regulation of phosphorylation	GO:0042327	87	0.031
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.031
phagocytosis	GO:0006909	215	0.031
axonogenesis	GO:0007409	290	0.031
stress activated protein kinase signaling cascade	GO:0031098	55	0.030
cytoskeleton dependent intracellular transport	GO:0030705	44	0.030
defense response	GO:0006952	300	0.029
regulation of molecular function	GO:0065009	217	0.029
notch signaling pathway	GO:0007219	120	0.029
chemical homeostasis	GO:0048878	92	0.028	Mouse
regulation of mitotic cell cycle	GO:0007346	190	0.028
heterocycle catabolic process	GO:0046700	166	0.028
ribose phosphate metabolic process	GO:0019693	145	0.028
epithelial cell development	GO:0002064	274	0.028	Mouse
phosphorylation	GO:0016310	294	0.028
regulation of growth	GO:0040008	233	0.028
membrane organization	GO:0061024	112	0.028
regulation of cell cycle	GO:0051726	291	0.027
positive regulation of signal transduction	GO:0009967	223	0.027
rho protein signal transduction	GO:0007266	14	0.027
organonitrogen compound metabolic process	GO:1901564	318	0.027
regulation of intracellular signal transduction	GO:1902531	236	0.027
regulation of response to stress	GO:0080134	200	0.027
regulation of adult chitin containing cuticle pigmentation	GO:0048082	13	0.027
lateral inhibition	GO:0046331	206	0.027
microtubule based transport	GO:0010970	42	0.027
nucleobase containing small molecule metabolic process	GO:0055086	174	0.026
cytoskeleton dependent cytokinesis	GO:0061640	81	0.026
embryo development ending in birth or egg hatching	GO:0009792	152	0.026
intracellular protein transport	GO:0006886	104	0.026
glycosyl compound catabolic process	GO:1901658	112	0.026
cation transport	GO:0006812	110	0.026
purine ribonucleotide metabolic process	GO:0009150	145	0.026
regulation of synapse organization	GO:0050807	110	0.025
organic cyclic compound catabolic process	GO:1901361	168	0.025
positive regulation of biosynthetic process	GO:0009891	316	0.025
single organism behavior	GO:0044708	391	0.025
positive regulation of molecular function	GO:0044093	136	0.025
nucleoside phosphate metabolic process	GO:0006753	162	0.025
axon guidance	GO:0007411	233	0.024
biological adhesion	GO:0022610	138	0.024
response to light stimulus	GO:0009416	124	0.024
carbohydrate derivative metabolic process	GO:1901135	217	0.024
nucleotide metabolic process	GO:0009117	161	0.024
signal transduction in response to dna damage	GO:0042770	3	0.023
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.023
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.023
regulation of cell development	GO:0060284	215	0.023
regulation of cellular component biogenesis	GO:0044087	201	0.023
regulation of protein modification process	GO:0031399	112	0.022
nucleoside catabolic process	GO:0009164	112	0.022
cell adhesion	GO:0007155	136	0.022
cellular macromolecular complex assembly	GO:0034622	153	0.022
muscle structure development	GO:0061061	224	0.022
tube development	GO:0035295	244	0.022	Mouse
regulation of cellular amine metabolic process	GO:0033238	3	0.021
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.021
regulation of developmental growth	GO:0048638	174	0.021
growth	GO:0040007	359	0.021	Mouse
regionalization	GO:0003002	416	0.021
single organism membrane organization	GO:0044802	93	0.021
skeletal muscle fiber development	GO:0048741	3	0.021
organic substance catabolic process	GO:1901575	308	0.021
secretion	GO:0046903	109	0.020
positive regulation of macromolecule metabolic process	GO:0010604	405	0.020
nuclear transport	GO:0051169	72	0.020
nucleobase containing compound catabolic process	GO:0034655	165	0.020
establishment of organelle localization	GO:0051656	122	0.020
neurological system process	GO:0050877	358	0.020	Mouse
purine containing compound metabolic process	GO:0072521	155	0.020
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.020
positive regulation of transport	GO:0051050	92	0.020
developmental growth	GO:0048589	280	0.020
positive regulation of catalytic activity	GO:0043085	118	0.020
nucleotide catabolic process	GO:0009166	109	0.020
sensory perception of mechanical stimulus	GO:0050954	72	0.020	Mouse
developmental maturation	GO:0021700	172	0.019
programmed cell death	GO:0012501	257	0.019
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.019
regulation of cell size	GO:0008361	63	0.019
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.019
embryonic development via the syncytial blastoderm	GO:0001700	148	0.019
embryonic pattern specification	GO:0009880	174	0.019
regulation of protein metabolic process	GO:0051246	256	0.019
immune response	GO:0006955	246	0.019
membrane fusion	GO:0061025	42	0.019
positive regulation of protein metabolic process	GO:0051247	128	0.019
aromatic compound catabolic process	GO:0019439	166	0.019
golgi localization	GO:0051645	2	0.019
actin filament organization	GO:0007015	126	0.018
morphogenesis of an epithelium	GO:0002009	276	0.018	Mouse
regulation of transport	GO:0051049	181	0.018
chemotaxis	GO:0006935	249	0.018
regulation of cuticle pigmentation	GO:0048079	16	0.018
positive regulation of mapk cascade	GO:0043410	63	0.018
eggshell formation	GO:0030703	105	0.018
cellular homeostasis	GO:0019725	80	0.018	Mouse
dna damage checkpoint	GO:0000077	78	0.018
response to nutrient levels	GO:0031667	114	0.018	Mouse
regulation of organelle organization	GO:0033043	196	0.018
cellular component assembly involved in morphogenesis	GO:0010927	151	0.018
small molecule metabolic process	GO:0044281	305	0.017
regulation of cellular localization	GO:0060341	136	0.017
nucleocytoplasmic transport	GO:0006913	72	0.017
gland morphogenesis	GO:0022612	145	0.017
metal ion transport	GO:0030001	74	0.017
cell junction assembly	GO:0034329	42	0.017
regulation of tube architecture open tracheal system	GO:0035152	68	0.017
regulation of synapse structure and activity	GO:0050803	128	0.017
chitin based cuticle sclerotization	GO:0007593	19	0.017
cell growth	GO:0016049	108	0.017
positive regulation of protein transport	GO:0051222	37	0.017
regulation of jnk cascade	GO:0046328	40	0.017
negative regulation of signal transduction	GO:0009968	206	0.017
nucleoside monophosphate catabolic process	GO:0009125	39	0.017
protein localization to organelle	GO:0033365	82	0.017
response to hexose	GO:0009746	3	0.017
ion transmembrane transport	GO:0034220	122	0.016
cell maturation	GO:0048469	144	0.016
regulation of cellular component size	GO:0032535	98	0.016
initiation of dorsal closure	GO:0007392	12	0.016
vesicle organization	GO:0016050	44	0.016
rna processing	GO:0006396	147	0.016
oocyte differentiation	GO:0009994	145	0.016
regulation of immune system process	GO:0002682	176	0.016
macromolecule catabolic process	GO:0009057	161	0.016
detection of stimulus	GO:0051606	156	0.016
cellular carbohydrate metabolic process	GO:0044262	22	0.016
regulation of hydrolase activity	GO:0051336	97	0.016
positive regulation of cellular amine metabolic process	GO:0033240	0	0.016
regulation of intracellular transport	GO:0032386	64	0.016
camera type eye development	GO:0043010	4	0.016	Mouse
eye morphogenesis	GO:0048592	260	0.016
cilium organization	GO:0044782	41	0.015
compound eye development	GO:0048749	307	0.015
response to organic substance	GO:0010033	284	0.015
negative regulation of cellular metabolic process	GO:0031324	382	0.015
carbohydrate derivative catabolic process	GO:1901136	118	0.015
ribonucleotide metabolic process	GO:0009259	145	0.015
sensory perception	GO:0007600	196	0.015	Mouse
nucleoside triphosphate catabolic process	GO:0009143	108	0.015
ph reduction	GO:0045851	7	0.015	Mouse
establishment of protein localization to organelle	GO:0072594	62	0.015
hippo signaling	GO:0035329	20	0.015
regulation of cellular catabolic process	GO:0031329	157	0.015
regulation of cellular amino acid metabolic process	GO:0006521	0	0.015
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.015
eye photoreceptor cell differentiation	GO:0001754	145	0.015
ion transport	GO:0006811	145	0.015
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.015
response to heat	GO:0009408	63	0.015
positive regulation of gene expression	GO:0010628	290	0.014
mapk cascade	GO:0000165	107	0.014
purine containing compound catabolic process	GO:0072523	112	0.014
peptidyl amino acid modification	GO:0018193	105	0.014
protein catabolic process	GO:0030163	101	0.014
positive regulation of hydrolase activity	GO:0051345	78	0.014
response to other organism	GO:0051707	293	0.014
purine nucleotide metabolic process	GO:0006163	146	0.014
defense response to gram negative bacterium	GO:0050829	94	0.014
maintenance of location	GO:0051235	73	0.014
segmentation	GO:0035282	207	0.014
positive regulation of intracellular signal transduction	GO:1902533	116	0.014
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.014
muscle attachment	GO:0016203	36	0.014
jnk cascade	GO:0007254	50	0.014
innate immune response	GO:0045087	144	0.014
negative regulation of programmed cell death	GO:0043069	72	0.014
positive regulation of protein modification process	GO:0031401	58	0.014
immune response activating signal transduction	GO:0002757	2	0.014
negative regulation of developmental process	GO:0051093	201	0.014
positive regulation of developmental growth	GO:0048639	62	0.014
actin cytoskeleton organization	GO:0030036	206	0.014
dephosphorylation	GO:0016311	51	0.014
stress activated mapk cascade	GO:0051403	52	0.014
imaginal disc fusion	GO:0046528	19	0.013
regulation of cellular response to stress	GO:0080135	89	0.013
negative regulation of cell differentiation	GO:0045596	143	0.013
central nervous system development	GO:0007417	201	0.013
gastrulation with mouth forming first	GO:0001703	36	0.013
single organism biosynthetic process	GO:0044711	206	0.013
regulation of intracellular protein transport	GO:0033157	46	0.013
anterior posterior axis specification embryo	GO:0008595	103	0.013
endomembrane system organization	GO:0010256	119	0.013
spermatid development	GO:0007286	98	0.013
positive regulation of cellular biosynthetic process	GO:0031328	316	0.013
regulation of nucleocytoplasmic transport	GO:0046822	35	0.013
regulation of cell cycle process	GO:0010564	181	0.013
localization of cell	GO:0051674	257	0.013
purine ribonucleoside metabolic process	GO:0046128	127	0.013
purine nucleoside catabolic process	GO:0006152	112	0.013
erk1 and erk2 cascade	GO:0070371	39	0.013
pole plasm assembly	GO:0007315	61	0.013
regulation of ras protein signal transduction	GO:0046578	93	0.013
protein dna complex subunit organization	GO:0071824	86	0.013
establishment of nucleus localization	GO:0040023	26	0.013
regulation of protein localization	GO:0032880	76	0.013
oocyte construction	GO:0007308	112	0.013
regulation of transferase activity	GO:0051338	58	0.013
cell division	GO:0051301	248	0.013
ovarian follicle cell development	GO:0030707	248	0.013
phagosome acidification	GO:0090383	1	0.013
multi organism reproductive behavior	GO:0044705	121	0.013
positive regulation of cellular protein metabolic process	GO:0032270	118	0.013
regulation of chitin based cuticle tanning	GO:0007564	14	0.013
kidney development	GO:0001822	3	0.012
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.012
positive regulation of growth	GO:0045927	75	0.012
molting cycle	GO:0042303	56	0.012
chromatin silencing	GO:0006342	76	0.012
regulation of tube size open tracheal system	GO:0035151	43	0.012
negative regulation of phosphorus metabolic process	GO:0010563	45	0.012
anterior posterior pattern specification	GO:0009952	136	0.012
response to radiation	GO:0009314	155	0.012
protein import	GO:0017038	55	0.012
anatomical structure homeostasis	GO:0060249	97	0.012
cellular response to dna damage stimulus	GO:0006974	223	0.012
negative regulation of intracellular signal transduction	GO:1902532	57	0.012
response to biotic stimulus	GO:0009607	294	0.012
response to glucose	GO:0009749	2	0.012
cell death	GO:0008219	279	0.012
single organism carbohydrate metabolic process	GO:0044723	72	0.012
regulation of protein transport	GO:0051223	57	0.012
collateral sprouting	GO:0048668	3	0.012
gene silencing	GO:0016458	138	0.012
ribonucleotide catabolic process	GO:0009261	109	0.012
positive regulation of cellular component organization	GO:0051130	156	0.012
multicellular organismal reproductive behavior	GO:0033057	110	0.012
multi multicellular organism process	GO:0044706	123	0.012
smoothened signaling pathway	GO:0007224	49	0.012
apoptotic process	GO:0006915	159	0.012
cytokinesis	GO:0000910	90	0.012
protein phosphorylation	GO:0006468	169	0.012
positive regulation of ras protein signal transduction	GO:0046579	43	0.012
detection of light stimulus	GO:0009583	58	0.012
ion homeostasis	GO:0050801	55	0.012	Mouse
positive regulation of cell migration	GO:0030335	2	0.012
response to external biotic stimulus	GO:0043207	293	0.012
dna integrity checkpoint	GO:0031570	81	0.012
purine ribonucleotide catabolic process	GO:0009154	109	0.012
protein complex assembly	GO:0006461	200	0.012
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.012
regulation of establishment of protein localization	GO:0070201	61	0.012
nuclear migration	GO:0007097	20	0.011
ribonucleoside catabolic process	GO:0042454	112	0.011
digestive system development	GO:0055123	149	0.011
posttranscriptional regulation of gene expression	GO:0010608	145	0.011
cell cell junction assembly	GO:0007043	38	0.011
hemocyte migration	GO:0035099	19	0.011
compound eye photoreceptor development	GO:0042051	78	0.011
maintenance of protein location	GO:0045185	28	0.011
renal filtration	GO:0097205	7	0.011
circulatory system process	GO:0003013	37	0.011
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.011
response to lipopolysaccharide	GO:0032496	4	0.011
nephron development	GO:0072006	3	0.011
positive regulation of cell projection organization	GO:0031346	29	0.011
cilium assembly	GO:0042384	38	0.011
cortical actin cytoskeleton organization	GO:0030866	24	0.011
regulation of cellular ph	GO:0030641	7	0.011	Mouse
organelle fission	GO:0048285	340	0.011
negative regulation of growth	GO:0045926	84	0.011
positive regulation of intracellular transport	GO:0032388	42	0.011
outflow tract morphogenesis	GO:0003151	4	0.011
positive regulation of cellular catabolic process	GO:0031331	95	0.011
protein targeting	GO:0006605	64	0.011
negative regulation of phosphate metabolic process	GO:0045936	45	0.011
signal transduction by phosphorylation	GO:0023014	107	0.011
eye pigmentation	GO:0048069	43	0.011
larval development	GO:0002164	104	0.011
compound eye morphogenesis	GO:0001745	249	0.011
neuromuscular junction development	GO:0007528	149	0.011
histone h4 k16 acetylation	GO:0043984	4	0.010
transmembrane transport	GO:0055085	139	0.010
pyridine containing compound metabolic process	GO:0072524	3	0.010
regulation of lipid storage	GO:0010883	22	0.010
immune response regulating signaling pathway	GO:0002764	2	0.010
cellular amine metabolic process	GO:0044106	12	0.010
protein import into nucleus	GO:0006606	51	0.010
regulation of cytoplasmic transport	GO:1903649	47	0.010
regulation of neuron differentiation	GO:0045664	103	0.010
cell aging	GO:0007569	2	0.010
organelle fusion	GO:0048284	46	0.010
rrna processing	GO:0006364	3	0.010
nuclear division	GO:0000280	332	0.010
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.010
amine metabolic process	GO:0009308	12	0.010
sensory perception of pain	GO:0019233	4	0.010
cellular monovalent inorganic cation homeostasis	GO:0030004	7	0.010	Mouse
membrane depolarization	GO:0051899	4	0.010

Clic disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.033
nervous system disease	DOID:863	0.022
eye disease	DOID:5614	0.014
eye and adnexa disease	DOID:1492	0.014
sensory system disease	DOID:0050155	0.014

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