Drosophila melanogaster

98 known processes

pk (Dmel_CG11084)

prickle

(Aliases: Pk-Sple,Sple,sple,CG11084,Dmel\CG11084,pk-sple,CG12830,Pk)

pk biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
morphogenesis of a polarized epitheliumGO:0001738930.998
imaginal disc derived wing hair organizationGO:0035317450.996
establishment of planar polarityGO:0001736870.991
establishment of tissue polarityGO:0007164870.974
morphogenesis of an epitheliumGO:00020092760.972
establishment of ommatidial planar polarityGO:0042067490.957
hair cell differentiationGO:0035315470.936
tissue morphogenesisGO:00487292970.906
imaginal disc derived wing hair site selectionGO:003532040.843
dendrite self avoidanceGO:007059380.839
Fly
post embryonic appendage morphogenesisGO:00351203850.834
compound eye morphogenesisGO:00017452490.825
establishment of imaginal disc derived wing hair orientationGO:0001737240.796
appendage morphogenesisGO:00351073970.758
imaginal disc derived appendage morphogenesisGO:00351143950.755
establishment of epithelial cell apical basal polarityGO:0045198100.753
epithelial cell differentiationGO:00308553220.729
establishment of body hair or bristle planar orientationGO:004810460.700
establishment of proximal distal cell polarityGO:002260640.682
non sensory hair organizationGO:0035316470.681
establishment or maintenance of cell polarityGO:00071631670.647
eye morphogenesisGO:00485922600.620
equator specificationGO:004531740.616
wing disc morphogenesisGO:00074723440.615
imaginal disc derived appendage developmentGO:00487373990.604
eye developmentGO:00016543230.602
establishment of apical basal cell polarityGO:0035089120.545
appendage developmentGO:00487364010.497
establishment of monopolar cell polarityGO:0061162150.463
muscle cell differentiationGO:00426921030.446
Human
cilium assemblyGO:0042384380.445
muscle cell fate commitmentGO:0042693140.441
compound eye developmentGO:00487493070.417
regulation of organ morphogenesisGO:2000027780.413
imaginal disc derived wing morphogenesisGO:00074763370.411
regulation of establishment of planar polarityGO:0090175220.391
establishment or maintenance of monopolar cell polarityGO:0061339150.378
cell divisionGO:00513012480.339
sensory organ morphogenesisGO:00905962600.314
establishment of body hair planar orientationGO:004810510.290
growthGO:00400073590.281
eye antennal disc developmentGO:0035214600.276
polarized epithelial cell differentiationGO:0030859100.260
regulation of multicellular organismal developmentGO:20000264140.258
Human
positive regulation of macromolecule metabolic processGO:00106044050.250
Human
regulation of tube architecture open tracheal systemGO:0035152680.244
digestive tract developmentGO:00485651490.228
Zebrafish
wnt signaling pathway planar cell polarity pathwayGO:006007160.208
regulation of anatomical structure sizeGO:00900661630.198
cellular protein modification processGO:00064644380.191
Human
protein modification processGO:00362114380.188
Human
tube morphogenesisGO:00352391910.188
Human Zebrafish
regulation of tube length open tracheal systemGO:0035159240.186
tube developmentGO:00352952440.183
Human Zebrafish
wnt signaling pathwayGO:0016055980.177
Human Zebrafish
embryonic morphogenesisGO:00485982060.175
Human Zebrafish
regulation of anatomical structure morphogenesisGO:00226032420.173
establishment or maintenance of apical basal cell polarityGO:0035088340.172
Mouse
blastoderm segmentationGO:00073501590.171
homophilic cell adhesion via plasma membrane adhesion moleculesGO:0007156180.171
antennal developmentGO:0007469250.155
regulation of protein metabolic processGO:00512462560.148
Human
regulation of molecular functionGO:00650092170.148
establishment or maintenance of epithelial cell apical basal polarityGO:0045197240.142
Mouse
cell proliferationGO:00082832990.137
digestive system developmentGO:00551231490.135
Zebrafish
regulation of tube size open tracheal systemGO:0035151430.134
chaeta developmentGO:0022416970.134
chaeta morphogenesisGO:0008407420.129
columnar cuboidal epithelial cell developmentGO:00020662490.129
regionalizationGO:00030024160.128
striated muscle cell differentiationGO:0051146900.117
Human
mushroom body developmentGO:0016319700.116
secretion by cellGO:00329401010.113
determination of imaginal disc primordiumGO:0007445110.111
cell cell adhesionGO:0098609260.107
developmental growth involved in morphogenesisGO:0060560650.104
regulation of growthGO:00400082330.103
chemotaxisGO:00069352490.103
regulation of cell proliferationGO:00421271630.103
actin cytoskeleton organizationGO:00300362060.101
ommatidial rotationGO:0016318200.100
negative regulation of cellular biosynthetic processGO:00313272770.096
Human
neurological system processGO:00508773580.095
compound eye photoreceptor fate commitmentGO:0001752360.095
epidermis developmentGO:0008544650.093
cell motilityGO:00488702510.092
Zebrafish
regulation of organelle organizationGO:00330431960.089
regulation of cell differentiationGO:00455953020.088
Human
cell cell adhesion via plasma membrane adhesion moleculesGO:0098742260.085
regulation of wnt signaling pathwayGO:0030111680.085
Human
compound eye photoreceptor cell differentiationGO:00017511400.084
respiratory system developmentGO:00605412130.083
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.082
Human
central nervous system developmentGO:00074172010.082
Zebrafish
neural retina developmentGO:000340740.080
Zebrafish
regulation of localizationGO:00328792750.079
axis elongationGO:000340130.078
nephron developmentGO:007200630.077
establishment or maintenance of bipolar cell polarityGO:0061245340.077
Mouse
cilium morphogenesisGO:0060271390.075
developmental growthGO:00485892800.075
establishment of cell polarityGO:0030010400.074
Zebrafish
leg disc developmentGO:0035218920.073
positive regulation of protein metabolic processGO:00512471280.072
Human
embryonic axis specificationGO:00005781070.071
ameboidal type cell migrationGO:00016671510.070
Zebrafish
epithelial cell developmentGO:00020642740.070
regulation of cell cycleGO:00517262910.069
establishment of epithelial cell polarityGO:0090162130.068
eye photoreceptor cell differentiationGO:00017541450.067
cell deathGO:00082192790.066
regulation of transcription from rna polymerase ii promoterGO:00063573780.065
negative regulation of cellular metabolic processGO:00313243820.064
Human
open tracheal system developmentGO:00074242040.063
imaginal disc derived leg segmentationGO:0036011260.063
wing and notum subfield formationGO:0035309130.063
negative regulation of biosynthetic processGO:00098902770.062
Human
anterior posterior pattern specificationGO:00099521360.062
biological adhesionGO:00226101380.060
positive regulation of cellular protein metabolic processGO:00322701180.060
Human
positive regulation of transcription dna templatedGO:00458932660.060
notch signaling pathwayGO:00072191200.059
positive regulation of gene expressionGO:00106282900.059
secretionGO:00469031090.059
regulation of tube sizeGO:0035150460.058
organic substance transportGO:00717022570.058
Human Rat
malpighian tubule developmentGO:0072002640.057
kidney morphogenesisGO:006099330.056
actin filament based processGO:00300292200.056
cilium organizationGO:0044782410.055
circulatory system developmentGO:0072359820.055
Human Zebrafish
embryonic pattern specificationGO:00098801740.055
formation of anatomical boundaryGO:0048859370.052
tissue migrationGO:00901301550.050
determination of genital disc primordiumGO:0035225100.050
epidermal cell differentiationGO:0009913510.049
negative regulation of nitrogen compound metabolic processGO:00511722650.048
Human
positive regulation of nucleobase containing compound metabolic processGO:00459353320.048
positive regulation of response to stimulusGO:00485843230.047
photoreceptor cell fate commitmentGO:0046552410.047
regulation of intracellular signal transductionGO:19025312360.047
cell adhesionGO:00071551360.045
dendrite developmentGO:00163582040.044
body morphogenesisGO:001017120.043
limb morphogenesisGO:003510810.042
cell fate commitment involved in pattern specificationGO:0060581310.042
regulation of cell cell adhesionGO:0022407210.042
eggshell formationGO:00307031050.041
positive regulation of nitrogen compound metabolic processGO:00511733540.041
regulation of developmental growthGO:00486381740.041
regulation of actin cytoskeleton organizationGO:0032956420.040
axon extensionGO:0048675320.040
regulation of embryonic developmentGO:0045995680.040
positive regulation of multicellular organismal processGO:00512401430.040
protein phosphorylationGO:00064681690.039
antennal morphogenesisGO:0048800140.039
mitotic cytokinesisGO:0000281500.038
female sex differentiationGO:0046660200.038
camera type eye photoreceptor cell differentiationGO:006021920.038
regulation of smoothened signaling pathwayGO:0008589280.038
positive regulation of biosynthetic processGO:00098913160.038
phosphorylationGO:00163102940.038
regulation of execution phase of apoptosisGO:190011750.038
development of primary female sexual characteristicsGO:0046545120.037
negative regulation of gene expressionGO:00106293870.037
Human
negative regulation of nucleic acid templated transcriptionGO:19035072400.037
Human
transcription from rna polymerase ii promoterGO:00063663680.037
dendrite morphogenesisGO:00488131990.037
cell cell adhesion mediated by cadherinGO:004433160.037
single organism cell adhesionGO:0098602470.036
convergent extensionGO:006002620.036
Zebrafish
positive regulation of nucleic acid templated transcriptionGO:19035082660.036
regulation of neuron projection developmentGO:0010975690.035
leg disc proximal distal pattern formationGO:000747990.035
appendage segmentationGO:0035285260.035
cellular component assembly involved in morphogenesisGO:00109271510.034
regulation of dendrite morphogenesisGO:0048814280.034
imaginal disc growthGO:0007446370.034
regulation of protein modification processGO:00313991120.034
Human
photoreceptor cell differentiationGO:00465301700.033
imaginal disc derived leg joint morphogenesisGO:0016348150.033
spinal cord patterningGO:002151110.032
axis specificationGO:00097981670.032
regulation of mitotic cell cycleGO:00073461900.032
proteolysisGO:00065081920.032
Human
regulation of cell divisionGO:0051302720.032
cuticle developmentGO:0042335860.032
negative regulation of developmental processGO:00510932010.032
Human
negative regulation of signal transductionGO:00099682060.032
genital disc sexually dimorphic developmentGO:003526340.032
regulation of proteolysisGO:0030162870.031
Human
neuron projection extensionGO:1990138320.031
non canonical wnt signaling pathwayGO:003556780.030
kidney developmentGO:000182230.030
eye photoreceptor cell fate commitmentGO:0042706370.029
negative regulation of response to stimulusGO:00485852580.029
imaginal disc derived leg morphogenesisGO:0007480800.028
negative regulation of rna biosynthetic processGO:19026792400.028
Human
anterior posterior axis specificationGO:00099481090.028
synapse organizationGO:00508081960.028
establishment of spindle orientationGO:0051294180.028
Zebrafish
regulation of cellular component sizeGO:0032535980.027
stem cell proliferationGO:0072089880.027
positive regulation of cell projection organizationGO:0031346290.027
morphogenesis of embryonic epitheliumGO:0016331940.027
Human
neuron migrationGO:000176450.027
Zebrafish
imaginal disc derived wing margin morphogenesisGO:0008587410.027
epithelial tube morphogenesisGO:0060562880.027
Human Zebrafish
urogenital system developmentGO:0001655720.027
negative regulation of transcription dna templatedGO:00458922370.027
Human
salivary gland developmentGO:00074311620.027
cell migrationGO:00164772380.027
Zebrafish
digestive tract morphogenesisGO:00485461270.026
Zebrafish
negative regulation of notch signaling pathwayGO:0045746410.026
negative regulation of wnt signaling pathwayGO:0030178280.025
Human
negative regulation of cell communicationGO:00106482230.025
regulation of imaginal disc derived wing sizeGO:0044719200.025
larval developmentGO:00021641040.025
organ formationGO:0048645390.025
single organismal cell cell adhesionGO:0016337450.025
positive regulation of developmental processGO:00510941430.025
regulation of catalytic activityGO:00507901850.024
regulation of phosphorus metabolic processGO:00511742100.024
limb developmentGO:006017310.024
regulation of programmed cell deathGO:00430671520.024
regulation of cell cycle processGO:00105641810.024
gonad developmentGO:0008406500.024
imaginal disc derived wing vein specificationGO:0007474480.023
wound healingGO:0042060750.023
leg disc morphogenesisGO:0007478800.023
rho protein signal transductionGO:0007266140.023
localization of cellGO:00516742570.022
Zebrafish
neuron recognitionGO:00080381010.022
Fly
negative regulation of cell deathGO:0060548810.022
regulation of peptidase activityGO:0052547390.022
regulation of imaginal disc growthGO:0045570260.022
axonogenesisGO:00074092900.022
columnar cuboidal epithelial cell differentiationGO:00020652560.021
positive regulation of cell communicationGO:00106472500.021
regulation of cellular component biogenesisGO:00440872010.021
locomotory behaviorGO:00076261760.021
epithelial cell migrationGO:00106311480.021
positive regulation of molecular functionGO:00440931360.021
negative regulation of signalingGO:00230572190.021
dorsal ventral pattern formationGO:00099531330.021
eye antennal disc morphogenesisGO:0007455340.020
regulation of cell morphogenesisGO:00226041630.020
r3 r4 cell fate commitmentGO:0007464100.019
cell cell junction organizationGO:0045216550.019
regulation of transportGO:00510491810.019
regulation of cell deathGO:00109411730.019
positive regulation of rna biosynthetic processGO:19026802660.019
sensory neuron axon guidanceGO:009737420.019
renal system developmentGO:0072001720.018
neuron fate commitmentGO:0048663500.018
regulation of nervous system developmentGO:00519602480.018
intracellular signal transductionGO:00355563000.018
learning or memoryGO:00076111410.018
activation of cysteine type endopeptidase activityGO:0097202170.018
posttranscriptional regulation of gene expressionGO:00106081450.018
female gonad developmentGO:0008585120.018
retina development in camera type eyeGO:006004140.018
Zebrafish
skin developmentGO:0043588650.017
apical protein localizationGO:004517650.017
embryonic hindgut morphogenesisGO:0048619480.017
regulation of cytoskeleton organizationGO:0051493890.017
negative regulation of macromolecule biosynthetic processGO:00105582700.017
Human
muscle attachmentGO:0016203360.017
carbohydrate derivative biosynthetic processGO:1901137850.017
regulation of cell developmentGO:00602842150.017
Human
skeletal muscle fiber developmentGO:004874130.017
Human
regulation of axonogenesisGO:0050770320.017
retina morphogenesis in camera type eyeGO:006004220.016
programmed cell deathGO:00125012570.016
negative chemotaxisGO:0050919150.016
tube formationGO:0035148210.016
Human
regulation of epithelial cell differentiationGO:003085640.016
negative regulation of programmed cell deathGO:0043069720.016
cell fate determinationGO:0001709910.016
regulation of apoptotic processGO:00429811300.016
reproductive structure developmentGO:0048608740.016
establishment of localization in cellGO:00516494020.015
Human Zebrafish Rat
positive regulation of peptidase activityGO:0010952290.015
regulation of epithelial cell proliferationGO:005067840.015
regulation of actin filament based processGO:0032970420.015
taxisGO:00423303040.015
negative regulation of rna metabolic processGO:00512532510.015
Human
nephron epithelium morphogenesisGO:007208830.015
regulation of neurogenesisGO:00507671580.015
somatic muscle developmentGO:0007525660.015
protein localizationGO:00081042840.015
Human Rat
macromolecular complex assemblyGO:00650032560.015
cell fate specificationGO:0001708710.015
spinal cord developmentGO:002151010.015
regulation of cellular protein metabolic processGO:00322682430.015
Human
catabolic processGO:00090564090.014
Human
amine metabolic processGO:0009308120.014
regulation of stress activated protein kinase signaling cascadeGO:0070302420.014
nonmotile primary cilium assemblyGO:003505880.014
positive regulation of cell differentiationGO:0045597640.014
female genitalia developmentGO:003054060.014
regulation of protein localizationGO:0032880760.014
regulation of cell shapeGO:00083601130.014
compound eye photoreceptor developmentGO:0042051780.014
cellular catabolic processGO:00442483720.014
Human
phagocytosisGO:00069092150.014
regulation of phosphate metabolic processGO:00192202100.014
adult chitin based cuticle developmentGO:000836520.013
cuticle pigmentationGO:0048067220.013
intracellular mrna localizationGO:0008298660.013
vesicle organizationGO:0016050440.013
negative regulation of cell cycle phase transitionGO:19019881030.013
nitrogen compound transportGO:0071705850.013
negative regulation of imaginal disc growthGO:004557180.013
regulation of hydrolase activityGO:0051336970.013
cell projection assemblyGO:0030031940.013
hemocyte differentiationGO:0042386380.013
malpighian tubule morphogenesisGO:0007443440.013
sex differentiationGO:0007548810.013
retinal cone cell differentiationGO:004267020.013
establishment of mitotic spindle orientationGO:0000132130.013
Zebrafish
stem cell differentiationGO:00488631170.012
Human
response to abiotic stimulusGO:00096283410.012
ovarian follicle cell developmentGO:00307072480.012
positive regulation of proteolysisGO:0045862520.012
Human
cellular homeostasisGO:0019725800.012
homeostatic processGO:00425921990.012
positive regulation of catalytic activityGO:00430851180.012
embryonic development via the syncytial blastodermGO:00017001480.012
epithelial cell proliferation involved in malpighian tubule morphogenesisGO:0061331110.012
nephrocyte diaphragm assemblyGO:003605930.012
positive regulation of signalingGO:00230562430.012
organic substance catabolic processGO:19015753080.011
Human
protein maturationGO:0051604710.011
cell recognitionGO:00080371020.011
Fly
positive regulation of cysteine type endopeptidase activityGO:2001056240.011
negative regulation of nervous system developmentGO:0051961920.011
regulation of erbb signaling pathwayGO:1901184420.011
head developmentGO:00603221350.011
Zebrafish
regulation of axon extensionGO:003051680.011
cell cell signaling involved in cell fate commitmentGO:00451682100.011
male gamete generationGO:00482322010.011
negative regulation of organelle organizationGO:0010639560.011
imaginal disc derived wing vein morphogenesisGO:0008586440.011
cell growthGO:00160491080.011
nephron morphogenesisGO:007202830.011
cell fate specification involved in pattern specificationGO:006057380.011
regulation of protein phosphorylationGO:0001932640.011
cuticle pattern formationGO:0035017270.011
rna localizationGO:00064031150.011
wnt signaling pathway calcium modulating pathwayGO:000722320.011
striated muscle cell developmentGO:0055002500.010
Human
regulation of actin filament lengthGO:0030832270.010
cardiovascular system developmentGO:0072358820.010
Human Zebrafish
muscle cell fate specificationGO:004269470.010
wing disc pattern formationGO:0035222660.010
actin polymerization or depolymerizationGO:0008154310.010
anterior posterior axis specification embryoGO:00085951030.010

pk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.039
Human