Drosophila melanogaster

0 known processes

tobi (Dmel_CG11909)

target of brain insulin

(Aliases: CT33098,Dmel\CG11909,CG11909)

tobi biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
organonitrogen compound metabolic processGO:19015643180.099
positive regulation of response to stimulusGO:00485843230.082
single organism behaviorGO:00447083910.081
carboxylic acid metabolic processGO:0019752920.074
imaginal disc derived appendage developmentGO:00487373990.073
vesicle mediated transportGO:00161923810.065
positive regulation of signal transductionGO:00099672230.063
response to abiotic stimulusGO:00096283410.063
organic acid metabolic processGO:00060821030.060
phagocytosisGO:00069092150.060
organic substance catabolic processGO:19015753080.057
ethanolamine containing compound metabolic processGO:004243940.057
response to organic substanceGO:00100332840.055
cholesterol transportGO:003030120.054
sterol homeostasisGO:005509240.053
small molecule metabolic processGO:00442813050.052
cellular amino acid metabolic processGO:0006520610.052
cholesterol homeostasisGO:004263230.051
positive regulation of cell communicationGO:00106472500.050
organelle fissionGO:00482853400.049
kidney developmentGO:000182230.049
imaginal disc derived appendage morphogenesisGO:00351143950.048
cellular catabolic processGO:00442483720.048
phospholipid homeostasisGO:005509110.046
regionalizationGO:00030024160.045
biological adhesionGO:00226101380.044
cellular protein modification processGO:00064644380.044
organic substance transportGO:00717022570.043
catabolic processGO:00090564090.043
oxoacid metabolic processGO:00434361030.040
negative regulation of gene expressionGO:00106293870.039
positive regulation of lipid storageGO:001088440.039
endocytosisGO:00068973100.039
imaginal disc derived wing morphogenesisGO:00074763370.038
sulfur compound metabolic processGO:0006790590.038
positive regulation of signalingGO:00230562430.038
carbohydrate derivative metabolic processGO:19011352170.038
anion homeostasisGO:005508130.037
negative regulation of cellular metabolic processGO:00313243820.036
locomotory behaviorGO:00076261760.035
regulation of behaviorGO:0050795750.035
organonitrogen compound catabolic processGO:19015651280.034
intracellular signal transductionGO:00355563000.034
single organism catabolic processGO:00447122280.034
hormone catabolic processGO:004244730.033
regulation of localizationGO:00328792750.033
response to oxygen containing compoundGO:19017002000.033
cellular modified amino acid metabolic processGO:0006575450.033
post embryonic appendage morphogenesisGO:00351203850.033
wing disc morphogenesisGO:00074723440.033
peptide metabolic processGO:0006518800.032
response to other organismGO:00517072930.032
regulation of intracellular signal transductionGO:19025312360.031
appendage morphogenesisGO:00351073970.031
nuclear divisionGO:00002803320.031
meiotic nuclear divisionGO:00071261510.031
positive regulation of intracellular signal transductionGO:19025331160.030
acylglycerol biosynthetic processGO:004646320.029
neutral lipid catabolic processGO:004646130.029
regulation of anatomical structure morphogenesisGO:00226032420.029
g protein coupled receptor signaling pathwayGO:00071861360.029
gland developmentGO:00487321910.028
phosphatidylethanolamine metabolic processGO:004633710.028
appendage developmentGO:00487364010.028
regulation of transportGO:00510491810.028
carbohydrate derivative biosynthetic processGO:1901137850.028
response to hypoxiaGO:0001666530.028
acylglycerol catabolic processGO:004646430.027
protein modification processGO:00362114380.027
neutral lipid biosynthetic processGO:004646020.027
secretionGO:00469031090.027
homeostatic processGO:00425921990.027
body morphogenesisGO:001017120.027
response to copper ionGO:004668840.026
phosphatidic acid metabolic processGO:004647310.026
epithelial cell developmentGO:00020642740.026
response to bacteriumGO:00096171980.026
cell cell signaling involved in cell fate commitmentGO:00451682100.025
oligosaccharide transportGO:001577220.025
ion transportGO:00068111450.025
glycoprotein biosynthetic processGO:0009101410.025
negative regulation of response to stimulusGO:00485852580.025
lateral inhibitionGO:00463312060.024
response to external biotic stimulusGO:00432072930.024
behavioral response to ethanolGO:0048149490.024
renal system developmentGO:0072001720.024
regulation of response to stressGO:00801342000.023
male meiosisGO:0007140520.023
lipid metabolic processGO:00066291210.023
developmental maturationGO:00217001720.023
organonitrogen compound biosynthetic processGO:19015661170.023
dorsal ventral pattern formationGO:00099531330.023
positive regulation of sequestering of triglycerideGO:001089010.022
response to temperature stimulusGO:00092661060.022
cellular amine metabolic processGO:0044106120.022
learningGO:0007612750.022
phosphorylationGO:00163102940.022
camera type eye developmentGO:004301040.022
cell deathGO:00082192790.022
response to decreased oxygen levelsGO:0036293580.022
cellular amide metabolic processGO:0043603800.022
meiotic cell cycle processGO:19030461320.022
triglyceride biosynthetic processGO:001943220.022
organophosphate metabolic processGO:00196371950.022
cognitionGO:00508901410.021
chemosensory behaviorGO:00076351060.021
negative regulation of cellular biosynthetic processGO:00313272770.021
regulation of cell shapeGO:00083601130.021
neurological system processGO:00508773580.021
negative regulation of macromolecule biosynthetic processGO:00105582700.021
synaptic transmissionGO:00072682880.021
cellular response to chemical stimulusGO:00708871990.021
actin filament based processGO:00300292200.021
monocarboxylic acid transportGO:001571830.021
adult behaviorGO:00305341370.021
cell adhesionGO:00071551360.021
cell proliferationGO:00082832990.020
regulation of lipid transportGO:003236830.020
actin cytoskeleton organizationGO:00300362060.020
cellular lipid metabolic processGO:0044255830.020
positive regulation of multicellular organismal processGO:00512401430.020
cellular response to organic substanceGO:00713101320.020
regulation of cell deathGO:00109411730.019
regulation of sterol transportGO:003237110.019
l glutamate importGO:005193810.019
response to extracellular stimulusGO:00099911160.019
embryonic pattern specificationGO:00098801740.019
establishment of localization in cellGO:00516494020.019
ras protein signal transductionGO:0007265880.019
transcription from rna polymerase ii promoterGO:00063663680.019
positive regulation of phosphorus metabolic processGO:00105621390.019
jak stat cascadeGO:0007259490.019
urogenital system developmentGO:0001655720.019
protein complex biogenesisGO:00702712010.019
epithelial cell differentiationGO:00308553220.019
salivary gland morphogenesisGO:00074351450.018
positive regulation of macromolecule metabolic processGO:00106044050.018
negative regulation of nucleic acid templated transcriptionGO:19035072400.018
rna processingGO:00063961470.018
mrna processingGO:00063971040.018
anatomical structure homeostasisGO:0060249970.018
amine metabolic processGO:0009308120.018
deathGO:00162652840.018
response to lipopolysaccharideGO:003249640.018
olfactory behaviorGO:0042048970.018
regulation of cell morphogenesisGO:00226041630.017
axis specificationGO:00097981670.017
small gtpase mediated signal transductionGO:0007264880.017
regulation of phosphorus metabolic processGO:00511742100.017
negative regulation of cell differentiationGO:00455961430.017
regulation of cellular protein metabolic processGO:00322682430.017
regulation of phosphate metabolic processGO:00192202100.017
regulation of sequestering of triglycerideGO:001088930.017
regulation of protein metabolic processGO:00512462560.017
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.017
cellularizationGO:0007349900.017
negative regulation of developmental processGO:00510932010.017
positive regulation of macromolecule biosynthetic processGO:00105572830.017
negative regulation of nucleobase containing compound metabolic processGO:00459342610.017
regulation of multicellular organismal developmentGO:20000264140.017
response to oxygen levelsGO:0070482590.017
drinking behaviorGO:004275620.017
nitrogen compound transportGO:0071705850.016
negative regulation of signal transductionGO:00099682060.016
mitotic nuclear divisionGO:00070672130.016
response to biotic stimulusGO:00096072940.016
positive regulation of nitrogen compound metabolic processGO:00511733540.016
anion transportGO:0006820410.016
circadian sleep wake cycle sleepGO:0050802230.016
glycosyl compound metabolic processGO:19016571270.016
carbohydrate derivative catabolic processGO:19011361180.016
organic hydroxy compound metabolic processGO:1901615830.016
response to alcoholGO:0097305950.016
heart processGO:0003015370.016
positive regulation of biosynthetic processGO:00098913160.016
carbohydrate metabolic processGO:0005975820.016
l amino acid importGO:004309220.016
regulation of heart rateGO:0002027110.016
single organism biosynthetic processGO:00447112060.016
matingGO:00076181200.016
telencephalon developmentGO:002153720.015
forebrain developmentGO:003090020.015
proteolysisGO:00065081920.015
tissue deathGO:00162711020.015
mating behaviorGO:00076171060.015
negative regulation of biosynthetic processGO:00098902770.015
positive regulation of phosphate metabolic processGO:00459371390.015
oocyte differentiationGO:00099941450.015
intracellular transportGO:00469072280.015
aggressive behaviorGO:0002118630.015
cellular response to dna damage stimulusGO:00069742230.015
negative regulation of protein metabolic processGO:0051248850.015
regulation of cholesterol transportGO:003237410.015
lipid localizationGO:0010876540.015
cell divisionGO:00513012480.015
digestive tract developmentGO:00485651490.015
regulation of cellular amine metabolic processGO:003323830.015
purine nucleotide metabolic processGO:00061631460.015
multicellular organismal agingGO:00102591400.015
organophosphate catabolic processGO:00464341120.015
positive regulation of transportGO:0051050920.015
spermatogenesisGO:00072832000.015
regulation of mitotic cell cycleGO:00073461900.015
positive regulation of gene expressionGO:00106282900.015
regulation of circadian rhythmGO:0042752490.015
detection of stimulus involved in sensory perceptionGO:0050906920.014
transmembrane transportGO:00550851390.014
macromolecule catabolic processGO:00090571610.014
chromosome segregationGO:00070591570.014
multi organism behaviorGO:00517051750.014
chromatin silencingGO:0006342760.014
negative regulation of nitrogen compound metabolic processGO:00511722650.014
glycoprotein metabolic processGO:0009100410.014
lipid homeostasisGO:0055088330.014
regulation of gene expression epigeneticGO:00400291280.014
regulation of molecular functionGO:00650092170.014
triglyceride catabolic processGO:001943330.014
mitochondrion organizationGO:0007005650.014
humoral immune responseGO:00069591170.014
protein complex assemblyGO:00064612000.014
adult locomotory behaviorGO:0008344760.014
cation transportGO:00068121100.014
positive regulation of cellular biosynthetic processGO:00313283160.014
regulation of cell cycleGO:00517262910.014
trehalose transportGO:001577110.014
salivary gland cell autophagic cell deathGO:0035071830.014
cell maturationGO:00484691440.014
regulation of cellular ketone metabolic processGO:001056530.014
single organism carbohydrate metabolic processGO:0044723720.014
blastoderm segmentationGO:00073501590.014
oocyte constructionGO:00073081120.014
negative regulation of cellular protein metabolic processGO:0032269850.014
positive regulation of nucleobase containing compound metabolic processGO:00459353320.013
negative regulation of signalingGO:00230572190.013
establishment of protein localizationGO:00451841630.013
positive regulation of cell motilityGO:200014730.013
regulation of multi organism processGO:00439001310.013
male gamete generationGO:00482322010.013
regulation of catabolic processGO:00098941700.013
tube developmentGO:00352952440.013
oocyte axis specificationGO:00073091080.013
regulation of catalytic activityGO:00507901850.013
segmentationGO:00352822070.013
cell cycle phase transitionGO:00447701400.013
macromolecular complex assemblyGO:00650032560.013
rna localizationGO:00064031150.013
columnar cuboidal epithelial cell developmentGO:00020662490.013
negative regulation of cell communicationGO:00106482230.013
meiosis iGO:0007127590.013
lipopolysaccharide mediated signaling pathwayGO:003166310.013
rhythmic processGO:00485111060.013
actin filament organizationGO:00070151260.013
protein phosphorylationGO:00064681690.012
nucleoside metabolic processGO:00091161270.012
neuropeptide signaling pathwayGO:0007218450.012
single organism cellular localizationGO:19025801800.012
immune system processGO:00023763470.012
meiotic cell cycleGO:00513211710.012
steroid catabolic processGO:000670610.012
organic cyclic compound catabolic processGO:19013611680.012
nucleotide metabolic processGO:00091171610.012
ribonucleotide metabolic processGO:00092591450.012
regulation of synaptic transmissionGO:0050804690.012
innate immune responseGO:00450871440.012
regulation of mitotic cell cycle phase transitionGO:19019901300.012
immune response regulating signaling pathwayGO:000276420.012
protein transportGO:00150311550.012
gland morphogenesisGO:00226121450.012
rhythmic behaviorGO:0007622760.012
photoreceptor cell differentiationGO:00465301700.012
histolysisGO:00075591020.012
inorganic ion transmembrane transportGO:0098660730.012
developmental programmed cell deathGO:00106231380.012
cellular response to molecule of bacterial originGO:007121930.012
nucleobase containing small molecule metabolic processGO:00550861740.012
negative regulation of rna metabolic processGO:00512532510.012
gene silencingGO:00164581380.012
positive regulation of cellular component organizationGO:00511301560.012
tissue morphogenesisGO:00487292970.012
mrna metabolic processGO:00160711240.012
organelle assemblyGO:00709251980.012
imaginal disc pattern formationGO:0007447910.012
larval behaviorGO:0030537420.012
response to ethanolGO:0045471590.012
mitotic spindle organizationGO:00070522200.012
regulation of small gtpase mediated signal transductionGO:0051056930.012
developmental growthGO:00485892800.012
response to organophosphorusGO:004668320.012
eye morphogenesisGO:00485922600.012
cellular nitrogen compound catabolic processGO:00442701650.012
autophagic cell deathGO:0048102830.012
sensory organ morphogenesisGO:00905962600.012
positive regulation of cell migrationGO:003033520.012
cellular macromolecule catabolic processGO:00442651360.012
regulation of mapk cascadeGO:0043408920.012
response to organonitrogen compoundGO:0010243750.012
single organism intracellular transportGO:19025822070.011
alditol phosphate metabolic processGO:005264620.011
apoptotic processGO:00069151590.011
sperm individualizationGO:0007291480.011
spinal cord developmentGO:002151010.011
ribonucleoside triphosphate metabolic processGO:00091991190.011
morphogenesis of an epitheliumGO:00020092760.011
negative regulation of translationGO:0017148280.011
regulation of cellular amino acid metabolic processGO:000652100.011
amino sugar catabolic processGO:004634830.011
cell migrationGO:00164772380.011
chromosome organizationGO:00512763600.011
cell motilityGO:00488702510.011
enzyme linked receptor protein signaling pathwayGO:00071671790.011
cellular ketone metabolic processGO:0042180240.011
metal ion transportGO:0030001740.011
nucleoside phosphate metabolic processGO:00067531620.011
multi multicellular organism processGO:00447061230.011
heart contractionGO:0060047260.011
ribonucleoside metabolic processGO:00091191270.011
protein processingGO:0016485680.011
cellular response to lipopolysaccharideGO:007122230.011
regulation of programmed cell deathGO:00430671520.011
inter male aggressive behaviorGO:0002121600.011
regulation of cell substrate adhesionGO:001081020.011
signal transduction by phosphorylationGO:00230141070.011
camera type eye morphogenesisGO:004859320.011
anterior posterior axis specification embryoGO:00085951030.011
tube morphogenesisGO:00352391910.011
cellular response to biotic stimulusGO:007121640.011
chemical homeostasisGO:0048878920.011
regulation of synapse structure and activityGO:00508031280.011
regulation of system processGO:0044057360.011
exocrine system developmentGO:00352721620.011
response to starvationGO:0042594970.011
positive regulation of cellular amine metabolic processGO:003324000.011
salivary gland histolysisGO:0035070880.011
response to heatGO:0009408630.011
lipid biosynthetic processGO:0008610460.011
positive regulation of phosphorylationGO:0042327870.011
heart developmentGO:0007507820.011
acylglycerol metabolic processGO:0006639120.011
growthGO:00400073590.011
purine containing compound metabolic processGO:00725211550.011
programmed cell deathGO:00125012570.011
alpha amino acid metabolic processGO:1901605200.010
multicellular organismal reproductive behaviorGO:00330571100.010
reproductive behaviorGO:00190981220.010
compound eye morphogenesisGO:00017452490.010
dorsal ventral axis specificationGO:0009950660.010
localization of cellGO:00516742570.010
mapk cascadeGO:00001651070.010
negative regulation of mitotic cell cycleGO:00459301090.010
wing disc pattern formationGO:0035222660.010
sodium dependent phosphate transportGO:004434120.010
tripartite regional subdivisionGO:00073511030.010
hormone metabolic processGO:0042445330.010
cytoplasmic transportGO:00164821300.010
larval locomotory behaviorGO:0008345270.010
extrinsic apoptotic signaling pathwayGO:009719110.010
limb developmentGO:006017310.010
positive regulation of rna biosynthetic processGO:19026802660.010
connective tissue developmentGO:006144830.010
oocyte microtubule cytoskeleton organizationGO:0016325350.010
multicellular organismal homeostasisGO:0048871410.010
sister chromatid segregationGO:0000819920.010
response to calcium ionGO:005159210.010
regulation of protein modification processGO:00313991120.010
hindbrain developmentGO:003090220.010
regulation of cellular catabolic processGO:00313291570.010
endomembrane system organizationGO:00102561190.010
cellular response to hormone stimulusGO:0032870440.010
regulation of organelle organizationGO:00330431960.010
phosphatidylcholine metabolic processGO:004647030.010
negative regulation of multicellular organismal processGO:00512411420.010

tobi disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.112
familial hyperlipidemiaDOID:116800.045
inherited metabolic disorderDOID:65500.045
lipid metabolism disorderDOID:314600.045
disease of metabolismDOID:001466700.045
familial combined hyperlipidemiaDOID:1380900.045
familial lipoprotein lipase deficiencyDOID:1411800.045
diabetes mellitusDOID:935100.044
type 2 diabetes mellitusDOID:935200.044
acquired metabolic diseaseDOID:006015800.044
glucose metabolism diseaseDOID:419400.044
carbohydrate metabolism diseaseDOID:005001300.044
hypotrichosisDOID:453500.040
integumentary system diseaseDOID:1600.040
hair diseaseDOID:42100.040
nervous system diseaseDOID:86300.032
familial hypertriglyceridemiaDOID:005052700.031
cardiovascular system diseaseDOID:128700.015
musculoskeletal system diseaseDOID:1700.015
urinary system diseaseDOID:1800.014
central nervous system diseaseDOID:33100.013
neurodegenerative diseaseDOID:128900.013
disease of cellular proliferationDOID:1456600.013
sensory system diseaseDOID:005015500.012
eye diseaseDOID:561400.011
eye and adnexa diseaseDOID:149200.011
cancerDOID:16200.011
organ system cancerDOID:005068600.011