IMP: Integrative Multi-species Prediction

Drosophila melanogaster

42 known processes

Spp (Dmel_CG11840)

Signal peptide protease

(Aliases: SPP,spp,Dmel\CG11840,CG11840)

FLYBASE: FBgn0031260
Entrez: 33227
UniProtKB: Q9VPQ7

Process Predictions
Disease Predictions

Spp biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cellular macromolecule localization	GO:0070727	220	0.264
protein localization	GO:0008104	284	0.234
carbohydrate derivative biosynthetic process	GO:1901137	85	0.232
cellular protein localization	GO:0034613	160	0.214
glycoprotein metabolic process	GO:0009100	41	0.187
carbohydrate derivative metabolic process	GO:1901135	217	0.154
protein glycosylation	GO:0006486	32	0.150
single organism intracellular transport	GO:1902582	207	0.135
cuticle development	GO:0042335	86	0.126
vesicle mediated transport	GO:0016192	381	0.121
central nervous system development	GO:0007417	201	0.121
cellular protein modification process	GO:0006464	438	0.120
intracellular transport	GO:0046907	228	0.113
response to topologically incorrect protein	GO:0035966	10	0.103
response to unfolded protein	GO:0006986	9	0.095
open tracheal system development	GO:0007424	204	0.094
protein catabolic process	GO:0030163	101	0.088
cytoplasmic transport	GO:0016482	130	0.087
cellular macromolecule catabolic process	GO:0044265	136	0.086
organonitrogen compound metabolic process	GO:1901564	318	0.086
immune system process	GO:0002376	347	0.083
glycoprotein biosynthetic process	GO:0009101	41	0.082
multi organism behavior	GO:0051705	175	0.075
intracellular protein transport	GO:0006886	104	0.074
response to bacterium	GO:0009617	198	0.073
brain development	GO:0007420	120	0.072
regulation of multi organism process	GO:0043900	131	0.071
response to other organism	GO:0051707	293	0.070
establishment of localization in cell	GO:0051649	402	0.069
peptidyl amino acid modification	GO:0018193	105	0.065
maintenance of location	GO:0051235	73	0.063
organic substance transport	GO:0071702	257	0.062
defense response to other organism	GO:0098542	225	0.058
regionalization	GO:0003002	416	0.056
forebrain development	GO:0030900	2	0.056
protein transport	GO:0015031	155	0.055
intracellular signal transduction	GO:0035556	300	0.054
multicellular organismal aging	GO:0010259	140	0.054
protein modification process	GO:0036211	438	0.053
catabolic process	GO:0009056	409	0.053
neuron projection guidance	GO:0097485	241	0.053
nucleotide metabolic process	GO:0009117	161	0.052
establishment of protein localization	GO:0045184	163	0.048
morphogenesis of an epithelium	GO:0002009	276	0.048
dendrite development	GO:0016358	204	0.047
carbohydrate metabolic process	GO:0005975	82	0.047
endocytosis	GO:0006897	310	0.046
response to external biotic stimulus	GO:0043207	293	0.044
regulation of cell death	GO:0010941	173	0.042
wing disc morphogenesis	GO:0007472	344	0.042
head development	GO:0060322	135	0.041
cell migration	GO:0016477	238	0.040
aging	GO:0007568	143	0.039
small molecule metabolic process	GO:0044281	305	0.039
phagocytosis	GO:0006909	215	0.039
cell motility	GO:0048870	251	0.039
embryo development ending in birth or egg hatching	GO:0009792	152	0.038
developmental programmed cell death	GO:0010623	138	0.036
defense response to gram negative bacterium	GO:0050829	94	0.036
defense response to bacterium	GO:0042742	178	0.036
regulation of reproductive process	GO:2000241	54	0.035
response to biotic stimulus	GO:0009607	294	0.034
ribonucleotide catabolic process	GO:0009261	109	0.033
regulation of localization	GO:0032879	275	0.033
positive regulation of biosynthetic process	GO:0009891	316	0.033
tube morphogenesis	GO:0035239	191	0.032
gland development	GO:0048732	191	0.032
peptidyl proline hydroxylation	GO:0019511	1	0.032
purine nucleotide metabolic process	GO:0006163	146	0.031
body morphogenesis	GO:0010171	2	0.030
single organism carbohydrate metabolic process	GO:0044723	72	0.030
macromolecule catabolic process	GO:0009057	161	0.030
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.029
regulation of transport	GO:0051049	181	0.029
positive regulation of cellular biosynthetic process	GO:0031328	316	0.029
morphogenesis of embryonic epithelium	GO:0016331	94	0.029
immune response	GO:0006955	246	0.029
multi multicellular organism process	GO:0044706	123	0.028
positive regulation of cellular component organization	GO:0051130	156	0.028
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.028
embryonic development via the syncytial blastoderm	GO:0001700	148	0.027
positive regulation of response to stimulus	GO:0048584	323	0.027
defense response	GO:0006952	300	0.027
anatomical structure homeostasis	GO:0060249	97	0.027
transcription from rna polymerase ii promoter	GO:0006366	368	0.027
lateral inhibition	GO:0046331	206	0.027
macromolecule glycosylation	GO:0043413	32	0.025
regulation of immune system process	GO:0002682	176	0.025
regulation of intracellular signal transduction	GO:1902531	236	0.025
proteolysis	GO:0006508	192	0.025
embryonic morphogenesis	GO:0048598	206	0.025
imaginal disc derived wing morphogenesis	GO:0007476	337	0.024
single organism cellular localization	GO:1902580	180	0.024
ovarian nurse cell to oocyte transport	GO:0007300	27	0.024
carbohydrate derivative catabolic process	GO:1901136	118	0.023
lipid storage	GO:0019915	38	0.023
protein hydroxylation	GO:0018126	1	0.023
regulation of cell cycle	GO:0051726	291	0.023
entry into cell of other organism involved in symbiotic interaction	GO:0051806	3	0.023
tube development	GO:0035295	244	0.022
regulation of multicellular organismal development	GO:2000026	414	0.022
protein n linked glycosylation	GO:0006487	9	0.022
male gamete generation	GO:0048232	201	0.022
multicellular organismal reproductive behavior	GO:0033057	110	0.022
oocyte differentiation	GO:0009994	145	0.022
cellular protein catabolic process	GO:0044257	83	0.021
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.021
ribose phosphate metabolic process	GO:0019693	145	0.021
protein localization to organelle	GO:0033365	82	0.021
protein complex biogenesis	GO:0070271	201	0.021
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.021
single organism behavior	GO:0044708	391	0.020
positive regulation of transcription dna templated	GO:0045893	266	0.020
dendrite morphogenesis	GO:0048813	199	0.020
positive regulation of cell communication	GO:0010647	250	0.020
cellular catabolic process	GO:0044248	372	0.020
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.020
cell death	GO:0008219	279	0.019
dorsal ventral pattern formation	GO:0009953	133	0.019
imaginal disc derived appendage development	GO:0048737	399	0.019
maintenance of protein location in cell	GO:0032507	26	0.019
digestive tract morphogenesis	GO:0048546	127	0.018
regulation of synapse organization	GO:0050807	110	0.018
multi organism reproductive behavior	GO:0044705	121	0.018
axonogenesis	GO:0007409	290	0.017
morphogenesis of follicular epithelium	GO:0016333	36	0.017
positive regulation of rna biosynthetic process	GO:1902680	266	0.017
positive regulation of developmental process	GO:0051094	143	0.017
negative regulation of cell communication	GO:0010648	223	0.017
mitotic cytokinesis	GO:0000281	50	0.017
nucleoside triphosphate metabolic process	GO:0009141	120	0.017
regulation of protein transport	GO:0051223	57	0.017
nucleobase containing small molecule metabolic process	GO:0055086	174	0.017
branching involved in open tracheal system development	GO:0060446	45	0.017
chitin based cuticle development	GO:0040003	49	0.017
organic substance catabolic process	GO:1901575	308	0.016
localization of cell	GO:0051674	257	0.016
tissue morphogenesis	GO:0048729	297	0.016
macromolecular complex assembly	GO:0065003	256	0.016
exocrine system development	GO:0035272	162	0.016
positive regulation of transport	GO:0051050	92	0.016
regulation of cell differentiation	GO:0045595	302	0.016
death	GO:0016265	284	0.016
terminal branching open tracheal system	GO:0007430	17	0.016
intracellular protein transmembrane transport	GO:0065002	4	0.016
ribonucleotide metabolic process	GO:0009259	145	0.016
digestive tract development	GO:0048565	149	0.015
single organism membrane organization	GO:0044802	93	0.015
protein complex assembly	GO:0006461	200	0.015
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.015
respiratory system development	GO:0060541	213	0.015
camera type eye development	GO:0043010	4	0.015
regulation of epithelial cell migration open tracheal system	GO:2000274	11	0.015
cytoskeleton dependent cytokinesis	GO:0061640	81	0.015
monocarboxylic acid metabolic process	GO:0032787	29	0.015
nucleoside catabolic process	GO:0009164	112	0.015
endomembrane system organization	GO:0010256	119	0.015
golgi organization	GO:0007030	66	0.014
axon development	GO:0061564	297	0.014
positive regulation of signal transduction	GO:0009967	223	0.014
purine ribonucleoside metabolic process	GO:0046128	127	0.014
regulation of molecular function	GO:0065009	217	0.014
meiotic cell cycle process	GO:1903046	132	0.014
purine ribonucleotide catabolic process	GO:0009154	109	0.014
positive regulation of macromolecule metabolic process	GO:0010604	405	0.014
negative regulation of response to stimulus	GO:0048585	258	0.014
negative regulation of cellular metabolic process	GO:0031324	382	0.014
urogenital system development	GO:0001655	72	0.014
response to virus	GO:0009615	28	0.014
response to abiotic stimulus	GO:0009628	341	0.014
telencephalon development	GO:0021537	2	0.014
chromatin organization	GO:0006325	207	0.014
nucleoside phosphate metabolic process	GO:0006753	162	0.014
glycosylation	GO:0070085	36	0.013
regulation of embryonic development	GO:0045995	68	0.013
dorsal closure	GO:0007391	79	0.013
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.013
organic acid metabolic process	GO:0006082	103	0.013
nucleotide catabolic process	GO:0009166	109	0.013
salivary gland development	GO:0007431	162	0.013
protein localization to endoplasmic reticulum	GO:0070972	2	0.013
organonitrogen compound biosynthetic process	GO:1901566	117	0.013
regulation of tube architecture open tracheal system	GO:0035152	68	0.012
axon guidance	GO:0007411	233	0.012
taxis	GO:0042330	304	0.012
spermatogenesis	GO:0007283	200	0.012
modification dependent macromolecule catabolic process	GO:0043632	79	0.012
regulation of protein localization	GO:0032880	76	0.012
purine ribonucleotide metabolic process	GO:0009150	145	0.012
reproductive behavior	GO:0019098	122	0.012
developmental maturation	GO:0021700	172	0.012
regulation of catalytic activity	GO:0050790	185	0.012
programmed cell death	GO:0012501	257	0.012
purine nucleoside metabolic process	GO:0042278	127	0.012
heart development	GO:0007507	82	0.012
movement in environment of other organism involved in symbiotic interaction	GO:0052192	3	0.012
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.012
salivary gland morphogenesis	GO:0007435	145	0.012
nucleoside triphosphate catabolic process	GO:0009143	108	0.011
secretion	GO:0046903	109	0.011
tissue migration	GO:0090130	155	0.011
positive regulation of hydrolase activity	GO:0051345	78	0.011
regulation of intracellular transport	GO:0032386	64	0.011
purine containing compound metabolic process	GO:0072521	155	0.011
appendage morphogenesis	GO:0035107	397	0.011
regulation of female receptivity	GO:0045924	24	0.011
regulation of response to stress	GO:0080134	200	0.011
positive regulation of rna metabolic process	GO:0051254	271	0.011
negative regulation of signaling	GO:0023057	219	0.011
regulation of protein import into nucleus	GO:0042306	28	0.011
nucleoside phosphate catabolic process	GO:1901292	110	0.011
immune effector process	GO:0002252	98	0.011
microtubule polymerization or depolymerization	GO:0031109	39	0.010
negative regulation of cell differentiation	GO:0045596	143	0.010
response to endoplasmic reticulum stress	GO:0034976	28	0.010
protein import	GO:0017038	55	0.010
positive regulation of signaling	GO:0023056	243	0.010
mesenchymal cell development	GO:0014031	1	0.010
mesoderm morphogenesis	GO:0048332	22	0.010
chemotaxis	GO:0006935	249	0.010
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.010
gland morphogenesis	GO:0022612	145	0.010

Spp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.015
cancer	DOID:162	0.015
organ system cancer	DOID:0050686	0.015
cardiovascular system disease	DOID:1287	0.011
disease of anatomical entity	DOID:7	0.011
disease of metabolism	DOID:0014667	0.011
musculoskeletal system disease	DOID:17	0.011

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