Drosophila melanogaster

34 known processes

Den1 (Dmel_CG8493)

Deneddylase 1

(Aliases: CG8493,DEN1,Dmel\CG8493)

Den1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
intracellular signal transductionGO:00355563000.046
regulation of cell cycleGO:00517262910.037
positive regulation of response to stimulusGO:00485843230.036
vesicle mediated transportGO:00161923810.035
negative regulation of gene expressionGO:00106293870.035
positive regulation of macromolecule metabolic processGO:00106044050.035
transcription from rna polymerase ii promoterGO:00063663680.033
endocytosisGO:00068973100.032
cellular protein modification processGO:00064644380.032
organonitrogen compound metabolic processGO:19015643180.031
regulation of phosphate metabolic processGO:00192202100.029
mitotic cell cycle phase transitionGO:00447721380.029
appendage morphogenesisGO:00351073970.028
eye developmentGO:00016543230.028
small molecule metabolic processGO:00442813050.028
immune system processGO:00023763470.027
regulation of intracellular signal transductionGO:19025312360.027
regionalizationGO:00030024160.027
positive regulation of signalingGO:00230562430.027
positive regulation of nitrogen compound metabolic processGO:00511733540.027
oxoacid metabolic processGO:00434361030.027
wing disc morphogenesisGO:00074723440.027
post embryonic appendage morphogenesisGO:00351203850.027
positive regulation of cell communicationGO:00106472500.026
cell proliferationGO:00082832990.026
compound eye developmentGO:00487493070.026
appendage developmentGO:00487364010.026
ras protein signal transductionGO:0007265880.026
negative regulation of cellular metabolic processGO:00313243820.026
cellular catabolic processGO:00442483720.026
protein modification processGO:00362114380.025
cell cycle phase transitionGO:00447701400.025
regulation of multicellular organismal developmentGO:20000264140.025
response to abiotic stimulusGO:00096283410.025
positive regulation of cellular biosynthetic processGO:00313283160.024
organic substance catabolic processGO:19015753080.024
regulation of mitotic cell cycleGO:00073461900.024
imaginal disc derived appendage developmentGO:00487373990.024
positive regulation of signal transductionGO:00099672230.024
phosphorylationGO:00163102940.023
sensory organ morphogenesisGO:00905962600.023
body morphogenesisGO:001017120.022
regulation of cellular protein metabolic processGO:00322682430.022
regulation of transcription from rna polymerase ii promoterGO:00063573780.022
imaginal disc derived wing morphogenesisGO:00074763370.022
eye morphogenesisGO:00485922600.021
cell cycle checkpointGO:0000075950.021
regulation of protein metabolic processGO:00512462560.021
camera type eye developmentGO:004301040.021
organic substance transportGO:00717022570.021
regulation of phosphorus metabolic processGO:00511742100.021
phagocytosisGO:00069092150.021
imaginal disc derived appendage morphogenesisGO:00351143950.021
proteolysisGO:00065081920.021
forebrain developmentGO:003090020.021
macromolecular complex assemblyGO:00650032560.021
single organism catabolic processGO:00447122280.021
regulation of cell cycle processGO:00105641810.021
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.020
carboxylic acid metabolic processGO:0019752920.020
mitotic cell cycle checkpointGO:0007093880.020
compound eye morphogenesisGO:00017452490.020
negative regulation of cell communicationGO:00106482230.020
small gtpase mediated signal transductionGO:0007264880.020
central nervous system developmentGO:00074172010.020
taxisGO:00423303040.020
negative regulation of mitotic cell cycle phase transitionGO:19019911030.020
cellular macromolecule localizationGO:00707272200.020
protein localizationGO:00081042840.020
single organism behaviorGO:00447083910.020
regulation of localizationGO:00328792750.020
negative regulation of cell cycle processGO:00109481090.019
catabolic processGO:00090564090.019
mitotic g2 m transition checkpointGO:0044818700.019
positive regulation of nucleic acid templated transcriptionGO:19035082660.019
organic acid metabolic processGO:00060821030.019
response to lipopolysaccharideGO:003249640.019
positive regulation of biosynthetic processGO:00098913160.019
organic cyclic compound catabolic processGO:19013611680.019
segmentationGO:00352822070.019
negative regulation of macromolecule biosynthetic processGO:00105582700.019
purine ribonucleoside catabolic processGO:00461301120.019
neurological system processGO:00508773580.019
carbohydrate derivative metabolic processGO:19011352170.018
cellular response to chemical stimulusGO:00708871990.018
regulation of cellular amine metabolic processGO:003323830.018
oocyte differentiationGO:00099941450.018
positive regulation of macromolecule biosynthetic processGO:00105572830.018
rna processingGO:00063961470.018
regulation of mitotic cell cycle phase transitionGO:19019901300.018
negative regulation of signal transductionGO:00099682060.018
dna integrity checkpointGO:0031570810.018
positive regulation of nucleobase containing compound metabolic processGO:00459353320.018
glycosyl compound catabolic processGO:19016581120.018
nuclear divisionGO:00002803320.018
response to organic substanceGO:00100332840.018
negative regulation of developmental processGO:00510932010.018
epithelial cell differentiationGO:00308553220.018
salivary gland developmentGO:00074311620.017
nucleotide metabolic processGO:00091171610.017
single organism cellular localizationGO:19025801800.017
organonitrogen compound catabolic processGO:19015651280.017
organelle fissionGO:00482853400.017
programmed cell deathGO:00125012570.017
deathGO:00162652840.017
telencephalon developmentGO:002153720.017
establishment of localization in cellGO:00516494020.017
cellular amino acid metabolic processGO:0006520610.017
positive regulation of transcription dna templatedGO:00458932660.017
regulation of cellular component biogenesisGO:00440872010.017
defense responseGO:00069523000.017
response to extracellular stimulusGO:00099911160.017
negative regulation of nitrogen compound metabolic processGO:00511722650.017
posttranscriptional regulation of gene expressionGO:00106081450.017
response to other organismGO:00517072930.017
immune responseGO:00069552460.017
regulation of molecular functionGO:00650092170.017
negative regulation of response to stimulusGO:00485852580.017
cell divisionGO:00513012480.017
spermatogenesisGO:00072832000.017
mitotic dna damage checkpointGO:0044773740.017
negative regulation of cell cycle phase transitionGO:19019881030.016
aromatic compound catabolic processGO:00194391660.016
negative regulation of nucleic acid templated transcriptionGO:19035072400.016
response to external biotic stimulusGO:00432072930.016
negative regulation of signalingGO:00230572190.016
response to biotic stimulusGO:00096072940.016
cellular macromolecular complex assemblyGO:00346221530.016
sterol homeostasisGO:005509240.016
regulation of cell cycle phase transitionGO:19019871300.016
organelle assemblyGO:00709251980.016
dna damage checkpointGO:0000077780.016
regulation of catalytic activityGO:00507901850.016
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.016
regulation of phosphorylationGO:00423251470.016
cellular ketone metabolic processGO:0042180240.016
cellularizationGO:0007349900.016
xenobiotic catabolic processGO:004217810.016
cellular nitrogen compound catabolic processGO:00442701650.016
mitotic dna integrity checkpointGO:0044774750.016
embryonic axis specificationGO:00005781070.016
developmental growthGO:00485892800.016
gland morphogenesisGO:00226121450.016
response to organophosphorusGO:004668320.015
positive regulation of rna biosynthetic processGO:19026802660.015
cell deathGO:00082192790.015
exocrine system developmentGO:00352721620.015
single organism intracellular transportGO:19025822070.015
nucleoside metabolic processGO:00091161270.015
cellular amine metabolic processGO:0044106120.015
connective tissue developmentGO:006144830.015
regulation of cell differentiationGO:00455953020.015
intracellular transportGO:00469072280.015
amine metabolic processGO:0009308120.015
negative regulation of mitotic cell cycleGO:00459301090.015
nucleoside phosphate catabolic processGO:19012921100.015
embryonic pattern specificationGO:00098801740.015
purine containing compound metabolic processGO:00725211550.015
regulation of cellular ketone metabolic processGO:001056530.015
head developmentGO:00603221350.015
cellular macromolecule catabolic processGO:00442651360.015
mitotic nuclear divisionGO:00070672130.015
developmental maturationGO:00217001720.015
photoreceptor cell differentiationGO:00465301700.015
negative regulation of cellular biosynthetic processGO:00313272770.015
negative regulation of biosynthetic processGO:00098902770.015
hindbrain developmentGO:003090220.015
defense response to other organismGO:00985422250.015
single organism biosynthetic processGO:00447112060.015
regulation of ras protein signal transductionGO:0046578930.015
positive regulation of rna metabolic processGO:00512542710.015
kidney developmentGO:000182230.015
homeostatic processGO:00425921990.015
purine nucleoside metabolic processGO:00422781270.014
negative regulation of rna metabolic processGO:00512532510.014
dendrite developmentGO:00163582040.014
ribonucleotide catabolic processGO:00092611090.014
negative regulation of cell differentiationGO:00455961430.014
g2 dna damage checkpointGO:0031572690.014
gland developmentGO:00487321910.014
negative regulation of nucleobase containing compound metabolic processGO:00459342610.014
ribonucleoside catabolic processGO:00424541120.014
regulation of cellular amino acid metabolic processGO:000652100.014
heterocycle catabolic processGO:00467001660.014
response to oxygen containing compoundGO:19017002000.014
regulation of immune system processGO:00026821760.014
regulation of multi organism processGO:00439001310.014
nucleoside catabolic processGO:00091641120.014
axonogenesisGO:00074092900.014
carbohydrate derivative catabolic processGO:19011361180.014
cellular protein localizationGO:00346131600.014
mitotic g2 dna damage checkpointGO:0007095690.014
purine ribonucleoside metabolic processGO:00461281270.014
blastoderm segmentationGO:00073501590.014
regulation of cell deathGO:00109411730.014
anion homeostasisGO:005508130.014
cytoplasmic transportGO:00164821300.014
hormone catabolic processGO:004244730.014
purine nucleotide catabolic processGO:00061951090.014
anterior posterior pattern specificationGO:00099521360.014
mesenchymal cell differentiationGO:004876210.014
salivary gland morphogenesisGO:00074351450.014
protein complex assemblyGO:00064612000.013
negative regulation of cell cycleGO:00457861160.013
eye photoreceptor cell differentiationGO:00017541450.013
purine nucleoside catabolic processGO:00061521120.013
innate immune responseGO:00450871440.013
purine containing compound catabolic processGO:00725231120.013
growthGO:00400073590.013
signal transduction by phosphorylationGO:00230141070.013
organophosphate catabolic processGO:00464341120.013
positive regulation of cell motilityGO:200014730.013
positive regulation of gene expressionGO:00106282900.013
nucleotide catabolic processGO:00091661090.013
spindle organizationGO:00070512530.013
positive regulation of phosphorus metabolic processGO:00105621390.013
regulation of anatomical structure morphogenesisGO:00226032420.013
cellular response to dna damage stimulusGO:00069742230.013
developmental programmed cell deathGO:00106231380.013
retina development in camera type eyeGO:006004140.013
neuromuscular junction developmentGO:00075281490.013
ribonucleotide metabolic processGO:00092591450.013
regulation of proteolysisGO:0030162870.013
compound eye photoreceptor cell differentiationGO:00017511400.013
monocarboxylic acid transportGO:001571830.013
axis specificationGO:00097981670.013
axon developmentGO:00615642970.013
nucleobase containing compound catabolic processGO:00346551650.013
ribonucleoside triphosphate catabolic processGO:00092031080.013
chemotaxisGO:00069352490.013
protein modification by small protein conjugation or removalGO:00706471060.013
regulation of i kappab kinase nf kappab signalingGO:004312220.013
regulation of epithelial cell proliferationGO:005067840.012
nucleobase containing small molecule metabolic processGO:00550861740.012
lateral inhibitionGO:00463312060.012
purine nucleoside triphosphate catabolic processGO:00091461080.012
regulation of programmed cell deathGO:00430671520.012
dendrite morphogenesisGO:00488131990.012
positive regulation of protein metabolic processGO:00512471280.012
regulation of notch signaling pathwayGO:00085931000.012
organophosphate metabolic processGO:00196371950.012
negative regulation of rna biosynthetic processGO:19026792400.012
anterior posterior axis specificationGO:00099481090.012
brain developmentGO:00074201200.012
male gamete generationGO:00482322010.012
synaptic transmissionGO:00072682880.012
cellular component assembly involved in morphogenesisGO:00109271510.012
ribonucleoside metabolic processGO:00091191270.012
epithelial cell developmentGO:00020642740.012
purine ribonucleotide metabolic processGO:00091501450.012
protein complex biogenesisGO:00702712010.012
response to starvationGO:0042594970.012
regulation of cellular localizationGO:00603411360.012
regulation of mapk cascadeGO:0043408920.012
wnt signaling pathwayGO:0016055980.012
regulation of synapse structure and activityGO:00508031280.012
positive regulation of intracellular signal transductionGO:19025331160.012
chromatin modificationGO:00165681470.012
protein maturationGO:0051604710.012
female meiotic divisionGO:0007143700.012
regulation of cell proliferationGO:00421271630.012
positive regulation of apoptotic signaling pathwayGO:200123540.012
mesenchymal cell developmentGO:001403110.012
regulation of transportGO:00510491810.012
regulation of small gtpase mediated signal transductionGO:0051056930.012
regulation of catabolic processGO:00098941700.012
negative regulation of transcription dna templatedGO:00458922370.012
cell migrationGO:00164772380.012
nucleoside phosphate metabolic processGO:00067531620.012
purine nucleotide metabolic processGO:00061631460.011
cell cell signaling involved in cell fate commitmentGO:00451682100.011
chromosome organizationGO:00512763600.011
autophagic cell deathGO:0048102830.011
positive regulation of phosphate metabolic processGO:00459371390.011
histolysisGO:00075591020.011
chromosome segregationGO:00070591570.011
regulation of apoptotic processGO:00429811300.011
mrna metabolic processGO:00160711240.011
regulation of nervous system developmentGO:00519602480.011
regulation of cellular catabolic processGO:00313291570.011
response to radiationGO:00093141550.011
tissue deathGO:00162711020.011
limb developmentGO:006017310.011
cell maturationGO:00484691440.011
regulation of epithelial cell differentiationGO:003085640.011
ion transportGO:00068111450.011
cellular response to organic substanceGO:00713101320.011
protein modification by small protein conjugationGO:0032446790.011
response to bacteriumGO:00096171980.011
neutral lipid biosynthetic processGO:004646020.011
localization of cellGO:00516742570.011
regulation of response to stressGO:00801342000.011
apoptotic processGO:00069151590.011
anterior posterior axis specification embryoGO:00085951030.011
guanosine containing compound catabolic processGO:1901069740.011
immune response regulating signaling pathwayGO:000276420.011
vitamin biosynthetic processGO:000911010.011
cholesterol homeostasisGO:004263230.011
protein ubiquitinationGO:0016567700.011
salivary gland histolysisGO:0035070880.011
guanosine containing compound metabolic processGO:1901068740.011
acylglycerol biosynthetic processGO:004646320.011
tissue morphogenesisGO:00487292970.011
triglyceride catabolic processGO:001943330.011
proteolysis involved in cellular protein catabolic processGO:0051603830.011
response to nutrient levelsGO:00316671140.011
response to glucoseGO:000974920.011
response to monosaccharideGO:003428440.011
salivary gland cell autophagic cell deathGO:0035071830.011
cellular protein catabolic processGO:0044257830.011
protein phosphorylationGO:00064681690.011
negative regulation of nervous system developmentGO:0051961920.011
negative regulation of multicellular organismal processGO:00512411420.011
immune response activating signal transductionGO:000275720.011
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.011
notch signaling pathwayGO:00072191200.011
endomembrane system organizationGO:00102561190.011
positive regulation of programmed cell deathGO:0043068620.011
detection of stimulusGO:00516061560.011
ethanolamine containing compound metabolic processGO:004243940.011
columnar cuboidal epithelial cell differentiationGO:00020652560.011
regulation of defense responseGO:00313471020.011
ribose phosphate metabolic processGO:00196931450.011
columnar cuboidal epithelial cell developmentGO:00020662490.010
protein transportGO:00150311550.010
response to copper ionGO:004668840.010
macromolecule catabolic processGO:00090571610.010
gene silencing by rnaGO:0031047570.010
tripartite regional subdivisionGO:00073511030.010
response to hexoseGO:000974630.010
glycosyl compound metabolic processGO:19016571270.010
positive regulation of molecular functionGO:00440931360.010
cell motilityGO:00488702510.010
immune effector processGO:0002252980.010
dna templated transcriptional preinitiation complex assemblyGO:0070897200.010
germarium derived egg chamber formationGO:00072931010.010
camera type eye morphogenesisGO:004859320.010
regulation of protein modification processGO:00313991120.010
positive regulation of mapk cascadeGO:0043410630.010
sulfur compound metabolic processGO:0006790590.010
epidermal growth factor receptor signaling pathwayGO:0007173580.010
protein processingGO:0016485680.010
gliogenesisGO:0042063800.010
positive regulation of cellular amine metabolic processGO:003324000.010
kidney epithelium developmentGO:007207330.010
regulation of hydrolase activityGO:0051336970.010

Den1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.042
disease of metabolismDOID:001466700.022
nervous system diseaseDOID:86300.020
inherited metabolic disorderDOID:65500.016
glucose metabolism diseaseDOID:419400.014
acquired metabolic diseaseDOID:006015800.014
carbohydrate metabolism diseaseDOID:005001300.014
cardiovascular system diseaseDOID:128700.014
disease of cellular proliferationDOID:1456600.012
organ system cancerDOID:005068600.012
cancerDOID:16200.012
musculoskeletal system diseaseDOID:1700.011
sensory system diseaseDOID:005015500.011
eye and adnexa diseaseDOID:149200.010
eye diseaseDOID:561400.010