Drosophila melanogaster

174 known processes

kto (Dmel_CG8491)

kohtalo

(Aliases: dTrap230,Srb8/KTO/TRAP230,siren1,Trap230,Dmel\CG8491,CG8491,med12/kto,dTRAP230,Med12,MED12,Kto,SRB8,Kto/Med12)

kto biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of transcription from rna polymerase ii promoterGO:00063573780.940
imaginal disc derived appendage morphogenesisGO:00351143950.901
positive regulation of biosynthetic processGO:00098913160.886
Mouse
positive regulation of nitrogen compound metabolic processGO:00511733540.836
Mouse
sex comb developmentGO:004549880.774
leg disc developmentGO:0035218920.773
imaginal disc derived leg morphogenesisGO:0007480800.693
positive regulation of rna metabolic processGO:00512542710.623
Mouse
leg disc morphogenesisGO:0007478800.621
regulation of multicellular organismal developmentGO:20000264140.617
positive regulation of cellular biosynthetic processGO:00313283160.597
Mouse
positive regulation of nucleobase containing compound metabolic processGO:00459353320.592
Mouse
cell cycle phase transitionGO:00447701400.585
negative regulation of cellular biosynthetic processGO:00313272770.575
neuroblast proliferationGO:0007405740.548
negative regulation of macromolecule biosynthetic processGO:00105582700.541
mitotic cell cycle phase transitionGO:00447721380.485
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.475
negative regulation of nucleic acid templated transcriptionGO:19035072400.448
immune system processGO:00023763470.433
programmed cell deathGO:00125012570.419
negative regulation of rna biosynthetic processGO:19026792400.419
appendage developmentGO:00487364010.411
post embryonic appendage morphogenesisGO:00351203850.407
transcription from rna polymerase ii promoterGO:00063663680.397
appendage morphogenesisGO:00351073970.396
catabolic processGO:00090564090.389
regulation of nervous system developmentGO:00519602480.389
regulation of cell cycle processGO:00105641810.379
cellular protein modification processGO:00064644380.365
response to alcoholGO:0097305950.347
negative regulation of transcription dna templatedGO:00458922370.345
negative regulation of nitrogen compound metabolic processGO:00511722650.334
imaginal disc derived wing margin morphogenesisGO:0008587410.327
mitotic g2 dna damage checkpointGO:0007095690.319
imaginal disc derived leg segmentationGO:0036011260.314
regulation of cell cycle phase transitionGO:19019871300.311
developmental programmed cell deathGO:00106231380.305
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.303
Mouse
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.297
negative regulation of mitotic cell cycle phase transitionGO:19019911030.291
cell proliferationGO:00082832990.288
positive regulation of nucleic acid templated transcriptionGO:19035082660.285
Mouse
positive regulation of transcription dna templatedGO:00458932660.275
Mouse
regulation of neurogenesisGO:00507671580.275
body morphogenesisGO:001017120.268
neural precursor cell proliferationGO:0061351750.262
mitotic dna integrity checkpointGO:0044774750.253
regulation of stem cell proliferationGO:0072091400.246
nucleobase containing compound catabolic processGO:00346551650.243
stem cell proliferationGO:0072089880.243
cellular catabolic processGO:00442483720.236
negative regulation of stem cell proliferationGO:2000647300.234
negative regulation of gene expressionGO:00106293870.215
negative regulation of neural precursor cell proliferationGO:2000178270.214
cellular macromolecule catabolic processGO:00442651360.212
negative regulation of cell cycle phase transitionGO:19019881030.210
regulation of mitotic cell cycle phase transitionGO:19019901300.205
negative regulation of developmental processGO:00510932010.204
nuclear divisionGO:00002803320.204
negative regulation of cell differentiationGO:00455961430.203
tissue deathGO:00162711020.197
negative regulation of nucleobase containing compound metabolic processGO:00459342610.191
mitotic dna damage checkpointGO:0044773740.188
mitotic nuclear divisionGO:00070672130.186
aromatic compound catabolic processGO:00194391660.183
organic substance catabolic processGO:19015753080.178
regulation of cell developmentGO:00602842150.176
retina development in camera type eyeGO:006004140.170
imaginal disc derived wing morphogenesisGO:00074763370.167
regionalizationGO:00030024160.167
positive regulation of macromolecule biosynthetic processGO:00105572830.164
Mouse
organic cyclic compound catabolic processGO:19013611680.163
positive regulation of rna biosynthetic processGO:19026802660.161
Mouse
camera type eye developmentGO:004301040.158
negative regulation of rna metabolic processGO:00512532510.152
imaginal disc pattern formationGO:0007447910.151
larval midgut histolysisGO:0035069220.150
molting cycleGO:0042303560.149
snrna processingGO:0016180140.148
negative regulation of neuroblast proliferationGO:0007406270.147
dendrite developmentGO:00163582040.144
wing disc pattern formationGO:0035222660.142
positive regulation of programmed cell deathGO:0043068620.140
anterior posterior pattern specificationGO:00099521360.138
Mouse
negative regulation of mitotic cell cycleGO:00459301090.133
protein modification by small protein conjugation or removalGO:00706471060.133
apposition of dorsal and ventral imaginal disc derived wing surfacesGO:0007475150.132
negative regulation of biosynthetic processGO:00098902770.123
negative regulation of cell cycle processGO:00109481090.116
kidney epithelium developmentGO:007207330.115
g2 dna damage checkpointGO:0031572690.110
protein ubiquitinationGO:0016567700.109
regulation of cellular component biogenesisGO:00440872010.109
cellular response to dna damage stimulusGO:00069742230.107
regulation of apoptotic processGO:00429811300.107
blastoderm segmentationGO:00073501590.105
regulation of neuroblast proliferationGO:1902692340.105
appendage segmentationGO:0035285260.103
negative regulation of cell proliferationGO:0008285690.102
macromolecule catabolic processGO:00090571610.102
organelle fissionGO:00482853400.101
morphogenesis of an epitheliumGO:00020092760.099
Mouse
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.098
protein modification processGO:00362114380.097
intracellular signal transductionGO:00355563000.096
regulation of cell proliferationGO:00421271630.096
positive regulation of gene expressionGO:00106282900.089
Mouse
response to oxygen containing compoundGO:19017002000.089
exocrine system developmentGO:00352721620.088
positive regulation of cell deathGO:0010942690.086
hematopoietic or lymphoid organ developmentGO:0048534570.084
sensory organ morphogenesisGO:00905962600.081
rna catabolic processGO:0006401370.081
cellular nitrogen compound catabolic processGO:00442701650.080
regulation of molecular functionGO:00650092170.080
regulation of cell differentiationGO:00455953020.080
deathGO:00162652840.079
growthGO:00400073590.077
Mouse
apoptotic processGO:00069151590.077
heterocycle catabolic processGO:00467001660.076
imaginal disc derived appendage developmentGO:00487373990.075
segmentationGO:00352822070.073
positive regulation of signal transductionGO:00099672230.073
intracellular steroid hormone receptor signaling pathwayGO:0030518120.073
regulation of cell cycleGO:00517262910.073
endocytosisGO:00068973100.072
dna metabolic processGO:00062592270.072
positive regulation of catalytic activityGO:00430851180.072
chaeta developmentGO:0022416970.071
cell deathGO:00082192790.070
small molecule metabolic processGO:00442813050.070
negative regulation of multicellular organismal processGO:00512411420.070
snrna metabolic processGO:0016073140.068
compound eye developmentGO:00487493070.068
positive regulation of macromolecule metabolic processGO:00106044050.067
Mouse
dorsal ventral pattern formation imaginal discGO:0007450510.067
regulation of intracellular signal transductionGO:19025312360.065
salivary gland morphogenesisGO:00074351450.064
regulation of cell deathGO:00109411730.063
dendrite morphogenesisGO:00488131990.063
mitotic cell cycle checkpointGO:0007093880.062
regulation of immune system processGO:00026821760.062
histolysisGO:00075591020.061
cell cycle checkpointGO:0000075950.061
positive regulation of cellular component organizationGO:00511301560.061
regulation of mitotic cell cycleGO:00073461900.059
oxoacid metabolic processGO:00434361030.059
response to radiationGO:00093141550.059
dna integrity checkpointGO:0031570810.058
proteolysisGO:00065081920.057
meiotic cell cycleGO:00513211710.057
positive regulation of response to stimulusGO:00485843230.057
regulation of neuron deathGO:1901214260.056
salivary gland cell autophagic cell deathGO:0035071830.056
organonitrogen compound metabolic processGO:19015643180.056
kidney developmentGO:000182230.056
response to sterolGO:0036314340.054
camera type eye morphogenesisGO:004859320.054
regulation of nuclear divisionGO:0051783580.053
organic acid metabolic processGO:00060821030.053
apoptotic signaling pathwayGO:0097190270.052
gonad developmentGO:0008406500.051
response to organic substanceGO:00100332840.051
protein phosphorylationGO:00064681690.051
regulation of multi organism processGO:00439001310.051
neurological system processGO:00508773580.050
wing disc morphogenesisGO:00074723440.050
chromosome organizationGO:00512763600.049
negative regulation of cell cycleGO:00457861160.048
regulation of chromosome organizationGO:0033044640.048
induction of programmed cell death by ecdysoneGO:0035078120.047
regulation of cellular catabolic processGO:00313291570.047
embryonic pattern specificationGO:00098801740.046
regulation of programmed cell deathGO:00430671520.046
negative regulation of neurogenesisGO:0050768530.044
mitotic g2 m transition checkpointGO:0044818700.044
positive regulation of molecular functionGO:00440931360.044
regulation of catalytic activityGO:00507901850.044
tripartite regional subdivisionGO:00073511030.044
response to biotic stimulusGO:00096072940.043
single organism catabolic processGO:00447122280.043
regulation of neuron differentiationGO:00456641030.043
phosphorylationGO:00163102940.043
embryonic axis specificationGO:00005781070.042
chromatin modificationGO:00165681470.042
negative regulation of apoptotic processGO:0043066630.042
response to extracellular stimulusGO:00099911160.042
respiratory system developmentGO:00605412130.042
negative regulation of cell deathGO:0060548810.041
chromatin remodelingGO:0006338720.041
histone modificationGO:00165701060.040
negative regulation of programmed cell deathGO:0043069720.040
g1 s transition of mitotic cell cycleGO:0000082310.040
ras protein signal transductionGO:0007265880.039
response to nutrient levelsGO:00316671140.038
dna damage checkpointGO:0000077780.038
response to ecdysoneGO:0035075340.037
regulation of reproductive processGO:2000241540.036
regulation of cellular ketone metabolic processGO:001056530.036
taxisGO:00423303040.036
response to light stimulusGO:00094161240.035
positive regulation of protein metabolic processGO:00512471280.035
regulation of cellular amino acid metabolic processGO:000652100.034
negative regulation of response to stimulusGO:00485852580.034
covalent chromatin modificationGO:00165691060.034
cellular response to radiationGO:0071478520.034
dna templated transcription initiationGO:0006352250.034
atp dependent chromatin remodelingGO:0043044220.034
negative regulation of nervous system developmentGO:0051961920.034
wing disc dorsal ventral pattern formationGO:0048190470.033
autophagic cell deathGO:0048102830.032
regulation of anatomical structure morphogenesisGO:00226032420.032
Mouse
eye antennal disc developmentGO:0035214600.032
regulation of gene expression epigeneticGO:00400291280.032
cell divisionGO:00513012480.032
autophagyGO:00069141080.031
regulation of small gtpase mediated signal transductionGO:0051056930.031
positive regulation of signalingGO:00230562430.031
negative regulation of neuron deathGO:1901215180.031
muscle structure developmentGO:00610612240.031
snrna 3 end processingGO:0034472140.031
developmental pigmentationGO:0048066680.030
regulation of ras protein signal transductionGO:0046578930.030
carboxylic acid metabolic processGO:0019752920.029
developmental maturationGO:00217001720.029
molting cycle chitin based cuticleGO:0007591560.028
negative regulation of cellular metabolic processGO:00313243820.028
ncrna metabolic processGO:0034660430.028
regulation of phosphorylationGO:00423251470.028
lipid metabolic processGO:00066291210.028
dna repairGO:0006281540.028
regulation of phosphorus metabolic processGO:00511742100.027
axon developmentGO:00615642970.027
purine ribonucleotide metabolic processGO:00091501450.027
tissue morphogenesisGO:00487292970.027
Mouse
response to external biotic stimulusGO:00432072930.027
nucleoside triphosphate catabolic processGO:00091431080.027
regulation of cellular amine metabolic processGO:003323830.027
eye developmentGO:00016543230.027
reproductive behaviorGO:00190981220.026
peptidyl lysine modificationGO:0018205570.026
phagocytosisGO:00069092150.026
regulation of synapse organizationGO:00508071100.026
neuron projection guidanceGO:00974852410.026
protein complex assemblyGO:00064612000.026
proteolysis involved in cellular protein catabolic processGO:0051603830.026
regulation of mitosisGO:0007088560.026
organophosphate metabolic processGO:00196371950.025
chromosome segregationGO:00070591570.025
gland morphogenesisGO:00226121450.025
development of primary sexual characteristicsGO:0045137500.025
dorsal ventral pattern formationGO:00099531330.025
negative regulation of cell developmentGO:0010721620.025
regulation of nucleotide metabolic processGO:0006140620.025
intrinsic apoptotic signaling pathwayGO:0097193160.024
negative regulation of cellular component organizationGO:00511291080.024
larval developmentGO:00021641040.024
ribose phosphate metabolic processGO:00196931450.024
multi multicellular organism processGO:00447061230.024
ncrna 3 end processingGO:0043628170.024
cellular response to organic substanceGO:00713101320.024
response to ketoneGO:1901654340.024
mrna catabolic processGO:0006402330.024
tube developmentGO:00352952440.023
Mouse
regulation of system processGO:0044057360.023
epithelial tube morphogenesisGO:0060562880.023
Mouse
peptidyl amino acid modificationGO:00181931050.023
positive regulation of cellular catabolic processGO:0031331950.023
regulation of neural precursor cell proliferationGO:2000177350.023
regulation of chromosome segregationGO:0051983320.022
axonogenesisGO:00074092900.022
response to oxidative stressGO:0006979860.022
muscle cell differentiationGO:00426921030.022
vesicle localizationGO:0051648550.022
specification of organ identityGO:001009230.022
amine metabolic processGO:0009308120.022
cellular response to chemical stimulusGO:00708871990.022
reproductive structure developmentGO:0048608740.022
triglyceride biosynthetic processGO:001943220.022
apoptotic process involved in morphogenesisGO:006056130.022
gene silencing by rnaGO:0031047570.022
ribonucleoside catabolic processGO:00424541120.022
induction of programmed cell deathGO:0012502120.021
imaginal disc derived wing vein morphogenesisGO:0008586440.021
positive regulation of phosphorus metabolic processGO:00105621390.021
pigmentationGO:0043473750.021
regulation of phosphate metabolic processGO:00192202100.021
positive regulation of cellular amine metabolic processGO:003324000.021
cellular response to extracellular stimulusGO:0031668640.021
small gtpase mediated signal transductionGO:0007264880.021
nucleoside phosphate metabolic processGO:00067531620.021
embryo development ending in birth or egg hatchingGO:00097921520.021
Mouse
malpighian tubule developmentGO:0072002640.020
cellular protein catabolic processGO:0044257830.020
brain developmentGO:00074201200.020
regulation of purine nucleotide metabolic processGO:1900542620.020
establishment or maintenance of microtubule cytoskeleton polarityGO:0030951410.020
cellular response to oxygen containing compoundGO:1901701790.020
cellular amine metabolic processGO:0044106120.020
regulation of embryonic developmentGO:0045995680.019
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919160.019
nucleotide metabolic processGO:00091171610.019
purine nucleotide metabolic processGO:00061631460.019
establishment or maintenance of cytoskeleton polarityGO:0030952440.018
phosphorylation of rna polymerase ii c terminal domainGO:007081610.018
axon guidanceGO:00074112330.018
regulation of hydrolase activityGO:0051336970.018
positive regulation of wnt signaling pathwayGO:0030177250.018
posttranscriptional gene silencingGO:0016441460.018
negative regulation of signal transductionGO:00099682060.018
connective tissue developmentGO:006144830.018
pigment metabolic processGO:0042440840.018
heart developmentGO:0007507820.018
Mouse
molting cycle processGO:0022404290.018
embryonic hemopoiesisGO:0035162260.018
positive regulation of multi organism processGO:0043902400.018
chromatin organizationGO:00063252070.018
purine nucleoside catabolic processGO:00061521120.017
cellular ketone metabolic processGO:0042180240.017
forebrain developmentGO:003090020.017
regulation of chromatin organizationGO:1902275320.017
regulation of organelle organizationGO:00330431960.017
regulation of proteolysisGO:0030162870.017
regulation of growthGO:00400082330.017
head developmentGO:00603221350.017
induction of programmed cell death by hormonesGO:0035081120.017
internal protein amino acid acetylationGO:0006475380.017
salivary gland developmentGO:00074311620.017
regulation of protein modification processGO:00313991120.017
gland developmentGO:00487321910.017
neuron apoptotic processGO:0051402170.017
mrna splicing via spliceosomeGO:0000398730.017
salivary gland histolysisGO:0035070880.017
immune system developmentGO:0002520570.017
cell type specific apoptotic processGO:0097285380.017
kidney morphogenesisGO:006099330.017
cellular amino acid metabolic processGO:0006520610.017
mapk cascadeGO:00001651070.017
sex differentiationGO:0007548810.016
response to lipidGO:0033993380.016
regulation of cellular localizationGO:00603411360.016
regulation of protein metabolic processGO:00512462560.016
retina morphogenesis in camera type eyeGO:006004220.016
sensory perceptionGO:00076001960.016
mitotic sister chromatid segregationGO:0000070870.016
regulation of vesicle mediated transportGO:0060627590.016
regulation of cell projection organizationGO:0031344920.016
morphogenesis of follicular epitheliumGO:0016333360.016
neuron deathGO:0070997270.016
gtp catabolic processGO:0006184720.016
cellular response to external stimulusGO:0071496660.015
zymogen activationGO:0031638200.015
cellular component disassemblyGO:0022411460.015
negative regulation of chromosome segregationGO:0051985140.015
positive regulation of apoptotic processGO:0043065470.015
epithelial cell differentiationGO:00308553220.015
response to virusGO:0009615280.015
protein catabolic processGO:00301631010.015
hemopoiesisGO:0030097460.015
regulation of endopeptidase activityGO:0052548360.015
defense response to other organismGO:00985422250.015
nucleobase containing small molecule metabolic processGO:00550861740.015
columnar cuboidal epithelial cell developmentGO:00020662490.015
organ growthGO:0035265560.015
nephron epithelium developmentGO:007200930.015
purine ribonucleoside catabolic processGO:00461301120.015
glycosyl compound metabolic processGO:19016571270.015
macromolecular complex assemblyGO:00650032560.015
positive regulation of cellular amino acid metabolic processGO:004576400.015
negative regulation of cell communicationGO:00106482230.015
imaginal disc derived wing vein specificationGO:0007474480.015
reproductive system developmentGO:0061458740.015
purine containing compound metabolic processGO:00725211550.014
branching morphogenesis of an epithelial tubeGO:0048754450.014
anatomical structure homeostasisGO:0060249970.014
negative regulation of neuron apoptotic processGO:0043524140.014
eye photoreceptor cell fate commitmentGO:0042706370.014
histone exchangeGO:0043486210.014
phosphatidylinositol mediated signalingGO:004801540.014
carbohydrate derivative metabolic processGO:19011352170.014
positive regulation of protein modification processGO:0031401580.014
renal system developmentGO:0072001720.014
positive regulation of intracellular signal transductionGO:19025331160.014
purine nucleoside triphosphate metabolic processGO:00091441190.014
cellular amide metabolic processGO:0043603800.014
oocyte differentiationGO:00099941450.014
protein dna complex subunit organizationGO:0071824860.014
rna processingGO:00063961470.013
response to other organismGO:00517072930.013
regulation of developmental growthGO:00486381740.013
protein targeting to nucleusGO:0044744510.013
ribonucleoside triphosphate catabolic processGO:00092031080.013
positive regulation of purine nucleotide metabolic processGO:1900544550.013
response to organic cyclic compoundGO:0014070890.013
regulation of cell growthGO:0001558430.013
positive regulation of hydrolase activityGO:0051345780.013
sister chromatid segregationGO:0000819920.013
open tracheal system developmentGO:00074242040.013
positive regulation of mapk cascadeGO:0043410630.013
protein maturationGO:0051604710.013
somatic stem cell divisionGO:0048103370.013
ubiquitin dependent protein catabolic processGO:0006511780.013
regulation of embryonic pattern specificationGO:1902875270.013
modification dependent protein catabolic processGO:0019941780.012
gene silencingGO:00164581380.012
cellular lipid metabolic processGO:0044255830.012
cell cell signaling involved in cell fate commitmentGO:00451682100.012
positive regulation of cellular protein metabolic processGO:00322701180.012
ecdysone mediated induction of salivary gland cell autophagic cell deathGO:0035072120.012
sensory perception of mechanical stimulusGO:0050954720.012
posttranscriptional regulation of gene expressionGO:00106081450.012
equator specificationGO:004531740.012
multi organism reproductive behaviorGO:00447051210.012
regulation of defense response to bacteriumGO:1900424300.012
response to uvGO:0009411240.012
intracellular receptor signaling pathwayGO:0030522190.012
regulation of sister chromatid cohesionGO:000706320.012
regulation of mitotic sister chromatid separationGO:0010965280.012
scf dependent proteasomal ubiquitin dependent protein catabolic processGO:003114610.012
hematopoietic progenitor cell differentiationGO:000224410.012
modification dependent macromolecule catabolic processGO:0043632790.012
negative regulation of phosphatidylinositol 3 kinase signalingGO:001406740.012
chromatin silencingGO:0006342760.012
regulation of nurse cell apoptotic processGO:004547790.012
nuclear transcribed mrna catabolic processGO:0000956240.012
macromolecule deacylationGO:0098732110.012
regulation of neuron apoptotic processGO:0043523160.012
ribonucleoside triphosphate metabolic processGO:00091991190.011
establishment or maintenance of cell polarityGO:00071631670.011
regulation of gtpase activityGO:0043087440.011
negative regulation of epithelial cell proliferationGO:005068040.011
jak stat cascadeGO:0007259490.011
peptidyl threonine modificationGO:001821030.011
positive regulation of developmental processGO:00510941430.011
optic placode formationGO:000174340.011
maintenance of location in cellGO:0051651280.011
posttranscriptional gene silencing by rnaGO:0035194450.011
positive regulation of organ growthGO:0046622120.011
regulation of localizationGO:00328792750.011
establishment of localization in cellGO:00516494020.011
response to abiotic stimulusGO:00096283410.011
cytoskeleton dependent intracellular transportGO:0030705440.011
erk1 and erk2 cascadeGO:0070371390.011
response to heatGO:0009408630.011
extrinsic apoptotic signaling pathwayGO:009719110.011
regulation of humoral immune responseGO:0002920510.010
positive regulation of cell communicationGO:00106472500.010
protein localizationGO:00081042840.010
spermatogenesisGO:00072832000.010
regulation of nucleoside metabolic processGO:0009118500.010
embryonic morphogenesisGO:00485982060.010
Mouse
positive regulation of cellular component biogenesisGO:0044089800.010
cellular response to uvGO:0034644120.010
positive regulation of transferase activityGO:0051347260.010
macromolecular complex disassemblyGO:0032984370.010
positive regulation of phosphate metabolic processGO:00459371390.010
metaphase anaphase transition of cell cycleGO:0044784280.010
negative regulation of cellular protein metabolic processGO:0032269850.010
positive regulation of apoptotic signaling pathwayGO:200123540.010
memoryGO:0007613940.010
imaginal disc growthGO:0007446370.010

kto disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.035
disease of anatomical entityDOID:700.032
organ system cancerDOID:005068600.028
cancerDOID:16200.028
nervous system diseaseDOID:86300.018