IMP: Integrative Multi-species Prediction

Drosophila melanogaster

61 known processes

tral (Dmel_CG10686)

trailer hitch

(Aliases: Lsm15,CG10686,p70,p67,TRAL,LSm15,Scd6p,DmLSm15,BEST:GH08269,anon-WO02059370.24,anon-EST:Posey139,Tral,Dmel\CG10686,anon-WO0172774.89)

FLYBASE: FBgn0041775
Entrez: 39430
UniProtKB: M9PI44
UniProtKB: Q9VTZ0
UniProtKB: M9PFB2
UniProtKB: M9PFG3
UniProtKB: M9PF14
UniProtKB: M9PF20
UniProtKB: M9PCB7
UniProtKB: M9PFF9

Process Predictions
Disease Predictions

tral biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
oocyte axis specification	GO:0007309	108	0.996
oocyte construction	GO:0007308	112	0.995
oocyte development	GO:0048599	124	0.994
oocyte differentiation	GO:0009994	145	0.985
anterior posterior axis specification embryo	GO:0008595	103	0.959
rna localization	GO:0006403	115	0.952
embryonic pattern specification	GO:0009880	174	0.945
oocyte anterior posterior axis specification	GO:0007314	72	0.938
blastoderm segmentation	GO:0007350	159	0.932
embryonic axis specification	GO:0000578	107	0.920
anterior posterior axis specification	GO:0009948	109	0.910
tripartite regional subdivision	GO:0007351	103	0.909
anterior posterior pattern specification	GO:0009952	136	0.899
pole plasm oskar mrna localization	GO:0045451	46	0.887
positive regulation of gene expression	GO:0010628	290	0.853
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.818
transcription from rna polymerase ii promoter	GO:0006366	368	0.809
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.808
regionalization	GO:0003002	416	0.773
chorion containing eggshell formation	GO:0007304	105	0.739
germarium derived egg chamber formation	GO:0007293	101	0.722
segmentation	GO:0035282	207	0.711
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.702
positive regulation of biosynthetic process	GO:0009891	316	0.697
pole plasm rna localization	GO:0007316	52	0.696
pole plasm mrna localization	GO:0019094	49	0.609
macromolecule catabolic process	GO:0009057	161	0.601
protein complex assembly	GO:0006461	200	0.595
positive regulation of rna biosynthetic process	GO:1902680	266	0.591
eggshell formation	GO:0030703	105	0.578
positive regulation of transcription dna templated	GO:0045893	266	0.572
rna catabolic process	GO:0006401	37	0.569
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.547
pole plasm assembly	GO:0007315	61	0.536
intracellular mrna localization	GO:0008298	66	0.534
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.514
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.492
cellular macromolecule catabolic process	GO:0044265	136	0.490
actin cytoskeleton organization	GO:0030036	206	0.488
nuclear transcribed mrna catabolic process deadenylation dependent decay	GO:0000288	14	0.486
positive regulation of rna metabolic process	GO:0051254	271	0.482
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.482
developmental maturation	GO:0021700	172	0.479
positive regulation of cellular biosynthetic process	GO:0031328	316	0.439
mitotic dna integrity checkpoint	GO:0044774	75	0.428
ribonucleoprotein complex biogenesis	GO:0022613	31	0.428	Human
death	GO:0016265	284	0.417	Worm
axis specification	GO:0009798	167	0.396
mrna metabolic process	GO:0016071	124	0.393
protein modification by small protein conjugation or removal	GO:0070647	106	0.390
translation	GO:0006412	69	0.387
nucleobase containing compound catabolic process	GO:0034655	165	0.385
cellular macromolecular complex assembly	GO:0034622	153	0.379	Human
negative regulation of biosynthetic process	GO:0009890	277	0.374
macromolecular complex assembly	GO:0065003	256	0.373	Human
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.369
cellular catabolic process	GO:0044248	372	0.330
positive regulation of mrna processing	GO:0050685	4	0.313
nuclear pore organization	GO:0006999	1	0.303
negative regulation of multicellular organismal process	GO:0051241	142	0.302
nuclear transcribed mrna catabolic process	GO:0000956	24	0.301
negative regulation of gene expression	GO:0010629	387	0.278
organic substance catabolic process	GO:1901575	308	0.273
positive regulation of mrna metabolic process	GO:1903313	5	0.269
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.267
regulation of mrna processing	GO:0050684	71	0.253
cytoplasm organization	GO:0007028	64	0.253
cellular response to abiotic stimulus	GO:0071214	58	0.248
gene silencing	GO:0016458	138	0.245
intracellular transport	GO:0046907	228	0.226
embryo development ending in birth or egg hatching	GO:0009792	152	0.223	Worm
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.213
establishment of localization in cell	GO:0051649	402	0.211
protein modification process	GO:0036211	438	0.211
negative regulation of translation	GO:0017148	28	0.205
dorsal appendage formation	GO:0046843	47	0.201
protein modification by small protein conjugation	GO:0032446	79	0.195
regulation of intracellular transport	GO:0032386	64	0.194
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.192
eggshell chorion assembly	GO:0007306	66	0.186
regulation of meiosis	GO:0040020	3	0.182
rna processing	GO:0006396	147	0.180
posttranscriptional regulation of gene expression	GO:0010608	145	0.180
catabolic process	GO:0009056	409	0.179
negative regulation of cellular metabolic process	GO:0031324	382	0.177
regulation of translation	GO:0006417	56	0.176
ribonucleoprotein complex assembly	GO:0022618	23	0.159	Human
regulation of synapse assembly	GO:0051963	94	0.154
protein localization to nucleus	GO:0034504	55	0.152
heterocycle catabolic process	GO:0046700	166	0.152
positive regulation of macromolecule metabolic process	GO:0010604	405	0.152
regulation of transport	GO:0051049	181	0.150
ribonucleoprotein complex subunit organization	GO:0071826	28	0.149	Human
organic cyclic compound catabolic process	GO:1901361	168	0.149
cell maturation	GO:0048469	144	0.146
gene silencing by rna	GO:0031047	57	0.145
dorsal ventral axis specification	GO:0009950	66	0.140
mitotic cell cycle checkpoint	GO:0007093	88	0.140
cellular macromolecule localization	GO:0070727	220	0.140
aromatic compound catabolic process	GO:0019439	166	0.137
negative regulation of cellular biosynthetic process	GO:0031327	277	0.137
mrna catabolic process	GO:0006402	33	0.137
regulation of mrna metabolic process	GO:1903311	72	0.132
posttranscriptional gene silencing	GO:0016441	46	0.130
organic substance transport	GO:0071702	257	0.122
regulation of cytoplasmic transport	GO:1903649	47	0.120
cellular component assembly involved in morphogenesis	GO:0010927	151	0.120
ncrna metabolic process	GO:0034660	43	0.115
epithelial cell development	GO:0002064	274	0.114
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.110
posttranscriptional gene silencing by rna	GO:0035194	45	0.107
mrna processing	GO:0006397	104	0.106
cellular protein modification process	GO:0006464	438	0.105
dna damage checkpoint	GO:0000077	78	0.104
cellular protein complex assembly	GO:0043623	71	0.103
cellular nitrogen compound catabolic process	GO:0044270	165	0.103
regulation of response to stress	GO:0080134	200	0.096
response to other organism	GO:0051707	293	0.092
nuclear transcribed mrna catabolic process nonsense mediated decay	GO:0000184	8	0.089
organelle assembly	GO:0070925	198	0.088	Human
regulation of mrna splicing via spliceosome	GO:0048024	64	0.086
protein ubiquitination	GO:0016567	70	0.083
regulation of cellular localization	GO:0060341	136	0.081
protein complex biogenesis	GO:0070271	201	0.081
cellular response to chemical stimulus	GO:0070887	199	0.081
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.080
centrosome duplication	GO:0051298	121	0.078
single organism intracellular transport	GO:1902582	207	0.077
protein targeting to nucleus	GO:0044744	51	0.076
body morphogenesis	GO:0010171	2	0.076
carboxylic acid metabolic process	GO:0019752	92	0.072
single organism nuclear import	GO:1902593	51	0.072
ovarian follicle cell development	GO:0030707	248	0.071
regulation of nucleocytoplasmic transport	GO:0046822	35	0.070
negative regulation of signal transduction by p53 class mediator	GO:1901797	1	0.067
regulation of localization	GO:0032879	275	0.066
spindle elongation	GO:0051231	83	0.065
single organism cellular localization	GO:1902580	180	0.065
modification dependent macromolecule catabolic process	GO:0043632	79	0.065
actin filament organization	GO:0007015	126	0.065
regulation of gene expression epigenetic	GO:0040029	128	0.064
chromatin organization	GO:0006325	207	0.064
taxis	GO:0042330	304	0.062
cell division	GO:0051301	248	0.062	Worm
response to biotic stimulus	GO:0009607	294	0.062
regulation of protein metabolic process	GO:0051246	256	0.061
muscle structure development	GO:0061061	224	0.060
regulation of multicellular organismal development	GO:2000026	414	0.058
positive regulation of protein import into nucleus	GO:0042307	21	0.057
actin filament based process	GO:0030029	220	0.056
multi organism behavior	GO:0051705	175	0.056
oocyte dorsal ventral axis specification	GO:0007310	34	0.056
nucleobase containing compound transport	GO:0015931	56	0.056
ncrna processing	GO:0034470	30	0.056
nls bearing protein import into nucleus	GO:0006607	5	0.055
chromosome condensation	GO:0030261	41	0.050
tissue death	GO:0016271	102	0.049
appendage morphogenesis	GO:0035107	397	0.048
regulation of cell cycle	GO:0051726	291	0.047
nuclear envelope organization	GO:0006998	7	0.047
centrosome organization	GO:0051297	163	0.046
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.046
neurological system process	GO:0050877	358	0.044
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.044
response to organic substance	GO:0010033	284	0.044
mitotic spindle organization	GO:0007052	220	0.044	Worm
dorsal ventral pattern formation	GO:0009953	133	0.043
sex differentiation	GO:0007548	81	0.043
positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay	GO:1900153	4	0.043
mitotic cell cycle phase transition	GO:0044772	138	0.042
centrosome cycle	GO:0007098	137	0.042
g2 dna damage checkpoint	GO:0031572	69	0.042
development of primary sexual characteristics	GO:0045137	50	0.042
response to organonitrogen compound	GO:0010243	75	0.041
rna transport	GO:0050658	46	0.041
negative regulation of developmental process	GO:0051093	201	0.040
regulation of phosphatase activity	GO:0010921	3	0.040
modification dependent protein catabolic process	GO:0019941	78	0.039
establishment of rna localization	GO:0051236	47	0.039
regulation of cell cycle phase transition	GO:1901987	130	0.038
response to oxygen containing compound	GO:1901700	200	0.037
rrna processing	GO:0006364	3	0.037
protein import	GO:0017038	55	0.036
meiotic cell cycle	GO:0051321	171	0.036
response to external biotic stimulus	GO:0043207	293	0.035
regulation of mitotic cell cycle	GO:0007346	190	0.035
protein import into nucleus	GO:0006606	51	0.034
meiotic chromosome segregation	GO:0045132	59	0.034
striated muscle cell development	GO:0055002	50	0.034
microtubule organizing center organization	GO:0031023	168	0.034
chaeta development	GO:0022416	97	0.034
regulation of multi organism process	GO:0043900	131	0.033
columnar cuboidal epithelial cell development	GO:0002066	249	0.033
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.033
epithelial cell differentiation	GO:0030855	322	0.032
programmed cell death	GO:0012501	257	0.032	Worm
negative regulation of oskar mrna translation	GO:0007319	5	0.032
maintenance of location	GO:0051235	73	0.029
positive regulation of developmental process	GO:0051094	143	0.029
oxoacid metabolic process	GO:0043436	103	0.029
humoral immune response	GO:0006959	117	0.028
protein localization	GO:0008104	284	0.028
regulation of oocyte development	GO:0060281	27	0.028
negative regulation of cell cycle phase transition	GO:1901988	103	0.028
negative regulation of protein metabolic process	GO:0051248	85	0.028
developmental programmed cell death	GO:0010623	138	0.027
positive regulation of multicellular organismal process	GO:0051240	143	0.027
regulation of embryonic development	GO:0045995	68	0.027
reproductive system development	GO:0061458	74	0.027
mitotic spindle elongation	GO:0000022	81	0.027
regulation of cell shape	GO:0008360	113	0.027
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.026
negative regulation of transposition	GO:0010529	12	0.026
carbohydrate derivative metabolic process	GO:1901135	217	0.026
cellular protein localization	GO:0034613	160	0.025
nucleocytoplasmic transport	GO:0006913	72	0.025
neuron projection guidance	GO:0097485	241	0.025
nuclear import	GO:0051170	51	0.025
covalent chromatin modification	GO:0016569	106	0.025
regulation of cellular protein metabolic process	GO:0032268	243	0.024
cellular protein catabolic process	GO:0044257	83	0.024
dna metabolic process	GO:0006259	227	0.024
regulation of response to external stimulus	GO:0032101	115	0.024
learning or memory	GO:0007611	141	0.024
histone lysine demethylation	GO:0070076	6	0.024
negative regulation of signal transduction	GO:0009968	206	0.023
regulation of protein import into nucleus	GO:0042306	28	0.023
positive regulation of cell proliferation	GO:0008284	47	0.023
organic acid metabolic process	GO:0006082	103	0.023
negative regulation of transcription dna templated	GO:0045892	237	0.022
single organism behavior	GO:0044708	391	0.022
muscle system process	GO:0003012	21	0.022
wing disc morphogenesis	GO:0007472	344	0.022
regulation of meiotic cell cycle	GO:0051445	9	0.022
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.022
cell death	GO:0008219	279	0.021	Worm
intracellular signal transduction	GO:0035556	300	0.021
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.021
vesicle mediated transport	GO:0016192	381	0.021
regulation of actin filament based process	GO:0032970	42	0.021
negative regulation of cellular protein metabolic process	GO:0032269	85	0.021
cell cycle phase transition	GO:0044770	140	0.020
regulation of transposition	GO:0010528	13	0.020
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.020
lipid metabolic process	GO:0006629	121	0.020
imaginal disc derived wing morphogenesis	GO:0007476	337	0.020
regulation of rna splicing	GO:0043484	69	0.020
negative regulation of rna biosynthetic process	GO:1902679	240	0.020
alternative mrna splicing via spliceosome	GO:0000380	60	0.020
tissue morphogenesis	GO:0048729	297	0.020
positive regulation of mitotic cell cycle phase transition	GO:1901992	20	0.020
wound healing	GO:0042060	75	0.019
protein catabolic process	GO:0030163	101	0.019
regulation of cellular component biogenesis	GO:0044087	201	0.019
response to abiotic stimulus	GO:0009628	341	0.019
protein polyubiquitination	GO:0000209	11	0.019
mitotic g2 dna damage checkpoint	GO:0007095	69	0.018
positive regulation of signaling	GO:0023056	243	0.018
mitotic cell cycle embryonic	GO:0045448	38	0.018
phagocytosis	GO:0006909	215	0.018
dna conformation change	GO:0071103	105	0.018
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.017
regulation of transcription factor import into nucleus	GO:0042990	22	0.017
organonitrogen compound metabolic process	GO:1901564	318	0.017
chromosome organization	GO:0051276	360	0.017
genitalia development	GO:0048806	26	0.017
morphogenesis of an epithelium	GO:0002009	276	0.016
nuclear transport	GO:0051169	72	0.016
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.016
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.016
chromatin modification	GO:0016568	147	0.016
oocyte localization involved in germarium derived egg chamber formation	GO:0030720	12	0.016
rna splicing	GO:0008380	83	0.016
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.016
regulation of establishment of protein localization	GO:0070201	61	0.016
mitotic dna damage checkpoint	GO:0044773	74	0.015
rna interference	GO:0016246	27	0.015
synapse assembly	GO:0007416	143	0.015
protein targeting	GO:0006605	64	0.015
cytoplasmic mrna processing body assembly	GO:0033962	10	0.015	Human
gonad development	GO:0008406	50	0.015
response to endogenous stimulus	GO:0009719	119	0.015
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.014
regulation of organelle organization	GO:0033043	196	0.014
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.014
response to nitrogen compound	GO:1901698	90	0.014
small gtpase mediated signal transduction	GO:0007264	88	0.014
nucleic acid transport	GO:0050657	46	0.014
positive regulation of protein metabolic process	GO:0051247	128	0.014
reproductive structure development	GO:0048608	74	0.014
antimicrobial humoral response	GO:0019730	99	0.013
positive regulation of lipid metabolic process	GO:0045834	4	0.013
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.013
germ line cyst formation	GO:0048134	44	0.013
dna packaging	GO:0006323	91	0.013
transposition rna mediated	GO:0032197	3	0.013
positive regulation of transport	GO:0051050	92	0.013
regulation of protein export from nucleus	GO:0046825	3	0.012
proteolysis	GO:0006508	192	0.012
regulation of oskar mrna translation	GO:0046011	8	0.012
multi organism reproductive behavior	GO:0044705	121	0.012
morphogenesis of follicular epithelium	GO:0016333	36	0.012
maintenance of protein location in cell	GO:0032507	26	0.012
regulation of protein complex assembly	GO:0043254	42	0.012
stem cell development	GO:0048864	79	0.012
axon choice point recognition	GO:0016198	26	0.012
germarium derived oocyte fate determination	GO:0007294	26	0.012
negative regulation of cell cycle process	GO:0010948	109	0.012
establishment of protein localization	GO:0045184	163	0.012
cellular response to radiation	GO:0071478	52	0.011
nuclear transcribed mrna poly a tail shortening	GO:0000289	12	0.011
regulation of intracellular protein transport	GO:0033157	46	0.011
negative regulation of cell cycle	GO:0045786	116	0.011
germarium derived oocyte differentiation	GO:0030706	29	0.011
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.011
regulation of hemocyte proliferation	GO:0035206	37	0.011
histone h3 k9 modification	GO:0061647	12	0.011
response to temperature stimulus	GO:0009266	106	0.011
long term memory	GO:0007616	62	0.011
ubiquitin dependent protein catabolic process	GO:0006511	78	0.011
defense response	GO:0006952	300	0.011
establishment of ommatidial planar polarity	GO:0042067	49	0.011
regulation of cell differentiation	GO:0045595	302	0.011
cellular response to light stimulus	GO:0071482	37	0.010
female germ line cyst formation	GO:0048135	42	0.010
head development	GO:0060322	135	0.010
positive regulation of cell cycle	GO:0045787	43	0.010
growth	GO:0040007	359	0.010
positive regulation of cellular component biogenesis	GO:0044089	80	0.010
peptide metabolic process	GO:0006518	80	0.010
muscle cell differentiation	GO:0042692	103	0.010
regulation of actin filament polymerization	GO:0030833	25	0.010
meiotic nuclear division	GO:0007126	151	0.010
meiotic chromosome condensation	GO:0010032	3	0.010
regulation of cellular response to stress	GO:0080135	89	0.010

tral disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
benign neoplasm	DOID:0060072	0.026
disease of cellular proliferation	DOID:14566	0.026
muscular disease	DOID:0080000	0.014
musculoskeletal system disease	DOID:17	0.014
myopathy	DOID:423	0.014
muscle tissue disease	DOID:66	0.014
disease of anatomical entity	DOID:7	0.014

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