Drosophila melanogaster

52 known processes

l(2)efl (Dmel_CG4533)

lethal (2) essential for life

(Aliases: Dmel\CG4533,el(2)13-1,CG4533,l(2)59Fa,l(2)13-1,l(2)Efl,L(2)efl)

l(2)efl biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
agingGO:00075681430.748
multicellular organismal agingGO:00102591400.227
determination of adult lifespanGO:00083401370.139
catabolic processGO:00090564090.094
Fly
cellular response to radiationGO:0071478520.091
intracellular signal transductionGO:00355563000.091
striated muscle cell differentiationGO:0051146900.087
innate immune response activating signal transductionGO:000275820.086
macromolecule catabolic processGO:00090571610.084
regulation of intracellular signal transductionGO:19025312360.082
positive regulation of nitrogen compound metabolic processGO:00511733540.081
phosphorylationGO:00163102940.074
organonitrogen compound metabolic processGO:19015643180.067
kidney developmentGO:000182230.056
immune response activating signal transductionGO:000275720.055
immune response regulating signaling pathwayGO:000276420.054
small molecule metabolic processGO:00442813050.052
organonitrogen compound catabolic processGO:19015651280.051
signal transduction by phosphorylationGO:00230141070.050
organic substance catabolic processGO:19015753080.050
humoral immune responseGO:00069591170.050
muscle structure developmentGO:00610612240.046
response to abiotic stimulusGO:00096283410.046
actin filament based processGO:00300292200.044
actin cytoskeleton organizationGO:00300362060.042
regulation of phosphate metabolic processGO:00192202100.041
cellular catabolic processGO:00442483720.041
Fly
nucleobase containing compound catabolic processGO:00346551650.041
response to organic substanceGO:00100332840.040
Fly
mapk cascadeGO:00001651070.039
cell agingGO:000756920.039
biological adhesionGO:00226101380.039
positive regulation of response to stimulusGO:00485843230.038
negative regulation of response to stimulusGO:00485852580.038
muscle cell differentiationGO:00426921030.038
appendage morphogenesisGO:00351073970.038
regulation of phosphorus metabolic processGO:00511742100.038
single organism catabolic processGO:00447122280.037
negative regulation of cellular metabolic processGO:00313243820.036
positive regulation of transcription dna templatedGO:00458932660.036
response to external biotic stimulusGO:00432072930.036
activation of innate immune responseGO:000221840.035
defense responseGO:00069523000.035
carbohydrate derivative metabolic processGO:19011352170.034
carbohydrate derivative catabolic processGO:19011361180.033
negative regulation of cell communicationGO:00106482230.033
response to biotic stimulusGO:00096072940.033
cellular response to chemical stimulusGO:00708871990.032
homeostatic processGO:00425921990.031
defense response to bacteriumGO:00427421780.031
oxoacid metabolic processGO:00434361030.031
endocytosisGO:00068973100.030
negative regulation of nucleobase containing compound metabolic processGO:00459342610.030
vesicle mediated transportGO:00161923810.030
open tracheal system developmentGO:00074242040.030
positive regulation of immune system processGO:0002684680.030
pattern recognition receptor signaling pathwayGO:000222120.029
response to oxygen containing compoundGO:19017002000.028
Fly
tube morphogenesisGO:00352391910.028
embryonic development via the syncytial blastodermGO:00017001480.028
defense response to other organismGO:00985422250.027
response to endogenous stimulusGO:00097191190.027
Fly
immune system developmentGO:0002520570.027
positive regulation of cell communicationGO:00106472500.026
cellular component assembly involved in morphogenesisGO:00109271510.026
organic acid metabolic processGO:00060821030.025
single organism behaviorGO:00447083910.025
regulation of cell differentiationGO:00455953020.025
morphogenesis of an epitheliumGO:00020092760.025
positive regulation of phosphorus metabolic processGO:00105621390.025
organophosphate metabolic processGO:00196371950.025
single organism biosynthetic processGO:00447112060.025
positive regulation of nucleobase containing compound metabolic processGO:00459353320.024
actin filament organizationGO:00070151260.024
cellular nitrogen compound catabolic processGO:00442701650.024
cell adhesionGO:00071551360.024
immune system processGO:00023763470.024
macromolecular complex assemblyGO:00650032560.024
regulation of transcription from rna polymerase ii promoterGO:00063573780.023
lipopolysaccharide mediated signaling pathwayGO:003166310.023
wing disc morphogenesisGO:00074723440.023
positive regulation of phosphate metabolic processGO:00459371390.023
response to other organismGO:00517072930.022
chromosome organizationGO:00512763600.022
positive regulation of signal transductionGO:00099672230.022
response to high light intensityGO:000964410.022
cellular protein modification processGO:00064644380.022
cellular amino acid metabolic processGO:0006520610.022
glycosyl compound metabolic processGO:19016571270.022
positive regulation of cellular biosynthetic processGO:00313283160.022
regulation of innate immune responseGO:0045088710.022
response to lipopolysaccharideGO:003249640.022
cellular response to abiotic stimulusGO:0071214580.022
body morphogenesisGO:001017120.021
regulation of cell shapeGO:00083601130.021
regulation of cellular amine metabolic processGO:003323830.021
transcription from rna polymerase ii promoterGO:00063663680.021
negative regulation of nitrogen compound metabolic processGO:00511722650.021
negative regulation of cell differentiationGO:00455961430.021
positive regulation of macromolecule biosynthetic processGO:00105572830.020
cellular response to organic substanceGO:00713101320.020
regulation of phosphorylationGO:00423251470.020
organelle fissionGO:00482853400.020
regulation of mapk cascadeGO:0043408920.020
imaginal disc derived appendage developmentGO:00487373990.020
stress activated protein kinase signaling cascadeGO:0031098550.020
organic cyclic compound catabolic processGO:19013611680.020
regulation of protein metabolic processGO:00512462560.020
purine ribonucleoside triphosphate catabolic processGO:00092071080.020
regulation of molecular functionGO:00650092170.019
purine ribonucleoside triphosphate metabolic processGO:00092051190.019
regulation of catabolic processGO:00098941700.019
Fly
syncytium formation by plasma membrane fusionGO:0000768430.019
nucleoside phosphate catabolic processGO:19012921100.019
cellular amine metabolic processGO:0044106120.019
posttranscriptional regulation of gene expressionGO:00106081450.019
positive regulation of hydrolase activityGO:0051345780.019
positive regulation of cellular amine metabolic processGO:003324000.019
regulation of anatomical structure morphogenesisGO:00226032420.018
appendage developmentGO:00487364010.018
regulation of immune system processGO:00026821760.018
positive regulation of intracellular signal transductionGO:19025331160.018
jnk cascadeGO:0007254500.018
tube developmentGO:00352952440.018
positive regulation of signalingGO:00230562430.018
peptidyl amino acid modificationGO:00181931050.018
myotube differentiationGO:0014902460.018
regulation of cellular catabolic processGO:00313291570.018
Fly
nucleoside metabolic processGO:00091161270.018
small gtpase mediated signal transductionGO:0007264880.018
digestive system developmentGO:00551231490.018
cellular response to molecule of bacterial originGO:007121930.017
immune responseGO:00069552460.017
regulation of multicellular organismal developmentGO:20000264140.017
regulation of cellular ketone metabolic processGO:001056530.017
cellular response to lipopolysaccharideGO:007122230.017
regulation of cellular amino acid metabolic processGO:000652100.017
regulation of immune responseGO:00507761180.017
regulation of cellular component biogenesisGO:00440872010.017
imaginal disc derived wing morphogenesisGO:00074763370.017
nucleoside phosphate metabolic processGO:00067531620.017
negative regulation of signal transductionGO:00099682060.017
purine ribonucleoside metabolic processGO:00461281270.016
stem cell differentiationGO:00488631170.016
syncytium formationGO:0006949430.016
heterocycle catabolic processGO:00467001660.016
protein catabolic processGO:00301631010.016
myoblast fusionGO:0007520430.016
organelle assemblyGO:00709251980.016
regulation of catalytic activityGO:00507901850.016
purine nucleoside metabolic processGO:00422781270.016
cellular response to light stimulusGO:0071482370.016
nucleoside triphosphate metabolic processGO:00091411200.016
stress activated mapk cascadeGO:0051403520.016
protein phosphorylationGO:00064681690.016
growthGO:00400073590.016
regulation of growthGO:00400082330.016
regulation of cellular response to stressGO:0080135890.016
positive regulation of nucleotide metabolic processGO:0045981550.016
single organism carbohydrate metabolic processGO:0044723720.016
hematopoietic progenitor cell differentiationGO:000224410.015
regulation of organelle organizationGO:00330431960.015
establishment of localization in cellGO:00516494020.015
response to virusGO:0009615280.015
nucleobase containing small molecule metabolic processGO:00550861740.015
cellular ketone metabolic processGO:0042180240.015
regulation of mitotic cell cycleGO:00073461900.015
nucleotide metabolic processGO:00091171610.015
positive regulation of biosynthetic processGO:00098913160.015
antimicrobial humoral responseGO:0019730990.015
defense response to gram negative bacteriumGO:0050829940.015
purine nucleoside triphosphate catabolic processGO:00091461080.015
mesoderm developmentGO:0007498780.015
cell motilityGO:00488702510.014
compound eye developmentGO:00487493070.014
negative regulation of cell cycle phase transitionGO:19019881030.014
dendrite morphogenesisGO:00488131990.014
negative regulation of cellular biosynthetic processGO:00313272770.014
ribonucleoside triphosphate metabolic processGO:00091991190.014
regulation of cell deathGO:00109411730.014
response to bacteriumGO:00096171980.014
post embryonic appendage morphogenesisGO:00351203850.014
positive regulation of catalytic activityGO:00430851180.014
regulation of ras protein signal transductionGO:0046578930.014
regionalizationGO:00030024160.014
defense response to virusGO:0051607230.014
positive regulation of cell migrationGO:003033520.014
protein localizationGO:00081042840.014
negative regulation of intracellular signal transductionGO:1902532570.014
protein complex biogenesisGO:00702712010.014
positive regulation of macromolecule metabolic processGO:00106044050.014
protein modification processGO:00362114380.014
regulation of muscle cell differentiationGO:005114780.014
aminoglycan metabolic processGO:0006022180.014
response to organonitrogen compoundGO:0010243750.014
Fly
dna metabolic processGO:00062592270.013
cellular response to biotic stimulusGO:007121640.013
eye morphogenesisGO:00485922600.013
cellular response to light intensityGO:007148410.013
purine ribonucleotide metabolic processGO:00091501450.013
regulation of response to stressGO:00801342000.013
purine nucleotide metabolic processGO:00061631460.013
positive regulation of cellular catabolic processGO:0031331950.013
purine containing compound metabolic processGO:00725211550.013
cell deathGO:00082192790.013
positive regulation of rna biosynthetic processGO:19026802660.013
localization of cellGO:00516742570.013
regulation of cellular localizationGO:00603411360.013
regulation of antimicrobial humoral responseGO:0002759500.013
imaginal disc derived appendage morphogenesisGO:00351143950.013
embryo development ending in birth or egg hatchingGO:00097921520.013
anatomical structure homeostasisGO:0060249970.013
cellular homeostasisGO:0019725800.013
negative regulation of signalingGO:00230572190.013
adult behaviorGO:00305341370.013
nuclear divisionGO:00002803320.013
phagocytosisGO:00069092150.013
respiratory system developmentGO:00605412130.012
positive regulation of molecular functionGO:00440931360.012
cellular macromolecule catabolic processGO:00442651360.012
regulation of circadian sleep wake cycle sleepGO:0045187210.012
negative regulation of immune system processGO:0002683500.012
microtubule polymerization or depolymerizationGO:0031109390.012
ribonucleotide catabolic processGO:00092611090.012
purine ribonucleoside catabolic processGO:00461301120.012
purine nucleoside triphosphate metabolic processGO:00091441190.012
protein complex assemblyGO:00064612000.012
mitotic g2 dna damage checkpointGO:0007095690.012
organonitrogen compound biosynthetic processGO:19015661170.012
negative regulation of developmental processGO:00510932010.012
positive regulation of cellular amino acid metabolic processGO:004576400.012
ion homeostasisGO:0050801550.012
cellular response to ionizing radiationGO:0071479150.012
negative regulation of multicellular organismal processGO:00512411420.012
ribonucleoside metabolic processGO:00091191270.012
purine containing compound catabolic processGO:00725231120.012
positive regulation of phosphorylationGO:0042327870.012
mitochondrion organizationGO:0007005650.012
response to radiationGO:00093141550.011
embryonic morphogenesisGO:00485982060.011
regulation of jnk cascadeGO:0046328400.011
ras protein signal transductionGO:0007265880.011
positive regulation of peptidyl tyrosine phosphorylationGO:005073140.011
antibacterial peptide productionGO:0002778220.011
negative regulation of phosphate metabolic processGO:0045936450.011
regulation of i kappab kinase nf kappab signalingGO:004312220.011
aromatic compound catabolic processGO:00194391660.011
cellular macromolecule localizationGO:00707272200.011
positive regulation of catabolic processGO:00098961050.011
forebrain developmentGO:003090020.011
deathGO:00162652840.011
positive regulation of antibacterial peptide biosynthetic processGO:0006963200.011
hematopoietic or lymphoid organ developmentGO:0048534570.011
notch signaling pathwayGO:00072191200.011
purine nucleoside catabolic processGO:00061521120.011
sarcomere organizationGO:0045214260.011
mitotic nuclear divisionGO:00070672130.011
regulation of apoptotic processGO:00429811300.011
locomotory behaviorGO:00076261760.011
ribonucleoside catabolic processGO:00424541120.011
regulation of cellular protein metabolic processGO:00322682430.011
regulation of multi organism processGO:00439001310.011
regulation of gene expression epigeneticGO:00400291280.011
regulation of stress activated mapk cascadeGO:0032872410.010
establishment of protein localizationGO:00451841630.010
regulation of purine nucleotide catabolic processGO:0033121480.010
amine metabolic processGO:0009308120.010
mitotic cell cycle checkpointGO:0007093880.010
regulation of purine nucleotide metabolic processGO:1900542620.010
negative regulation of catabolic processGO:0009895360.010
detection of external biotic stimulusGO:009858120.010
regulation of cell cycleGO:00517262910.010
positive regulation of transportGO:0051050920.010
regulation of protein phosphorylationGO:0001932640.010
translationGO:0006412690.010
wnt signaling pathwayGO:0016055980.010
chemical homeostasisGO:0048878920.010
developmental growthGO:00485892800.010
negative regulation of rna metabolic processGO:00512532510.010
single organism cellular localizationGO:19025801800.010
actin filament based movementGO:0030048260.010

l(2)efl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.052
cardiovascular system diseaseDOID:128700.040
musculoskeletal system diseaseDOID:1700.016
muscle tissue diseaseDOID:6600.016
muscular diseaseDOID:008000000.016
nervous system diseaseDOID:86300.013
sensory system diseaseDOID:005015500.012
artery diseaseDOID:005082800.012
hypertensionDOID:1076300.012
vascular diseaseDOID:17800.012
eye and adnexa diseaseDOID:149200.011
eye diseaseDOID:561400.011