Drosophila melanogaster

83 known processes

Buffy (Dmel_CG8238)

CG8238 gene product from transcript CG8238-RA

(Aliases: Buffy/Borg2,Drob2,dBorg-2,CG8238,buffy,dBORG-2/BUFFY,Dmel\CG8238,BUFFY,Bcl-2-48AE,Dbx,Buffy/dBorg-2,Buffy/DBorg-2,dbuffy,dBorg2)

Buffy biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
developmental programmed cell deathGO:00106231380.148
programmed cell deathGO:00125012570.126
response to other organismGO:00517072930.103
protein modification processGO:00362114380.090
positive regulation of response to stimulusGO:00485843230.072
response to abiotic stimulusGO:00096283410.070
Fly
lipid metabolic processGO:00066291210.067
multicellular organismal agingGO:00102591400.060
response to external biotic stimulusGO:00432072930.060
positive regulation of signal transductionGO:00099672230.059
response to organic substanceGO:00100332840.058
columnar cuboidal epithelial cell developmentGO:00020662490.057
small molecule metabolic processGO:00442813050.056
organonitrogen compound metabolic processGO:19015643180.056
positive regulation of macromolecule metabolic processGO:00106044050.056
Human
regulation of programmed cell deathGO:00430671520.055
carboxylic acid metabolic processGO:0019752920.053
deathGO:00162652840.052
positive regulation of signalingGO:00230562430.051
imaginal disc derived appendage morphogenesisGO:00351143950.050
immune responseGO:00069552460.050
cellular catabolic processGO:00442483720.048
morphogenesis of embryonic epitheliumGO:0016331940.048
cellular protein modification processGO:00064644380.048
regulation of response to stressGO:00801342000.047
cell deathGO:00082192790.046
autophagyGO:00069141080.046
tissue morphogenesisGO:00487292970.045
defense response to other organismGO:00985422250.045
positive regulation of cell communicationGO:00106472500.044
defense responseGO:00069523000.043
establishment of localization in cellGO:00516494020.043
organic hydroxy compound metabolic processGO:1901615830.043
phosphorylationGO:00163102940.043
agingGO:00075681430.043
regulation of cellular protein metabolic processGO:00322682430.041
Human
response to oxygen containing compoundGO:19017002000.040
regulation of protein metabolic processGO:00512462560.039
Human
chemical homeostasisGO:0048878920.039
open tracheal system developmentGO:00074242040.039
organelle fissionGO:00482853400.038
cell divisionGO:00513012480.038
oxoacid metabolic processGO:00434361030.038
protein ubiquitinationGO:0016567700.037
detection of stimulusGO:00516061560.037
forebrain developmentGO:003090020.037
columnar cuboidal epithelial cell differentiationGO:00020652560.036
regulation of apoptotic processGO:00429811300.036
cellular response to dna damage stimulusGO:00069742230.036
Fly
catabolic processGO:00090564090.035
immune system processGO:00023763470.035
regulation of immune system processGO:00026821760.035
cellular amino acid metabolic processGO:0006520610.035
regulation of intracellular signal transductionGO:19025312360.035
response to bacteriumGO:00096171980.035
regulation of synaptic transmissionGO:0050804690.035
proteolysisGO:00065081920.034
Human
immune response regulating signaling pathwayGO:000276420.034
immune effector processGO:0002252980.034
endocytosisGO:00068973100.034
regulation of cell deathGO:00109411730.034
apoptotic processGO:00069151590.034
epithelial cell differentiationGO:00308553220.033
response to biotic stimulusGO:00096072940.033
cellular macromolecule catabolic processGO:00442651360.033
vesicle mediated transportGO:00161923810.032
ovarian follicle cell migrationGO:00072971210.032
protein modification by small protein conjugationGO:0032446790.032
neurological system processGO:00508773580.031
posttranscriptional regulation of gene expressionGO:00106081450.031
organic substance transportGO:00717022570.031
gland morphogenesisGO:00226121450.031
negative regulation of developmental processGO:00510932010.031
defense response to bacteriumGO:00427421780.031
single organism biosynthetic processGO:00447112060.030
organic substance catabolic processGO:19015753080.030
imaginal disc derived appendage developmentGO:00487373990.030
tube morphogenesisGO:00352391910.030
immune response activating signal transductionGO:000275720.030
intracellular signal transductionGO:00355563000.030
Human Fly
cellular response to chemical stimulusGO:00708871990.029
gliogenesisGO:0042063800.029
Rat
apoptotic process involved in developmentGO:1902742200.029
Fly
response to radiationGO:00093141550.029
Fly
regulation of catalytic activityGO:00507901850.029
Human
body morphogenesisGO:001017120.028
chromatin modificationGO:00165681470.028
nuclear divisionGO:00002803320.028
response to endogenous stimulusGO:00097191190.028
salivary gland morphogenesisGO:00074351450.028
regulation of catabolic processGO:00098941700.027
response to starvationGO:0042594970.027
embryonic pattern specificationGO:00098801740.027
cell proliferationGO:00082832990.027
Human
morphogenesis of an epitheliumGO:00020092760.027
glial cell differentiationGO:0010001350.027
Rat
regulation of multi organism processGO:00439001310.027
regulation of cellular catabolic processGO:00313291570.027
single organism catabolic processGO:00447122280.027
organic acid metabolic processGO:00060821030.027
regulation of multicellular organismal developmentGO:20000264140.027
response to organic cyclic compoundGO:0014070890.027
homeostatic processGO:00425921990.027
Fly
exocrine system developmentGO:00352721620.026
response to glucoseGO:000974920.026
positive regulation of rna metabolic processGO:00512542710.026
regulation of cellular amino acid metabolic processGO:000652100.026
positive regulation of cellular amino acid metabolic processGO:004576400.025
amine metabolic processGO:0009308120.025
segmentationGO:00352822070.025
cellular amine metabolic processGO:0044106120.025
synaptic transmissionGO:00072682880.025
compound eye developmentGO:00487493070.025
protein modification by small protein conjugation or removalGO:00706471060.024
macroautophagyGO:0016236420.024
regulation of defense responseGO:00313471020.024
negative regulation of multicellular organismal processGO:00512411420.024
positive regulation of cell deathGO:0010942690.024
morphogenesis of a polarized epitheliumGO:0001738930.024
post embryonic appendage morphogenesisGO:00351203850.024
dna damage checkpointGO:0000077780.024
response to hexoseGO:000974630.024
regulation of immune responseGO:00507761180.023
hormone metabolic processGO:0042445330.023
regulation of proteolysisGO:0030162870.023
Human
chromosome segregationGO:00070591570.023
positive regulation of immune responseGO:0050778630.023
chaeta developmentGO:0022416970.023
appendage morphogenesisGO:00351073970.023
protein maturationGO:0051604710.023
Human
regulation of cell cycle processGO:00105641810.023
stem cell differentiationGO:00488631170.023
positive regulation of nucleobase containing compound metabolic processGO:00459353320.022
salivary gland developmentGO:00074311620.022
ion transportGO:00068111450.022
positive regulation of hydrolase activityGO:0051345780.022
Human
response to monosaccharideGO:003428440.022
regulation of cell cycleGO:00517262910.022
histolysisGO:00075591020.022
cellular ketone metabolic processGO:0042180240.022
regulation of transcription from rna polymerase ii promoterGO:00063573780.022
organic cyclic compound catabolic processGO:19013611680.022
negative regulation of nervous system developmentGO:0051961920.022
positive regulation of peptidase activityGO:0010952290.022
Human
cellular response to hexose stimulusGO:007133110.021
mrna metabolic processGO:00160711240.021
regulation of response to external stimulusGO:00321011150.021
positive regulation of cysteine type endopeptidase activityGO:2001056240.021
Human
regulation of phosphorus metabolic processGO:00511742100.021
regulation of response to biotic stimulusGO:0002831630.021
epithelial cell developmentGO:00020642740.021
appendage developmentGO:00487364010.021
single organism cellular localizationGO:19025801800.021
positive regulation of nitrogen compound metabolic processGO:00511733540.020
establishment of protein localizationGO:00451841630.020
cellular amide metabolic processGO:0043603800.020
protein phosphorylationGO:00064681690.020
salivary gland cell autophagic cell deathGO:0035071830.020
positive regulation of transportGO:0051050920.020
positive regulation of macroautophagyGO:001623980.020
nitrogen compound transportGO:0071705850.020
protein localizationGO:00081042840.020
phagocytosisGO:00069092150.019
intracellular transportGO:00469072280.019
tissue deathGO:00162711020.019
positive regulation of gene expressionGO:00106282900.019
establishment or maintenance of cell polarityGO:00071631670.019
pigment metabolic processGO:0042440840.019
dorsal ventral pattern formationGO:00099531330.019
g protein coupled receptor signaling pathwayGO:00071861360.019
steroid catabolic processGO:000670610.019
cellular response to organic substanceGO:00713101320.019
negative regulation of programmed cell deathGO:0043069720.019
cellular response to abiotic stimulusGO:0071214580.019
mesenchymal cell differentiationGO:004876210.019
wing disc morphogenesisGO:00074723440.019
mitotic dna integrity checkpointGO:0044774750.018
central nervous system developmentGO:00074172010.018
Rat
camera type eye developmentGO:004301040.018
developmental maturationGO:00217001720.018
mitotic nuclear divisionGO:00070672130.018
negative regulation of cell deathGO:0060548810.018
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.018
humoral immune responseGO:00069591170.018
regulation of cellular amine metabolic processGO:003323830.018
locomotory behaviorGO:00076261760.018
synapse organizationGO:00508081960.018
multicellular organismal reproductive behaviorGO:00330571100.018
regulation of mitotic cell cycle phase transitionGO:19019901300.018
ovarian follicle cell developmentGO:00307072480.017
regulation of transportGO:00510491810.017
mapk cascadeGO:00001651070.017
molting cycle processGO:0022404290.017
positive regulation of cellular amine metabolic processGO:003324000.017
positive regulation of transcription dna templatedGO:00458932660.017
actin cytoskeleton organizationGO:00300362060.017
regulation of execution phase of apoptosisGO:190011750.017
Human
acylglycerol biosynthetic processGO:004646320.017
developmental growthGO:00485892800.017
urogenital system developmentGO:0001655720.017
positive regulation of protein metabolic processGO:00512471280.017
Human
multi organism reproductive behaviorGO:00447051210.017
regulation of cellular ketone metabolic processGO:001056530.017
determination of adult lifespanGO:00083401370.017
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280230.017
Human
positive regulation of cellular protein metabolic processGO:00322701180.017
Human
cellular response to ionizing radiationGO:0071479150.017
peptidyl amino acid modificationGO:00181931050.017
neuropeptide signaling pathwayGO:0007218450.016
regulation of molecular functionGO:00650092170.016
Human
macromolecule catabolic processGO:00090571610.016
apoptotic process involved in morphogenesisGO:006056130.016
Fly
positive regulation of catalytic activityGO:00430851180.016
Human
response to nitrogen compoundGO:1901698900.016
cytoplasmic transportGO:00164821300.016
positive regulation of intracellular signal transductionGO:19025331160.016
negative regulation of cellular metabolic processGO:00313243820.016
organelle localizationGO:00516401480.016
transcription from rna polymerase ii promoterGO:00063663680.016
negative regulation of mitotic cell cycleGO:00459301090.016
male mating behaviorGO:0060179700.016
cell type specific apoptotic processGO:0097285380.016
Mouse Fly
protein processingGO:0016485680.016
Human
salivary gland histolysisGO:0035070880.016
signal transduction in response to dna damageGO:004277030.016
glial cell migrationGO:0008347310.016
retina development in camera type eyeGO:006004140.016
negative regulation of gene expressionGO:00106293870.016
developmental pigmentationGO:0048066680.016
positive regulation of defense responseGO:0031349590.016
multi multicellular organism processGO:00447061230.015
response to lipopolysaccharideGO:003249640.015
innate immune response activating signal transductionGO:000275820.015
regulation of innate immune responseGO:0045088710.015
extracellular structure organizationGO:0043062460.015
chromosome organizationGO:00512763600.015
positive regulation of programmed cell deathGO:0043068620.015
kidney developmentGO:000182230.015
innate immune responseGO:00450871440.015
regulation of cellular amide metabolic processGO:0034248390.015
molting cycleGO:0042303560.015
stem cell developmentGO:0048864790.015
organic hydroxy compound biosynthetic processGO:1901617210.015
mitotic cell cycle phase transitionGO:00447721380.015
dendrite developmentGO:00163582040.015
sterol homeostasisGO:005509240.015
telencephalon developmentGO:002153720.015
secondary metabolic processGO:0019748750.015
dna integrity checkpointGO:0031570810.015
regulation of phosphate metabolic processGO:00192202100.015
positive regulation of cellular biosynthetic processGO:00313283160.015
cellular protein catabolic processGO:0044257830.015
regulation of wnt signaling pathwayGO:0030111680.015
positive regulation of phosphate metabolic processGO:00459371390.015
tube developmentGO:00352952440.015
negative regulation of response to stimulusGO:00485852580.015
axis specificationGO:00097981670.015
autophagic cell deathGO:0048102830.015
anion homeostasisGO:005508130.014
cell cycle checkpointGO:0000075950.014
hematopoietic progenitor cell differentiationGO:000224410.014
localization of cellGO:00516742570.014
sex differentiationGO:0007548810.014
Rat
positive regulation of macromolecule biosynthetic processGO:00105572830.014
meiotic cell cycleGO:00513211710.014
defense response to gram negative bacteriumGO:0050829940.014
regulation of translationGO:0006417560.014
negative regulation of cell cycle processGO:00109481090.014
neutral lipid biosynthetic processGO:004646020.014
regulation of humoral immune responseGO:0002920510.014
positive regulation of immune system processGO:0002684680.014
regionalizationGO:00030024160.014
cell cycle phase transitionGO:00447701400.014
negative regulation of nucleobase containing compound metabolic processGO:00459342610.014
sensory perception of smellGO:0007608800.014
regulation of i kappab kinase nf kappab signalingGO:004312220.014
establishment of vesicle localizationGO:0051650510.014
regulation of cysteine type endopeptidase activityGO:2000116270.014
Human
positive regulation of biosynthetic processGO:00098913160.014
cellular homeostasisGO:0019725800.014
Fly
rna localizationGO:00064031150.014
sensory organ morphogenesisGO:00905962600.013
eye morphogenesisGO:00485922600.013
regulation of localizationGO:00328792750.013
cell migrationGO:00164772380.013
antimicrobial humoral responseGO:0019730990.013
hormone catabolic processGO:004244730.013
gland developmentGO:00487321910.013
stress activated mapk cascadeGO:0051403520.013
cellular response to extracellular stimulusGO:0031668640.013
positive regulation of apoptotic processGO:0043065470.013
Human Rat
protein catabolic processGO:00301631010.013
positive regulation of molecular functionGO:00440931360.013
Human
eye developmentGO:00016543230.013
protein transportGO:00150311550.013
negative regulation of cell differentiationGO:00455961430.013
regulation of notch signaling pathwayGO:00085931000.013
regulation of intracellular transportGO:0032386640.013
cuticle developmentGO:0042335860.013
signal transduction by phosphorylationGO:00230141070.013
hindgut developmentGO:0061525580.013
nuclear transportGO:0051169720.013
meiotic chromosome segregationGO:0045132590.013
cellular nitrogen compound catabolic processGO:00442701650.013
connective tissue developmentGO:006144830.013
regulation of protein modification processGO:00313991120.013
regulation of cellular localizationGO:00603411360.013
hindgut morphogenesisGO:0007442580.013
molting cycle chitin based cuticleGO:0007591560.013
regulation of mitotic cell cycleGO:00073461900.013
digestive tract developmentGO:00485651490.013
ameboidal type cell migrationGO:00016671510.013
positive regulation of endopeptidase activityGO:0010950260.013
Human
cell cycle arrestGO:000705040.013
amide biosynthetic processGO:0043604420.012
extrinsic apoptotic signaling pathwayGO:009719110.012
regulation of cellular response to stressGO:0080135890.012
translationGO:0006412690.012
adult behaviorGO:00305341370.012
activation of innate immune responseGO:000221840.012
positive regulation of response to biotic stimulusGO:0002833310.012
dorsal ventral pattern formation imaginal discGO:0007450510.012
heterocycle catabolic processGO:00467001660.012
negative regulation of cellular protein metabolic processGO:0032269850.012
regulation of protein localizationGO:0032880760.012
negative regulation of signalingGO:00230572190.012
regulation of phosphorylationGO:00423251470.012
pattern recognition receptor signaling pathwayGO:000222120.012
small gtpase mediated signal transductionGO:0007264880.012
imaginal disc pattern formationGO:0007447910.012
regulation of immune effector processGO:0002697520.012
tissue migrationGO:00901301550.012
outflow tract morphogenesisGO:000315140.012
response to ethanolGO:0045471590.012
positive regulation of phosphorus metabolic processGO:00105621390.012
cellular protein localizationGO:00346131600.012
cellular response to monosaccharide stimulusGO:007132620.012
cellular response to nutrient levelsGO:0031669620.012
cellular response to radiationGO:0071478520.012
kidney morphogenesisGO:006099330.012
triglyceride biosynthetic processGO:001943220.012
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:007005940.012
single organism membrane organizationGO:0044802930.012
positive regulation of nucleic acid templated transcriptionGO:19035082660.012
positive regulation of cell motilityGO:200014730.012
cell motilityGO:00488702510.012
positive regulation of wnt signaling pathwayGO:0030177250.012
regulation of mapk cascadeGO:0043408920.012
positive regulation of i kappab kinase nf kappab signalingGO:004312310.012
nucleobase containing compound catabolic processGO:00346551650.012
compound eye photoreceptor cell differentiationGO:00017511400.011
response to ionizing radiationGO:0010212320.011
Fly
positive regulation of cellular catabolic processGO:0031331950.011
female meiosis chromosome segregationGO:0016321330.011
regulation of antimicrobial peptide biosynthetic processGO:0002805380.011
mitotic cell cycle checkpointGO:0007093880.011
growthGO:00400073590.011
cellular response to mechanical stimulusGO:007126020.011
nucleocytoplasmic transportGO:0006913720.011
negative regulation of erk1 and erk2 cascadeGO:007037330.011
muscle organ developmentGO:00075171270.011
negative regulation of protein metabolic processGO:0051248850.011
positive regulation of catabolic processGO:00098961050.011
mesoderm developmentGO:0007498780.011
leg disc morphogenesisGO:0007478800.011
carbohydrate metabolic processGO:0005975820.011
aromatic compound catabolic processGO:00194391660.011
peripheral nervous system developmentGO:0007422520.011
regulation of protein transportGO:0051223570.011
embryonic morphogenesisGO:00485982060.011
hindbrain developmentGO:003090220.011
antimicrobial peptide productionGO:0002775460.011
limb morphogenesisGO:003510810.011
single organism intracellular transportGO:19025822070.011
androgen metabolic processGO:000820910.011
regulation of nervous system developmentGO:00519602480.011
positive regulation of production of molecular mediator of immune responseGO:0002702280.011
embryonic development via the syncytial blastodermGO:00017001480.011
chromatin organizationGO:00063252070.011
hippo signalingGO:0035329200.010
positive regulation of retinal cell programmed cell deathGO:004667090.010
phosphate ion transportGO:000681740.010
ras protein signal transductionGO:0007265880.010
mrna processingGO:00063971040.010
photoreceptor cell fate commitmentGO:0046552410.010
wnt signaling pathwayGO:0016055980.010
instar larval developmentGO:0002168550.010
positive regulation of rna biosynthetic processGO:19026802660.010
sensory perceptionGO:00076001960.010
negative regulation of nitrogen compound metabolic processGO:00511722650.010
positive regulation of canonical wnt signaling pathwayGO:009026370.010
stress activated protein kinase signaling cascadeGO:0031098550.010
regulation of protein ubiquitinationGO:0031396220.010
cholesterol homeostasisGO:004263230.010
negative regulation of neurogenesisGO:0050768530.010
secretionGO:00469031090.010
mesenchymal cell developmentGO:001403110.010
regulation of endopeptidase activityGO:0052548360.010
Human
reproductive behaviorGO:00190981220.010
digestive system developmentGO:00551231490.010
production of molecular mediator of immune responseGO:0002440460.010
regulation of hydrolase activityGO:0051336970.010
Human
limb developmentGO:006017310.010
peptidyl lysine acetylationGO:0018394390.010
rna processingGO:00063961470.010

Buffy disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.031
urinary system diseaseDOID:1800.016
nervous system diseaseDOID:86300.016
sensory system diseaseDOID:005015500.011
disease of metabolismDOID:001466700.011
inherited metabolic disorderDOID:65500.010