Drosophila melanogaster

147 known processes

Sce (Dmel_CG5595)

Sex combs extra

(Aliases: Ding,dRing1,DRING,dRING,Dmel\CG5595,SCE,dring,Dring,RING1,CG5595,dRING1,Ring/Sce,RING,dRing,Rnf2,Ring)

Sce biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of cellular biosynthetic processGO:00313272770.993
regulation of transcription from rna polymerase ii promoterGO:00063573780.944
Mouse
negative regulation of nitrogen compound metabolic processGO:00511722650.922
negative regulation of macromolecule biosynthetic processGO:00105582700.922
negative regulation of biosynthetic processGO:00098902770.917
chromatin organizationGO:00063252070.909
ovarian follicle cell developmentGO:00307072480.904
negative regulation of gene expressionGO:00106293870.855
negative regulation of cellular metabolic processGO:00313243820.825
negative regulation of transcription dna templatedGO:00458922370.820
negative regulation of rna metabolic processGO:00512532510.761
negative regulation of nucleic acid templated transcriptionGO:19035072400.734
chromosome organizationGO:00512763600.733
negative regulation of developmental processGO:00510932010.688
Worm
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.658
Mouse
negative regulation of nucleobase containing compound metabolic processGO:00459342610.638
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.603
stem cell maintenanceGO:0019827670.596
cell proliferationGO:00082832990.507
protein modification by small protein conjugation or removalGO:00706471060.482
positive regulation of gene expressionGO:00106282900.468
epithelial cell differentiationGO:00308553220.436
embryo development ending in birth or egg hatchingGO:00097921520.434
Zebrafish
negative regulation of rna biosynthetic processGO:19026792400.431
meiotic nuclear divisionGO:00071261510.411
negative regulation of cell proliferationGO:0008285690.408
regionalizationGO:00030024160.398
Mouse
protein localizationGO:00081042840.390
columnar cuboidal epithelial cell differentiationGO:00020652560.388
stem cell differentiationGO:00488631170.377
cellular protein modification processGO:00064644380.370
central nervous system developmentGO:00074172010.367
Rat
nuclear divisionGO:00002803320.357
larval developmentGO:00021641040.340
Worm
transcription from rna polymerase ii promoterGO:00063663680.329
Mouse
positive regulation of rna biosynthetic processGO:19026802660.307
cell maturationGO:00484691440.291
regulation of phosphorylationGO:00423251470.282
cytokinesisGO:0000910900.278
positive regulation of nitrogen compound metabolic processGO:00511733540.269
negative regulation of multicellular organismal processGO:00512411420.265
Worm
protein modification by small protein conjugationGO:0032446790.258
positive regulation of rna metabolic processGO:00512542710.256
regulation of protein metabolic processGO:00512462560.254
regulation of cell differentiationGO:00455953020.251
Zebrafish
positive regulation of macromolecule biosynthetic processGO:00105572830.244
ubiquitin dependent protein catabolic processGO:0006511780.239
meiotic cell cycleGO:00513211710.236
segmentationGO:00352822070.231
regulation of phosphate metabolic processGO:00192202100.225
cellular protein localizationGO:00346131600.223
sex differentiationGO:0007548810.217
Worm
columnar cuboidal epithelial cell developmentGO:00020662490.214
positive regulation of response to stimulusGO:00485843230.213
regulation of epithelial cell proliferationGO:005067840.208
protein modification processGO:00362114380.205
cell migrationGO:00164772380.203
Worm
positive regulation of nucleic acid templated transcriptionGO:19035082660.201
negative regulation of cell differentiationGO:00455961430.199
positive regulation of transcription dna templatedGO:00458932660.196
regulation of cell proliferationGO:00421271630.192
nucleosome positioningGO:001658430.184
epithelial cell developmentGO:00020642740.183
blastoderm segmentationGO:00073501590.181
positive regulation of macromolecule metabolic processGO:00106044050.174
positive regulation of cell communicationGO:00106472500.169
protein catabolic processGO:00301631010.164
protein palmitoylationGO:001834520.162
cytoskeleton dependent cytokinesisGO:0061640810.160
phosphorylationGO:00163102940.160
mitotic cytokinesisGO:0000281500.156
cell divisionGO:00513012480.152
regulation of response to gamma radiationGO:200122840.147
chromatin remodelingGO:0006338720.144
endocytosisGO:00068973100.137
protein complex biogenesisGO:00702712010.134
regulation of wnt signaling pathwayGO:0030111680.132
organelle fissionGO:00482853400.132
single organism cellular localizationGO:19025801800.131
reproductive structure developmentGO:0048608740.127
positive regulation of cell deathGO:0010942690.126
taxisGO:00423303040.123
axon developmentGO:00615642970.122
regulation of cellular protein metabolic processGO:00322682430.122
chromosome segregationGO:00070591570.120
regulation of organelle organizationGO:00330431960.120
vesicle mediated transportGO:00161923810.118
body morphogenesisGO:001017120.115
regulation of response to stressGO:00801342000.113
multicellular organismal reproductive behaviorGO:00330571100.113
dna replicationGO:0006260480.113
positive regulation of programmed cell deathGO:0043068620.111
embryonic organ developmentGO:0048568500.110
Zebrafish
chromatin assembly or disassemblyGO:0006333520.109
reproductive behaviorGO:00190981220.109
establishment or maintenance of cell polarityGO:00071631670.106
positive regulation of cellular component organizationGO:00511301560.104
neuron projection guidanceGO:00974852410.104
chromatin silencingGO:0006342760.103
regulation of phosphorus metabolic processGO:00511742100.101
enzyme linked receptor protein signaling pathwayGO:00071671790.098
wing disc morphogenesisGO:00074723440.098
imaginal disc derived appendage morphogenesisGO:00351143950.096
oocyte developmentGO:00485991240.096
gonad developmentGO:0008406500.096
growthGO:00400073590.096
modification dependent protein catabolic processGO:0019941780.093
negative regulation of response to stimulusGO:00485852580.090
Zebrafish
intracellular transportGO:00469072280.090
dna packagingGO:0006323910.090
neuroblast proliferationGO:0007405740.090
establishment of localization in cellGO:00516494020.089
axonogenesisGO:00074092900.088
chemosensory behaviorGO:00076351060.087
cellular component assembly involved in morphogenesisGO:00109271510.086
proteolysisGO:00065081920.086
mitotic nuclear divisionGO:00070672130.085
germarium derived egg chamber formationGO:00072931010.085
stem cell proliferationGO:0072089880.084
posttranscriptional gene silencing by rnaGO:0035194450.082
multi organism behaviorGO:00517051750.082
gene silencingGO:00164581380.081
multi organism reproductive behaviorGO:00447051210.081
positive regulation of nucleobase containing compound metabolic processGO:00459353320.078
regulation of protein modification processGO:00313991120.076
single organism biosynthetic processGO:00447112060.075
histone h4 acetylationGO:0043967130.074
negative regulation of epithelial cell proliferationGO:005068040.073
regulation of meiosisGO:004002030.073
hindbrain developmentGO:003090220.073
camera type eye morphogenesisGO:004859320.072
Zebrafish Mouse
regulation of gene expression epigeneticGO:00400291280.071
regulation of multicellular organismal developmentGO:20000264140.070
Zebrafish Worm
regulation of mapk cascadeGO:0043408920.069
multi multicellular organism processGO:00447061230.068
cell motilityGO:00488702510.068
Worm
development of primary sexual characteristicsGO:0045137500.067
stem cell developmentGO:0048864790.066
compound eye photoreceptor cell differentiationGO:00017511400.065
regulation of cell developmentGO:00602842150.065
regulation of chromatin modificationGO:1903308280.065
cell fate determinationGO:0001709910.064
genitalia developmentGO:0048806260.063
ribonucleoprotein complex subunit organizationGO:0071826280.063
post embryonic appendage morphogenesisGO:00351203850.063
heterochromatin organizationGO:0070828250.063
spindle organizationGO:00070512530.063
imaginal disc derived wing morphogenesisGO:00074763370.059
cellularizationGO:0007349900.059
dendrite morphogenesisGO:00488131990.059
sensory organ morphogenesisGO:00905962600.058
Zebrafish Mouse
nucleosome organizationGO:0034728590.057
regulation of gene silencingGO:0060968630.057
regulation of dna templated transcription elongationGO:0032784170.056
dendrite developmentGO:00163582040.056
digestive tract morphogenesisGO:00485461270.056
Mouse
notch signaling pathwayGO:00072191200.055
immune responseGO:00069552460.055
gland developmentGO:00487321910.055
regulation of cellular amino acid metabolic processGO:000652100.055
appendage developmentGO:00487364010.054
Zebrafish
protein dna complex subunit organizationGO:0071824860.054
muscle organ developmentGO:00075171270.053
cellular protein catabolic processGO:0044257830.052
germ line stem cell maintenanceGO:0030718500.052
histone modificationGO:00165701060.052
proteasomal protein catabolic processGO:0010498590.051
peptidyl amino acid modificationGO:00181931050.051
female germ line cyst formationGO:0048135420.051
male meiosisGO:0007140520.051
positive regulation of multi organism processGO:0043902400.050
positive regulation of signal transductionGO:00099672230.050
reproductive system developmentGO:0061458740.050
ameboidal type cell migrationGO:00016671510.050
regulation of cellular localizationGO:00603411360.050
heart developmentGO:0007507820.049
negative regulation of signal transductionGO:00099682060.049
Zebrafish
epithelial cell migrationGO:00106311480.047
developmental maturationGO:00217001720.047
histone exchangeGO:0043486210.047
imaginal disc derived appendage developmentGO:00487373990.046
modification dependent macromolecule catabolic processGO:0043632790.045
neural precursor cell proliferationGO:0061351750.045
protein complex assemblyGO:00064612000.045
eye antennal disc developmentGO:0035214600.045
stem cell divisionGO:0017145690.044
negative regulation of wnt signaling pathwayGO:0030178280.044
macromolecular complex assemblyGO:00650032560.043
rhythmic processGO:00485111060.043
epithelium migrationGO:00901321480.043
oocyte differentiationGO:00099941450.042
histone acetylationGO:0016573380.042
compound eye developmentGO:00487493070.041
chemotaxisGO:00069352490.041
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.040
developmental pigmentationGO:0048066680.040
regulation of anatomical structure morphogenesisGO:00226032420.040
ovipositionGO:0018991190.040
wnt signaling pathwayGO:0016055980.039
dna conformation changeGO:00711031050.039
regulation of chromosome organizationGO:0033044640.039
multicellular organismal agingGO:00102591400.039
phagocytosisGO:00069092150.039
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.038
regulation of dna metabolic processGO:0051052340.038
ovarian follicle cell migrationGO:00072971210.037
locomotor rhythmGO:0045475560.037
embryonic morphogenesisGO:00485982060.037
Zebrafish Mouse
regulation of programmed cell deathGO:00430671520.037
Zebrafish
axon guidanceGO:00074112330.036
appendage morphogenesisGO:00351073970.036
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.036
regulation of chromatin organizationGO:1902275320.036
dna templated transcription elongationGO:0006354180.035
camera type eye developmentGO:004301040.035
Zebrafish Mouse
positive regulation of protein metabolic processGO:00512471280.034
covalent chromatin modificationGO:00165691060.034
atp dependent chromatin remodelingGO:0043044220.034
macromolecule catabolic processGO:00090571610.034
negative regulation of signalingGO:00230572190.034
Zebrafish
regulation of growthGO:00400082330.033
dna dependent dna replicationGO:0006261170.033
mapk cascadeGO:00001651070.033
cellular macromolecule localizationGO:00707272200.033
organelle assemblyGO:00709251980.033
cuticle developmentGO:0042335860.033
protein ubiquitinationGO:0016567700.033
positive regulation of cell proliferationGO:0008284470.033
lipoprotein biosynthetic processGO:004215860.033
protein transportGO:00150311550.032
defense responseGO:00069523000.032
regulation of neuroblast proliferationGO:1902692340.032
agingGO:00075681430.032
methylationGO:0032259470.032
tube developmentGO:00352952440.032
Mouse
localization of cellGO:00516742570.032
Worm
negative regulation of cellular component organizationGO:00511291080.032
intracellular signal transductionGO:00355563000.031
Zebrafish
positive regulation of cellular biosynthetic processGO:00313283160.031
positive regulation of signalingGO:00230562430.031
secretionGO:00469031090.031
regulation of molecular functionGO:00650092170.031
Mouse
proteolysis involved in cellular protein catabolic processGO:0051603830.031
positive regulation of protein modification processGO:0031401580.031
positive regulation of biosynthetic processGO:00098913160.030
single organism membrane organizationGO:0044802930.030
negative regulation of phosphate metabolic processGO:0045936450.030
protein phosphorylationGO:00064681690.030
catabolic processGO:00090564090.030
regulation of cell cycle processGO:00105641810.030
neuron remodelingGO:0016322290.030
positive regulation of phosphorylationGO:0042327870.030
chromatin assemblyGO:0031497480.030
defense response to other organismGO:00985422250.029
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic processGO:0031145300.029
enteroendocrine cell differentiationGO:003588310.028
eye photoreceptor cell differentiationGO:00017541450.028
protein localization to organelleGO:0033365820.028
regulation of cellular component biogenesisGO:00440872010.028
histone ubiquitinationGO:001657440.028
regulation of cellular amine metabolic processGO:003323830.027
respiratory system developmentGO:00605412130.027
cellular response to dna damage stimulusGO:00069742230.027
nephron developmentGO:007200630.027
protein acylationGO:0043543420.027
establishment of protein localizationGO:00451841630.027
regulation of cell morphogenesisGO:00226041630.027
organic substance transportGO:00717022570.026
regulation of rna splicingGO:0043484690.026
positive regulation of cellular protein metabolic processGO:00322701180.026
cellular macromolecular complex assemblyGO:00346221530.026
regulation of stem cell proliferationGO:0072091400.026
positive regulation of antimicrobial peptide productionGO:0002225280.026
regulation of transferase activityGO:0051338580.025
spinal cord developmentGO:002151010.025
Rat
exocrine system developmentGO:00352721620.024
response to other organismGO:00517072930.024
molting cycleGO:0042303560.024
negative regulation of meiotic cell cycleGO:005144720.023
imaginal disc derived wing vein morphogenesisGO:0008586440.023
developmental growthGO:00485892800.023
response to abiotic stimulusGO:00096283410.023
dna integrity checkpointGO:0031570810.023
regulation of multi organism processGO:00439001310.022
tissue migrationGO:00901301550.022
regulation of cellular ketone metabolic processGO:001056530.022
negative regulation of cell cycleGO:00457861160.022
renal tubule morphogenesisGO:0061333440.022
regulation of protein modification by small protein conjugation or removalGO:1903320250.021
somatic stem cell maintenanceGO:0035019140.021
endomembrane system organizationGO:00102561190.021
memoryGO:0007613940.021
ribonucleoprotein complex biogenesisGO:0022613310.021
chromosome localizationGO:0050000200.021
deathGO:00162652840.021
Zebrafish
positive regulation of production of molecular mediator of immune responseGO:0002702280.021
smoothened signaling pathwayGO:0007224490.020
segment specificationGO:0007379330.020
germarium derived female germ line cyst formationGO:0030727420.020
regulation of immune system processGO:00026821760.020
imaginal disc derived leg morphogenesisGO:0007480800.020
regulation of intracellular protein transportGO:0033157460.020
negative regulation of notch signaling pathwayGO:0045746410.020
dorsal ventral pattern formationGO:00099531330.020
regulation of mitotic sister chromatid segregationGO:0033047280.020
histone deacetylationGO:001657590.020
organic substance catabolic processGO:19015753080.020
histone methylationGO:0016571400.019
meiosis iGO:0007127590.019
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434370.019
gene silencing by rnaGO:0031047570.019
negative regulation of intracellular signal transductionGO:1902532570.019
Zebrafish
embryonic pattern specificationGO:00098801740.019
peptidyl threonine modificationGO:001821030.019
regulation of cell cycleGO:00517262910.019
eye morphogenesisGO:00485922600.019
Zebrafish Mouse
regulation of transcription elongation from rna polymerase ii promoterGO:0034243150.018
negative regulation of phosphorylationGO:0042326350.018
positive regulation of phosphorus metabolic processGO:00105621390.018
mitotic g2 m transition checkpointGO:0044818700.018
cell fate specificationGO:0001708710.018
olfactory behaviorGO:0042048970.018
regulation of protein phosphorylationGO:0001932640.018
neurological system processGO:00508773580.018
regulation of epithelial cell differentiationGO:003085640.018
regulation of protein ubiquitinationGO:0031396220.018
kidney morphogenesisGO:006099330.018
epithelial cell proliferationGO:0050673150.017
positive regulation of cell cycleGO:0045787430.017
cellular ketone metabolic processGO:0042180240.017
posttranscriptional gene silencingGO:0016441460.017
eye developmentGO:00016543230.017
Zebrafish Mouse
cell cycle phase transitionGO:00447701400.017
regulation of cell deathGO:00109411730.017
Zebrafish
positive regulation of apoptotic signaling pathwayGO:200123540.017
response to radiationGO:00093141550.017
mrna splice site selectionGO:000637610.017
regulation of sister chromatid segregationGO:0033045280.017
cullin deneddylationGO:001038830.017
regulation of mitotic cell cycleGO:00073461900.017
regulation of nervous system developmentGO:00519602480.017
cell adhesionGO:00071551360.017
germ line cyst formationGO:0048134440.017
positive regulation of developmental growthGO:0048639620.017
regulation of intracellular signal transductionGO:19025312360.017
Zebrafish
cellular response to oxygen containing compoundGO:1901701790.017
chromatin modificationGO:00165681470.016
regulation of sister chromatid cohesionGO:000706320.016
tissue morphogenesisGO:00487292970.016
cilium morphogenesisGO:0060271390.016
regulation of kinase activityGO:0043549530.016
response to sterolGO:0036314340.016
signal transduction by phosphorylationGO:00230141070.016
negative regulation of neural precursor cell proliferationGO:2000178270.016
tube morphogenesisGO:00352391910.016
Mouse
regulation of cell divisionGO:0051302720.016
skin developmentGO:0043588650.016
cellular protein complex assemblyGO:0043623710.016
mitotic dna integrity checkpointGO:0044774750.015
amine metabolic processGO:0009308120.015
oocyte constructionGO:00073081120.015
protein alkylationGO:0008213430.015
regulation of dna templated transcription in response to stressGO:004362040.015
negative regulation of nervous system developmentGO:0051961920.015
regulation of protein kinase activityGO:0045859510.015
chromosome condensationGO:0030261410.015
imaginal disc pattern formationGO:0007447910.015
immune system processGO:00023763470.015
regulation of developmental growthGO:00486381740.014
cellular macromolecule catabolic processGO:00442651360.014
cellular response to organic cyclic compoundGO:0071407320.014
apoptotic processGO:00069151590.014
Zebrafish
cellular amine metabolic processGO:0044106120.014
nephron epithelium developmentGO:007200930.014
compound eye pigmentationGO:0048072170.014
sister chromatid segregationGO:0000819920.014
rhythmic behaviorGO:0007622760.014
negative regulation of neuroblast proliferationGO:0007406270.014
positive regulation of growthGO:0045927750.014
nephron morphogenesisGO:007202830.013
compound eye morphogenesisGO:00017452490.013
instar larval developmentGO:0002168550.013
regulation of localizationGO:00328792750.013
Worm
regulation of catalytic activityGO:00507901850.013
Mouse
multicellular organism growthGO:0035264460.013
response to oxygen containing compoundGO:19017002000.013
Rat
positive regulation of apoptotic processGO:0043065470.013
axis elongationGO:000340130.013
intracellular protein transportGO:00068861040.013
internal protein amino acid acetylationGO:0006475380.013
response to ecdysoneGO:0035075340.013
response to biotic stimulusGO:00096072940.013
negative regulation of cell communicationGO:00106482230.013
Zebrafish
apposition of dorsal and ventral imaginal disc derived wing surfacesGO:0007475150.013
regulation of establishment of protein localizationGO:0070201610.013
response to temperature stimulusGO:00092661060.013
tissue deathGO:00162711020.013
cell deathGO:00082192790.013
Zebrafish
positive regulation of cellular amino acid metabolic processGO:004576400.013
positive regulation of multicellular organismal processGO:00512401430.013
internal peptidyl lysine acetylationGO:0018393380.013
regulation of protein deacetylationGO:009031120.013
pigmentationGO:0043473750.012
g2 dna damage checkpointGO:0031572690.012
histone h4 k12 acetylationGO:004398320.012
tripartite regional subdivisionGO:00073511030.012
regulation of neurogenesisGO:00507671580.012
negative regulation of mitotic cell cycleGO:00459301090.012
cellular response to chemical stimulusGO:00708871990.012
mitotic cell cycle phase transitionGO:00447721380.012
negative regulation of cell cycle processGO:00109481090.012
production of small rna involved in gene silencing by rnaGO:0070918150.012
regulation of transcription by chromatin organizationGO:003440130.012
response to dsrnaGO:0043331150.012
negative regulation of protein metabolic processGO:0051248850.012
positive regulation of organ growthGO:0046622120.012
cellular catabolic processGO:00442483720.012
negative regulation of gene expression epigeneticGO:0045814770.012
rna localizationGO:00064031150.012
regulation of mitosisGO:0007088560.012
negative regulation of response to gamma radiationGO:200122940.012
circulatory system developmentGO:0072359820.012
regulation of multicellular organism growthGO:0040014400.012
negative regulation of dna dependent dna replicationGO:200010420.012
dna damage checkpointGO:0000077780.012
small molecule metabolic processGO:00442813050.012
connective tissue developmentGO:006144830.012
Zebrafish
mitotic g2 dna damage checkpointGO:0007095690.012
histolysisGO:00075591020.012
mitotic dna damage checkpointGO:0044773740.012
neuron fate commitmentGO:0048663500.012
forebrain developmentGO:003090020.011
regulation of intracellular transportGO:0032386640.011
protein lipidationGO:000649760.011
innate immune responseGO:00450871440.011
determination of adult lifespanGO:00083401370.011
salivary gland developmentGO:00074311620.011
g1 s transition of mitotic cell cycleGO:0000082310.011
germarium derived female germ line cyst encapsulationGO:003070880.011
glandular epithelial cell differentiationGO:000206710.011
cilium assemblyGO:0042384380.011
histone h2a acetylationGO:004396810.011
establishment of organelle localizationGO:00516561220.011
digestive system developmentGO:00551231490.011
Mouse
regulation of stem cell differentiationGO:2000736140.011
organelle localizationGO:00516401480.011
nitrogen compound transportGO:0071705850.011
negative regulation of organelle organizationGO:0010639560.011
cellular response to organic substanceGO:00713101320.011
regulation of erbb signaling pathwayGO:1901184420.011
kidney developmentGO:000182230.011
sex comb developmentGO:004549880.011
morphogenesis of an epitheliumGO:00020092760.011
purine ribonucleoside monophosphate catabolic processGO:0009169380.010
renal system developmentGO:0072001720.010
gene silencing by mirnaGO:0035195220.010
mitotic sister chromatid separationGO:0051306300.010
regulation of protein transportGO:0051223570.010
protein import into nucleusGO:0006606510.010
regulation of protein localizationGO:0032880760.010
regulation of neural precursor cell proliferationGO:2000177350.010
regulation of cytoplasmic transportGO:1903649470.010

Sce disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
organ system cancerDOID:005068600.049
cancerDOID:16200.049
disease of cellular proliferationDOID:1456600.049