IMP: Integrative Multi-species Prediction

Drosophila melanogaster

10 known processes

hebe (Dmel_CG1623)

CG1623 gene product from transcript CG1623-RD

(Aliases: CG1623,Dmel\CG1623)

FLYBASE: FBgn0033448
Entrez: 36011
UniProtKB: Q7K568

Process Predictions
Disease Predictions

hebe biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
response to organic substance	GO:0010033	284	0.112
immune response regulating signaling pathway	GO:0002764	2	0.112
multicellular organismal aging	GO:0010259	140	0.110
determination of adult lifespan	GO:0008340	137	0.106
organonitrogen compound metabolic process	GO:1901564	318	0.103
innate immune response activating signal transduction	GO:0002758	2	0.093
aging	GO:0007568	143	0.090
cellular protein modification process	GO:0006464	438	0.081
regulation of protein metabolic process	GO:0051246	256	0.075
carbohydrate derivative metabolic process	GO:1901135	217	0.075
growth	GO:0040007	359	0.073
cellular amide metabolic process	GO:0043603	80	0.072
catabolic process	GO:0009056	409	0.070
response to external biotic stimulus	GO:0043207	293	0.068
positive regulation of response to stimulus	GO:0048584	323	0.065
regulation of multi organism process	GO:0043900	131	0.063
protein modification process	GO:0036211	438	0.061
regulation of response to stress	GO:0080134	200	0.061
phosphorylation	GO:0016310	294	0.061
organic substance catabolic process	GO:1901575	308	0.059
ion transport	GO:0006811	145	0.057
regulation of phosphate metabolic process	GO:0019220	210	0.056
pattern recognition receptor signaling pathway	GO:0002221	2	0.056
negative regulation of cellular metabolic process	GO:0031324	382	0.056
intracellular signal transduction	GO:0035556	300	0.055
activation of innate immune response	GO:0002218	4	0.054
regulation of phosphorus metabolic process	GO:0051174	210	0.053
response to oxygen containing compound	GO:1901700	200	0.052
regulation of cellular protein metabolic process	GO:0032268	243	0.052
negative regulation of signal transduction	GO:0009968	206	0.049
developmental growth	GO:0048589	280	0.046
peptide metabolic process	GO:0006518	80	0.045
transmembrane transport	GO:0055085	139	0.043
phosphatidic acid metabolic process	GO:0046473	1	0.043
defense response to bacterium	GO:0042742	178	0.042
regulation of response to external stimulus	GO:0032101	115	0.041
regulation of intracellular signal transduction	GO:1902531	236	0.041
cation transmembrane transport	GO:0098655	88	0.040
negative regulation of cell communication	GO:0010648	223	0.040
defense response	GO:0006952	300	0.040
negative regulation of signaling	GO:0023057	219	0.040
kidney development	GO:0001822	3	0.040
regulation of multicellular organismal development	GO:2000026	414	0.039
hormone catabolic process	GO:0042447	3	0.038
lipid metabolic process	GO:0006629	121	0.038
protein phosphorylation	GO:0006468	169	0.037
organophosphate metabolic process	GO:0019637	195	0.036
single organism catabolic process	GO:0044712	228	0.035
immune response activating signal transduction	GO:0002757	2	0.034
defense response to other organism	GO:0098542	225	0.033
regulation of immune system process	GO:0002682	176	0.033
production of molecular mediator of immune response	GO:0002440	46	0.032
cellular amino acid metabolic process	GO:0006520	61	0.032
regulation of cellular catabolic process	GO:0031329	157	0.032
humoral immune response	GO:0006959	117	0.032
tissue morphogenesis	GO:0048729	297	0.032
homeostatic process	GO:0042592	199	0.031
cellular ketone metabolic process	GO:0042180	24	0.031
response to abiotic stimulus	GO:0009628	341	0.031
cellular catabolic process	GO:0044248	372	0.030
cell death	GO:0008219	279	0.030
programmed cell death	GO:0012501	257	0.030
cell motility	GO:0048870	251	0.030
organonitrogen compound biosynthetic process	GO:1901566	117	0.030
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.030
camera type eye development	GO:0043010	4	0.030
localization of cell	GO:0051674	257	0.029
immune response	GO:0006955	246	0.029
endocytosis	GO:0006897	310	0.029
carbohydrate derivative catabolic process	GO:1901136	118	0.029
cellular response to chemical stimulus	GO:0070887	199	0.028
body morphogenesis	GO:0010171	2	0.028
positive regulation of cellular protein metabolic process	GO:0032270	118	0.028
sleep	GO:0030431	49	0.028
response to biotic stimulus	GO:0009607	294	0.028
imaginal disc derived appendage development	GO:0048737	399	0.028
immune effector process	GO:0002252	98	0.027
vesicle mediated transport	GO:0016192	381	0.027
appendage morphogenesis	GO:0035107	397	0.027
neurological system process	GO:0050877	358	0.027
appendage development	GO:0048736	401	0.027
negative regulation of response to stimulus	GO:0048585	258	0.026
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.026
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.025
regulation of cell differentiation	GO:0045595	302	0.025
establishment of tissue polarity	GO:0007164	87	0.025
cellular nitrogen compound catabolic process	GO:0044270	165	0.025
regulation of immune effector process	GO:0002697	52	0.025
ion transmembrane transport	GO:0034220	122	0.025
purine nucleotide catabolic process	GO:0006195	109	0.025
organic substance transport	GO:0071702	257	0.025
regulation of molecular function	GO:0065009	217	0.025
death	GO:0016265	284	0.024
wing disc morphogenesis	GO:0007472	344	0.024
nucleotide metabolic process	GO:0009117	161	0.024
regulation of immune response	GO:0050776	118	0.024
positive regulation of signal transduction	GO:0009967	223	0.024
regulation of programmed cell death	GO:0043067	152	0.024
cellular amine metabolic process	GO:0044106	12	0.024
regulation of phosphorylation	GO:0042325	147	0.024
response to lipopolysaccharide	GO:0032496	4	0.024
positive regulation of signaling	GO:0023056	243	0.024
chemotaxis	GO:0006935	249	0.024
insecticide catabolic process	GO:0046701	1	0.024
positive regulation of cell communication	GO:0010647	250	0.024
regulation of catalytic activity	GO:0050790	185	0.023
small molecule metabolic process	GO:0044281	305	0.023
single organism cellular localization	GO:1902580	180	0.023
phagocytosis	GO:0006909	215	0.023
positive regulation of phosphorus metabolic process	GO:0010562	139	0.023
circadian sleep wake cycle	GO:0042745	28	0.023
response to oxidative stress	GO:0006979	86	0.023
cellular response to organic substance	GO:0071310	132	0.022
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.022
response to other organism	GO:0051707	293	0.022
morphogenesis of an epithelium	GO:0002009	276	0.022
regulation of protein modification process	GO:0031399	112	0.022
positive regulation of cell migration	GO:0030335	2	0.022
signal transduction by phosphorylation	GO:0023014	107	0.022
response to organic cyclic compound	GO:0014070	89	0.021
positive regulation of macromolecule metabolic process	GO:0010604	405	0.021
glycosyl compound metabolic process	GO:1901657	127	0.021
regulation of response to biotic stimulus	GO:0002831	63	0.021
positive regulation of immune response	GO:0050778	63	0.021
nucleoside triphosphate metabolic process	GO:0009141	120	0.021
nucleoside triphosphate catabolic process	GO:0009143	108	0.021
cation transport	GO:0006812	110	0.021
regulation of mapk cascade	GO:0043408	92	0.021
carboxylic acid metabolic process	GO:0019752	92	0.021
nucleotide catabolic process	GO:0009166	109	0.021
purine nucleoside catabolic process	GO:0006152	112	0.021
single organism behavior	GO:0044708	391	0.021
post embryonic appendage morphogenesis	GO:0035120	385	0.021
response to bacterium	GO:0009617	198	0.021
antimicrobial humoral response	GO:0019730	99	0.021
nucleobase containing compound catabolic process	GO:0034655	165	0.021
regulation of defense response	GO:0031347	102	0.021
small molecule biosynthetic process	GO:0044283	37	0.020
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.020
single organism biosynthetic process	GO:0044711	206	0.020
eye development	GO:0001654	323	0.020
mapk cascade	GO:0000165	107	0.020
negative regulation of cellular protein metabolic process	GO:0032269	85	0.020
macromolecule catabolic process	GO:0009057	161	0.020
positive regulation of cellular biosynthetic process	GO:0031328	316	0.020
positive regulation of phosphate metabolic process	GO:0045937	139	0.020
ribonucleotide metabolic process	GO:0009259	145	0.020
positive regulation of molecular function	GO:0044093	136	0.020
positive regulation of multicellular organismal process	GO:0051240	143	0.020
positive regulation of protein metabolic process	GO:0051247	128	0.020
imaginal disc derived wing morphogenesis	GO:0007476	337	0.020
rhythmic behavior	GO:0007622	76	0.020
circadian behavior	GO:0048512	76	0.020
regulation of cell cycle	GO:0051726	291	0.019
regulation of production of molecular mediator of immune response	GO:0002700	44	0.019
organonitrogen compound catabolic process	GO:1901565	128	0.019
regulation of antimicrobial humoral response	GO:0002759	50	0.019
negative regulation of immune system process	GO:0002683	50	0.019
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.019
insecticide metabolic process	GO:0017143	2	0.019
monocarboxylic acid transport	GO:0015718	3	0.019
regulation of developmental growth	GO:0048638	174	0.019
regulation of humoral immune response	GO:0002920	51	0.019
regulation of hydrolase activity	GO:0051336	97	0.019
taxis	GO:0042330	304	0.018
heterocycle catabolic process	GO:0046700	166	0.018
anion transport	GO:0006820	41	0.018
establishment of localization in cell	GO:0051649	402	0.018
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.018
nucleoside phosphate metabolic process	GO:0006753	162	0.018
nucleobase containing small molecule metabolic process	GO:0055086	174	0.018
positive regulation of catalytic activity	GO:0043085	118	0.018
morphogenesis of a polarized epithelium	GO:0001738	93	0.018
cellular lipid metabolic process	GO:0044255	83	0.018
embryonic development via the syncytial blastoderm	GO:0001700	148	0.017
cuticle development	GO:0042335	86	0.017
epithelial cell migration	GO:0010631	148	0.017
compound eye development	GO:0048749	307	0.017
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.017
peptide biosynthetic process	GO:0043043	42	0.017
regulation of cellular ketone metabolic process	GO:0010565	3	0.017
negative regulation of defense response	GO:0031348	35	0.017
purine ribonucleoside metabolic process	GO:0046128	127	0.017
transcription from rna polymerase ii promoter	GO:0006366	368	0.017
response to alcohol	GO:0097305	95	0.017
purine ribonucleoside catabolic process	GO:0046130	112	0.017
regulation of cellular amine metabolic process	GO:0033238	3	0.017
stress activated protein kinase signaling cascade	GO:0031098	55	0.017
intracellular transport	GO:0046907	228	0.017
negative regulation of protein metabolic process	GO:0051248	85	0.017
negative regulation of gene expression	GO:0010629	387	0.017
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.016
jnk cascade	GO:0007254	50	0.016
regulation of antimicrobial peptide production	GO:0002784	44	0.016
amide biosynthetic process	GO:0043604	42	0.016
positive regulation of hydrolase activity	GO:0051345	78	0.016
forebrain development	GO:0030900	2	0.016
oxoacid metabolic process	GO:0043436	103	0.016
aromatic compound catabolic process	GO:0019439	166	0.016
organic cyclic compound catabolic process	GO:1901361	168	0.016
regulation of cellular response to stress	GO:0080135	89	0.016
positive regulation of cell motility	GO:2000147	3	0.016
regulation of apoptotic process	GO:0042981	130	0.016
negative regulation of cellular biosynthetic process	GO:0031327	277	0.016
columnar cuboidal epithelial cell development	GO:0002066	249	0.016
biological adhesion	GO:0022610	138	0.016
positive regulation of response to biotic stimulus	GO:0002833	31	0.016
purine containing compound catabolic process	GO:0072523	112	0.016
regulation of catabolic process	GO:0009894	170	0.016
developmental maturation	GO:0021700	172	0.016
regulation of cellular component biogenesis	GO:0044087	201	0.016
ras protein signal transduction	GO:0007265	88	0.016
single organism intracellular transport	GO:1902582	207	0.016
regulation of anatomical structure morphogenesis	GO:0022603	242	0.016
response to endogenous stimulus	GO:0009719	119	0.016
nucleoside catabolic process	GO:0009164	112	0.016
positive regulation of gene expression	GO:0010628	290	0.016
organophosphate catabolic process	GO:0046434	112	0.015
small gtpase mediated signal transduction	GO:0007264	88	0.015
immune system process	GO:0002376	347	0.015
cellular response to biotic stimulus	GO:0071216	4	0.015
nitrogen compound transport	GO:0071705	85	0.015
chemical homeostasis	GO:0048878	92	0.015
response to virus	GO:0009615	28	0.015
negative regulation of biosynthetic process	GO:0009890	277	0.015
neuron death	GO:0070997	27	0.015
posttranscriptional regulation of gene expression	GO:0010608	145	0.015
regulation of stress activated mapk cascade	GO:0032872	41	0.015
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.015
regionalization	GO:0003002	416	0.015
purine nucleotide metabolic process	GO:0006163	146	0.015
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.015
steroid catabolic process	GO:0006706	1	0.015
secondary metabolite catabolic process	GO:0090487	1	0.015
aminoglycan metabolic process	GO:0006022	18	0.015
regulation of nucleotide catabolic process	GO:0030811	48	0.015
epithelial cell differentiation	GO:0030855	322	0.015
sulfur compound metabolic process	GO:0006790	59	0.015
ethanolamine containing compound metabolic process	GO:0042439	4	0.015
apoptotic process	GO:0006915	159	0.015
glycosyl compound catabolic process	GO:1901658	112	0.015
antimicrobial peptide production	GO:0002775	46	0.014
negative regulation of phosphorylation	GO:0042326	35	0.014
cellular macromolecule localization	GO:0070727	220	0.014
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.014
negative regulation of response to external stimulus	GO:0032102	22	0.014
ovarian follicle cell development	GO:0030707	248	0.014
ribonucleotide catabolic process	GO:0009261	109	0.014
positive regulation of biosynthetic process	GO:0009891	316	0.014
nucleoside phosphate catabolic process	GO:1901292	110	0.014
detection of stimulus	GO:0051606	156	0.014
negative regulation of phosphorus metabolic process	GO:0010563	45	0.014
nucleoside metabolic process	GO:0009116	127	0.014
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.014
ribonucleoside catabolic process	GO:0042454	112	0.014
cell growth	GO:0016049	108	0.014
ribose phosphate metabolic process	GO:0019693	145	0.014
proteolysis	GO:0006508	192	0.014
regulation of localization	GO:0032879	275	0.014
positive regulation of catabolic process	GO:0009896	105	0.014
l glutamate import	GO:0051938	1	0.014
eye morphogenesis	GO:0048592	260	0.014
cellular protein localization	GO:0034613	160	0.014
tissue migration	GO:0090130	155	0.014
regulation of cellular amide metabolic process	GO:0034248	39	0.014
retina development in camera type eye	GO:0060041	4	0.013
gtp metabolic process	GO:0046039	72	0.013
l amino acid import	GO:0043092	2	0.013
positive regulation of defense response	GO:0031349	59	0.013
connective tissue development	GO:0061448	3	0.013
organic hydroxy compound metabolic process	GO:1901615	83	0.013
sensory perception	GO:0007600	196	0.013
pigment metabolic process	GO:0042440	84	0.013
regulation of proteolysis	GO:0030162	87	0.013
leg disc morphogenesis	GO:0007478	80	0.013
cellular response to molecule of bacterial origin	GO:0071219	3	0.013
positive regulation of intracellular signal transduction	GO:1902533	116	0.013
water homeostasis	GO:0030104	3	0.013
regulation of growth	GO:0040008	233	0.013
regulation of behavior	GO:0050795	75	0.013
regulation of ras protein signal transduction	GO:0046578	93	0.013
hormone metabolic process	GO:0042445	33	0.013
regulation of hormone levels	GO:0010817	40	0.013
regulation of translation	GO:0006417	56	0.013
regulation of cellular component size	GO:0032535	98	0.013
lipid catabolic process	GO:0016042	21	0.013
organic acid metabolic process	GO:0006082	103	0.012
gland development	GO:0048732	191	0.012
macromolecular complex assembly	GO:0065003	256	0.012
response to extracellular stimulus	GO:0009991	116	0.012
positive regulation of antibacterial peptide production	GO:0002803	20	0.012
cellular response to extracellular stimulus	GO:0031668	64	0.012
epithelial cell development	GO:0002064	274	0.012
regulation of nucleoside metabolic process	GO:0009118	50	0.012
cellular response to starvation	GO:0009267	61	0.012
methylation	GO:0032259	47	0.012
multicellular organismal reproductive behavior	GO:0033057	110	0.012
leg disc development	GO:0035218	92	0.012
rhythmic process	GO:0048511	106	0.012
cellular response to external stimulus	GO:0071496	66	0.012
positive regulation of response to external stimulus	GO:0032103	44	0.012
endomembrane system organization	GO:0010256	119	0.012
estrogen metabolic process	GO:0008210	1	0.012
stress activated mapk cascade	GO:0051403	52	0.012
vitamin biosynthetic process	GO:0009110	1	0.012
carbohydrate metabolic process	GO:0005975	82	0.012
ameboidal type cell migration	GO:0001667	151	0.012
sensory perception of chemical stimulus	GO:0007606	116	0.012
phosphatidylethanolamine metabolic process	GO:0046337	1	0.012
acyl coa metabolic process	GO:0006637	3	0.012
purine nucleoside metabolic process	GO:0042278	127	0.012
response to monosaccharide	GO:0034284	4	0.012
positive regulation of phosphorylation	GO:0042327	87	0.012
defense response to gram negative bacterium	GO:0050829	94	0.012
protein alkylation	GO:0008213	43	0.012
germ cell migration	GO:0008354	43	0.011
regulation of cell death	GO:0010941	173	0.011
regulation of anatomical structure size	GO:0090066	163	0.011
inorganic ion transmembrane transport	GO:0098660	73	0.011
centrosome organization	GO:0051297	163	0.011
central nervous system development	GO:0007417	201	0.011
response to nitrogen compound	GO:1901698	90	0.011
polyol biosynthetic process	GO:0046173	3	0.011
microtubule organizing center organization	GO:0031023	168	0.011
anion homeostasis	GO:0055081	3	0.011
regulation of transport	GO:0051049	181	0.011
negative regulation of cell differentiation	GO:0045596	143	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
positive regulation of cellular amine metabolic process	GO:0033240	0	0.011
tube development	GO:0035295	244	0.011
negative regulation of intracellular signal transduction	GO:1902532	57	0.011
positive regulation of protein modification process	GO:0031401	58	0.011
regulation of organelle organization	GO:0033043	196	0.011
androgen metabolic process	GO:0008209	1	0.011
phosphate ion transport	GO:0006817	4	0.011
gtp catabolic process	GO:0006184	72	0.011
response to inorganic substance	GO:0010035	44	0.011
mrna metabolic process	GO:0016071	124	0.011
telencephalon development	GO:0021537	2	0.011
renal system development	GO:0072001	72	0.011
defense response to virus	GO:0051607	23	0.011
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.011
epithelium migration	GO:0090132	148	0.011
wnt signaling pathway	GO:0016055	98	0.011
melanin metabolic process	GO:0006582	47	0.011
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.011
ribonucleoside metabolic process	GO:0009119	127	0.011
positive regulation of developmental process	GO:0051094	143	0.011
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.011
cellular response to dna damage stimulus	GO:0006974	223	0.011
cellular response to carbohydrate stimulus	GO:0071322	4	0.011
guanosine containing compound metabolic process	GO:1901068	74	0.011
metal ion transport	GO:0030001	74	0.011
positive regulation of cellular catabolic process	GO:0031331	95	0.010
macromolecule methylation	GO:0043414	45	0.010
sensory organ morphogenesis	GO:0090596	260	0.010
regulation of lipid transport	GO:0032368	3	0.010
phosphatidylcholine metabolic process	GO:0046470	3	0.010
purine ribonucleotide catabolic process	GO:0009154	109	0.010
cellular response to nitrogen compound	GO:1901699	51	0.010
cell adhesion	GO:0007155	136	0.010
salivary gland morphogenesis	GO:0007435	145	0.010
imaginal disc pattern formation	GO:0007447	91	0.010
oxidation reduction process	GO:0055114	123	0.010
rho protein signal transduction	GO:0007266	14	0.010
cellular response to oxygen containing compound	GO:1901701	79	0.010
centrosome cycle	GO:0007098	137	0.010
peptidoglycan metabolic process	GO:0000270	3	0.010
regulation of establishment of planar polarity	GO:0090175	22	0.010
antibacterial peptide biosynthetic process	GO:0002780	22	0.010
positive regulation of cell death	GO:0010942	69	0.010
lauric acid metabolic process	GO:0048252	1	0.010
toxin metabolic process	GO:0009404	2	0.010
positive regulation of nucleotide catabolic process	GO:0030813	46	0.010
single organism cell adhesion	GO:0098602	47	0.010

hebe disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.056
musculoskeletal system disease	DOID:17	0.024
nervous system disease	DOID:863	0.019
cardiovascular system disease	DOID:1287	0.014
connective tissue disease	DOID:65	0.012
disease of cellular proliferation	DOID:14566	0.011
cancer	DOID:162	0.011
organ system cancer	DOID:0050686	0.011
bone disease	DOID:0080001	0.011
eye disease	DOID:5614	0.011
sensory system disease	DOID:0050155	0.011
eye and adnexa disease	DOID:1492	0.011
urinary system disease	DOID:18	0.010

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