IMP: Integrative Multi-species Prediction

Drosophila melanogaster

37 known processes

Rpb4 (Dmel_CG33520)

CG33520 gene product from transcript CG33520-RF

(Aliases: Ada2a/Rpb4,Dmel\CG33520,CG7150,CG31237,ADA2a,ADA2A,CG31318,Ada2a,anon-WO0118547.402,DmRPB4,Ada2A,dAda2a,CG33520,dAda2A,dRpb4,RPB4)

Entrez: 326128
FLYBASE: FBgn0053520
UniProtKB: Q7KSD8
UniProtKB: E1JIP2

Process Predictions
Disease Predictions

Rpb4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
internal protein amino acid acetylation	GO:0006475	38	0.496
chromatin organization	GO:0006325	207	0.390
chromosome organization	GO:0051276	360	0.379
protein acetylation	GO:0006473	39	0.267
histone modification	GO:0016570	106	0.225
transcription from rna polymerase ii promoter	GO:0006366	368	0.209
steroid biosynthetic process	GO:0006694	16	0.195
histone acetylation	GO:0016573	38	0.176
protein acylation	GO:0043543	42	0.161
covalent chromatin modification	GO:0016569	106	0.160
chromatin remodeling	GO:0006338	72	0.145
positive regulation of macromolecule metabolic process	GO:0010604	405	0.144	Fly
single organism biosynthetic process	GO:0044711	206	0.134
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.134
chromatin modification	GO:0016568	147	0.129
negative regulation of cellular biosynthetic process	GO:0031327	277	0.126
rna processing	GO:0006396	147	0.124
morphogenesis of an epithelium	GO:0002009	276	0.121
small molecule biosynthetic process	GO:0044283	37	0.113
regulation of cellular protein metabolic process	GO:0032268	243	0.113	Fly
small molecule metabolic process	GO:0044281	305	0.112
internal peptidyl lysine acetylation	GO:0018393	38	0.110
protein dna complex assembly	GO:0065004	63	0.109
positive regulation of response to stimulus	GO:0048584	323	0.101
regulation of protein metabolic process	GO:0051246	256	0.100	Fly
cellular protein modification process	GO:0006464	438	0.095
negative regulation of gene expression epigenetic	GO:0045814	77	0.095
protein modification process	GO:0036211	438	0.095
male gamete generation	GO:0048232	201	0.095
cellular ketone metabolic process	GO:0042180	24	0.087
hormone biosynthetic process	GO:0042446	20	0.083
regulation of mitotic cell cycle	GO:0007346	190	0.080
gene silencing	GO:0016458	138	0.076
dendrite development	GO:0016358	204	0.073
positive regulation of mitotic cell cycle phase transition	GO:1901992	20	0.071
negative regulation of cell cycle	GO:0045786	116	0.071
alcohol metabolic process	GO:0006066	25	0.070
peptidyl lysine acetylation	GO:0018394	39	0.069
organic hydroxy compound metabolic process	GO:1901615	83	0.067
mitotic g2 dna damage checkpoint	GO:0007095	69	0.066
regulation of anatomical structure morphogenesis	GO:0022603	242	0.065
cellular response to dna damage stimulus	GO:0006974	223	0.064
sterol biosynthetic process	GO:0016126	9	0.063
protein catabolic process	GO:0030163	101	0.062
organic substance catabolic process	GO:1901575	308	0.061
dendrite morphogenesis	GO:0048813	199	0.060
regulation of cell cycle	GO:0051726	291	0.058
columnar cuboidal epithelial cell development	GO:0002066	249	0.056
alcohol biosynthetic process	GO:0046165	14	0.055
lipid metabolic process	GO:0006629	121	0.053
regulation of rna splicing	GO:0043484	69	0.052
negative regulation of biosynthetic process	GO:0009890	277	0.052
spermatogenesis	GO:0007283	200	0.051
histone h3 acetylation	GO:0043966	11	0.049
cellular macromolecule catabolic process	GO:0044265	136	0.049
localization of cell	GO:0051674	257	0.048
rna splicing	GO:0008380	83	0.047
ameboidal type cell migration	GO:0001667	151	0.047
regulation of growth	GO:0040008	233	0.047
golgi organization	GO:0007030	66	0.046
peptidyl lysine modification	GO:0018205	57	0.046
catabolic process	GO:0009056	409	0.046
positive regulation of organelle organization	GO:0010638	65	0.045	Fly
cell cycle phase transition	GO:0044770	140	0.045
regulation of cell cycle phase transition	GO:1901987	130	0.044
ketone biosynthetic process	GO:0042181	16	0.044
regulation of gene expression epigenetic	GO:0040029	128	0.044
g2 dna damage checkpoint	GO:0031572	69	0.044
synaptic growth at neuromuscular junction	GO:0051124	119	0.043
regulation of organelle organization	GO:0033043	196	0.043	Fly
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.042
modification dependent macromolecule catabolic process	GO:0043632	79	0.042
negative regulation of rna metabolic process	GO:0051253	251	0.042
cellular nitrogen compound catabolic process	GO:0044270	165	0.041
positive regulation of gene expression	GO:0010628	290	0.041
macromolecular complex assembly	GO:0065003	256	0.040
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.040
lipid biosynthetic process	GO:0008610	46	0.040
chromosome separation	GO:0051304	42	0.039
positive regulation of biosynthetic process	GO:0009891	316	0.039
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.039
positive regulation of protein metabolic process	GO:0051247	128	0.038	Fly
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.038
chromatin assembly or disassembly	GO:0006333	52	0.038
single organism catabolic process	GO:0044712	228	0.037
regulation of cell cycle process	GO:0010564	181	0.037
peptidyl amino acid modification	GO:0018193	105	0.036
positive regulation of cellular component organization	GO:0051130	156	0.036	Fly
positive regulation of cellular biosynthetic process	GO:0031328	316	0.035
negative regulation of cellular metabolic process	GO:0031324	382	0.035
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.034
organelle assembly	GO:0070925	198	0.034
cell division	GO:0051301	248	0.033
positive regulation of cell communication	GO:0010647	250	0.032
negative regulation of cell cycle process	GO:0010948	109	0.032
chromatin assembly	GO:0031497	48	0.032
positive regulation of signaling	GO:0023056	243	0.032
endomembrane system organization	GO:0010256	119	0.031
sterol metabolic process	GO:0016125	12	0.031
regulation of multicellular organismal development	GO:2000026	414	0.031
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.030
rna 3 end processing	GO:0031123	45	0.030
cellular macromolecular complex assembly	GO:0034622	153	0.030
cellularization	GO:0007349	90	0.030
organic hydroxy compound biosynthetic process	GO:1901617	21	0.029
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.029
mitotic cell cycle phase transition	GO:0044772	138	0.028
negative regulation of cell cycle phase transition	GO:1901988	103	0.028
compound eye development	GO:0048749	307	0.028
negative regulation of gene expression	GO:0010629	387	0.028
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.028
positive regulation of catalytic activity	GO:0043085	118	0.028
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.028
regulation of cellular catabolic process	GO:0031329	157	0.028
anatomical structure homeostasis	GO:0060249	97	0.027
steroid metabolic process	GO:0008202	20	0.027
appendage development	GO:0048736	401	0.027
eye morphogenesis	GO:0048592	260	0.027
positive regulation of mitotic cell cycle	GO:0045931	34	0.026
mitotic sister chromatid separation	GO:0051306	30	0.026
cellular hormone metabolic process	GO:0034754	23	0.025
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.025
ecdysteroid biosynthetic process	GO:0045456	15	0.025
nucleosome organization	GO:0034728	59	0.025
positive regulation of cell cycle phase transition	GO:1901989	20	0.025
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.024
dna packaging	GO:0006323	91	0.024
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.024
regulation of response to stress	GO:0080134	200	0.024
phagocytosis	GO:0006909	215	0.024
secretion	GO:0046903	109	0.024
eye development	GO:0001654	323	0.024
wnt signaling pathway	GO:0016055	98	0.024
protein localization	GO:0008104	284	0.023
protein complex assembly	GO:0006461	200	0.023
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.023
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.023
imaginal disc derived leg morphogenesis	GO:0007480	80	0.023
compound eye morphogenesis	GO:0001745	249	0.023
regulation of chromatin silencing	GO:0031935	36	0.023
protein dna complex subunit organization	GO:0071824	86	0.023
regulation of organ morphogenesis	GO:2000027	78	0.023
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.022
leg disc development	GO:0035218	92	0.022
carbohydrate derivative metabolic process	GO:1901135	217	0.022
organonitrogen compound metabolic process	GO:1901564	318	0.022
positive regulation of rna metabolic process	GO:0051254	271	0.022
mitotic sister chromatid segregation	GO:0000070	87	0.022
single organism behavior	GO:0044708	391	0.021
proteasomal protein catabolic process	GO:0010498	59	0.021
regulation of catabolic process	GO:0009894	170	0.021
positive regulation of cell death	GO:0010942	69	0.021
regulation of mitosis	GO:0007088	56	0.021
cytoplasmic transport	GO:0016482	130	0.021
ovarian follicle cell development	GO:0030707	248	0.020
ubiquitin dependent protein catabolic process	GO:0006511	78	0.020
regulation of catalytic activity	GO:0050790	185	0.020
heterocycle catabolic process	GO:0046700	166	0.020
epithelial cell differentiation	GO:0030855	322	0.020
programmed cell death	GO:0012501	257	0.020
protein complex biogenesis	GO:0070271	201	0.020
cellular catabolic process	GO:0044248	372	0.020
post embryonic appendage morphogenesis	GO:0035120	385	0.020
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.019
negative regulation of transcription dna templated	GO:0045892	237	0.019
positive regulation of signal transduction	GO:0009967	223	0.019
organonitrogen compound biosynthetic process	GO:1901566	117	0.019
chemical homeostasis	GO:0048878	92	0.019
homeostatic process	GO:0042592	199	0.019
response to gamma radiation	GO:0010332	17	0.018
posttranscriptional gene silencing by rna	GO:0035194	45	0.018
regulation of chromosome organization	GO:0033044	64	0.018	Fly
sleep	GO:0030431	49	0.018
microtubule organizing center organization	GO:0031023	168	0.018
positive regulation of transcription dna templated	GO:0045893	266	0.018
rna catabolic process	GO:0006401	37	0.018
imaginal disc derived appendage development	GO:0048737	399	0.018
mitotic g2 m transition checkpoint	GO:0044818	70	0.017
rhythmic behavior	GO:0007622	76	0.017
dna conformation change	GO:0071103	105	0.017
regulation of sister chromatid segregation	GO:0033045	28	0.017
retina development in camera type eye	GO:0060041	4	0.017
dna integrity checkpoint	GO:0031570	81	0.017
chaeta development	GO:0022416	97	0.017
regulation of molecular function	GO:0065009	217	0.017
chromatin silencing	GO:0006342	76	0.017
purine nucleoside catabolic process	GO:0006152	112	0.017
neuromuscular junction development	GO:0007528	149	0.017
regulation of proteolysis	GO:0030162	87	0.016
actin filament based process	GO:0030029	220	0.016
aromatic compound catabolic process	GO:0019439	166	0.016
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.016
nuclear division	GO:0000280	332	0.016
hormone metabolic process	GO:0042445	33	0.016
positive regulation of proteolysis	GO:0045862	52	0.016
epithelial cell migration open tracheal system	GO:0007427	32	0.016
cell death	GO:0008219	279	0.015
regulation of cell division	GO:0051302	72	0.015
establishment of tissue polarity	GO:0007164	87	0.015
response to radiation	GO:0009314	155	0.015
mrna processing	GO:0006397	104	0.015
multicellular organism growth	GO:0035264	46	0.015
positive regulation of rna biosynthetic process	GO:1902680	266	0.015
endocytosis	GO:0006897	310	0.015
positive regulation of cellular amine metabolic process	GO:0033240	0	0.015
cation transport	GO:0006812	110	0.015
tissue morphogenesis	GO:0048729	297	0.015
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.015
nucleotide metabolic process	GO:0009117	161	0.014
negative regulation of mitotic cell cycle	GO:0045930	109	0.014
organic cyclic compound catabolic process	GO:1901361	168	0.014
establishment of localization in cell	GO:0051649	402	0.014
regulation of intracellular signal transduction	GO:1902531	236	0.014
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.014
intracellular signal transduction	GO:0035556	300	0.014
modification dependent protein catabolic process	GO:0019941	78	0.014
positive regulation of hydrolase activity	GO:0051345	78	0.014
regulation of nuclear division	GO:0051783	58	0.013
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.013
regulation of gene silencing	GO:0060968	63	0.013
glycosyl compound catabolic process	GO:1901658	112	0.013
ribonucleotide metabolic process	GO:0009259	145	0.013
metaphase anaphase transition of cell cycle	GO:0044784	28	0.013
imaginal disc derived wing morphogenesis	GO:0007476	337	0.013
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.013
regulation of protein catabolic process	GO:0042176	55	0.013
regulation of synapse assembly	GO:0051963	94	0.013
positive regulation of catabolic process	GO:0009896	105	0.013
regulation of hydrolase activity	GO:0051336	97	0.013
protein modification by small protein removal	GO:0070646	28	0.013
ras protein signal transduction	GO:0007265	88	0.013
regulation of cell differentiation	GO:0045595	302	0.013
negative regulation of developmental process	GO:0051093	201	0.012
dna damage checkpoint	GO:0000077	78	0.012
histolysis	GO:0007559	102	0.012
central nervous system development	GO:0007417	201	0.012
sperm individualization	GO:0007291	48	0.012
positive regulation of programmed cell death	GO:0043068	62	0.012
cellular lipid metabolic process	GO:0044255	83	0.012
sensory organ morphogenesis	GO:0090596	260	0.012
humoral immune response	GO:0006959	117	0.012
regulation of epithelial cell differentiation	GO:0030856	4	0.012
positive regulation of phosphate metabolic process	GO:0045937	139	0.012
purine ribonucleoside metabolic process	GO:0046128	127	0.012
salivary gland cell autophagic cell death	GO:0035071	83	0.011
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.011
proteolysis	GO:0006508	192	0.011
autophagic cell death	GO:0048102	83	0.011
organophosphate metabolic process	GO:0019637	195	0.011
negative regulation of growth	GO:0045926	84	0.011
regulation of hormone levels	GO:0010817	40	0.011
positive regulation of molecular function	GO:0044093	136	0.011
nucleobase containing compound catabolic process	GO:0034655	165	0.011
response to biotic stimulus	GO:0009607	294	0.011
vesicle mediated transport	GO:0016192	381	0.011
macromolecule catabolic process	GO:0009057	161	0.011
protein modification by small protein conjugation or removal	GO:0070647	106	0.011
wing disc morphogenesis	GO:0007472	344	0.011
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
mitotic dna damage checkpoint	GO:0044773	74	0.011
regulation of localization	GO:0032879	275	0.011
organic substance transport	GO:0071702	257	0.010
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.010
regulation of mitotic sister chromatid separation	GO:0010965	28	0.010
positive regulation of wnt signaling pathway	GO:0030177	25	0.010
regulation of multi organism process	GO:0043900	131	0.010
regionalization	GO:0003002	416	0.010	Fly
regulation of wnt signaling pathway	GO:0030111	68	0.010
regulation of chromosome segregation	GO:0051983	32	0.010
gene silencing by mirna	GO:0035195	22	0.010
positive regulation of gtp catabolic process	GO:0033126	43	0.010
nephron development	GO:0072006	3	0.010
amide biosynthetic process	GO:0043604	42	0.010
sister chromatid segregation	GO:0000819	92	0.010
photoreceptor cell differentiation	GO:0046530	170	0.010
embryo development ending in birth or egg hatching	GO:0009792	152	0.010
negative regulation of response to stimulus	GO:0048585	258	0.010
regulation of response to external stimulus	GO:0032101	115	0.010
morphogenesis of a polarized epithelium	GO:0001738	93	0.010
eggshell formation	GO:0030703	105	0.010
regulation of notch signaling pathway	GO:0008593	100	0.010
posttranscriptional regulation of gene expression	GO:0010608	145	0.010

Rpb4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.014
	nervous system disease	DOID:863	0	0.012

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