IMP: Integrative Multi-species Prediction

Drosophila melanogaster

96 known processes

numb (Dmel_CG3779)

CG3779 gene product from transcript CG3779-RB

(Aliases: l(2)3235,numbs,dNumb,CG3779,l(2)s2201,Nb,l(2)03235,d-numb,Numb,Dmel\CG3779,N7-1,nb)

Entrez: 34263
FLYBASE: FBgn0002973
UniProtKB: M9PCN6
UniProtKB: P16554

Process Predictions
Disease Predictions

numb biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
asymmetric neuroblast division	GO:0055059	33	1.000
asymmetric cell division	GO:0008356	37	0.999
neuron projection guidance	GO:0097485	241	0.996
axonogenesis	GO:0007409	290	0.995	Mouse
taxis	GO:0042330	304	0.993
neuroblast fate determination	GO:0007400	12	0.992
malpighian tubule tip cell differentiation	GO:0061382	9	0.991
chemotaxis	GO:0006935	249	0.989
stem cell fate commitment	GO:0048865	25	0.989
localization of cell	GO:0051674	257	0.983
motor neuron axon guidance	GO:0008045	58	0.979
embryonic morphogenesis	GO:0048598	206	0.977
regulation of anatomical structure morphogenesis	GO:0022603	242	0.967	Mouse Rat
cell fate determination	GO:0001709	91	0.961
brain development	GO:0007420	120	0.960	Mouse Fly
muscle cell differentiation	GO:0042692	103	0.959
regulation of cell projection organization	GO:0031344	92	0.946	Rat
negative regulation of signal transduction	GO:0009968	206	0.940	Zebrafish Mouse
negative regulation of cell communication	GO:0010648	223	0.929	Zebrafish Mouse
neuroblast fate commitment	GO:0014017	19	0.912
positive regulation of cellular biosynthetic process	GO:0031328	316	0.902
regulation of cell development	GO:0060284	215	0.901
tissue morphogenesis	GO:0048729	297	0.899	Mouse
morphogenesis of embryonic epithelium	GO:0016331	94	0.897
regionalization	GO:0003002	416	0.892
neuroblast differentiation	GO:0014016	29	0.890
organelle assembly	GO:0070925	198	0.880
regulation of multicellular organismal development	GO:2000026	414	0.879
substrate dependent cell migration	GO:0006929	3	0.874
regulation of neurogenesis	GO:0050767	158	0.868
cellular protein modification process	GO:0006464	438	0.863
organelle localization	GO:0051640	148	0.834
chaeta development	GO:0022416	97	0.829
cell adhesion	GO:0007155	136	0.827
death	GO:0016265	284	0.827
eye photoreceptor cell differentiation	GO:0001754	145	0.826
regulation of nervous system development	GO:0051960	248	0.816
neural precursor cell proliferation	GO:0061351	75	0.814
axon guidance	GO:0007411	233	0.809
synapse assembly	GO:0007416	143	0.800
protein modification process	GO:0036211	438	0.796
spermatid differentiation	GO:0048515	114	0.794
synapse organization	GO:0050808	196	0.778
regulation of cellular protein metabolic process	GO:0032268	243	0.764
actin filament based process	GO:0030029	220	0.751
neurological system process	GO:0050877	358	0.730
axon development	GO:0061564	297	0.729	Mouse
regulation of dendrite development	GO:0050773	37	0.720	Rat
rna localization	GO:0006403	115	0.719
regulation of protein metabolic process	GO:0051246	256	0.707
actin cytoskeleton organization	GO:0030036	206	0.665
cell motility	GO:0048870	251	0.643
cell death	GO:0008219	279	0.636
positive regulation of cell differentiation	GO:0045597	64	0.627	Mouse Rat
regulation of cell cycle phase transition	GO:1901987	130	0.604
regulation of cell cycle	GO:0051726	291	0.601
regulation of protein modification process	GO:0031399	112	0.597
asymmetric stem cell division	GO:0098722	49	0.596
phosphorylation	GO:0016310	294	0.588
regulation of anatomical structure size	GO:0090066	163	0.576
biological adhesion	GO:0022610	138	0.576
regulation of wnt signaling pathway	GO:0030111	68	0.573
embryo development ending in birth or egg hatching	GO:0009792	152	0.570
regulation of neuron projection development	GO:0010975	69	0.567	Rat
positive regulation of nervous system development	GO:0051962	69	0.562	Mouse Rat
cell migration	GO:0016477	238	0.555
vesicle mediated transport	GO:0016192	381	0.547
regulation of cell division	GO:0051302	72	0.544
actin filament organization	GO:0007015	126	0.528
protein phosphorylation	GO:0006468	169	0.527
regulation of cellular amine metabolic process	GO:0033238	3	0.522
gastrulation	GO:0007369	70	0.522
cilium organization	GO:0044782	41	0.497
regulation of cell cycle process	GO:0010564	181	0.487
negative regulation of signaling	GO:0023057	219	0.480	Zebrafish Mouse
hematopoietic or lymphoid organ development	GO:0048534	57	0.477	Zebrafish
renal system development	GO:0072001	72	0.474
neuroblast proliferation	GO:0007405	74	0.463
regulation of phosphate metabolic process	GO:0019220	210	0.461
endodermal cell fate commitment	GO:0001711	3	0.450
centrosome cycle	GO:0007098	137	0.431
cilium morphogenesis	GO:0060271	39	0.426
response to abiotic stimulus	GO:0009628	341	0.424
establishment or maintenance of cell polarity	GO:0007163	167	0.418
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.414
stem cell differentiation	GO:0048863	117	0.413
stem cell proliferation	GO:0072089	88	0.407
cellular response to oxygen containing compound	GO:1901701	79	0.405
negative regulation of cellular metabolic process	GO:0031324	382	0.398
regulation of phosphorus metabolic process	GO:0051174	210	0.395
cardiovascular system development	GO:0072358	82	0.386
centriole assembly	GO:0098534	24	0.382
regulation of molecular function	GO:0065009	217	0.379
neuroblast division	GO:0055057	35	0.374
positive regulation of molecular function	GO:0044093	136	0.367
cardiac cell fate commitment	GO:0060911	17	0.358
morphogenesis of an epithelium	GO:0002009	276	0.356	Mouse
digestive system development	GO:0055123	149	0.355
regulation of synapse assembly	GO:0051963	94	0.353
positive regulation of response to stimulus	GO:0048584	323	0.353	Worm
regulation of protein phosphorylation	GO:0001932	64	0.350
epithelial cell differentiation	GO:0030855	322	0.343	Mouse
single organism cellular localization	GO:1902580	180	0.334	Human Worm
spermatid development	GO:0007286	98	0.330
cell proliferation	GO:0008283	299	0.328
positive regulation of rna metabolic process	GO:0051254	271	0.322
centrosome organization	GO:0051297	163	0.322
regulation of immune system process	GO:0002682	176	0.322
programmed cell death	GO:0012501	257	0.317
positive regulation of multicellular organismal process	GO:0051240	143	0.314	Mouse Rat
dendrite development	GO:0016358	204	0.310	Rat
mesoderm development	GO:0007498	78	0.309
central nervous system development	GO:0007417	201	0.300	Mouse Fly
macromolecular complex assembly	GO:0065003	256	0.299
cognition	GO:0050890	141	0.289
telencephalon development	GO:0021537	2	0.289	Mouse
regulation of neuron differentiation	GO:0045664	103	0.288	Rat
positive regulation of cell development	GO:0010720	61	0.287	Mouse Rat
organ formation	GO:0048645	39	0.285
actin polymerization or depolymerization	GO:0008154	31	0.281
dendrite morphogenesis	GO:0048813	199	0.280	Rat
stem cell fate determination	GO:0048867	15	0.275
regulation of synapse structure and activity	GO:0050803	128	0.273
positive regulation of proteolysis	GO:0045862	52	0.271
protein modification by small protein conjugation	GO:0032446	79	0.270
regulation of catalytic activity	GO:0050790	185	0.264
urogenital system development	GO:0001655	72	0.257
cell projection assembly	GO:0030031	94	0.256
imaginal disc pattern formation	GO:0007447	91	0.256
regulation of cytoskeleton organization	GO:0051493	89	0.254
muscle organ development	GO:0007517	127	0.253
intracellular signal transduction	GO:0035556	300	0.253
apoptotic process	GO:0006915	159	0.252
regulation of cell morphogenesis	GO:0022604	163	0.251	Rat
positive regulation of developmental process	GO:0051094	143	0.248	Mouse Rat
regulation of organelle organization	GO:0033043	196	0.244
positive regulation of macromolecule metabolic process	GO:0010604	405	0.242
wnt signaling pathway	GO:0016055	98	0.242
regulation of cellular component size	GO:0032535	98	0.240
regulation of cell differentiation	GO:0045595	302	0.238
cell cell adhesion	GO:0098609	26	0.237
negative regulation of developmental process	GO:0051093	201	0.237
mesenchymal cell differentiation	GO:0048762	1	0.233
response to radiation	GO:0009314	155	0.233
cell recognition	GO:0008037	102	0.233
male gamete generation	GO:0048232	201	0.232
circulatory system development	GO:0072359	82	0.230
cell cycle phase transition	GO:0044770	140	0.224
notch signaling pathway	GO:0007219	120	0.223	Zebrafish Mouse
endocytosis	GO:0006897	310	0.223
phagocytosis	GO:0006909	215	0.223	Fly
ameboidal type cell migration	GO:0001667	151	0.220
neuronal stem cell division	GO:0036445	35	0.217
organonitrogen compound metabolic process	GO:1901564	318	0.217
cilium assembly	GO:0042384	38	0.215
developmental maturation	GO:0021700	172	0.215	Fly
regulation of dendrite morphogenesis	GO:0048814	28	0.213	Rat
peptidyl tyrosine modification	GO:0018212	24	0.213
regulation of growth	GO:0040008	233	0.213
muscle structure development	GO:0061061	224	0.212
camera type eye morphogenesis	GO:0048593	2	0.211
wing disc morphogenesis	GO:0007472	344	0.210
cellular amino acid metabolic process	GO:0006520	61	0.209
negative regulation of mitotic cell cycle	GO:0045930	109	0.205
positive regulation of biosynthetic process	GO:0009891	316	0.202
regulation of apoptotic process	GO:0042981	130	0.202
negative regulation of cell cycle	GO:0045786	116	0.194
cellular amine metabolic process	GO:0044106	12	0.192
somatic stem cell division	GO:0048103	37	0.189
single organism cell adhesion	GO:0098602	47	0.187
negative regulation of response to stimulus	GO:0048585	258	0.186	Zebrafish Mouse
regulation of synapse organization	GO:0050807	110	0.186
response to organic substance	GO:0010033	284	0.184	Human
embryonic heart tube development	GO:0035050	22	0.179
positive regulation of immune system process	GO:0002684	68	0.179
formation of primary germ layer	GO:0001704	24	0.178
hair cell differentiation	GO:0035315	47	0.174
positive regulation of transcription dna templated	GO:0045893	266	0.174
regulation of actin polymerization or depolymerization	GO:0008064	27	0.174
photoreceptor cell differentiation	GO:0046530	170	0.171
sensory perception	GO:0007600	196	0.167
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.166
positive regulation of gliogenesis	GO:0014015	5	0.164
imaginal disc derived wing morphogenesis	GO:0007476	337	0.163
regulation of axonogenesis	GO:0050770	32	0.162
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.160
protein ubiquitination	GO:0016567	70	0.160
wnt signaling pathway involved in heart development	GO:0003306	3	0.159
cardiocyte differentiation	GO:0035051	29	0.159
positive regulation of rna biosynthetic process	GO:1902680	266	0.158
protein complex assembly	GO:0006461	200	0.155
formation of organ boundary	GO:0010160	30	0.154
regulation of cellular ketone metabolic process	GO:0010565	3	0.154
chaeta morphogenesis	GO:0008407	42	0.153
positive regulation of cellular protein metabolic process	GO:0032270	118	0.153
response to light stimulus	GO:0009416	124	0.153
positive regulation of neurogenesis	GO:0050769	41	0.152	Mouse Rat
regulation of embryonic development	GO:0045995	68	0.150
eye photoreceptor cell development	GO:0042462	81	0.149
digestive tract development	GO:0048565	149	0.149
embryonic development via the syncytial blastoderm	GO:0001700	148	0.149
regulation of protein kinase activity	GO:0045859	51	0.148
positive regulation of gene expression	GO:0010628	290	0.144
spermatogenesis	GO:0007283	200	0.144
amine metabolic process	GO:0009308	12	0.141
regulation of protein stability	GO:0031647	43	0.140
cardiac muscle tissue development	GO:0048738	9	0.140
establishment of planar polarity	GO:0001736	87	0.138
mitotic spindle organization	GO:0007052	220	0.136
forebrain development	GO:0030900	2	0.134	Mouse
compound eye morphogenesis	GO:0001745	249	0.133
embryonic pattern specification	GO:0009880	174	0.133
response to nitrogen compound	GO:1901698	90	0.132
protein targeting	GO:0006605	64	0.131	Worm
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.127
cellular protein localization	GO:0034613	160	0.127	Human Worm
hindbrain development	GO:0030902	2	0.127
heart development	GO:0007507	82	0.123
cellular ketone metabolic process	GO:0042180	24	0.122
regulation of proteolysis	GO:0030162	87	0.121
peripheral nervous system development	GO:0007422	52	0.120
regulation of meiosis	GO:0040020	3	0.118
malpighian tubule development	GO:0072002	64	0.114
regulation of actin cytoskeleton organization	GO:0032956	42	0.114
immune response	GO:0006955	246	0.113
protein localization	GO:0008104	284	0.113
striated muscle cell differentiation	GO:0051146	90	0.112
cellular catabolic process	GO:0044248	372	0.111
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.111
positive regulation of cell cycle	GO:0045787	43	0.108
positive regulation of signal transduction	GO:0009967	223	0.108	Worm
regulation of actin filament polymerization	GO:0030833	25	0.105
activation of rac gtpase activity	GO:0032863	3	0.105
protein modification by small protein conjugation or removal	GO:0070647	106	0.099
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.099
photoreceptor cell development	GO:0042461	96	0.099
regulation of transferase activity	GO:0051338	58	0.098
immune system process	GO:0002376	347	0.097	Zebrafish
negative regulation of organelle organization	GO:0010639	56	0.097
mesenchymal cell development	GO:0014031	1	0.097
regulation of response to stress	GO:0080134	200	0.097
tube development	GO:0035295	244	0.096
negative regulation of binding	GO:0051100	5	0.095
proteolysis	GO:0006508	192	0.094
positive regulation of cell motility	GO:2000147	3	0.093	Human
regulation of immune response	GO:0050776	118	0.092
reproductive system development	GO:0061458	74	0.091
negative regulation of cell proliferation	GO:0008285	69	0.091
cellular macromolecular complex assembly	GO:0034622	153	0.090
regulation of actin filament length	GO:0030832	27	0.090
positive regulation of cell cycle process	GO:0090068	28	0.086
peptidyl tyrosine phosphorylation	GO:0018108	24	0.086
regulation of phosphorylation	GO:0042325	147	0.086
compound eye photoreceptor cell differentiation	GO:0001751	140	0.085
digestive tract morphogenesis	GO:0048546	127	0.084
neuron recognition	GO:0008038	101	0.084
dorsal closure	GO:0007391	79	0.084
negative regulation of synapse assembly	GO:0051964	39	0.083
protein transport	GO:0015031	155	0.083	Worm
regulation of cellular component movement	GO:0051270	42	0.082	Human
cell division	GO:0051301	248	0.081
negative regulation of gene expression	GO:0010629	387	0.080
positive regulation of phagocytosis engulfment	GO:0060100	1	0.080
regulation of canonical wnt signaling pathway	GO:0060828	15	0.079
regulation of cell adhesion	GO:0030155	27	0.079
regulation of cellular amino acid metabolic process	GO:0006521	0	0.079
positive regulation of phosphorus metabolic process	GO:0010562	139	0.077
regulation of mitotic cell cycle	GO:0007346	190	0.077
organophosphate metabolic process	GO:0019637	195	0.076
carbohydrate derivative metabolic process	GO:1901135	217	0.076
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.075	Worm
glial cell differentiation	GO:0010001	35	0.075
synaptic growth at neuromuscular junction	GO:0051124	119	0.074
spindle organization	GO:0007051	253	0.073
cellular component assembly involved in morphogenesis	GO:0010927	151	0.073
stem cell fate specification	GO:0048866	2	0.072
mitochondrial fission	GO:0000266	8	0.072
regulation of immune effector process	GO:0002697	52	0.071
locomotory behavior	GO:0007626	176	0.070
regulation of establishment of planar polarity	GO:0090175	22	0.070
small molecule metabolic process	GO:0044281	305	0.070
imaginal disc derived wing hair organization	GO:0035317	45	0.069
establishment of spindle localization	GO:0051293	22	0.068
establishment of tissue polarity	GO:0007164	87	0.067
regulation of programmed cell death	GO:0043067	152	0.067
oocyte differentiation	GO:0009994	145	0.067
epidermis development	GO:0008544	65	0.065
ras protein signal transduction	GO:0007265	88	0.064
nucleobase containing small molecule metabolic process	GO:0055086	174	0.063
spindle assembly involved in male meiosis	GO:0007053	5	0.062
prostaglandin biosynthetic process	GO:0001516	1	0.062
cellular response to growth factor stimulus	GO:0071363	30	0.061
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.061
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.059
positive regulation of phosphate metabolic process	GO:0045937	139	0.058
rac protein signal transduction	GO:0016601	3	0.058
positive regulation of catalytic activity	GO:0043085	118	0.057
lamellipodium assembly	GO:0030032	21	0.057
negative regulation of epithelial cell proliferation	GO:0050680	4	0.056
ubiquitin dependent protein catabolic process	GO:0006511	78	0.056
head development	GO:0060322	135	0.056	Mouse Fly
r3 r4 cell differentiation	GO:0048056	12	0.054
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.054	Worm
regulation of localization	GO:0032879	275	0.052
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.052
regulation of response to external stimulus	GO:0032101	115	0.051
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.051
modification dependent protein catabolic process	GO:0019941	78	0.051
negative regulation of cellular protein metabolic process	GO:0032269	85	0.051
organic acid metabolic process	GO:0006082	103	0.050
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.050
positive regulation of phosphorylation	GO:0042327	87	0.050
retinal ganglion cell axon guidance	GO:0031290	12	0.049
anterior posterior pattern specification	GO:0009952	136	0.049
response to nutrient levels	GO:0031667	114	0.048
multicellular organismal aging	GO:0010259	140	0.048
peptidyl amino acid modification	GO:0018193	105	0.048
mitotic nuclear division	GO:0007067	213	0.048
transcription from rna polymerase ii promoter	GO:0006366	368	0.047
microtubule organizing center organization	GO:0031023	168	0.047
development of primary sexual characteristics	GO:0045137	50	0.047
positive regulation of protein metabolic process	GO:0051247	128	0.047
endodermal cell differentiation	GO:0035987	3	0.047
chorion containing eggshell formation	GO:0007304	105	0.047
regulation of organ morphogenesis	GO:2000027	78	0.046	Mouse
cortical actin cytoskeleton organization	GO:0030866	24	0.046
positive regulation of immune response	GO:0050778	63	0.046
male meiosis chromosome segregation	GO:0007060	10	0.046
growth	GO:0040007	359	0.046
regulation of cellular component biogenesis	GO:0044087	201	0.045
regulation of glial cell differentiation	GO:0045685	1	0.045
positive regulation of apoptotic process	GO:0043065	47	0.044
connective tissue development	GO:0061448	3	0.044
positive regulation of cell communication	GO:0010647	250	0.044	Worm
canonical wnt signaling pathway	GO:0060070	21	0.043
negative regulation of catalytic activity	GO:0043086	42	0.043
blastoderm segmentation	GO:0007350	159	0.043
positive regulation of protein modification process	GO:0031401	58	0.043
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.043
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.043
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.042
regulation of actin filament based process	GO:0032970	42	0.042
regulation of protein polymerization	GO:0032271	28	0.042
cellular macromolecule localization	GO:0070727	220	0.041	Human Worm
neuromuscular junction development	GO:0007528	149	0.041
regulation of cell cell adhesion	GO:0022407	21	0.041
negative regulation of protein metabolic process	GO:0051248	85	0.040
regulation of apoptotic signaling pathway	GO:2001233	10	0.040
positive regulation of canonical wnt signaling pathway	GO:0090263	7	0.040
embryonic organ development	GO:0048568	50	0.039
endoderm formation	GO:0001706	3	0.039
cellular component disassembly	GO:0022411	46	0.039
cellular response to organonitrogen compound	GO:0071417	36	0.039
eye development	GO:0001654	323	0.038
positive regulation of chromatin silencing at telomere	GO:0031940	2	0.038
mesenchyme development	GO:0060485	9	0.038
body morphogenesis	GO:0010171	2	0.038
receptor mediated endocytosis	GO:0006898	21	0.037
regulation of cell proliferation	GO:0042127	163	0.037
positive regulation of neuron differentiation	GO:0045666	26	0.036	Rat
regulation of viral genome replication	GO:0045069	4	0.036
regulation of developmental growth	GO:0048638	174	0.036
specification of organ identity	GO:0010092	3	0.036
negative regulation of cell death	GO:0060548	81	0.035
developmental programmed cell death	GO:0010623	138	0.035
homeostatic process	GO:0042592	199	0.035	Zebrafish
negative regulation of rna metabolic process	GO:0051253	251	0.035
mesoderm morphogenesis	GO:0048332	22	0.034
regulation of microtubule based process	GO:0032886	49	0.034
tissue death	GO:0016271	102	0.034
regulation of stem cell proliferation	GO:0072091	40	0.034
macromolecule catabolic process	GO:0009057	161	0.034
spindle assembly	GO:0051225	80	0.034
actin filament polymerization	GO:0030041	27	0.034
activation of protein kinase activity	GO:0032147	12	0.034
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.033
cytoplasmic transport	GO:0016482	130	0.033
compound eye development	GO:0048749	307	0.033
mitotic cell cycle phase transition	GO:0044772	138	0.032
muscle tissue morphogenesis	GO:0060415	2	0.032
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.032
negative regulation of cellular component organization	GO:0051129	108	0.032	Human
positive regulation of transferase activity	GO:0051347	26	0.031
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.031
regulation of peptidyl tyrosine phosphorylation	GO:0050730	10	0.031
planar cell polarity pathway involved in axis elongation	GO:0003402	3	0.031
response to oxygen containing compound	GO:1901700	200	0.031
response to bacterium	GO:0009617	198	0.031
camera type eye development	GO:0043010	4	0.031
regulation of hemocyte proliferation	GO:0035206	37	0.030
sex differentiation	GO:0007548	81	0.030
establishment of mitotic spindle localization	GO:0040001	17	0.030
epithelial cell development	GO:0002064	274	0.030
membrane disassembly	GO:0030397	4	0.029
negative regulation of nervous system development	GO:0051961	92	0.029
carboxylic acid metabolic process	GO:0019752	92	0.029
gland morphogenesis	GO:0022612	145	0.029
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.029
compound eye photoreceptor development	GO:0042051	78	0.029
regulation of cytoplasmic transport	GO:1903649	47	0.029
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	12	0.029	Rat
regulation of defense response	GO:0031347	102	0.028
multi organism behavior	GO:0051705	175	0.028
regulation of epithelial cell migration	GO:0010632	12	0.028
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.028	Rat
epidermal cell differentiation	GO:0009913	51	0.028
positive regulation of cellular component biogenesis	GO:0044089	80	0.028
cell junction assembly	GO:0034329	42	0.028
positive regulation of programmed cell death	GO:0043068	62	0.027
lateral inhibition	GO:0046331	206	0.027
tripartite regional subdivision	GO:0007351	103	0.026
nuclear division	GO:0000280	332	0.026
establishment of organelle localization	GO:0051656	122	0.026
positive regulation of actin filament polymerization	GO:0030838	11	0.026
reproductive structure development	GO:0048608	74	0.026
detection of stimulus	GO:0051606	156	0.025
regulation of r7 cell differentiation	GO:0045676	15	0.025
wing disc dorsal ventral pattern formation	GO:0048190	47	0.025
chromosome segregation	GO:0007059	157	0.025
skin development	GO:0043588	65	0.025
regulation of cell shape	GO:0008360	113	0.025
nucleobase containing compound catabolic process	GO:0034655	165	0.025
regulation of protein localization	GO:0032880	76	0.025	Human
circulatory system process	GO:0003013	37	0.025
regulation of kinase activity	GO:0043549	53	0.024
stem cell division	GO:0017145	69	0.024
positive regulation of cell projection organization	GO:0031346	29	0.024	Rat
posttranscriptional regulation of gene expression	GO:0010608	145	0.024
small gtpase mediated signal transduction	GO:0007264	88	0.024
blood circulation	GO:0008015	26	0.024
regulation of transport	GO:0051049	181	0.023
positive regulation of neuron apoptotic process	GO:0043525	1	0.023
segmentation	GO:0035282	207	0.023
skeletal muscle fiber development	GO:0048741	3	0.023
meiotic nuclear division	GO:0007126	151	0.023
protein polymerization	GO:0051258	42	0.023
positive regulation of protein phosphorylation	GO:0001934	34	0.023
defense response to bacterium	GO:0042742	178	0.023
immune response regulating signaling pathway	GO:0002764	2	0.023
lymph gland development	GO:0048542	28	0.023
regulation of notch signaling pathway	GO:0008593	100	0.022	Zebrafish Mouse
cellular protein complex assembly	GO:0043623	71	0.022
regulation of cell size	GO:0008361	63	0.022
cell cell adhesion via plasma membrane adhesion molecules	GO:0098742	26	0.022
negative regulation of cell differentiation	GO:0045596	143	0.022
detection of stimulus involved in sensory perception	GO:0050906	92	0.022
meiotic cell cycle process	GO:1903046	132	0.022
response to other organism	GO:0051707	293	0.022
regulation of endocytosis	GO:0030100	37	0.022
syncytium formation by plasma membrane fusion	GO:0000768	43	0.022
anterior posterior axis specification embryo	GO:0008595	103	0.021
antimicrobial peptide production	GO:0002775	46	0.021
stem cell development	GO:0048864	79	0.021
negative regulation of protein modification process	GO:0031400	29	0.021
hemopoiesis	GO:0030097	46	0.021	Zebrafish
positive regulation of cell migration	GO:0030335	2	0.021	Human
positive regulation of cellular catabolic process	GO:0031331	95	0.021
genitalia development	GO:0048806	26	0.021
adherens junction organization	GO:0034332	27	0.021	Mouse
immune system development	GO:0002520	57	0.020	Zebrafish
protein complex biogenesis	GO:0070271	201	0.020
response to ionizing radiation	GO:0010212	32	0.020
multi multicellular organism process	GO:0044706	123	0.020
left right pattern formation	GO:0060972	1	0.020
cell fate commitment involved in pattern specification	GO:0060581	31	0.020
positive regulation of cell proliferation	GO:0008284	47	0.020
germarium derived female germ line cyst formation	GO:0030727	42	0.019
negative chemotaxis	GO:0050919	15	0.019
positive regulation of signaling	GO:0023056	243	0.019	Worm
regulation of nucleotide metabolic process	GO:0006140	62	0.019
regulation of cellular amide metabolic process	GO:0034248	39	0.019
microtubule bundle formation	GO:0001578	27	0.018
positive regulation of developmental growth	GO:0048639	62	0.018
regulation of protein depolymerization	GO:1901879	27	0.018
response to growth factor	GO:0070848	31	0.018
regulation of cellular localization	GO:0060341	136	0.018	Human
initiation of dorsal closure	GO:0007392	12	0.018
neuronal action potential	GO:0019228	10	0.018
purine nucleotide metabolic process	GO:0006163	146	0.018
regulation of asymmetric cell division	GO:0009786	3	0.018
dendrite guidance	GO:0070983	21	0.018
hindgut morphogenesis	GO:0007442	58	0.018
response to organonitrogen compound	GO:0010243	75	0.017
negative regulation of neurogenesis	GO:0050768	53	0.017
embryonic hemopoiesis	GO:0035162	26	0.017	Zebrafish
positive regulation of kinase activity	GO:0033674	25	0.017
regulation of wnt signaling pathway planar cell polarity pathway	GO:2000095	2	0.017
regulation of intracellular signal transduction	GO:1902531	236	0.017
catabolic process	GO:0009056	409	0.017
regulation of epithelial cell proliferation	GO:0050678	4	0.017
amnioserosa maintenance	GO:0046665	5	0.017
single organism behavior	GO:0044708	391	0.017
skeletal muscle organ development	GO:0060538	48	0.017
positive regulation of cellular amine metabolic process	GO:0033240	0	0.017
cell migration involved in gastrulation	GO:0042074	9	0.017

numb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.115
	nervous system disease	DOID:863	0	0.047

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