IMP: Integrative Multi-species Prediction

Drosophila melanogaster

28 known processes

inx3 (Dmel_CG1448)

innexin 3

(Aliases: Inx3,CG1448,Dm-inx3,Dmel\CG1448,inx-3,Ix3,INX-3)

FLYBASE: FBgn0028373
Entrez: 44266
UniProtKB: Q9VAS7

Process Predictions
Disease Predictions

inx3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
tube morphogenesis	GO:0035239	191	0.404
regionalization	GO:0003002	416	0.254
epithelial cell differentiation	GO:0030855	322	0.167
digestive system development	GO:0055123	149	0.140
morphogenesis of an epithelium	GO:0002009	276	0.139
segmentation	GO:0035282	207	0.122
detection of stimulus	GO:0051606	156	0.118
embryonic morphogenesis	GO:0048598	206	0.114
mitotic cytokinesis	GO:0000281	50	0.113
tube development	GO:0035295	244	0.109
tissue morphogenesis	GO:0048729	297	0.109
embryonic pattern specification	GO:0009880	174	0.105
cell proliferation	GO:0008283	299	0.102
blastoderm segmentation	GO:0007350	159	0.102
appendage morphogenesis	GO:0035107	397	0.098	Fly
regulation of anatomical structure size	GO:0090066	163	0.093
axis specification	GO:0009798	167	0.090
post embryonic appendage morphogenesis	GO:0035120	385	0.088	Fly
dorsal ventral axis specification	GO:0009950	66	0.084
response to light stimulus	GO:0009416	124	0.081
digestive tract morphogenesis	GO:0048546	127	0.079
cell cycle phase transition	GO:0044770	140	0.078
negative regulation of cell communication	GO:0010648	223	0.075
response to radiation	GO:0009314	155	0.074
respiratory system development	GO:0060541	213	0.074
regulation of cell differentiation	GO:0045595	302	0.066
detection of light stimulus	GO:0009583	58	0.065
organic substance transport	GO:0071702	257	0.065
digestive tract development	GO:0048565	149	0.062
wnt signaling pathway	GO:0016055	98	0.059
response to organic substance	GO:0010033	284	0.058
cell division	GO:0051301	248	0.056
imaginal disc derived wing morphogenesis	GO:0007476	337	0.056	Fly
axonogenesis	GO:0007409	290	0.055
regulation of cell cycle	GO:0051726	291	0.054
olfactory behavior	GO:0042048	97	0.054
phototransduction visible light	GO:0007603	27	0.054
establishment of localization in cell	GO:0051649	402	0.054
oocyte differentiation	GO:0009994	145	0.054
regulation of multicellular organismal development	GO:2000026	414	0.051
organelle fission	GO:0048285	340	0.051
axon guidance	GO:0007411	233	0.050
cell maturation	GO:0048469	144	0.050
exocrine system development	GO:0035272	162	0.049
dorsal ventral pattern formation	GO:0009953	133	0.048
smoothened signaling pathway	GO:0007224	49	0.048
connective tissue development	GO:0061448	3	0.047
wing disc morphogenesis	GO:0007472	344	0.047	Fly
negative regulation of gene expression	GO:0010629	387	0.047
embryonic development via the syncytial blastoderm	GO:0001700	148	0.047
phototransduction	GO:0007602	52	0.047
regulation of smoothened signaling pathway	GO:0008589	28	0.047
single organism behavior	GO:0044708	391	0.046	Fly
organic substance catabolic process	GO:1901575	308	0.045
imaginal disc derived appendage development	GO:0048737	399	0.045	Fly
cell recognition	GO:0008037	102	0.045
forebrain development	GO:0030900	2	0.045
open tracheal system development	GO:0007424	204	0.044
columnar cuboidal epithelial cell development	GO:0002066	249	0.044
learning or memory	GO:0007611	141	0.044	Fly
regulation of mitotic cell cycle	GO:0007346	190	0.043
morphogenesis of embryonic epithelium	GO:0016331	94	0.041
regulation of localization	GO:0032879	275	0.040
meiotic cell cycle	GO:0051321	171	0.040
detection of external stimulus	GO:0009581	66	0.040
epithelial cell development	GO:0002064	274	0.040
nephron development	GO:0072006	3	0.039
anterior posterior axis specification embryo	GO:0008595	103	0.039
oocyte development	GO:0048599	124	0.039
salivary gland morphogenesis	GO:0007435	145	0.039
single organism biosynthetic process	GO:0044711	206	0.039
appendage development	GO:0048736	401	0.038	Fly
detection of stimulus involved in sensory perception	GO:0050906	92	0.038
positive regulation of transcription dna templated	GO:0045893	266	0.038
negative regulation of signaling	GO:0023057	219	0.037
negative regulation of multicellular organismal process	GO:0051241	142	0.037
mesenchymal cell differentiation	GO:0048762	1	0.036
vesicle mediated transport	GO:0016192	381	0.036
cytokinesis	GO:0000910	90	0.036
central nervous system development	GO:0007417	201	0.036
regulation of cell cycle process	GO:0010564	181	0.036
gland morphogenesis	GO:0022612	145	0.036
organonitrogen compound metabolic process	GO:1901564	318	0.035
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.035
limb morphogenesis	GO:0035108	1	0.035
response to abiotic stimulus	GO:0009628	341	0.035
regulation of multi organism process	GO:0043900	131	0.035
immune system process	GO:0002376	347	0.034
detection of visible light	GO:0009584	38	0.033
salivary gland development	GO:0007431	162	0.033
cellular response to dna damage stimulus	GO:0006974	223	0.033
regulation of tube size open tracheal system	GO:0035151	43	0.033
detection of abiotic stimulus	GO:0009582	66	0.032
response to external biotic stimulus	GO:0043207	293	0.032
negative regulation of signal transduction	GO:0009968	206	0.032
protein modification process	GO:0036211	438	0.032
periodic partitioning	GO:0007365	29	0.031
kidney epithelium development	GO:0072073	3	0.031
catabolic process	GO:0009056	409	0.031
intracellular signal transduction	GO:0035556	300	0.031
imaginal disc pattern formation	GO:0007447	91	0.031
transcription from rna polymerase ii promoter	GO:0006366	368	0.031
sex differentiation	GO:0007548	81	0.031
macromolecule catabolic process	GO:0009057	161	0.030
positive regulation of developmental process	GO:0051094	143	0.029
cytoskeleton dependent cytokinesis	GO:0061640	81	0.029
neuron projection guidance	GO:0097485	241	0.029
chemotaxis	GO:0006935	249	0.029
protein localization	GO:0008104	284	0.029
negative regulation of rna biosynthetic process	GO:1902679	240	0.028
body morphogenesis	GO:0010171	2	0.028
lateral inhibition	GO:0046331	206	0.028
anatomical structure homeostasis	GO:0060249	97	0.028
anterior posterior pattern specification	GO:0009952	136	0.028
kidney development	GO:0001822	3	0.028
protein catabolic process	GO:0030163	101	0.028
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.028	Fly
microtubule organizing center organization	GO:0031023	168	0.027
regulation of cell cycle phase transition	GO:1901987	130	0.027
posttranscriptional regulation of gene expression	GO:0010608	145	0.027
eye morphogenesis	GO:0048592	260	0.027
establishment of tissue polarity	GO:0007164	87	0.027
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.027
axon development	GO:0061564	297	0.026
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.026
negative regulation of response to stimulus	GO:0048585	258	0.026
stem cell differentiation	GO:0048863	117	0.026
mitotic cell cycle phase transition	GO:0044772	138	0.025
cell cycle checkpoint	GO:0000075	95	0.025
regulation of oocyte development	GO:0060281	27	0.025
nephron epithelium development	GO:0072009	3	0.025
protein transport	GO:0015031	155	0.025
regulation of intracellular signal transduction	GO:1902531	236	0.025
oocyte construction	GO:0007308	112	0.025
morphogenesis of a polarized epithelium	GO:0001738	93	0.024
regulation of anatomical structure morphogenesis	GO:0022603	242	0.024
negative regulation of rna metabolic process	GO:0051253	251	0.024
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.024
tripartite regional subdivision	GO:0007351	103	0.024
larval development	GO:0002164	104	0.024
response to biotic stimulus	GO:0009607	294	0.023
negative regulation of cellular metabolic process	GO:0031324	382	0.023
chemosensory behavior	GO:0007635	106	0.023
establishment or maintenance of cell polarity	GO:0007163	167	0.023
endocytosis	GO:0006897	310	0.023
regulation of cellular localization	GO:0060341	136	0.023
phagocytosis	GO:0006909	215	0.023
motor neuron axon guidance	GO:0008045	58	0.022
embryo development ending in birth or egg hatching	GO:0009792	152	0.022
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.022
negative regulation of cell cycle process	GO:0010948	109	0.022
small molecule metabolic process	GO:0044281	305	0.022
cell junction assembly	GO:0034329	42	0.022
cellular macromolecule localization	GO:0070727	220	0.022
embryonic axis specification	GO:0000578	107	0.021
mesodermal cell migration	GO:0008078	7	0.021
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.021
positive regulation of signal transduction	GO:0009967	223	0.021
stem cell proliferation	GO:0072089	88	0.021
negative regulation of cell cycle	GO:0045786	116	0.021
sensory perception	GO:0007600	196	0.021
determination of adult lifespan	GO:0008340	137	0.021
regulation of cell development	GO:0060284	215	0.021
regulation of epithelial cell proliferation	GO:0050678	4	0.021
cellular protein modification process	GO:0006464	438	0.020
eye development	GO:0001654	323	0.020
oocyte axis specification	GO:0007309	108	0.020
ameboidal type cell migration	GO:0001667	151	0.020
detection of chemical stimulus	GO:0009593	93	0.020
camera type eye development	GO:0043010	4	0.020
cuticle development	GO:0042335	86	0.020
ion transport	GO:0006811	145	0.020
skin development	GO:0043588	65	0.020
negative regulation of cell differentiation	GO:0045596	143	0.019
positive regulation of signaling	GO:0023056	243	0.019
zygotic determination of anterior posterior axis embryo	GO:0007354	27	0.019
mitotic spindle organization	GO:0007052	220	0.019
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.019
protein maturation	GO:0051604	71	0.019
cellular macromolecular complex assembly	GO:0034622	153	0.019
regulation of embryonic development	GO:0045995	68	0.019
negative regulation of developmental process	GO:0051093	201	0.019
intracellular mrna localization	GO:0008298	66	0.019
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.018
positive regulation of cell communication	GO:0010647	250	0.018
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.018
regulation of growth	GO:0040008	233	0.018
gastrulation	GO:0007369	70	0.018
anterior posterior axis specification	GO:0009948	109	0.018
cellular protein localization	GO:0034613	160	0.018
chitin based cuticle development	GO:0040003	49	0.018
regulation of molecular function	GO:0065009	217	0.018
leg disc development	GO:0035218	92	0.018
response to lipopolysaccharide	GO:0032496	4	0.018
lipid localization	GO:0010876	54	0.018
cellular response to ethanol	GO:0071361	4	0.018
developmental maturation	GO:0021700	172	0.017
establishment of planar polarity	GO:0001736	87	0.017
compound eye morphogenesis	GO:0001745	249	0.017
negative regulation of cellular biosynthetic process	GO:0031327	277	0.017
negative regulation of cell development	GO:0010721	62	0.017
camera type eye morphogenesis	GO:0048593	2	0.017
meiotic cell cycle process	GO:1903046	132	0.017
single organism catabolic process	GO:0044712	228	0.017
establishment of protein localization	GO:0045184	163	0.017
nf kappab import into nucleus	GO:0042348	1	0.017
sensory organ morphogenesis	GO:0090596	260	0.017
imaginal disc derived wing hair organization	GO:0035317	45	0.017
gland development	GO:0048732	191	0.017
regulation of response to stress	GO:0080134	200	0.017
hormone catabolic process	GO:0042447	3	0.017
defense response	GO:0006952	300	0.017
homeostatic process	GO:0042592	199	0.017
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.017
growth	GO:0040007	359	0.016
regulation of reproductive process	GO:2000241	54	0.016
negative regulation of growth	GO:0045926	84	0.016
gastrulation with mouth forming first	GO:0001703	36	0.016
retina development in camera type eye	GO:0060041	4	0.016
positive regulation of epithelial cell differentiation	GO:0030858	1	0.016
cell migration	GO:0016477	238	0.016
oocyte dorsal ventral axis specification	GO:0007310	34	0.016
genital disc development	GO:0035215	44	0.016
meiotic nuclear division	GO:0007126	151	0.016
death	GO:0016265	284	0.016
reproductive structure development	GO:0048608	74	0.016
regulation of cellular ketone metabolic process	GO:0010565	3	0.016
response to nitrogen compound	GO:1901698	90	0.016
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.016
regulation of wnt signaling pathway	GO:0030111	68	0.016
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.016
negative regulation of protein metabolic process	GO:0051248	85	0.016
maintenance of location	GO:0051235	73	0.016
cellular response to organic substance	GO:0071310	132	0.015
negative regulation of cellular protein metabolic process	GO:0032269	85	0.015
regulation of protein transport	GO:0051223	57	0.015
neuron recognition	GO:0008038	101	0.015
chromosome organization	GO:0051276	360	0.015
regulation of transport	GO:0051049	181	0.015
positive regulation of defense response	GO:0031349	59	0.015
cellular catabolic process	GO:0044248	372	0.015
dna metabolic process	GO:0006259	227	0.015
nitrogen compound transport	GO:0071705	85	0.015
amine metabolic process	GO:0009308	12	0.015
adult locomotory behavior	GO:0008344	76	0.015
chromosome segregation	GO:0007059	157	0.015
synaptic transmission	GO:0007268	288	0.015
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.015
phosphorylation	GO:0016310	294	0.015
segment polarity determination	GO:0007367	25	0.014
cellular macromolecule catabolic process	GO:0044265	136	0.014
heart development	GO:0007507	82	0.014
regulation of epithelial cell differentiation	GO:0030856	4	0.014
positive regulation of cellular biosynthetic process	GO:0031328	316	0.014
establishment of organelle localization	GO:0051656	122	0.014
regulation of phosphorus metabolic process	GO:0051174	210	0.014
spindle organization	GO:0007051	253	0.014
cell cell junction assembly	GO:0007043	38	0.014
cell growth	GO:0016049	108	0.014
nuclear division	GO:0000280	332	0.014
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.014
modification dependent macromolecule catabolic process	GO:0043632	79	0.014
cellular amino acid metabolic process	GO:0006520	61	0.014
antimicrobial humoral response	GO:0019730	99	0.014
regulation of catalytic activity	GO:0050790	185	0.014
response to oxygen containing compound	GO:1901700	200	0.014
single organism intracellular transport	GO:1902582	207	0.014
compound eye development	GO:0048749	307	0.014
synapse assembly	GO:0007416	143	0.014
programmed cell death	GO:0012501	257	0.014
regulation of cytoskeleton organization	GO:0051493	89	0.014
taxis	GO:0042330	304	0.014
cognition	GO:0050890	141	0.014	Fly
intracellular transport	GO:0046907	228	0.014
signal transduction by phosphorylation	GO:0023014	107	0.014
ubiquitin dependent protein catabolic process	GO:0006511	78	0.013
positive regulation of cell cycle	GO:0045787	43	0.013
mitotic sister chromatid segregation	GO:0000070	87	0.013
carbohydrate derivative metabolic process	GO:1901135	217	0.013
deactivation of rhodopsin mediated signaling	GO:0016059	17	0.013
regulation of tube length open tracheal system	GO:0035159	24	0.013
cellular protein catabolic process	GO:0044257	83	0.013
reproductive system development	GO:0061458	74	0.013
positive regulation of rna metabolic process	GO:0051254	271	0.013
nephron morphogenesis	GO:0072028	3	0.013
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.013
negative regulation of biosynthetic process	GO:0009890	277	0.013
neurological system process	GO:0050877	358	0.013	Fly
positive regulation of response to stimulus	GO:0048584	323	0.012
positive regulation of gene expression	GO:0010628	290	0.012
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.012
limb development	GO:0060173	1	0.012
spermatogenesis	GO:0007283	200	0.012
renal filtration cell differentiation	GO:0061318	12	0.012
regulation of protein metabolic process	GO:0051246	256	0.012
positive regulation of cell motility	GO:2000147	3	0.012
developmental programmed cell death	GO:0010623	138	0.012
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.012
epidermis development	GO:0008544	65	0.012
response to hexose	GO:0009746	3	0.012
aging	GO:0007568	143	0.012
macromolecular complex assembly	GO:0065003	256	0.012
secretion by cell	GO:0032940	101	0.012
synaptic target recognition	GO:0008039	45	0.012
non sensory hair organization	GO:0035316	47	0.012
protein complex assembly	GO:0006461	200	0.012
negative regulation of transcription dna templated	GO:0045892	237	0.012
mitotic dna integrity checkpoint	GO:0044774	75	0.012
single organism cellular localization	GO:1902580	180	0.012
activation of innate immune response	GO:0002218	4	0.012
negative regulation of fibroblast growth factor receptor signaling pathway	GO:0040037	2	0.012
response to alcohol	GO:0097305	95	0.012
eggshell formation	GO:0030703	105	0.012
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.012
adult behavior	GO:0030534	137	0.012
ovarian follicle cell development	GO:0030707	248	0.012
regulation of g protein coupled receptor protein signaling pathway	GO:0008277	23	0.012
cell death	GO:0008219	279	0.011
regulation of protein catabolic process	GO:0042176	55	0.011
positive regulation of rna biosynthetic process	GO:1902680	266	0.011
cell junction organization	GO:0034330	57	0.011
regulation of establishment of protein localization	GO:0070201	61	0.011
germarium derived egg chamber formation	GO:0007293	101	0.011
negative regulation of cell cycle phase transition	GO:1901988	103	0.011
regulation of cell proliferation	GO:0042127	163	0.011
instar larval development	GO:0002168	55	0.011
response to other organism	GO:0051707	293	0.011
mesenchymal cell development	GO:0014031	1	0.011
embryonic organ development	GO:0048568	50	0.011
malpighian tubule development	GO:0072002	64	0.011
monocarboxylic acid transport	GO:0015718	3	0.011
negative regulation of wnt signaling pathway	GO:0030178	28	0.011
peripheral nervous system development	GO:0007422	52	0.011
mitotic dna damage checkpoint	GO:0044773	74	0.011
olfactory learning	GO:0008355	56	0.011
organic cyclic compound catabolic process	GO:1901361	168	0.011
embryonic hindgut morphogenesis	GO:0048619	48	0.011
positive regulation of protein transport	GO:0051222	37	0.011
epithelial tube morphogenesis	GO:0060562	88	0.011
response to bacterium	GO:0009617	198	0.011
regulation of proteolysis	GO:0030162	87	0.011
positive regulation of multicellular organismal process	GO:0051240	143	0.011
response to organic cyclic compound	GO:0014070	89	0.010
lipid metabolic process	GO:0006629	121	0.010
carbohydrate metabolic process	GO:0005975	82	0.010
hindgut development	GO:0061525	58	0.010
dna repair	GO:0006281	54	0.010
cell cell junction organization	GO:0045216	55	0.010
protein processing	GO:0016485	68	0.010
leg disc morphogenesis	GO:0007478	80	0.010
cellular ketone metabolic process	GO:0042180	24	0.010
male gamete generation	GO:0048232	201	0.010
response to endogenous stimulus	GO:0009719	119	0.010
hematopoietic progenitor cell differentiation	GO:0002244	1	0.010
rna localization	GO:0006403	115	0.010
pattern recognition receptor signaling pathway	GO:0002221	2	0.010
eye photoreceptor cell differentiation	GO:0001754	145	0.010

inx3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
sensory system disease	DOID:0050155	0.029
disease of anatomical entity	DOID:7	0.029
eye and adnexa disease	DOID:1492	0.029
nervous system disease	DOID:863	0.029
disease of cellular proliferation	DOID:14566	0.014
cancer	DOID:162	0.014
disease of metabolism	DOID:0014667	0.013
eye disease	DOID:5614	0.011

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network