IMP: Integrative Multi-species Prediction

Drosophila melanogaster

2 known processes

Pbgs (Dmel_CG10335)

Porphobilinogen synthase

(Aliases: Dmel\CG10335,CG10335,DmPBGS)

Entrez: 39402
FLYBASE: FBgn0036271
UniProtKB: Q9VTV9

Process Predictions
Disease Predictions

Pbgs biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
mitochondrion organization	GO:0007005	65	0.075
response to abiotic stimulus	GO:0009628	341	0.074
cytoplasmic transport	GO:0016482	130	0.070
sulfur compound metabolic process	GO:0006790	59	0.067
oxoacid metabolic process	GO:0043436	103	0.054
small molecule metabolic process	GO:0044281	305	0.053
single organism cellular localization	GO:1902580	180	0.051
organic substance transport	GO:0071702	257	0.048
intracellular transport	GO:0046907	228	0.045
protein modification process	GO:0036211	438	0.040
establishment of localization in cell	GO:0051649	402	0.040
protein transport	GO:0015031	155	0.038
mitochondrial transport	GO:0006839	8	0.038
cellular macromolecule localization	GO:0070727	220	0.037
organic acid metabolic process	GO:0006082	103	0.036
cellular protein modification process	GO:0006464	438	0.034
intracellular protein transport	GO:0006886	104	0.034
organonitrogen compound metabolic process	GO:1901564	318	0.031
cellular amino acid metabolic process	GO:0006520	61	0.031
establishment of protein localization	GO:0045184	163	0.031
protein localization	GO:0008104	284	0.028
carboxylic acid metabolic process	GO:0019752	92	0.027
cellular protein localization	GO:0034613	160	0.027
body morphogenesis	GO:0010171	2	0.026
ion transport	GO:0006811	145	0.025
protein targeting	GO:0006605	64	0.024
positive regulation of signaling	GO:0023056	243	0.024
cellular modified amino acid metabolic process	GO:0006575	45	0.024
response to oxygen containing compound	GO:1901700	200	0.024
protein localization to organelle	GO:0033365	82	0.022
regulation of molecular function	GO:0065009	217	0.021
response to organic substance	GO:0010033	284	0.021
spindle organization	GO:0007051	253	0.021
macromolecular complex assembly	GO:0065003	256	0.020
cellular amide metabolic process	GO:0043603	80	0.020
regulation of cell cycle	GO:0051726	291	0.019
regulation of catalytic activity	GO:0050790	185	0.019
carbohydrate metabolic process	GO:0005975	82	0.019
endocytosis	GO:0006897	310	0.019
organic substance catabolic process	GO:1901575	308	0.019
positive regulation of cell communication	GO:0010647	250	0.018
response to other organism	GO:0051707	293	0.018
positive regulation of signal transduction	GO:0009967	223	0.018
pigment metabolic process	GO:0042440	84	0.017
response to temperature stimulus	GO:0009266	106	0.017
vesicle mediated transport	GO:0016192	381	0.017
cellular catabolic process	GO:0044248	372	0.017
transcription from rna polymerase ii promoter	GO:0006366	368	0.017
catabolic process	GO:0009056	409	0.016
homeostatic process	GO:0042592	199	0.016
phosphorylation	GO:0016310	294	0.016
central nervous system development	GO:0007417	201	0.016
acyl coa metabolic process	GO:0006637	3	0.016
regulation of localization	GO:0032879	275	0.016
regulation of transport	GO:0051049	181	0.016
regionalization	GO:0003002	416	0.016
organonitrogen compound catabolic process	GO:1901565	128	0.016
response to heat	GO:0009408	63	0.016
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.016
axon development	GO:0061564	297	0.015
oocyte differentiation	GO:0009994	145	0.015
taxis	GO:0042330	304	0.015
single organism catabolic process	GO:0044712	228	0.015
response to nutrient levels	GO:0031667	114	0.015
response to extracellular stimulus	GO:0009991	116	0.015
cellular response to chemical stimulus	GO:0070887	199	0.015
lateral inhibition	GO:0046331	206	0.015
positive regulation of response to stimulus	GO:0048584	323	0.015
protein complex biogenesis	GO:0070271	201	0.015
peptide metabolic process	GO:0006518	80	0.015
regulation of multicellular organismal development	GO:2000026	414	0.015
nucleoside metabolic process	GO:0009116	127	0.015
carbohydrate derivative metabolic process	GO:1901135	217	0.015
carbohydrate derivative biosynthetic process	GO:1901137	85	0.014
positive regulation of molecular function	GO:0044093	136	0.014
nitrogen compound transport	GO:0071705	85	0.014
phagocytosis	GO:0006909	215	0.014
response to biotic stimulus	GO:0009607	294	0.014
glutathione metabolic process	GO:0006749	37	0.014
pyridine containing compound metabolic process	GO:0072524	3	0.014
regulation of cellular localization	GO:0060341	136	0.014
negative regulation of cellular metabolic process	GO:0031324	382	0.014
nucleobase containing compound transport	GO:0015931	56	0.014
negative regulation of gene expression	GO:0010629	387	0.013
transmembrane transport	GO:0055085	139	0.013
single organism biosynthetic process	GO:0044711	206	0.013
pigmentation	GO:0043473	75	0.013
neuron projection guidance	GO:0097485	241	0.013
death	GO:0016265	284	0.013
respiratory system development	GO:0060541	213	0.013
mitotic spindle organization	GO:0007052	220	0.013
organophosphate metabolic process	GO:0019637	195	0.013
neurological system process	GO:0050877	358	0.013
positive regulation of catalytic activity	GO:0043085	118	0.013
ion transmembrane transport	GO:0034220	122	0.013
protein targeting to mitochondrion	GO:0006626	1	0.013
regulation of immune system process	GO:0002682	176	0.013
positive regulation of rna biosynthetic process	GO:1902680	266	0.012
cellular response to dna damage stimulus	GO:0006974	223	0.012
response to decreased oxygen levels	GO:0036293	58	0.012
rna localization	GO:0006403	115	0.012
nucleoside phosphate metabolic process	GO:0006753	162	0.012
rna processing	GO:0006396	147	0.012
purine ribonucleoside metabolic process	GO:0046128	127	0.012
oocyte axis specification	GO:0007309	108	0.012
eye pigment biosynthetic process	GO:0006726	32	0.012
intracellular signal transduction	GO:0035556	300	0.012
cellular nitrogen compound catabolic process	GO:0044270	165	0.012
chromatin organization	GO:0006325	207	0.012
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.012
chromosome organization	GO:0051276	360	0.012
forebrain development	GO:0030900	2	0.012
ribose phosphate metabolic process	GO:0019693	145	0.012
gland development	GO:0048732	191	0.012
nucleotide metabolic process	GO:0009117	161	0.012
response to organophosphorus	GO:0046683	2	0.011
developmental pigmentation	GO:0048066	68	0.011
purine nucleoside metabolic process	GO:0042278	127	0.011
protein complex assembly	GO:0006461	200	0.011
glycoprotein metabolic process	GO:0009100	41	0.011
purine containing compound metabolic process	GO:0072521	155	0.011
negative regulation of signal transduction	GO:0009968	206	0.011
organonitrogen compound biosynthetic process	GO:1901566	117	0.011
xenobiotic catabolic process	GO:0042178	1	0.011
response to hypoxia	GO:0001666	53	0.011
retina development in camera type eye	GO:0060041	4	0.011
protein glycosylation	GO:0006486	32	0.011
amine metabolic process	GO:0009308	12	0.011
regulation of cell death	GO:0010941	173	0.011
positive regulation of cell migration	GO:0030335	2	0.011
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.011
chaeta development	GO:0022416	97	0.011
regulation of nervous system development	GO:0051960	248	0.010
regulation of cellular protein metabolic process	GO:0032268	243	0.010
regulation of multi organism process	GO:0043900	131	0.010
single organism intracellular transport	GO:1902582	207	0.010
metal ion homeostasis	GO:0055065	44	0.010
cellular macromolecular complex assembly	GO:0034622	153	0.010
regulation of cellular component biogenesis	GO:0044087	201	0.010
single organism carbohydrate metabolic process	GO:0044723	72	0.010
brain development	GO:0007420	120	0.010
negative regulation of cell communication	GO:0010648	223	0.010
positive regulation of lipid metabolic process	GO:0045834	4	0.010
response to starvation	GO:0042594	97	0.010
regulation of anatomical structure morphogenesis	GO:0022603	242	0.010

Pbgs disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.036
disease of metabolism	DOID:0014667	0.013
nervous system disease	DOID:863	0.011

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