IMP: Integrative Multi-species Prediction

Drosophila melanogaster

70 known processes

Su(z)2 (Dmel_CG3905)

Suppressor of zeste 2

(Aliases: Arp,CG3905,Su(z)[[2]],SUZ2,SU(Z)2,su(z)2,Dmel\CG3905,l(2)k06344)

FLYBASE: FBgn0008654
Entrez: 36432
UniProtKB: E1JH51
UniProtKB: P25172

Process Predictions
Disease Predictions

Su(z)2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of rna biosynthetic process	GO:1902679	240	0.834
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.787
negative regulation of transcription dna templated	GO:0045892	237	0.765
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.660
chromatin organization	GO:0006325	207	0.511	Mouse Fly
single organism behavior	GO:0044708	391	0.501
histone modification	GO:0016570	106	0.489	Mouse
negative regulation of rna metabolic process	GO:0051253	251	0.479
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.476
taxis	GO:0042330	304	0.419	Fly
regionalization	GO:0003002	416	0.338	Mouse
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.333	Human Mouse
dendrite morphogenesis	GO:0048813	199	0.329
negative regulation of signal transduction	GO:0009968	206	0.317	Mouse
dendrite development	GO:0016358	204	0.285
covalent chromatin modification	GO:0016569	106	0.284	Mouse
negative regulation of cellular biosynthetic process	GO:0031327	277	0.281
single organism biosynthetic process	GO:0044711	206	0.260
appendage development	GO:0048736	401	0.251
imaginal disc derived wing morphogenesis	GO:0007476	337	0.232
chromatin modification	GO:0016568	147	0.225	Mouse Fly
regulation of growth	GO:0040008	233	0.224
imaginal disc derived appendage development	GO:0048737	399	0.218
regulation of gene expression epigenetic	GO:0040029	128	0.205
positive regulation of transcription dna templated	GO:0045893	266	0.202
small molecule metabolic process	GO:0044281	305	0.196
peptidyl lysine modification	GO:0018205	57	0.186	Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.172
appendage morphogenesis	GO:0035107	397	0.168
positive regulation of response to stimulus	GO:0048584	323	0.168
neurological system process	GO:0050877	358	0.166
cell motility	GO:0048870	251	0.151	Zebrafish
macromolecular complex assembly	GO:0065003	256	0.144
post embryonic appendage morphogenesis	GO:0035120	385	0.143
peptidyl lysine acetylation	GO:0018394	39	0.142	Mouse
negative regulation of cellular metabolic process	GO:0031324	382	0.140
regulation of localization	GO:0032879	275	0.140
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.139
neuron projection guidance	GO:0097485	241	0.138	Fly
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.135
negative regulation of gene expression	GO:0010629	387	0.133
protein complex biogenesis	GO:0070271	201	0.132
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.132
cellular response to chemical stimulus	GO:0070887	199	0.131	Mouse
cellular protein modification process	GO:0006464	438	0.130	Human Mouse
ocellus pigment metabolic process	GO:0046158	19	0.127
courtship behavior	GO:0007619	68	0.125
regulation of protein modification process	GO:0031399	112	0.124	Human
brain development	GO:0007420	120	0.122	Zebrafish Mouse
male mating behavior	GO:0060179	70	0.115
negative regulation of signaling	GO:0023057	219	0.114	Mouse
negative regulation of biosynthetic process	GO:0009890	277	0.109
regulation of cell development	GO:0060284	215	0.105
mating behavior	GO:0007617	106	0.105
eye antennal disc development	GO:0035214	60	0.105
response to abiotic stimulus	GO:0009628	341	0.104
antennal development	GO:0007469	25	0.097
amine metabolic process	GO:0009308	12	0.096
cell proliferation	GO:0008283	299	0.096	Human Mouse
memory	GO:0007613	94	0.094
cellular amine metabolic process	GO:0044106	12	0.094
protein acetylation	GO:0006473	39	0.094	Mouse
camera type eye development	GO:0043010	4	0.093
locomotory behavior	GO:0007626	176	0.092
organonitrogen compound metabolic process	GO:1901564	318	0.087
oxoacid metabolic process	GO:0043436	103	0.086
vesicle mediated transport	GO:0016192	381	0.085
sensory perception of sound	GO:0007605	56	0.085
retina development in camera type eye	GO:0060041	4	0.085
regulation of cellular ketone metabolic process	GO:0010565	3	0.084
male courtship behavior	GO:0008049	63	0.083
positive regulation of rna metabolic process	GO:0051254	271	0.083
protein complex assembly	GO:0006461	200	0.083
transcription from rna polymerase ii promoter	GO:0006366	368	0.082	Human Mouse
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.078
negative regulation of response to stimulus	GO:0048585	258	0.078	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	85	0.074
negative regulation of small gtpase mediated signal transduction	GO:0051058	13	0.074
cellular amino acid metabolic process	GO:0006520	61	0.072
establishment of localization in cell	GO:0051649	402	0.070
regulation of r7 cell differentiation	GO:0045676	15	0.069
cell division	GO:0051301	248	0.068	Mouse
ameboidal type cell migration	GO:0001667	151	0.067
cuticle development	GO:0042335	86	0.067
negative regulation of gene expression epigenetic	GO:0045814	77	0.066
negative regulation of cell differentiation	GO:0045596	143	0.066
immune system process	GO:0002376	347	0.066	Human Zebrafish Mouse
adult locomotory behavior	GO:0008344	76	0.065
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.064
cognition	GO:0050890	141	0.063
regulation of photoreceptor cell differentiation	GO:0046532	34	0.062
epithelial cell migration	GO:0010631	148	0.062
larval behavior	GO:0030537	42	0.061
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.060	Human Mouse
chromatin mediated maintenance of transcription	GO:0048096	7	0.060
peptidyl amino acid modification	GO:0018193	105	0.059	Mouse
intracellular protein transport	GO:0006886	104	0.059
regulation of gene silencing	GO:0060968	63	0.058
chromatin remodeling	GO:0006338	72	0.058	Fly
central nervous system development	GO:0007417	201	0.056	Zebrafish Mouse
negative regulation of chromatin silencing	GO:0031936	9	0.056
regulation of response to nutrient levels	GO:0032107	18	0.056
cellular ketone metabolic process	GO:0042180	24	0.056
regulation of protein metabolic process	GO:0051246	256	0.056	Human
single organism cellular localization	GO:1902580	180	0.056
nephron tubule development	GO:0072080	3	0.055
mating	GO:0007618	120	0.055
negative regulation of cell communication	GO:0010648	223	0.055	Mouse
mitotic cell cycle embryonic	GO:0045448	38	0.054	Fly
protein acylation	GO:0043543	42	0.054	Mouse
gene silencing	GO:0016458	138	0.052
tube morphogenesis	GO:0035239	191	0.052
forebrain development	GO:0030900	2	0.051
eye photoreceptor cell differentiation	GO:0001754	145	0.051
lipid metabolic process	GO:0006629	121	0.051
cellular response to organic substance	GO:0071310	132	0.050
compound eye pigmentation	GO:0048072	17	0.050
pigment metabolic process	GO:0042440	84	0.049
embryo development ending in birth or egg hatching	GO:0009792	152	0.048	Mouse
nephron tubule morphogenesis	GO:0072078	3	0.047
positive regulation of gene expression	GO:0010628	290	0.047
cell migration	GO:0016477	238	0.047	Zebrafish
stem cell differentiation	GO:0048863	117	0.046
hindbrain development	GO:0030902	2	0.046	Zebrafish
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.046
photoreceptor cell differentiation	GO:0046530	170	0.045
epithelial tube morphogenesis	GO:0060562	88	0.045
wing disc morphogenesis	GO:0007472	344	0.045
glycerolipid metabolic process	GO:0046486	34	0.045
r7 cell differentiation	GO:0045466	43	0.045
circadian rhythm	GO:0007623	105	0.045
regulation of multicellular organismal development	GO:2000026	414	0.044	Mouse
antennal morphogenesis	GO:0048800	14	0.043
organelle localization	GO:0051640	148	0.043
negative regulation of multicellular organismal process	GO:0051241	142	0.042
mitotic chromosome condensation	GO:0007076	22	0.041
response to extracellular stimulus	GO:0009991	116	0.040
chromosome organization	GO:0051276	360	0.040	Mouse Fly
positive regulation of organelle organization	GO:0010638	65	0.040
phagocytosis	GO:0006909	215	0.040
positive regulation of gene expression epigenetic	GO:0045815	16	0.040
positive regulation of rna biosynthetic process	GO:1902680	266	0.039
sensory perception of mechanical stimulus	GO:0050954	72	0.039
adult behavior	GO:0030534	137	0.038
dna methylation or demethylation	GO:0044728	4	0.038	Mouse
muscle organ development	GO:0007517	127	0.038
pigmentation	GO:0043473	75	0.038
macromolecule catabolic process	GO:0009057	161	0.038
segment specification	GO:0007379	33	0.038
positive regulation of cellular biosynthetic process	GO:0031328	316	0.037
small molecule biosynthetic process	GO:0044283	37	0.037
protein modification process	GO:0036211	438	0.036	Human Mouse
positive regulation of macroautophagy	GO:0016239	8	0.036
embryonic morphogenesis	GO:0048598	206	0.036	Mouse
regulation of organelle organization	GO:0033043	196	0.035
cuticle pattern formation	GO:0035017	27	0.035
regulation of epithelial cell differentiation	GO:0030856	4	0.035
epithelial cell migration open tracheal system	GO:0007427	32	0.035
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.034
negative regulation of growth	GO:0045926	84	0.034
regulation of neuron differentiation	GO:0045664	103	0.033
peptidyl lysine methylation	GO:0018022	16	0.033
localization of cell	GO:0051674	257	0.033	Zebrafish
regulation of molecular function	GO:0065009	217	0.033	Human Mouse
positive regulation of cellular protein metabolic process	GO:0032270	118	0.033	Human
regulation of cellular amine metabolic process	GO:0033238	3	0.033
organonitrogen compound biosynthetic process	GO:1901566	117	0.033
meiotic cell cycle process	GO:1903046	132	0.032
regulation of cellular protein metabolic process	GO:0032268	243	0.032	Human
sulfur compound metabolic process	GO:0006790	59	0.031
notch signaling pathway	GO:0007219	120	0.031
open tracheal system development	GO:0007424	204	0.031
sensory perception	GO:0007600	196	0.031
apoptotic process	GO:0006915	159	0.031	Mouse
female genitalia development	GO:0030540	6	0.031
regulation of dna templated transcription elongation	GO:0032784	17	0.030
negative regulation of phosphate metabolic process	GO:0045936	45	0.030
regulation of intracellular signal transduction	GO:1902531	236	0.030
nephron development	GO:0072006	3	0.030
cell fate determination	GO:0001709	91	0.030
nephron epithelium development	GO:0072009	3	0.030
carboxylic acid metabolic process	GO:0019752	92	0.030
determination of adult lifespan	GO:0008340	137	0.030
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	4	0.029
internal peptidyl lysine acetylation	GO:0018393	38	0.029	Mouse
cellular modified amino acid metabolic process	GO:0006575	45	0.029
camera type eye morphogenesis	GO:0048593	2	0.028
single organism intracellular transport	GO:1902582	207	0.028
learning or memory	GO:0007611	141	0.028
telencephalon development	GO:0021537	2	0.028
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.028
negative regulation of photoreceptor cell differentiation	GO:0046533	8	0.027
regulation of cellular amino acid metabolic process	GO:0006521	0	0.027
kidney epithelium development	GO:0072073	3	0.027
cytokinesis	GO:0000910	90	0.027
embryonic hemopoiesis	GO:0035162	26	0.027	Zebrafish
negative regulation of protein metabolic process	GO:0051248	85	0.027
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.027
kidney morphogenesis	GO:0060993	3	0.027
positive regulation of cellular component organization	GO:0051130	156	0.026
aging	GO:0007568	143	0.026
regulation of chromosome organization	GO:0033044	64	0.026
epithelial cell differentiation	GO:0030855	322	0.026
epithelium migration	GO:0090132	148	0.026
regulation of chromatin silencing	GO:0031935	36	0.025
negative regulation of intracellular signal transduction	GO:1902532	57	0.025
cellular response to abiotic stimulus	GO:0071214	58	0.025
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.025
intracellular transport	GO:0046907	228	0.025
negative regulation of nervous system development	GO:0051961	92	0.025
cellular protein catabolic process	GO:0044257	83	0.025
eye antennal disc morphogenesis	GO:0007455	34	0.024
reproductive structure development	GO:0048608	74	0.024
rhythmic process	GO:0048511	106	0.024
positive regulation of macromolecule metabolic process	GO:0010604	405	0.024	Human
regulation of cellular component biogenesis	GO:0044087	201	0.024
heterochromatin organization	GO:0070828	25	0.024
malpighian tubule development	GO:0072002	64	0.023
regulation of erbb signaling pathway	GO:1901184	42	0.023
dna alkylation	GO:0006305	4	0.023	Mouse
regulation of tyrosine phosphorylation of stat protein	GO:0042509	1	0.023
response to wounding	GO:0009611	94	0.023
dendrite guidance	GO:0070983	21	0.023
digestive tract morphogenesis	GO:0048546	127	0.023
spindle organization	GO:0007051	253	0.023
organophosphate metabolic process	GO:0019637	195	0.023
response to hexose	GO:0009746	3	0.023
golgi organization	GO:0007030	66	0.023
chemotaxis	GO:0006935	249	0.022	Fly
imaginal disc derived female genitalia development	GO:0007486	6	0.022
renal tubule development	GO:0061326	64	0.022
pigment biosynthetic process	GO:0046148	36	0.022
regulation of multi organism process	GO:0043900	131	0.022
cellular response to dna damage stimulus	GO:0006974	223	0.022
regulation of protein deacetylation	GO:0090311	2	0.022
rhythmic behavior	GO:0007622	76	0.022
histone acetylation	GO:0016573	38	0.022	Mouse
chemosensory behavior	GO:0007635	106	0.022
regulation of chromatin modification	GO:1903308	28	0.022
neural retina development	GO:0003407	4	0.022
spermatogenesis	GO:0007283	200	0.021
gravitaxis	GO:0042332	26	0.021
regulation of dendrite morphogenesis	GO:0048814	28	0.021
hematopoietic progenitor cell differentiation	GO:0002244	1	0.021
regulation of cell cycle process	GO:0010564	181	0.021
histone h4 k16 acetylation	GO:0043984	4	0.021
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.021
negative regulation of protein modification process	GO:0031400	29	0.021
regulation of chromatin organization	GO:1902275	32	0.021
immune system development	GO:0002520	57	0.021	Human Zebrafish Mouse
body morphogenesis	GO:0010171	2	0.020
positive regulation of response to extracellular stimulus	GO:0032106	8	0.020
regulation of notch signaling pathway	GO:0008593	100	0.020
regulation of cell death	GO:0010941	173	0.020	Mouse
compound eye photoreceptor development	GO:0042051	78	0.020
regulation of compound eye cone cell fate specification	GO:0042682	4	0.020
mitotic nuclear division	GO:0007067	213	0.020
sex differentiation	GO:0007548	81	0.020
regulation of embryonic development	GO:0045995	68	0.020
regulation of response to extracellular stimulus	GO:0032104	18	0.020
reproductive system development	GO:0061458	74	0.020
regulation of actin filament based process	GO:0032970	42	0.020
dna metabolic process	GO:0006259	227	0.020	Mouse
respiratory system development	GO:0060541	213	0.019
regulation of dna metabolic process	GO:0051052	34	0.019
chitin based cuticle development	GO:0040003	49	0.019
regulation of phosphorus metabolic process	GO:0051174	210	0.019
biological adhesion	GO:0022610	138	0.019
positive regulation of biosynthetic process	GO:0009891	316	0.019
response to organophosphorus	GO:0046683	2	0.019
anterior posterior pattern specification	GO:0009952	136	0.019	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.019
kidney development	GO:0001822	3	0.019
regulation of transcription elongation from rna polymerase ii promoter	GO:0034243	15	0.019
cellular response to endogenous stimulus	GO:0071495	80	0.018
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.018
multi organism behavior	GO:0051705	175	0.018
columnar cuboidal epithelial cell development	GO:0002066	249	0.018
signal transduction in response to dna damage	GO:0042770	3	0.018
dna methylation	GO:0006306	4	0.018	Mouse
dna templated transcription elongation	GO:0006354	18	0.018
mitotic spindle organization	GO:0007052	220	0.018
axon development	GO:0061564	297	0.018	Fly
response to gravity	GO:0009629	26	0.018
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.018
striated muscle adaptation	GO:0014888	1	0.018
intracellular signal transduction	GO:0035556	300	0.018
response to nutrient levels	GO:0031667	114	0.018
gland development	GO:0048732	191	0.018
urogenital system development	GO:0001655	72	0.017
skin development	GO:0043588	65	0.017
head development	GO:0060322	135	0.017	Zebrafish Mouse
chromosome segregation	GO:0007059	157	0.017
methylation	GO:0032259	47	0.017	Mouse
connective tissue development	GO:0061448	3	0.017
regulation of developmental pigmentation	GO:0048070	24	0.017
cellular macromolecular complex assembly	GO:0034622	153	0.017
endocytosis	GO:0006897	310	0.017
postreplication repair	GO:0006301	2	0.017
positive regulation of cell cycle	GO:0045787	43	0.017
regulation of mrna 3 end processing	GO:0031440	7	0.017
positive regulation of cellular amine metabolic process	GO:0033240	0	0.017
regulation of developmental growth	GO:0048638	174	0.016
regulation of programmed cell death	GO:0043067	152	0.016	Mouse
outflow tract morphogenesis	GO:0003151	4	0.016
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	4	0.016
response to other organism	GO:0051707	293	0.016
regulation of immune system process	GO:0002682	176	0.016	Mouse
positive regulation of protein metabolic process	GO:0051247	128	0.016	Human
axon guidance	GO:0007411	233	0.016	Fly
cardiac cell fate determination	GO:0060913	3	0.016
tissue death	GO:0016271	102	0.016
regulation of dna templated transcription in response to stress	GO:0043620	4	0.015
male courtship behavior veined wing generated song production	GO:0045433	20	0.015
cell cycle arrest	GO:0007050	4	0.015
response to endogenous stimulus	GO:0009719	119	0.015
regulation of cell cycle	GO:0051726	291	0.015
nephron tubule formation	GO:0072079	3	0.015
imaginal disc derived leg morphogenesis	GO:0007480	80	0.015
regulation of nuclear division	GO:0051783	58	0.015
ensheathment of neurons	GO:0007272	10	0.015
neuron recognition	GO:0008038	101	0.015
cell fate specification	GO:0001708	71	0.015
pigment cell differentiation	GO:0050931	3	0.015
multicellular organism growth	GO:0035264	46	0.015
regulation of response to stress	GO:0080134	200	0.015
regulation of multicellular organism growth	GO:0040014	40	0.015
neuroblast fate commitment	GO:0014017	19	0.015
nuclear division	GO:0000280	332	0.015
cellular response to oxygen containing compound	GO:1901701	79	0.015	Mouse
regulation of epithelial cell proliferation	GO:0050678	4	0.015
cranial nerve development	GO:0021545	1	0.014
lipid biosynthetic process	GO:0008610	46	0.014
tissue migration	GO:0090130	155	0.014
skeletal muscle adaptation	GO:0043501	1	0.014
response to radiation	GO:0009314	155	0.014
hair cell differentiation	GO:0035315	47	0.014
organophosphate biosynthetic process	GO:0090407	46	0.014
epithelial cell development	GO:0002064	274	0.014
negative regulation of erbb signaling pathway	GO:1901185	29	0.014
neuronal stem cell maintenance	GO:0097150	4	0.014
axon ensheathment in central nervous system	GO:0032291	3	0.014
molting cycle chitin based cuticle	GO:0007591	56	0.014
asymmetric cell division	GO:0008356	37	0.014
negative regulation of ras protein signal transduction	GO:0046580	13	0.014
dna replication	GO:0006260	48	0.014
transcription elongation from rna polymerase ii promoter	GO:0006368	18	0.014
organic substance transport	GO:0071702	257	0.014
response to light stimulus	GO:0009416	124	0.014
cellular response to growth factor stimulus	GO:0071363	30	0.014
multicellular organismal aging	GO:0010259	140	0.014
circadian regulation of gene expression	GO:0032922	5	0.014
organelle fission	GO:0048285	340	0.013
protein modification by small protein conjugation or removal	GO:0070647	106	0.013	Human Mouse
regulation of phosphate metabolic process	GO:0019220	210	0.013
positive regulation of cellular component biogenesis	GO:0044089	80	0.013
imaginal disc derived wing vein specification	GO:0007474	48	0.013
regulation of histone deacetylation	GO:0031063	2	0.013
macromolecule methylation	GO:0043414	45	0.013	Mouse
establishment of organelle localization	GO:0051656	122	0.013
nephron morphogenesis	GO:0072028	3	0.013
carbohydrate homeostasis	GO:0033500	12	0.013
regulation of proteolysis	GO:0030162	87	0.013
response to organic substance	GO:0010033	284	0.013
regulation of anatomical structure morphogenesis	GO:0022603	242	0.013
skeletal muscle fiber development	GO:0048741	3	0.013
response to starvation	GO:0042594	97	0.013
positive regulation of response to nutrient levels	GO:0032109	8	0.013
regulation of anatomical structure size	GO:0090066	163	0.013
detection of chemical stimulus	GO:0009593	93	0.013
stem cell fate commitment	GO:0048865	25	0.013
embryonic hindgut morphogenesis	GO:0048619	48	0.013
negative regulation of developmental process	GO:0051093	201	0.012
regulation of cellular catabolic process	GO:0031329	157	0.012
compound eye morphogenesis	GO:0001745	249	0.012
organic cyclic compound catabolic process	GO:1901361	168	0.012
exocytosis	GO:0006887	28	0.012
response to temperature stimulus	GO:0009266	106	0.012
death	GO:0016265	284	0.012	Mouse
negative regulation of protein phosphorylation	GO:0001933	17	0.012
ocellus pigmentation	GO:0033060	19	0.012
tube formation	GO:0035148	21	0.012
stem cell division	GO:0017145	69	0.012	Mouse
cellular lipid metabolic process	GO:0044255	83	0.012
locomotor rhythm	GO:0045475	56	0.012
chromosome condensation	GO:0030261	41	0.012
histone deacetylation	GO:0016575	9	0.012
histone methylation	GO:0016571	40	0.012
acylglycerol metabolic process	GO:0006639	12	0.012
negative regulation of phosphorylation	GO:0042326	35	0.012
lateral inhibition	GO:0046331	206	0.012
renal system development	GO:0072001	72	0.012
hematopoietic or lymphoid organ development	GO:0048534	57	0.012	Human Zebrafish Mouse
olfactory learning	GO:0008355	56	0.012
response to oxidative stress	GO:0006979	86	0.012	Mouse
oocyte maturation	GO:0001556	3	0.012
regulation of response to oxidative stress	GO:1902882	4	0.012
anion transport	GO:0006820	41	0.012
developmental pigmentation	GO:0048066	68	0.012
secondary metabolite biosynthetic process	GO:0044550	24	0.011
organic acid metabolic process	GO:0006082	103	0.011
positive regulation of epithelial cell differentiation	GO:0030858	1	0.011
larval somatic muscle development	GO:0007526	19	0.011
cellular catabolic process	GO:0044248	372	0.011
regulation of phosphorylation	GO:0042325	147	0.011
response to lipopolysaccharide	GO:0032496	4	0.011
positive regulation of cell motility	GO:2000147	3	0.011
positive regulation of notch signaling pathway	GO:0045747	34	0.011
maintenance of location	GO:0051235	73	0.011
operant conditioning	GO:0035106	2	0.011
olfactory behavior	GO:0042048	97	0.011
endoderm formation	GO:0001706	3	0.011
regulation of mitotic cell cycle	GO:0007346	190	0.011
endodermal cell fate commitment	GO:0001711	3	0.011
positive regulation of histone acetylation	GO:0035066	3	0.011
genitalia development	GO:0048806	26	0.011
eye photoreceptor cell development	GO:0042462	81	0.011
dna packaging	GO:0006323	91	0.011
cellular response to starvation	GO:0009267	61	0.011
response to ionizing radiation	GO:0010212	32	0.011
malpighian tubule morphogenesis	GO:0007443	44	0.011
actin filament polymerization	GO:0030041	27	0.011
negative regulation of epithelial cell proliferation	GO:0050680	4	0.011
protein catabolic process	GO:0030163	101	0.011
cardiac muscle cell differentiation	GO:0055007	4	0.011
cellular biogenic amine metabolic process	GO:0006576	9	0.011
myotube cell development	GO:0014904	3	0.011
regulation of cellular response to stress	GO:0080135	89	0.011
axis specification	GO:0009798	167	0.011
cell death	GO:0008219	279	0.011	Mouse
positive regulation of cell migration	GO:0030335	2	0.011
photoreceptor cell fate commitment	GO:0046552	41	0.010
regulation of neuroblast proliferation	GO:1902692	34	0.010
protein alkylation	GO:0008213	43	0.010
cellular response to hexose stimulus	GO:0071331	1	0.010
positive regulation of protein modification process	GO:0031401	58	0.010	Human
cellular response to nutrient levels	GO:0031669	62	0.010
learning	GO:0007612	75	0.010
regulation of catabolic process	GO:0009894	170	0.010
stem cell development	GO:0048864	79	0.010
positive regulation of cellular catabolic process	GO:0031331	95	0.010
regulation of cellular component movement	GO:0051270	42	0.010
secretion	GO:0046903	109	0.010
positive regulation of signal transduction	GO:0009967	223	0.010
compound eye development	GO:0048749	307	0.010
regulation of transport	GO:0051049	181	0.010
regulation of protein complex assembly	GO:0043254	42	0.010
cardiac muscle tissue development	GO:0048738	9	0.010
muscle structure development	GO:0061061	224	0.010
dorsal ventral pattern formation	GO:0009953	133	0.010
cellular response to hormone stimulus	GO:0032870	44	0.010
membrane depolarization	GO:0051899	4	0.010

Su(z)2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.089
musculoskeletal system disease	DOID:17	0.022
disease of cellular proliferation	DOID:14566	0.015
cancer	DOID:162	0.015
organ system cancer	DOID:0050686	0.015
nervous system disease	DOID:863	0.010

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