IMP: Integrative Multi-species Prediction

Drosophila melanogaster

149 known processes

CSN8 (Dmel_CG42522)

COP9 complex homolog subunit 8

(Aliases: CG13383,Dmel_CG13383,Dmel\CG42522,csn8,CG42522,l(2)SH1829,Dch8,l(2)SH2 1829,CG33297,CH8,Csn8)

Entrez: 49077
FLYBASE: FBgn0261437
UniProtKB: Q7KTH8

Process Predictions
Disease Predictions

CSN8 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
positive regulation of biosynthetic process	GO:0009891	316	0.804
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.784
regionalization	GO:0003002	416	0.764
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.717
imaginal disc derived appendage development	GO:0048737	399	0.676
regulation of protein metabolic process	GO:0051246	256	0.535
post embryonic appendage morphogenesis	GO:0035120	385	0.510
positive regulation of macromolecule metabolic process	GO:0010604	405	0.507
negative regulation of transcription dna templated	GO:0045892	237	0.499
negative regulation of cellular biosynthetic process	GO:0031327	277	0.482
posttranscriptional regulation of gene expression	GO:0010608	145	0.435
negative regulation of biosynthetic process	GO:0009890	277	0.434
positive regulation of antimicrobial peptide production	GO:0002225	28	0.428
development of primary sexual characteristics	GO:0045137	50	0.401
protein modification process	GO:0036211	438	0.366
regulation of cellular protein metabolic process	GO:0032268	243	0.346
proteolysis	GO:0006508	192	0.301
dorsal ventral pattern formation	GO:0009953	133	0.300
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.268
negative regulation of cellular metabolic process	GO:0031324	382	0.266
sex differentiation	GO:0007548	81	0.257
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.251
catabolic process	GO:0009056	409	0.238
tissue death	GO:0016271	102	0.229
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.221
appendage development	GO:0048736	401	0.221
mitotic cell cycle phase transition	GO:0044772	138	0.218
protein modification by small protein removal	GO:0070646	28	0.217
mitotic cell cycle checkpoint	GO:0007093	88	0.213
positive regulation of growth	GO:0045927	75	0.212
mitotic g2 m transition checkpoint	GO:0044818	70	0.205
positive regulation of gene expression	GO:0010628	290	0.201
positive regulation of rna metabolic process	GO:0051254	271	0.194
positive regulation of developmental process	GO:0051094	143	0.191
gland morphogenesis	GO:0022612	145	0.191
histolysis	GO:0007559	102	0.184
positive regulation of multi organism process	GO:0043902	40	0.184
multicellular organismal reproductive behavior	GO:0033057	110	0.182
negative regulation of rna metabolic process	GO:0051253	251	0.176
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.173
regulation of cell differentiation	GO:0045595	302	0.170
regulation of cellular ketone metabolic process	GO:0010565	3	0.170
response to other organism	GO:0051707	293	0.168
positive regulation of rna biosynthetic process	GO:1902680	266	0.166
histone modification	GO:0016570	106	0.165
regulation of growth	GO:0040008	233	0.165
reproductive structure development	GO:0048608	74	0.159
cell cycle phase transition	GO:0044770	140	0.153
positive regulation of transcription dna templated	GO:0045893	266	0.149
regulation of rna splicing	GO:0043484	69	0.149
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.149
regulation of multi organism process	GO:0043900	131	0.148
positive regulation of cellular protein metabolic process	GO:0032270	118	0.136
negative regulation of cell cycle phase transition	GO:1901988	103	0.132
regulation of mitotic cell cycle	GO:0007346	190	0.127
gland development	GO:0048732	191	0.124
growth	GO:0040007	359	0.122
developmental programmed cell death	GO:0010623	138	0.120
rna splicing	GO:0008380	83	0.119
positive regulation of protein metabolic process	GO:0051247	128	0.119
defense response	GO:0006952	300	0.118
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.118
positive regulation of cellular biosynthetic process	GO:0031328	316	0.114
nucleosome organization	GO:0034728	59	0.109
dorsal ventral axis specification	GO:0009950	66	0.109
positive regulation of signal transduction	GO:0009967	223	0.108
regulation of cell cycle phase transition	GO:1901987	130	0.106
regulation of cell proliferation	GO:0042127	163	0.105
regulation of cell cycle process	GO:0010564	181	0.105
positive regulation of multicellular organismal process	GO:0051240	143	0.098
muscle organ development	GO:0007517	127	0.098
peptidyl amino acid modification	GO:0018193	105	0.098
organic substance catabolic process	GO:1901575	308	0.094
negative regulation of gene expression	GO:0010629	387	0.094
modification dependent macromolecule catabolic process	GO:0043632	79	0.093
g1 s transition of mitotic cell cycle	GO:0000082	31	0.093
apposition of dorsal and ventral imaginal disc derived wing surfaces	GO:0007475	15	0.092
negative regulation of cell proliferation	GO:0008285	69	0.090
salivary gland cell autophagic cell death	GO:0035071	83	0.090
modification dependent protein catabolic process	GO:0019941	78	0.089
salivary gland morphogenesis	GO:0007435	145	0.084
cell death	GO:0008219	279	0.083
exocrine system development	GO:0035272	162	0.081
axon development	GO:0061564	297	0.080
columnar cuboidal epithelial cell development	GO:0002066	249	0.080
positive regulation of cell death	GO:0010942	69	0.079
ubiquitin dependent protein catabolic process	GO:0006511	78	0.079
eye development	GO:0001654	323	0.078
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.074
positive regulation of cellular amine metabolic process	GO:0033240	0	0.073
immune system process	GO:0002376	347	0.072
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.072
heart development	GO:0007507	82	0.072
peptidyl lysine modification	GO:0018205	57	0.072
protein ubiquitination	GO:0016567	70	0.070
response to biotic stimulus	GO:0009607	294	0.068
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.067
negative regulation of protein metabolic process	GO:0051248	85	0.065
transcription from rna polymerase ii promoter	GO:0006366	368	0.064
wing disc pattern formation	GO:0035222	66	0.063
negative regulation of cellular protein metabolic process	GO:0032269	85	0.063
cellular protein modification process	GO:0006464	438	0.063
macromolecule catabolic process	GO:0009057	161	0.063
cellular amine metabolic process	GO:0044106	12	0.061
genitalia development	GO:0048806	26	0.061
negative regulation of cell differentiation	GO:0045596	143	0.060
autophagic cell death	GO:0048102	83	0.059
compound eye morphogenesis	GO:0001745	249	0.059
rna catabolic process	GO:0006401	37	0.058
regulation of neural precursor cell proliferation	GO:2000177	35	0.057
negative regulation of cell cycle process	GO:0010948	109	0.056
regulation of chromosome organization	GO:0033044	64	0.056
negative regulation of rna biosynthetic process	GO:1902679	240	0.056
protein modification by small protein conjugation or removal	GO:0070647	106	0.055
amine metabolic process	GO:0009308	12	0.055
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.055
regulation of protein stability	GO:0031647	43	0.055
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.054
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.054
defense response to other organism	GO:0098542	225	0.054
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.052
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.052
macromolecular complex assembly	GO:0065003	256	0.051
cellular macromolecule catabolic process	GO:0044265	136	0.051
salivary gland histolysis	GO:0035070	88	0.051
negative regulation of multicellular organismal process	GO:0051241	142	0.051
negative regulation of mitotic cell cycle	GO:0045930	109	0.051
organonitrogen compound metabolic process	GO:1901564	318	0.050
imaginal disc derived wing morphogenesis	GO:0007476	337	0.050
regulation of cellular amine metabolic process	GO:0033238	3	0.049
protein catabolic process	GO:0030163	101	0.049
cellular amide metabolic process	GO:0043603	80	0.049
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.048
cytokinesis	GO:0000910	90	0.046
appendage morphogenesis	GO:0035107	397	0.046
chromosome organization	GO:0051276	360	0.045
positive regulation of cell communication	GO:0010647	250	0.044
oocyte development	GO:0048599	124	0.044
cell maturation	GO:0048469	144	0.043
cellular amino acid metabolic process	GO:0006520	61	0.043
mrna metabolic process	GO:0016071	124	0.043
regulation of catalytic activity	GO:0050790	185	0.042
positive regulation of cellular component organization	GO:0051130	156	0.041
organ growth	GO:0035265	56	0.041
positive regulation of developmental growth	GO:0048639	62	0.041
reproductive system development	GO:0061458	74	0.040
rna processing	GO:0006396	147	0.039
positive regulation of apoptotic process	GO:0043065	47	0.038
epithelial cell differentiation	GO:0030855	322	0.038
chromatin organization	GO:0006325	207	0.038
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.038
positive regulation of proteolysis	GO:0045862	52	0.038
response to endogenous stimulus	GO:0009719	119	0.037
mitotic g2 dna damage checkpoint	GO:0007095	69	0.037
regulation of programmed cell death	GO:0043067	152	0.036
establishment or maintenance of cell polarity	GO:0007163	167	0.035
positive regulation of molecular function	GO:0044093	136	0.035
mrna catabolic process	GO:0006402	33	0.034
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.034
regulation of molecular function	GO:0065009	217	0.034
endocytosis	GO:0006897	310	0.034
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.034
mitotic dna damage checkpoint	GO:0044773	74	0.034
death	GO:0016265	284	0.034
larval lymph gland hemopoiesis	GO:0035167	17	0.034
muscle structure development	GO:0061061	224	0.034
nephron morphogenesis	GO:0072028	3	0.033
nephron tubule morphogenesis	GO:0072078	3	0.033
regulation of mrna splicing via spliceosome	GO:0048024	64	0.033
salivary gland development	GO:0007431	162	0.033
covalent chromatin modification	GO:0016569	106	0.032
posttranscriptional gene silencing by rna	GO:0035194	45	0.031
programmed cell death	GO:0012501	257	0.030
axonogenesis	GO:0007409	290	0.030
cullin deneddylation	GO:0010388	3	0.030
nephron epithelium morphogenesis	GO:0072088	3	0.029
regulation of stem cell proliferation	GO:0072091	40	0.029
kidney morphogenesis	GO:0060993	3	0.029
negative regulation of defense response	GO:0031348	35	0.029
photoreceptor cell differentiation	GO:0046530	170	0.028
response to external biotic stimulus	GO:0043207	293	0.028
regulation of immune system process	GO:0002682	176	0.028
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.028
eye photoreceptor cell differentiation	GO:0001754	145	0.027
regulation of mrna processing	GO:0050684	71	0.027
regulation of proteolysis	GO:0030162	87	0.027
cellular protein catabolic process	GO:0044257	83	0.027
cell cycle g1 s phase transition	GO:0044843	31	0.026
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.026
intracellular signal transduction	GO:0035556	300	0.026
segmentation	GO:0035282	207	0.026
cellular macromolecular complex assembly	GO:0034622	153	0.025
positive regulation of signaling	GO:0023056	243	0.025
oocyte dorsal ventral axis specification	GO:0007310	34	0.025
peptide metabolic process	GO:0006518	80	0.024
vesicle mediated transport	GO:0016192	381	0.024
gonad development	GO:0008406	50	0.024
reproductive behavior	GO:0019098	122	0.024
imaginal disc pattern formation	GO:0007447	91	0.024
multi organism reproductive behavior	GO:0044705	121	0.024
positive regulation of intracellular signal transduction	GO:1902533	116	0.023
regulation of cell cycle	GO:0051726	291	0.023
respiratory system development	GO:0060541	213	0.023
regulation of cellular catabolic process	GO:0031329	157	0.023
negative regulation of developmental process	GO:0051093	201	0.023
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.023
regulation of organelle organization	GO:0033043	196	0.023
multi organism behavior	GO:0051705	175	0.023
nephron development	GO:0072006	3	0.022
cell division	GO:0051301	248	0.022
positive regulation of response to stimulus	GO:0048584	323	0.022
compound eye photoreceptor cell differentiation	GO:0001751	140	0.022
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.022
organic acid metabolic process	GO:0006082	103	0.022
developmental growth	GO:0048589	280	0.022
regulation of translation	GO:0006417	56	0.021
peptide biosynthetic process	GO:0043043	42	0.021
rna splicing via transesterification reactions	GO:0000375	73	0.021
oocyte differentiation	GO:0009994	145	0.021
nuclear transcribed mrna catabolic process	GO:0000956	24	0.020
regulation of protein catabolic process	GO:0042176	55	0.020
developmental maturation	GO:0021700	172	0.020
regulation of protein modification process	GO:0031399	112	0.020
oxoacid metabolic process	GO:0043436	103	0.020
mrna processing	GO:0006397	104	0.020
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.020
regulation of cellular amino acid metabolic process	GO:0006521	0	0.020
regulation of epithelial cell differentiation	GO:0030856	4	0.019
positive regulation of cellular protein catabolic process	GO:1903364	24	0.019
protein modification by small protein conjugation	GO:0032446	79	0.019
immune system development	GO:0002520	57	0.019
spinal cord development	GO:0021510	1	0.019
cellular protein localization	GO:0034613	160	0.018
cellular catabolic process	GO:0044248	372	0.018
cellular response to dna damage stimulus	GO:0006974	223	0.018
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.018
negative regulation of neuroblast proliferation	GO:0007406	27	0.018
defense response to bacterium	GO:0042742	178	0.018
kidney epithelium development	GO:0072073	3	0.018
mrna splicing via spliceosome	GO:0000398	73	0.018
negative regulation of translation	GO:0017148	28	0.018
dna integrity checkpoint	GO:0031570	81	0.018
positive regulation of organelle organization	GO:0010638	65	0.017
regulation of cellular protein catabolic process	GO:1903362	44	0.017
regulation of cell development	GO:0060284	215	0.017
regulation of proteasomal protein catabolic process	GO:0061136	39	0.017
mitotic dna integrity checkpoint	GO:0044774	75	0.017
positive regulation of antimicrobial humoral response	GO:0002760	28	0.017
long term memory	GO:0007616	62	0.017
stem cell proliferation	GO:0072089	88	0.016
proteasomal protein catabolic process	GO:0010498	59	0.016
cellular macromolecule localization	GO:0070727	220	0.016
regulation of immune effector process	GO:0002697	52	0.016
positive regulation of programmed cell death	GO:0043068	62	0.015
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.015
apoptotic process	GO:0006915	159	0.015
multicellular organism growth	GO:0035264	46	0.015
regulation of multicellular organism growth	GO:0040014	40	0.015
wing disc morphogenesis	GO:0007472	344	0.014
notch signaling pathway	GO:0007219	120	0.014
positive regulation of cellular catabolic process	GO:0031331	95	0.014
regulation of localization	GO:0032879	275	0.014
regulation of transport	GO:0051049	181	0.014
regulation of nuclear division	GO:0051783	58	0.014
protein alkylation	GO:0008213	43	0.014
nephron epithelium development	GO:0072009	3	0.014
cellular response to extracellular stimulus	GO:0031668	64	0.014
cell proliferation	GO:0008283	299	0.013
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.013
regulation of cellular amide metabolic process	GO:0034248	39	0.013
histone ubiquitination	GO:0016574	4	0.013
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.013
chromatin modification	GO:0016568	147	0.013
positive regulation of response to biotic stimulus	GO:0002833	31	0.013
regulation of response to stress	GO:0080134	200	0.013
positive regulation of catabolic process	GO:0009896	105	0.013
single organism catabolic process	GO:0044712	228	0.012
posttranscriptional gene silencing	GO:0016441	46	0.012
immune effector process	GO:0002252	98	0.012
protein import	GO:0017038	55	0.012
protein deubiquitination	GO:0016579	17	0.012
dendrite development	GO:0016358	204	0.012
peptidyl lysine acetylation	GO:0018394	39	0.012
regulation of imaginal disc growth	GO:0045570	26	0.012
axis specification	GO:0009798	167	0.012
regulation of notch signaling pathway	GO:0008593	100	0.012
regulation of cellular localization	GO:0060341	136	0.012
regulation of defense response	GO:0031347	102	0.012
regulation of antimicrobial peptide production	GO:0002784	44	0.011
ribonucleoprotein complex biogenesis	GO:0022613	31	0.011
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.011
neuron fate commitment	GO:0048663	50	0.011
alternative mrna splicing via spliceosome	GO:0000380	60	0.011
regulation of chromosome segregation	GO:0051983	32	0.011
regulation of cell death	GO:0010941	173	0.011
stem cell development	GO:0048864	79	0.011
oviposition	GO:0018991	19	0.011
multi multicellular organism process	GO:0044706	123	0.011
striated muscle tissue development	GO:0014706	27	0.011
positive regulation of protein catabolic process	GO:0045732	34	0.011
positive regulation of transport	GO:0051050	92	0.011
ncrna metabolic process	GO:0034660	43	0.011
carboxylic acid metabolic process	GO:0019752	92	0.011
cellular ketone metabolic process	GO:0042180	24	0.011
regulation of intracellular signal transduction	GO:1902531	236	0.011
regulation of mrna metabolic process	GO:1903311	72	0.010
centrosome cycle	GO:0007098	137	0.010
lipid localization	GO:0010876	54	0.010
cellular nitrogen compound catabolic process	GO:0044270	165	0.010
regulation of meiosis	GO:0040020	3	0.010
cellular response to nutrient levels	GO:0031669	62	0.010
regulation of epidermal cell differentiation	GO:0045604	3	0.010
histone h4 acetylation	GO:0043967	13	0.010
male gamete generation	GO:0048232	201	0.010
protein localization to nucleus	GO:0034504	55	0.010
protein localization	GO:0008104	284	0.010
morphogenesis of an epithelium	GO:0002009	276	0.010

CSN8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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