IMP: Integrative Multi-species Prediction

Drosophila melanogaster

137 known processes

Pi3K59F (Dmel_CG5373)

Phosphotidylinositol 3 kinase 59F

(Aliases: CG5373,VPS34,dVps34/PI3K59F,PI3K,DmVps34,dVps34,dPI3K,PI3K-59F,Dmel\CG5373,PI[[3]]K,PI(3)K,PI3K_59F,Pi3K_59F,Vps34)

FLYBASE: FBgn0015277
Entrez: 37733
UniProtKB: Q9W1M7

Process Predictions
Disease Predictions

Pi3K59F biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
larval midgut histolysis	GO:0035069	22	0.997
autophagic vacuole assembly	GO:0000045	2	0.954	Rat
positive regulation of autophagy	GO:0010508	21	0.943
regulation of autophagy	GO:0010506	62	0.937
autophagy	GO:0006914	108	0.854
developmental programmed cell death	GO:0010623	138	0.812
programmed cell death	GO:0012501	257	0.770
negative regulation of phosphatidylinositol 3 kinase signaling	GO:0014067	4	0.708
cellular response to extracellular stimulus	GO:0031668	64	0.701
larval midgut cell programmed cell death	GO:0035096	19	0.694
cellular catabolic process	GO:0044248	372	0.683
regulation of cellular catabolic process	GO:0031329	157	0.677
cellular response to starvation	GO:0009267	61	0.648
death	GO:0016265	284	0.622
tissue death	GO:0016271	102	0.605
regulation of catabolic process	GO:0009894	170	0.501
regulation of tor signaling	GO:0032006	21	0.492
cellular response to nutrient levels	GO:0031669	62	0.424
growth	GO:0040007	359	0.404
cell death	GO:0008219	279	0.377
histolysis	GO:0007559	102	0.295
catabolic process	GO:0009056	409	0.294
response to nutrient levels	GO:0031667	114	0.287
response to extracellular stimulus	GO:0009991	116	0.285
response to starvation	GO:0042594	97	0.235
cellular response to external stimulus	GO:0071496	66	0.214
macroautophagy	GO:0016236	42	0.210	Rat
apoptotic process	GO:0006915	159	0.209
regulation of growth	GO:0040008	233	0.203
organelle assembly	GO:0070925	198	0.178	Rat
positive regulation of multicellular organismal process	GO:0051240	143	0.162
positive regulation of catabolic process	GO:0009896	105	0.161
endosome transport via multivesicular body sorting pathway	GO:0032509	12	0.159
positive regulation of macromolecule metabolic process	GO:0010604	405	0.147
lipid metabolic process	GO:0006629	121	0.137
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.136
tor signaling	GO:0031929	32	0.128
phosphorylation	GO:0016310	294	0.126
positive regulation of phosphate metabolic process	GO:0045937	139	0.113
salivary gland development	GO:0007431	162	0.106
regulation of developmental growth	GO:0048638	174	0.100
cell growth	GO:0016049	108	0.100
protein maturation	GO:0051604	71	0.098	Rat
vacuolar transport	GO:0007034	13	0.097
positive regulation of developmental process	GO:0051094	143	0.097
positive regulation of nurse cell apoptotic process	GO:0045850	5	0.095
cellular protein modification process	GO:0006464	438	0.095
organelle membrane fusion	GO:0090174	16	0.095
response to biotic stimulus	GO:0009607	294	0.092
salivary gland morphogenesis	GO:0007435	145	0.089
intracellular signal transduction	GO:0035556	300	0.088	Rat
protein modification process	GO:0036211	438	0.086
membrane organization	GO:0061024	112	0.085
endosomal transport	GO:0016197	44	0.083
autophagic vacuole fusion	GO:0000046	15	0.082
single organism membrane organization	GO:0044802	93	0.080
regulation of intracellular signal transduction	GO:1902531	236	0.079
salivary gland histolysis	GO:0035070	88	0.076
ribonucleoside metabolic process	GO:0009119	127	0.076
positive regulation of signaling	GO:0023056	243	0.075
regulation of multi organism process	GO:0043900	131	0.072
regulation of response to external stimulus	GO:0032101	115	0.072
regulation of cell death	GO:0010941	173	0.070
vacuole organization	GO:0007033	8	0.070	Rat
single organism intracellular transport	GO:1902582	207	0.070
regulation of response to biotic stimulus	GO:0002831	63	0.068
multicellular organism growth	GO:0035264	46	0.066
single organism membrane fusion	GO:0044801	42	0.064
response to other organism	GO:0051707	293	0.064
positive regulation of growth	GO:0045927	75	0.062
proteolysis	GO:0006508	192	0.061
positive regulation of cellular catabolic process	GO:0031331	95	0.061
exocrine system development	GO:0035272	162	0.060
carbohydrate derivative metabolic process	GO:1901135	217	0.060
negative regulation of signal transduction	GO:0009968	206	0.059
gland morphogenesis	GO:0022612	145	0.058
phosphatidylinositol mediated signaling	GO:0048015	4	0.057	Rat
macromolecular complex assembly	GO:0065003	256	0.056
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.055
epithelial cell differentiation	GO:0030855	322	0.054
negative regulation of cellular metabolic process	GO:0031324	382	0.053
insulin receptor signaling pathway	GO:0008286	25	0.053
regionalization	GO:0003002	416	0.052
aging	GO:0007568	143	0.051
negative regulation of rna metabolic process	GO:0051253	251	0.051
positive regulation of biosynthetic process	GO:0009891	316	0.050
positive regulation of rna biosynthetic process	GO:1902680	266	0.050
protein complex assembly	GO:0006461	200	0.050
positive regulation of phosphorus metabolic process	GO:0010562	139	0.049
regulation of cell growth	GO:0001558	43	0.049
organonitrogen compound metabolic process	GO:1901564	318	0.049
negative regulation of response to stimulus	GO:0048585	258	0.048
regulation of multicellular organism growth	GO:0040014	40	0.048
autophagic cell death	GO:0048102	83	0.048
positive regulation of programmed cell death	GO:0043068	62	0.048
salivary gland cell autophagic cell death	GO:0035071	83	0.047
endocytosis	GO:0006897	310	0.047
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.047
small molecule metabolic process	GO:0044281	305	0.047
negative regulation of growth	GO:0045926	84	0.045
multicellular organismal aging	GO:0010259	140	0.045
positive regulation of rna metabolic process	GO:0051254	271	0.044
mapk cascade	GO:0000165	107	0.043
establishment of protein localization to membrane	GO:0090150	11	0.042
positive regulation of signal transduction	GO:0009967	223	0.042
phosphatidylinositol 3 kinase signaling	GO:0014065	4	0.042
positive regulation of cellular biosynthetic process	GO:0031328	316	0.041
developmental growth	GO:0048589	280	0.041
vesicle organization	GO:0016050	44	0.041
vesicle fusion	GO:0006906	19	0.041
determination of adult lifespan	GO:0008340	137	0.041
positive regulation of cell communication	GO:0010647	250	0.041
cellular macromolecule catabolic process	GO:0044265	136	0.040
vesicle mediated transport	GO:0016192	381	0.040
regulation of phosphorus metabolic process	GO:0051174	210	0.040
single organism behavior	GO:0044708	391	0.040
regulation of defense response to virus	GO:0050688	14	0.039
regulation of programmed cell death	GO:0043067	152	0.039
regulation of mapk cascade	GO:0043408	92	0.037
regulation of apoptotic process	GO:0042981	130	0.037
regulation of nurse cell apoptotic process	GO:0045477	9	0.037
ribonucleotide metabolic process	GO:0009259	145	0.037
organic substance catabolic process	GO:1901575	308	0.036
positive regulation of gene expression	GO:0010628	290	0.036
ribose phosphate metabolic process	GO:0019693	145	0.035
regulation of cellular protein metabolic process	GO:0032268	243	0.035
inositol lipid mediated signaling	GO:0048017	4	0.035	Rat
positive regulation of developmental growth	GO:0048639	62	0.034
positive regulation of molecular function	GO:0044093	136	0.034
regulation of cell development	GO:0060284	215	0.034
regulation of catalytic activity	GO:0050790	185	0.034
cellular macromolecule localization	GO:0070727	220	0.033
cellular protein localization	GO:0034613	160	0.033
cytoplasmic transport	GO:0016482	130	0.033
regulation of immune system process	GO:0002682	176	0.033
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.032
response to oxidative stress	GO:0006979	86	0.032
single organism cellular localization	GO:1902580	180	0.032
regulation of multicellular organismal development	GO:2000026	414	0.031
cellular metal ion homeostasis	GO:0006875	31	0.031
cellular amino acid metabolic process	GO:0006520	61	0.031
regulation of epithelial cell proliferation	GO:0050678	4	0.031
organic acid metabolic process	GO:0006082	103	0.031
protein catabolic process	GO:0030163	101	0.031
macromolecule catabolic process	GO:0009057	161	0.031
lateral inhibition	GO:0046331	206	0.030
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.030
purine ribonucleoside metabolic process	GO:0046128	127	0.030
purine containing compound metabolic process	GO:0072521	155	0.029
establishment of localization in cell	GO:0051649	402	0.029	Rat
intracellular transport	GO:0046907	228	0.029
positive regulation of transcription dna templated	GO:0045893	266	0.028
positive regulation of mapk cascade	GO:0043410	63	0.028
positive regulation of response to stimulus	GO:0048584	323	0.028
positive regulation of multicellular organism growth	GO:0040018	21	0.027
early endosome to late endosome transport	GO:0045022	3	0.027
stress activated protein kinase signaling cascade	GO:0031098	55	0.027
oxoacid metabolic process	GO:0043436	103	0.027
regulation of localization	GO:0032879	275	0.027	Rat
organophosphate metabolic process	GO:0019637	195	0.027
regulation of phosphate metabolic process	GO:0019220	210	0.027
columnar cuboidal epithelial cell development	GO:0002066	249	0.027
maintenance of location	GO:0051235	73	0.027
cellular nitrogen compound catabolic process	GO:0044270	165	0.027
nucleoside triphosphate metabolic process	GO:0009141	120	0.027
cellular ion homeostasis	GO:0006873	39	0.026
protein complex biogenesis	GO:0070271	201	0.026
signal transduction by phosphorylation	GO:0023014	107	0.026
regulation of humoral immune response	GO:0002920	51	0.026
organic cyclic compound catabolic process	GO:1901361	168	0.026
positive regulation of tor signaling	GO:0032008	13	0.026
stress activated mapk cascade	GO:0051403	52	0.025
positive regulation of cell development	GO:0010720	61	0.025
guanosine containing compound metabolic process	GO:1901068	74	0.025
glycosyl compound metabolic process	GO:1901657	127	0.025
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.025
response to external biotic stimulus	GO:0043207	293	0.024
protein modification by small protein conjugation or removal	GO:0070647	106	0.024
phagocytosis	GO:0006909	215	0.024
nucleoside triphosphate catabolic process	GO:0009143	108	0.024
nucleobase containing compound catabolic process	GO:0034655	165	0.024
carboxylic acid metabolic process	GO:0019752	92	0.024
purine ribonucleotide metabolic process	GO:0009150	145	0.024
membrane budding	GO:0006900	4	0.024
response to oxygen containing compound	GO:1901700	200	0.023	Rat
nucleobase containing small molecule metabolic process	GO:0055086	174	0.023
lipoprotein biosynthetic process	GO:0042158	6	0.023
translation	GO:0006412	69	0.023
nucleoside metabolic process	GO:0009116	127	0.023
purine nucleotide metabolic process	GO:0006163	146	0.023
regulation of cytoskeleton organization	GO:0051493	89	0.022
negative regulation of cellular component organization	GO:0051129	108	0.022
positive regulation of phosphorylation	GO:0042327	87	0.022
negative regulation of organ growth	GO:0046621	15	0.022
single organism catabolic process	GO:0044712	228	0.022	Rat
mitochondrion degradation	GO:0000422	8	0.021
purine ribonucleotide catabolic process	GO:0009154	109	0.021
cellular ketone metabolic process	GO:0042180	24	0.021
response to organophosphorus	GO:0046683	2	0.021
protein modification by small protein conjugation	GO:0032446	79	0.021
cellular protein catabolic process	GO:0044257	83	0.021
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.021
gland development	GO:0048732	191	0.021
necrotic cell death	GO:0070265	1	0.021
lipid localization	GO:0010876	54	0.020
organonitrogen compound catabolic process	GO:1901565	128	0.020
regulation of immune response	GO:0050776	118	0.020
positive regulation of cell death	GO:0010942	69	0.020
protein processing	GO:0016485	68	0.020	Rat
neurological system process	GO:0050877	358	0.020
negative regulation of signaling	GO:0023057	219	0.020
negative regulation of multicellular organismal process	GO:0051241	142	0.020
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.019
positive regulation of apoptotic process	GO:0043065	47	0.019
positive regulation of intracellular signal transduction	GO:1902533	116	0.019
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.019
regulation of hydrolase activity	GO:0051336	97	0.019
regulation of proteolysis	GO:0030162	87	0.019
axon development	GO:0061564	297	0.018
protein lipidation	GO:0006497	6	0.018
oocyte construction	GO:0007308	112	0.018
establishment of protein localization	GO:0045184	163	0.018	Rat
negative regulation of epithelial cell proliferation	GO:0050680	4	0.018
negative regulation of cell proliferation	GO:0008285	69	0.018
regulation of phosphatidylinositol 3 kinase signaling	GO:0014066	4	0.018
guanosine containing compound catabolic process	GO:1901069	74	0.018
embryo development ending in birth or egg hatching	GO:0009792	152	0.018
protein localization	GO:0008104	284	0.017	Rat
cellular response to oxidative stress	GO:0034599	28	0.017
regulation of ras gtpase activity	GO:0032318	38	0.017
regulation of protein catabolic process	GO:0042176	55	0.017
hindbrain development	GO:0030902	2	0.017
heterocycle catabolic process	GO:0046700	166	0.017
purine nucleoside metabolic process	GO:0042278	127	0.017
phosphatidylinositol phosphorylation	GO:0046854	10	0.017
nucleotide metabolic process	GO:0009117	161	0.017
cellular cation homeostasis	GO:0030003	38	0.017
positive regulation of protein metabolic process	GO:0051247	128	0.017
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.017
actin cytoskeleton organization	GO:0030036	206	0.016
protein targeting to membrane	GO:0006612	2	0.016
cellular iron ion homeostasis	GO:0006879	3	0.016
regulation of defense response	GO:0031347	102	0.016
embryonic development via the syncytial blastoderm	GO:0001700	148	0.016
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.016
imaginal disc pattern formation	GO:0007447	91	0.016
oxidation reduction process	GO:0055114	123	0.016
purine containing compound catabolic process	GO:0072523	112	0.016
vesicle targeting to from or within golgi	GO:0048199	1	0.016
cellular response to chemical stimulus	GO:0070887	199	0.016
carbohydrate metabolic process	GO:0005975	82	0.016
cell type specific apoptotic process	GO:0097285	38	0.016
organic substance transport	GO:0071702	257	0.016
antimicrobial humoral response	GO:0019730	99	0.016
humoral immune response	GO:0006959	117	0.016
defense response to other organism	GO:0098542	225	0.015
proteasomal protein catabolic process	GO:0010498	59	0.015
cellular macromolecular complex assembly	GO:0034622	153	0.015
purine nucleoside catabolic process	GO:0006152	112	0.015
negative regulation of protein metabolic process	GO:0051248	85	0.015
positive regulation of cell differentiation	GO:0045597	64	0.015
small gtpase mediated signal transduction	GO:0007264	88	0.015
regulation of cell cycle	GO:0051726	291	0.015
transcription from rna polymerase ii promoter	GO:0006366	368	0.015
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.015
cellular response to insulin stimulus	GO:0032869	28	0.015
protein localization to organelle	GO:0033365	82	0.015
glycerolipid metabolic process	GO:0046486	34	0.015
protein transport	GO:0015031	155	0.015	Rat
purine nucleotide catabolic process	GO:0006195	109	0.015
protein ubiquitination	GO:0016567	70	0.014
negative regulation of developmental growth	GO:0048640	64	0.014
cellular protein complex assembly	GO:0043623	71	0.014
establishment or maintenance of cell polarity	GO:0007163	167	0.014
gtp metabolic process	GO:0046039	72	0.014
modification dependent protein catabolic process	GO:0019941	78	0.014
single organism carbohydrate metabolic process	GO:0044723	72	0.014
immune system process	GO:0002376	347	0.014
ion homeostasis	GO:0050801	55	0.014
protein localization to plasma membrane	GO:0072659	13	0.014
cellular amine metabolic process	GO:0044106	12	0.014
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.014
cellular calcium ion homeostasis	GO:0006874	21	0.014
ion transport	GO:0006811	145	0.014
membrane biogenesis	GO:0044091	8	0.014
epithelial cell development	GO:0002064	274	0.014
regulation of macroautophagy	GO:0016241	15	0.014
regulation of cell shape	GO:0008360	113	0.014
lipid storage	GO:0019915	38	0.014
cellular lipid metabolic process	GO:0044255	83	0.013
regulation of cellular component size	GO:0032535	98	0.013
positive regulation of reproductive process	GO:2000243	7	0.013
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.013
protein heterooligomerization	GO:0051291	4	0.013
gtp catabolic process	GO:0006184	72	0.013
telencephalon development	GO:0021537	2	0.013
establishment of protein localization to organelle	GO:0072594	62	0.013
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.013
axonogenesis	GO:0007409	290	0.013
endosome organization	GO:0007032	9	0.013	Rat
nucleoside phosphate catabolic process	GO:1901292	110	0.013
appendage development	GO:0048736	401	0.013
negative regulation of cell communication	GO:0010648	223	0.013
oocyte differentiation	GO:0009994	145	0.013
cellular response to nitrogen compound	GO:1901699	51	0.012
regulation of nucleotide metabolic process	GO:0006140	62	0.012
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.012
organonitrogen compound biosynthetic process	GO:1901566	117	0.012
rho protein signal transduction	GO:0007266	14	0.012
larval development	GO:0002164	104	0.012
wing disc morphogenesis	GO:0007472	344	0.012
positive regulation of cellular protein metabolic process	GO:0032270	118	0.012
protein phosphorylation	GO:0006468	169	0.012
oocyte development	GO:0048599	124	0.012
kidney development	GO:0001822	3	0.012
regulation of rac protein signal transduction	GO:0035020	3	0.012
negative regulation of intracellular signal transduction	GO:1902532	57	0.012
ras protein signal transduction	GO:0007265	88	0.012
endomembrane system organization	GO:0010256	119	0.012	Rat
golgi vesicle transport	GO:0048193	27	0.012
negative regulation of biosynthetic process	GO:0009890	277	0.012
membrane fusion	GO:0061025	42	0.012
cellular homeostasis	GO:0019725	80	0.012
ethanolamine containing compound metabolic process	GO:0042439	4	0.012
chromosome organization	GO:0051276	360	0.012
embryonic morphogenesis	GO:0048598	206	0.012
positive regulation of exocytosis	GO:0045921	4	0.012
somatic muscle development	GO:0007525	66	0.012
regulation of cellular amine metabolic process	GO:0033238	3	0.011
actin filament based process	GO:0030029	220	0.011
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.011
positive regulation of cell growth	GO:0030307	19	0.011
single organism membrane budding	GO:1902591	2	0.011
ovarian follicle cell development	GO:0030707	248	0.011
response to abiotic stimulus	GO:0009628	341	0.011
intracellular protein transport	GO:0006886	104	0.011
positive regulation of transport	GO:0051050	92	0.011
mitotic nuclear division	GO:0007067	213	0.011
ribonucleotide catabolic process	GO:0009261	109	0.011
ubiquitin dependent protein catabolic process	GO:0006511	78	0.011
innate immune response	GO:0045087	144	0.011
purine ribonucleoside catabolic process	GO:0046130	112	0.011
regulation of nucleoside metabolic process	GO:0009118	50	0.011
cation homeostasis	GO:0055080	51	0.011
cell maturation	GO:0048469	144	0.011
regulation of molecular function	GO:0065009	217	0.011
membrane invagination	GO:0010324	11	0.011
positive regulation of catalytic activity	GO:0043085	118	0.011
immune response	GO:0006955	246	0.011
establishment or maintenance of epithelial cell apical basal polarity	GO:0045197	24	0.011
positive regulation of cellular response to insulin stimulus	GO:1900078	4	0.011
protein kinase b signaling	GO:0043491	1	0.011
regulation of phosphorylation	GO:0042325	147	0.011
skeletal muscle fiber development	GO:0048741	3	0.011
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.011
glycosyl compound catabolic process	GO:1901658	112	0.011
positive regulation of hydrolase activity	GO:0051345	78	0.010
regulation of purine nucleotide catabolic process	GO:0033121	48	0.010
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway	GO:0043162	8	0.010
regulation of ras protein signal transduction	GO:0046578	93	0.010
organophosphate catabolic process	GO:0046434	112	0.010
smoothened signaling pathway	GO:0007224	49	0.010
protein localization to membrane	GO:0072657	19	0.010
nucleoside phosphate metabolic process	GO:0006753	162	0.010

Pi3K59F disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.017
disease of anatomical entity	DOID:7	0.013
cancer	DOID:162	0.013
nervous system disease	DOID:863	0.013

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