IMP: Integrative Multi-species Prediction

Drosophila melanogaster

111 known processes

lid (Dmel_CG9088)

little imaginal discs

(Aliases: Lid,dJARID1,l(2)10424,KDM5,CG9088,Dmel\CG9088)

FLYBASE: FBgn0031759
Entrez: 33837
UniProtKB: M9NEV0
UniProtKB: Q9VMJ7

Process Predictions
Disease Predictions

lid biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of transcription dna templated	GO:0045892	237	0.964	Human Mouse
gene silencing	GO:0016458	138	0.949
negative regulation of cellular biosynthetic process	GO:0031327	277	0.939	Human Mouse
regulation of gene expression epigenetic	GO:0040029	128	0.898
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.879	Human Mouse
negative regulation of gene expression	GO:0010629	387	0.803	Human Mouse
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.732	Human Mouse
regulation of gene silencing	GO:0060968	63	0.700
negative regulation of biosynthetic process	GO:0009890	277	0.691	Human Mouse
chromosome organization	GO:0051276	360	0.676
chromatin silencing	GO:0006342	76	0.670
circadian rhythm	GO:0007623	105	0.665
circadian behavior	GO:0048512	76	0.634
regulation of chromatin silencing	GO:0031935	36	0.603
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.587	Human Mouse
negative regulation of rna metabolic process	GO:0051253	251	0.584	Human Mouse
gene silencing by mirna	GO:0035195	22	0.575
negative regulation of signal transduction	GO:0009968	206	0.560
negative regulation of signaling	GO:0023057	219	0.533
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.515	Human Mouse
locomotor rhythm	GO:0045475	56	0.504
negative regulation of cellular metabolic process	GO:0031324	382	0.492	Human Mouse
dna metabolic process	GO:0006259	227	0.486
rhythmic behavior	GO:0007622	76	0.485
negative regulation of rna biosynthetic process	GO:1902679	240	0.483	Human Mouse
rhythmic process	GO:0048511	106	0.467
regulation of intracellular signal transduction	GO:1902531	236	0.453
neurological system process	GO:0050877	358	0.447
negative regulation of gene expression epigenetic	GO:0045814	77	0.446
peptidyl lysine modification	GO:0018205	57	0.442
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.397	Human Mouse
aggressive behavior	GO:0002118	63	0.380
gravitaxis	GO:0042332	26	0.373
central nervous system development	GO:0007417	201	0.372
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.360
inter male aggressive behavior	GO:0002121	60	0.342
histone deubiquitination	GO:0016578	8	0.335
negative regulation of cell communication	GO:0010648	223	0.333
positive regulation of biosynthetic process	GO:0009891	316	0.326
mitotic cell cycle embryonic	GO:0045448	38	0.319
positive regulation of cellular biosynthetic process	GO:0031328	316	0.295
regulation of cellular catabolic process	GO:0031329	157	0.289
positive regulation of transcription dna templated	GO:0045893	266	0.279
cellular catabolic process	GO:0044248	372	0.276
immune system process	GO:0002376	347	0.265
cellular macromolecular complex assembly	GO:0034622	153	0.253
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.248
dendrite morphogenesis	GO:0048813	199	0.243
histone h4 acetylation	GO:0043967	13	0.240
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.234
multi organism behavior	GO:0051705	175	0.234
single organism behavior	GO:0044708	391	0.224
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.222
response to abiotic stimulus	GO:0009628	341	0.215
macromolecular complex assembly	GO:0065003	256	0.215
chromatin organization	GO:0006325	207	0.214
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.214
hindbrain development	GO:0030902	2	0.210
ribonucleoprotein complex assembly	GO:0022618	23	0.206
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.203
chromatin modification	GO:0016568	147	0.202
autophagy	GO:0006914	108	0.191
intracellular protein transport	GO:0006886	104	0.178
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.177
response to gravity	GO:0009629	26	0.172
positive regulation of rna biosynthetic process	GO:1902680	266	0.169
locomotory behavior	GO:0007626	176	0.167
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.166
covalent chromatin modification	GO:0016569	106	0.164
protein alkylation	GO:0008213	43	0.152
body morphogenesis	GO:0010171	2	0.135
multicellular organismal aging	GO:0010259	140	0.131	Worm
catabolic process	GO:0009056	409	0.130
protein modification by small protein conjugation or removal	GO:0070647	106	0.130
ribonucleoprotein complex subunit organization	GO:0071826	28	0.126
negative regulation of response to stimulus	GO:0048585	258	0.123
death	GO:0016265	284	0.121	Zebrafish
negative regulation of chromatin silencing	GO:0031936	9	0.116
regulation of compound eye cone cell fate specification	GO:0042682	4	0.114
positive regulation of gene expression	GO:0010628	290	0.111
positive regulation of gene expression epigenetic	GO:0045815	16	0.108
positive regulation of rna metabolic process	GO:0051254	271	0.106
heterocycle catabolic process	GO:0046700	166	0.105
chromatin remodeling	GO:0006338	72	0.104
protein modification by small protein conjugation	GO:0032446	79	0.104
regulation of circadian rhythm	GO:0042752	49	0.099
transcription from rna polymerase ii promoter	GO:0006366	368	0.098
cellular protein catabolic process	GO:0044257	83	0.098
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.095
macromolecule catabolic process	GO:0009057	161	0.092
mitotic spindle organization	GO:0007052	220	0.092
negative regulation of notch signaling pathway	GO:0045746	41	0.092
gene silencing by rna	GO:0031047	57	0.091
regulation of molecular function	GO:0065009	217	0.090	Mouse
dendrite development	GO:0016358	204	0.087
histone modification	GO:0016570	106	0.087
regulation of stem cell proliferation	GO:0072091	40	0.085
negative regulation of stem cell proliferation	GO:2000647	30	0.083
response to radiation	GO:0009314	155	0.082
organic substance catabolic process	GO:1901575	308	0.081
protein ubiquitination	GO:0016567	70	0.077
cellular macromolecule catabolic process	GO:0044265	136	0.077
response to alcohol	GO:0097305	95	0.077
methylation	GO:0032259	47	0.073
immune system development	GO:0002520	57	0.068
mitotic cell cycle phase transition	GO:0044772	138	0.068
negative regulation of neuroblast proliferation	GO:0007406	27	0.065
dna methylation	GO:0006306	4	0.063
internal protein amino acid acetylation	GO:0006475	38	0.063
nuclear division	GO:0000280	332	0.062
dorsal ventral pattern formation	GO:0009953	133	0.059
single organism catabolic process	GO:0044712	228	0.059
dosage compensation	GO:0007549	16	0.059
mrna metabolic process	GO:0016071	124	0.057
dna methylation or demethylation	GO:0044728	4	0.057
regulation of protein ubiquitination	GO:0031396	22	0.057
rna catabolic process	GO:0006401	37	0.057
aging	GO:0007568	143	0.057	Worm
chromatin mediated maintenance of transcription	GO:0048096	7	0.055
jak stat cascade	GO:0007259	49	0.054
posttranscriptional gene silencing by rna	GO:0035194	45	0.054
cellular response to dna damage stimulus	GO:0006974	223	0.053
negative regulation of apoptotic process	GO:0043066	63	0.051	Zebrafish
regulation of mitotic cell cycle	GO:0007346	190	0.051
cellular response to organic cyclic compound	GO:0071407	32	0.050
regulation of neuroblast proliferation	GO:1902692	34	0.049
protein targeting to nucleus	GO:0044744	51	0.049
startle response	GO:0001964	16	0.047
positive regulation of cell death	GO:0010942	69	0.047
dna damage checkpoint	GO:0000077	78	0.047
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.046
telomere maintenance	GO:0000723	21	0.046
purine ribonucleotide metabolic process	GO:0009150	145	0.045
r7 cell differentiation	GO:0045466	43	0.045
chromosome condensation	GO:0030261	41	0.044
anatomical structure homeostasis	GO:0060249	97	0.043
cell death	GO:0008219	279	0.043	Zebrafish
regulation of cell cycle phase transition	GO:1901987	130	0.043
head development	GO:0060322	135	0.043
phagocytosis	GO:0006909	215	0.043
dna alkylation	GO:0006305	4	0.040
eye photoreceptor cell fate commitment	GO:0042706	37	0.040
meiotic chromosome segregation	GO:0045132	59	0.039
regionalization	GO:0003002	416	0.039
cellular response to light stimulus	GO:0071482	37	0.038
aromatic compound catabolic process	GO:0019439	166	0.038
protein complex assembly	GO:0006461	200	0.038
organic substance transport	GO:0071702	257	0.038
regulation of erbb signaling pathway	GO:1901184	42	0.038
regulation of nucleocytoplasmic transport	GO:0046822	35	0.038
translation	GO:0006412	69	0.038
negative regulation of cell cycle phase transition	GO:1901988	103	0.037
taxis	GO:0042330	304	0.037
mrna catabolic process	GO:0006402	33	0.037
small gtpase mediated signal transduction	GO:0007264	88	0.037
stem cell proliferation	GO:0072089	88	0.037
compound eye photoreceptor fate commitment	GO:0001752	36	0.036
histone acetylation	GO:0016573	38	0.036
regulation of protein metabolic process	GO:0051246	256	0.036	Mouse
nuclear envelope organization	GO:0006998	7	0.036
mitotic nuclear division	GO:0007067	213	0.035
signal transduction in response to dna damage	GO:0042770	3	0.035
positive regulation of chromatin silencing	GO:0031937	16	0.034
establishment of localization in cell	GO:0051649	402	0.034
regulation of cell differentiation	GO:0045595	302	0.034
rna processing	GO:0006396	147	0.034
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.034
programmed cell death	GO:0012501	257	0.033	Zebrafish
regulation of hydrolase activity	GO:0051336	97	0.033	Mouse
posttranscriptional gene silencing	GO:0016441	46	0.033
negative regulation of chromosome segregation	GO:0051985	14	0.033
protein acylation	GO:0043543	42	0.033
cellular response to external stimulus	GO:0071496	66	0.032
localization of cell	GO:0051674	257	0.032
negative regulation of cellular protein metabolic process	GO:0032269	85	0.032	Mouse
neuromuscular process	GO:0050905	21	0.032
positive regulation of cellular catabolic process	GO:0031331	95	0.032
regulation of cell proliferation	GO:0042127	163	0.032
r1 r6 cell differentiation	GO:0048052	4	0.031
long term memory	GO:0007616	62	0.031
regulation of chromosome organization	GO:0033044	64	0.031	Mouse
cell aging	GO:0007569	2	0.031
compound eye cone cell fate commitment	GO:0042676	5	0.031
cellular protein complex assembly	GO:0043623	71	0.031
cellular response to organic substance	GO:0071310	132	0.030
ribonucleoprotein complex biogenesis	GO:0022613	31	0.030
positive regulation of macromolecule metabolic process	GO:0010604	405	0.030
larval development	GO:0002164	104	0.030	Worm
neuron fate commitment	GO:0048663	50	0.028
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.028
cell proliferation	GO:0008283	299	0.027
chemosensory behavior	GO:0007635	106	0.027
endocytosis	GO:0006897	310	0.027
male courtship behavior veined wing generated song production	GO:0045433	20	0.027
imaginal disc derived appendage development	GO:0048737	399	0.027
syncytial blastoderm mitotic cell cycle	GO:0035186	21	0.027
apoptotic process	GO:0006915	159	0.027	Zebrafish
small molecule metabolic process	GO:0044281	305	0.027
exocrine system development	GO:0035272	162	0.026
regulation of proteolysis	GO:0030162	87	0.026
female meiotic division	GO:0007143	70	0.025
posttranscriptional regulation of gene expression	GO:0010608	145	0.024
nuclear pore organization	GO:0006999	1	0.024
photoreceptor cell fate commitment	GO:0046552	41	0.024
cellular nitrogen compound catabolic process	GO:0044270	165	0.024
neuroblast proliferation	GO:0007405	74	0.024
compound eye development	GO:0048749	307	0.023
humoral immune response	GO:0006959	117	0.023
cell cycle checkpoint	GO:0000075	95	0.023
negative regulation of intracellular signal transduction	GO:1902532	57	0.023
response to sterol	GO:0036314	34	0.022
dna integrity checkpoint	GO:0031570	81	0.022
protein modification process	GO:0036211	438	0.022
brain development	GO:0007420	120	0.021
nucleocytoplasmic transport	GO:0006913	72	0.021
negative regulation of catabolic process	GO:0009895	36	0.021
cellular response to abiotic stimulus	GO:0071214	58	0.021
regulation of mrna processing	GO:0050684	71	0.021
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.021
ubiquitin dependent protein catabolic process	GO:0006511	78	0.021
single organism biosynthetic process	GO:0044711	206	0.021
ribose phosphate metabolic process	GO:0019693	145	0.020
positive regulation of molecular function	GO:0044093	136	0.020
response to extracellular stimulus	GO:0009991	116	0.020
compound eye cone cell differentiation	GO:0042675	13	0.020
signal transduction by p53 class mediator	GO:0072331	6	0.020
negative regulation of cell death	GO:0060548	81	0.020	Zebrafish
mitotic dna integrity checkpoint	GO:0044774	75	0.020
macromolecule methylation	GO:0043414	45	0.020
oviposition	GO:0018991	19	0.020
response to starvation	GO:0042594	97	0.019
regulation of cytoplasmic transport	GO:1903649	47	0.019
appendage morphogenesis	GO:0035107	397	0.019
regulation of cell development	GO:0060284	215	0.019
regulation of catabolic process	GO:0009894	170	0.019
nucleus organization	GO:0006997	45	0.019
male courtship behavior veined wing vibration	GO:0016545	21	0.018
organic cyclic compound catabolic process	GO:1901361	168	0.018
positive regulation of cell cycle	GO:0045787	43	0.018
telomere organization	GO:0032200	21	0.018
mrna splicing via spliceosome	GO:0000398	73	0.018
meiotic chromosome condensation	GO:0010032	3	0.018
negative regulation of cell cycle process	GO:0010948	109	0.017
regulation of cell fate commitment	GO:0010453	29	0.017
ribonucleoside metabolic process	GO:0009119	127	0.017
organelle localization	GO:0051640	148	0.017
negative regulation of protein metabolic process	GO:0051248	85	0.017	Mouse
regulation of protein targeting	GO:1903533	29	0.017
purine containing compound catabolic process	GO:0072523	112	0.017
protein import	GO:0017038	55	0.017
regulation of nucleobase containing compound transport	GO:0032239	4	0.017
histone h3 acetylation	GO:0043966	11	0.017
cellular response to oxidative stress	GO:0034599	28	0.017
axon guidance	GO:0007411	233	0.016
dna recombination	GO:0006310	32	0.016
response to nitrogen compound	GO:1901698	90	0.016
regulation of mrna metabolic process	GO:1903311	72	0.016
negative regulation of translation	GO:0017148	28	0.016
g2 m transition of mitotic cell cycle	GO:0000086	19	0.016
growth	GO:0040007	359	0.016
icosanoid biosynthetic process	GO:0046456	1	0.015
mesenchymal cell development	GO:0014031	1	0.015
imaginal disc derived wing morphogenesis	GO:0007476	337	0.015
determination of adult lifespan	GO:0008340	137	0.015	Worm
positive regulation of protein deacetylation	GO:0090312	2	0.015
ncrna metabolic process	GO:0034660	43	0.015
regulation of translation	GO:0006417	56	0.015
translesion synthesis	GO:0019985	2	0.015
protein complex biogenesis	GO:0070271	201	0.015
male courtship behavior veined wing extension	GO:0048065	22	0.015
negative regulation of neural precursor cell proliferation	GO:2000178	27	0.015
chromosome segregation	GO:0007059	157	0.014
purine nucleotide catabolic process	GO:0006195	109	0.014
regulation of autophagy	GO:0010506	62	0.014
response to organic substance	GO:0010033	284	0.014
response to oxidative stress	GO:0006979	86	0.014
regulation of chromatin modification	GO:1903308	28	0.014	Mouse
cell motility	GO:0048870	251	0.014
response to other organism	GO:0051707	293	0.014
sex differentiation	GO:0007548	81	0.014
regulation of organelle organization	GO:0033043	196	0.014	Mouse
glycosyl compound metabolic process	GO:1901657	127	0.014
mrna processing	GO:0006397	104	0.014
positive regulation of apoptotic process	GO:0043065	47	0.014
positive regulation of programmed cell death	GO:0043068	62	0.014
protein processing	GO:0016485	68	0.014
regulation of chromosome segregation	GO:0051983	32	0.014
eggshell chorion gene amplification	GO:0007307	9	0.014
negative regulation of mitotic cell cycle	GO:0045930	109	0.014
protein transport	GO:0015031	155	0.014
organelle fission	GO:0048285	340	0.013
negative regulation of erk1 and erk2 cascade	GO:0070373	3	0.013
protein acetylation	GO:0006473	39	0.013
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	16	0.013
secretion	GO:0046903	109	0.013
modification dependent macromolecule catabolic process	GO:0043632	79	0.013
negative regulation of developmental process	GO:0051093	201	0.013
regulation of glial cell differentiation	GO:0045685	1	0.013
response to organic cyclic compound	GO:0014070	89	0.013
positive regulation of ion transmembrane transporter activity	GO:0032414	4	0.013
regulation of localization	GO:0032879	275	0.013
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.013
single organism cellular localization	GO:1902580	180	0.012
regulation of protein complex assembly	GO:0043254	42	0.012
wing disc pattern formation	GO:0035222	66	0.012
mesenchymal cell differentiation	GO:0048762	1	0.012
regulation of notch signaling pathway	GO:0008593	100	0.012
protein import into nucleus	GO:0006606	51	0.012
positive regulation of catalytic activity	GO:0043085	118	0.012
cellular response to ketone	GO:1901655	17	0.012
positive regulation of catabolic process	GO:0009896	105	0.012
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.012
filtration diaphragm assembly	GO:0036058	4	0.012
pigment cell differentiation	GO:0050931	3	0.012
hematopoietic or lymphoid organ development	GO:0048534	57	0.012
sensory perception of mechanical stimulus	GO:0050954	72	0.012
cell fate determination	GO:0001709	91	0.012
cell cycle phase transition	GO:0044770	140	0.012
wing disc morphogenesis	GO:0007472	344	0.012
regulation of catalytic activity	GO:0050790	185	0.012	Mouse
reproductive behavior	GO:0019098	122	0.012
nucleoside metabolic process	GO:0009116	127	0.012
protein methylation	GO:0006479	43	0.012
response to nutrient levels	GO:0031667	114	0.012
camera type eye development	GO:0043010	4	0.012
antennal development	GO:0007469	25	0.012
sensory organ precursor cell fate determination	GO:0016360	19	0.012
histone h4 k16 acetylation	GO:0043984	4	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.011
male meiosis chromosome segregation	GO:0007060	10	0.011
proteolysis	GO:0006508	192	0.011
response to ketone	GO:1901654	34	0.011
response to decreased oxygen levels	GO:0036293	58	0.011
ommochrome biosynthetic process	GO:0006727	19	0.011
appendage development	GO:0048736	401	0.011
regulation of programmed cell death	GO:0043067	152	0.011	Zebrafish
mitotic cell cycle checkpoint	GO:0007093	88	0.011
regulation of protein import into nucleus	GO:0042306	28	0.011
dna templated transcription initiation	GO:0006352	25	0.011
embryonic development via the syncytial blastoderm	GO:0001700	148	0.011
spliceosomal complex assembly	GO:0000245	1	0.011
regulation of transport	GO:0051049	181	0.011
muscle fiber development	GO:0048747	12	0.011
multi organism reproductive behavior	GO:0044705	121	0.011
regulation of nurse cell apoptotic process	GO:0045477	9	0.011
cytoplasmic mrna processing body assembly	GO:0033962	10	0.011
regulation of secretion	GO:0051046	44	0.011
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.011
male meiosis i	GO:0007141	9	0.010
nuclear transport	GO:0051169	72	0.010
regulation of neurogenesis	GO:0050767	158	0.010
protein dna complex subunit organization	GO:0071824	86	0.010
cellular response to hydrogen peroxide	GO:0070301	7	0.010
smad protein import into nucleus	GO:0007184	11	0.010
immune response	GO:0006955	246	0.010
transcription elongation from rna polymerase ii promoter	GO:0006368	18	0.010
positive regulation of peptidase activity	GO:0010952	29	0.010

lid disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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